Best herbs for managing diabetes: A review of clinical studies

Brazilian Journal of Pharmaceutical Sciences

Volumn 49, Issue 3, 2013, Pages 413-422

  Ghorbani, Ahmad ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Diabetes clinical trials; Diabetes treatment; Medicinal plants diabetes treatment

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIDIABETIC AGENT; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; GLIBENCLAMIDE; GLUCOSE; GYMNEMA SYLVESTRE EXTRACT; HEMOGLOBIN A1C; HERBACEOUS AGENT; HIGH DENSITY LIPOPROTEIN; INSULIN; LOW DENSITY LIPOPROTEIN; METFORMIN; MOMORDICA CHARANTIA EXTRACT; PLACEBO; PLANT EXTRACT; ROSIGLITAZONE; SALACIA RETICULATE EXTRACT; SILYMARIN; SULFONYLUREA; TRIGONELLA FOENUM GRAECUM EXTRACT; UNCLASSIFIED DRUG; VEGETABLE OIL; VERY LOW DENSITY LIPOPROTEIN;

AEGLE MARMELOS; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTIDIABETIC ACTIVITY; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLACK CUMIN; CHOLESTEROL BLOOD LEVEL; DIABETES MELLITUS; DIABETIC RETINOPATHY; DIET SUPPLEMENTATION; DIET THERAPY; DRUG DOSE REDUCTION; FENUGREEK; FRUIT; GINSENG; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLYCEMIC CONTROL; GYMNEMA SYLVESTRE; HEART INFARCTION; HEMOGLOBIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; LIPOPROTEIN BLOOD LEVEL; METABOLIC SYNDROME X; MOMORDICA CHARANTIA; NON INSULIN DEPENDENT DIABETES MELLITUS; OCIMUM TENUIFLORUM; ONION; PANAX QUINQUEFOLIUS; PLANT LEAF; PLANT SEED; PLANT STEM; REVIEW; SALACIA; SALACIA RETICULATE; SILYBUM MARIANUM; SINGLE DRUG DOSE; TREATMENT DURATION; TREATMENT RESPONSE;

EID: 84887147624     PISSN: 19848250     EISSN: 21759790     Source Type: Journal    
DOI: 10.1590/S1984-82502013000300003     Document Type: Review

References (64)

1. Abdel-Barry, J.A.; Abdel-Hassan, I.A.; Jawad, A.M.; Al-Hakiem, M.H. Hypoglycaemic effect of aqueous extract of the leaves of Trigonella foenum-graecum in healthy volunteers. East Mediterr. Health J., v.6, p.83-88, 2000.
2. AGRAWAL, P.; RAI, V.; SINGH, R.B. Randomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus. Int. Clin. Pharmacol. Ther., v.34, p.406-409, 1996.
3. AHMAD, N.; HASSAN, M.R.; HALDER, H.; BENNOOR, K.S. Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients. Bangladesh Med. Res. Counc. Bull., v.25, p.11-13, 1999.
4. Al-Romaiyan, A.; Al-Romaiyan, A.; LIU, B.; Asare-Anane, H.; MAITY, C.R.; CHATTERJEE, S.K.; KOLEY, N.; BISWAS, T.; CHATTERJI, A.K.; HUANG, G.C.; AMIEL, S.A.; PERSAUD, S.J.; JONES, P.M. A novel Gymnema sylvestre extract stimulates insulin secretion from human islets in vivo and in vitro. Phytother. Res., v.24, p.1370-1376, 2010.
5. BALDWA, V.S.; BHANDARI, C.M.; PANGARIA, A.; GOYAL, R.K. Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant source. Upsala J. Med. Sci., v.82, p.39-41, 1977.
6. BAMOSA, A.O.; KAATABI, H.; LEBDA, F.M.; ELQ, A.M.A.; Al-Sultan, A. Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian J. Physiol. Pharmacol., v.54, p.344-354, 2010.
7. Baskaran, K.; Ahamath, K.; Shanmugasundaram, K.R.; Shanmugasundaram, E.R.B. Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J. Ethnopharmacol., v.30, p.295-305, 1990.
8. BILAL, A.; MASUD, T.; UPPAL, A.M.; NAVEED, A.K. Effects of Nigella sativa oil on some blood parameters in type 2 diabetes mellitus patients. Asian J. Chem., v.21, p.5373-5381, 2009.
9. BLEVINS, S.M.; LEYVA, M.J.; BROWN, J.; WRIGHT, J.; SCOFIELD, R.H.; ASTON, C.E. Effect of cinnamon on glucose and lipid levels in non insulin-dependent type 2 diabetes. Diabetes Care, v.30, p.2236-2237, 2007.
10. CRAWFORD, P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J. Am. Board Fam. Med., v.22, p.507-512, 2009.
11. DANS, A.M.L.; VILLARRUZ, M.V.C.; JIMENO, C.A.; JAVELOSA, M.A.U.; CHUA, J.; BAUTISTA, R.; VELEZ, G.G.B. The effect of Momordica charantia capsule preparation on glycemic control in Type 2 Diabetes Mellitus needs further studies. J. Clin. Epidemiol., v.60, p.554-549, 2007.
12. DESHPANDE, A.D.; Harris-Hayes, M.; SCHOOTMAN, M. Epidemiology of diabetes and diabetes-related complications. Phys. Ther., v.88, p.1254-1264, 2008.
13. DIXIT, N.; BABOOTA, S.; KOHLI, K.; AHMAD, S.; ALI, J. Silymarin: a review of pharmacological aspects and bioavailability enhancement approaches. Indian J. Pharmacol., v.39, p.172-179, 2007.
14. ELDIN, I.M.T.; AHMED, E.M.; ABD ELWAHAB, H.M. Preliminary study of the clinical hypoglycemic effects of Allium cepa (red onion) in type 1 and type 2 diabetic patients. Env. Health Insights, v.4, p.71-77, 2010.
15. FALLAH HOSEINI, H.; LARIJANI, B.; HESHMAT, R.; FAKHRZADEH, H.; RADJABIPOUR, B.; TOLIAT, T.; RAZA, M. The efficacy of Silybum marianum (L.) gaertn. (Silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial. Phytother. Res., v.20, p.1036-1039, 2006.
16. Fu-Rong, L.; LIN, S.; YOU, Q.; LAN, G.; HENG, L.; YI, D. Clinical observation on Trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus. Chin. J. Integr. Med., v.14, p.56-60, 208.
17. FUANGCHAN, A.; SONTHISOMBAT, P.; SEUBNUKARN, T.; CHANOUAN, T.; CHOTCHAISUWAT, P.; SIRIGULSATIEN, V.; INGKANINAN, K.; PLIANBANGCHANG, P.; HAINES, S.T. Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients. J. Ethnopharmacol., v.134, p.422-428, 2011.
18. GHORBANI, A.; RAKHSHANDEH, H. The most effective herbs for diabetes. Mashhad: Mashhad University of Medical Sciences Publisher, p.21-127, 2012.
19. GHORBANI, A.; VAREDI, M.; HADJZADEH, M.R.; OMRANI, G.H. Type-1 diabetes induces depot-specifc alterations in adipocyte diameter and mass of adipose tissues in the rat. Exp. Clin. Endocrinol. Diabetes., v.118, p.442-448, 2010.
20. GROVER, J.K.; GUPTA, S.R. Hypoglycemic activity of seeds of Momordica charantia. Eur. J. Pharmacol., v.183, p.1026-1027, 1990.
21. GUPTA, A.; GUPTA, R.; LAL, B. Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study. J. Assoc. Physicians India, v.49, p.1057-1061, 2001.
22. HUSSAIN, S.A.R. Silymarin as an adjunct to glibenclamide therapy improves long-term and postprandial glycemic control and body mass index in type 2 diabetes. J. Med. Food., v.10, p.543-547, 2007.
23. ISMAIL, M.Y.M. Clinical evaluation of antidiabetic activity of Trigonella seeds and Aegle marmelos leaves. World Appl. Sci. J., v.7, p.1231-1234, 2009a.
24. ISMAIL, M.Y.M. Clinical evaluation of antidiabetic activity of Bael leaves. World Appl. Sci. J., v.6, p.1518-1520, 2009b.
25. JAYAWARDENA, M.H.S.; ALWIS, N.M.W.; HETTIGODA, V.; FERNANDO, D.J.S. A double blind randomised placebo controlled cross over study of a herbal preparation containing Salaciareticulata in the treatment of type 2 diabetes. J. Ethnopharmacol., v.97, p.215-218, 2005.
26. JOFFE, D.J.; FREED, S.H. Effect of extended release Gymnema sylvestre leaf extract alone or in combination with oral hypoglycemics or insulin regimens for type 1 and type 2 diabetes. Diabetes Control Newsletter, v.76, p.30. 2001.
27. JOSE, M.A.; ABRAHAM, A.; NARMADHA, M.P. Effect of silymarin in diabetes mellitus patients with liver disease. J. Pharmacol. Pharmacother., v.2, p.287-289, 2011.
28. KAJIMOTO, O.; KAWAMORI, S.; SHIMODA, H.; KAWAHARA, Y.; HIRATA, H.; TAKAHASHI, T. Effects of a diet containing Salacia reticulata on mild type 2 diabetes in humans. A placebo-controlled, cross-over trial. J. Jpn. Soc. Nutr. Food Sci., v.53, p.199-205, 2000.
29. KASSAIAN, N.; AZADBAKHT, L.; FORGHANI, B.; AMINI, M. Effect of fenugreek seeds on blood glucose and lipid profles in type 2 diabetic patients. Int. J. Vitam. Nutr. Res., v.79, p.34-39, 2009.
30. KHAN, R.; KHAN, Z.; SHAH, S.H. Cinnamon may reduce glucose, lipid and cholesterol level in type 2 diabetic individuals. Pakistan J. Nut., v.9, p.430-433, 2010.
31. KHANNA, P.; JAIN, S.C.; PANAGARIYA, A.; DIXIT, V.P. Hypoglycemic activity of polypeptide-p from a plant source. J. Nat. Prod., v.44, p.648-655, 1981.
32. KOCHHAR, A.; SHARMA, N.; SCHDEVA, R. Effect of supplementation of tulsi (Ocimum sanctum) and neem (Azadirachta indica) leaf powder on diabetic symptoms, anthropometric parameters and blood pressure of non insulin dependent male diabetics. Ethno-Med., v.3, p.5-9, 2009.
33. LEATHERDALE, B.A.; PANESAR, R.K.; SINGH, G.; ATKINS, T.W.; BAILEY, C.J.; BIGNELL, A.H.C. Improvement in glucose tolerance due to momordica charantia (karela). Brit. Med. J., v.282, p.1823-1824, 1981.
34. LORENZATI, B.; ZUCCO, C.; MIGLIETTA, S.; LAMBERTI, F.; BRUNO, G. Oral hypoglycemic drugs: pathophysiological basis of their mechanism of action. Pharmaceuticals, v.3, p.3005-3020, 2010.
35. MATHEW, P.T.; AUGUSTI, K.T. Hypoglycaemic effects of onion, allium cepa linn. on diabetes mellitus - a preliminary report. Indian J. Physiol. Pharmacol., v.19, p.213-217, 1975.
36. MANG, B.; WOLTERS, M.; SCHMITT, B.; KELB, K.; LICHTINGHAGEN, R.; STICHTENOTH, D.O.; HAHN, A. Effects of a cinnamon extract on plasma glucose, HbA1c, and serum lipids in diabetes mellitus type 2. Eur. J. Clin. Invest., v.36, p.340-344, 2006.
37. MEHTA, B.K.; PANDIT, V.; GUPTA, M. New principles from seeds of Nigella sativa. Nat. Prod. Res., v.23, p.138-148, 2009.
38. MITRA, A.; BHATTACHARYA, D. Dose-dependent effects of fenugreek composite in diabetes with dyslipidaemia. Int. J. Food Safety, v.8, p.49-55, 2006.
39. MIZUNO, C.S.; RIMANDO, A.M. Blueberries and metabolic syndrome. Silpakorn U. Sci. Tech. J., v.3, p.7-17, 2009.
40. MYINT, Z.; HTUN, H.L.; THWIN, T.; MAR, T.T.; NEW, M.M.; OO, A.M.; MAW, L.Z.; OO, T.K.K.; KYAW, M.T. Acute effect of onion (Allium cepa) on blood glucose level of diabetic patients. Myanmar Health Sci. Res., v.21, p.22-25, 2009.
41. NAJMI, A.; HAQUE, S.F.; KHAN, R.A.; NASIRUDDIN, M. Therapeutic Effect of Nigella Sativa oil on different clinical and biochemical parameters in metabolic syndrome. Int. J. Diabetes Metabol., v.16, p.85-87, 2009.
42. Paliwal, R.; Kathori, S.; Upadhyay, B. Effect of Gurmar (Gymnema sylvestre) powder intervention on the blood glucose levels among diabetics. Ethno-Med., v.3, p.133-135, 2009.
43. QIDWAI, W.; HAMZA, HB.; QURESHI, R.; GILANI, A. Effectiveness, safety, and tolerability of powdered Nigella sativa (Kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial. J. Alt. Compl. Med. v.15, p.639-644, 2009.
44. RADHA, R.; AMRITHAVENI, M. Role of medicinal plant Salacia Reticulata in the management of type II diabetic subjects. Ancient. Sci. Life, v.29, p.14-16, 2009.
45. RAHMAN, I.; MALIK, S.A.; BASHIR, M.; KHAN, R.; IQBAL, M. Serum sialic acid changes in non-insulin-dependant diabetes mellitus (NIDDM) patients following bitter melon (Momordica charantia) and rosiglitazone (Avandia) treatment. Phytomed., v.16, p.401-405, 2009.
46. RAI, V.; MANI, U.V.; IYER, U.M. Effect of Ocimum sanctum leaf powder in blood lipoproteins, glycated proteins and total amino acids in patients with non-insulin-dependent diabetes mellitus. J. Nut. Env. Med., v.7, p.113-118, 1997.
47. RAMEZANI, M.; AZAR ABADI, M.; FALAH HOSSEINI, H.; ABDI, H.; BAHER, G.R.; HOSSEINI, M.A.S. The effect of Silybum marinum (L.) gaertn. Seed extract on glycemic control in type II diabetic patient's candidate for insulin therapy visiting endocrinology clinic in Baqiyatallah hospital in the years of 2006. J. Med. Plants, v.7, p.79-84, 2008.
48. REEDS, DN.; PATTERSON, B.W.; OKUNADE, A.; HOLLOSZY, J.O.; POLONSKY, K.S.; KLEIN, S. Ginseng and ginsenoside Re do not improve β-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes. Diabetes Care, v.34, p.1071-1076, 2011.
49. SANKHLA, A.; SHARMA, S.; SHARMA, N. Hypoglycemic effect of bael patra (Aegle Marmelos) in NIDDM paients. J. Dairying Food H.S., v.28, p.233-236, 2009.
50. Shafiee-Nick, R.; GHORBANI, A.; VAFAEE, F.; RAKHSHANDEH, H. Chronic administration of a combination of six herbs inhibits the progression of hyperglycemia and decreases serum lipids and aspartate amino transferase activity in diabetic rats. Adv. Pharmacol. Sci., v.2012, 2012.
51. SHANMUGASUNDARAM, E.R.B.; RAJESWARI, G.; BASKARAN, K.; KUMAR, B.R.R.; SHANMUGASUNDARAM, K.R.; AHMATH, B.K. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J. Ethnopharmacol., v.30, p.281-294, 1990.
52. SHARMA, R.D. Effect of fenugreek seeds and leaves on blood glucose and serum insulin responses in human subjects. Nutr. Res., v.6, p.1353-1364, 1986.
53. SHARMA, R.D.; RAGHURAN, T.C. Hypoglycaemic effect of fenugreek seeds in non-insulin dependent diabetic subjects. Nutr. Res., v.10, p.731-739, 1990a.
54. SHARMA, R.D.; RAGHURAN, T.C.; RAO, N.S. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur. J. Clin. Nutr., v.44, p.301-306, 1990b.
55. SIRVASTAVA, Y.; Venkatakrishna-Bhatt, H.; VERMA, Y.; VENKAIAH, K. Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation. Phytother. Res., v.7, p.285-289, 1993.
56. SOTANIEMI, E.A.; HAAPAKOSKI, E.; RAUTIO, A. Ginseng therapy in non-insulin-dependent diabetic patients. Diabetes Care, v.18, p.1373-1375, 1995.
57. SUPPAPITIPORN, S.; KANPAKSI, N. The effect of cinnamon cassia powder in type 2 diabetes mellitus. J. Med. Assoc. Thai., v.89, p.S200-205, 2006.
58. TZOULAKI, I.; MOLOKHIA, M.; CURCIN, V.; LITTLE, M.P.; MILLETT, C.J.; NG, A.; HUGHES, R.I.; KHUNTI, K.; WILKINS, M.R.; MAJEED, A.; ELLIOTT, P. Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database. BMJ, v.339, p.b4731, 2009.
59. VELUSSI, M.; CERNIGOI, A.M.; De Monte, A.; DAPAS, F.; CAFFAU, C.; ZILLI, M. Long-term (12 months) treatment with an anti-oxidant drug (silymarin) is effective on hyperinsulinemia, exogenous insulin need and malondialdehyde levels in cirrhotic diabetic patients. J. Hepatol., v.26, p.871-879, 1997.
60. VELUSSI, M.; CERNIGOI, A.M.; VIEZZOLI, L.; DAPAS, F.; CAFFAU, C.; ZILLI, M. SILYMARIN reduces hyperinsulinemia, malondialdehyde levels, and daily insulin needs in cirrhotic diabetic patients. Curr. Ther. Res., v.53, p.533-545, 1993.
61. VUKSAN, V.; SIEVENPIPER, J.L.; KOO, V.Y.Y.; FRANCIS, T.; Beljan-Zdravkovic, U.; XU, Z.; VIDGEN, E. American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch. Intern. Med., v.160, p.1009-1013, 2000a.
62. VUKSAN, V.; STAVRO, M.P.; SIEVENPIPER, J.L.; Beljan-Zdravkovic, U.; LEITER, L.A.; JOSSE, R.G.; XU, Z. Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes mellitus. Diabetes Care, v.23, p.1221-1226, 2000b.
63. WAHEED, A.; MIANA, G.A.; SHARAFATULLAH, T.; AHMAD, S.I. Clinical investigation of hypoglycemic effect of unripe fruit on Momordica charantia in type-2 (NIDDM) diabetes mellitus. Pakistan J. Pharmacol., v.25, p.7-12, 2008.
64. WELHINDA, J.; KARUNANAYAKE, E.H.; SHERIFF, M.H.H.; JAYASINGHE, K.S.A. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J. Ethnopharmacol., v.17, p.277-282, 1986.