Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus

Phytomedicine

Volumn 14, Issue 9, 2007, Pages 621-627

  Hosseinzadeh, Hossein ^a   Parvardeh, Siavash ^b   Asl, Marjan Nassiri ^b   Sadeghnia, Hamid R ^b   Ziaee, Toktam ^b  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

ischemia reperfusion; lipid peroxidation; Nigella sativa; rat; thymoquinone

Indexed keywords

MALONALDEHYDE; NIGELLA SATIVA EXTRACT; PHENYTOIN; SODIUM CHLORIDE; THIOBARBITURIC ACID; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THYMOQUINONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL OCCLUSION; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; HIPPOCAMPUS; LIPID PEROXIDATION; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; BENZOQUINONES; BRAIN ISCHEMIA; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; LIPID PEROXIDATION; MALE; NEUROPROTECTIVE AGENTS; NIGELLA SATIVA; PHYTOTHERAPY; PLANT OILS; RATS; RATS, INBRED STRAINS; SEEDS;

ANIMALIA; NIGELLA SATIVA; RATTUS;

EID: 34547395342     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2006.12.005     Document Type: Article

References (51)

1. Abdel-Fattah A.F.M., Matsumoto K., and Watanabe H. Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, in mice. Eur. J. Pharmacol. 400 (2000) 89-97
2. Al-Ghamdi M.S. The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. J. Ethnopharmacol. 76 (2001) 45-48
3. Al-Gharably N.M., Badary O.A., Nagi M.N., Al-Sawaf H.A., Al-Rikabi A.C., and Al-Bekairi A.M. Protective effect of thymoquinone against carbon tetrachloride-induced hepatotoxicity in mice. Res. Commun. Pharmacol. Toxicol. 2 (1997) 41-50
4. Ali B.H., and Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother. Res. 17 (2003) 299-305
5. Badary O.A., and Gamal A.M. Inhibitory effects of thymoquinone against 20-methylcholantherene-induced fibrosarcoma tumorigenesis. Cancer Detec. Prev. 25 (2001) 362-368
6. Badary O.A., Nagi M.N., Al-Shabanah O.A., Al-Shawaf H.A., Al-Sohaibani M.O., and Al-Bekairi A.M. Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity. Can. J. Physiol. Pharmacol. 75 (1997) 1356-1361
7. Badary O.A., Al-Shabanah O.A., Nagi M.N., Al Bakairi A.M., and Elmazar M.M.A. Acute and subchronic toxicity of thymochinone in mice. Drug Dev. Res. 44 (1998) 56-61
8. Badary O.A., Al-Shabanah O.A., Nagi M.N., Al-Rikabi A.C., and Almazar M.M.A. Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone. Eur. J. Cancer Prev. 8 (1999) 435-440
9. Burits M., and Bucar F. Antioxidant activity of Nigella sativa essential oil. Phytother. Res. 14 (2000) 323-328
10. Cheeseman K.H. Mechanisms and effects of lipid peroxidation. Mol. Aspects Med. 14 (1993) 191-197
11. Daba M.H., and Abdel-Rahman M.S. Hepatoprotective activity of thymoquinone in isolated rat hepatocytes. Toxicol. Lett. 95 (1998) 23-29
12. Dubinsky J.M., Kristal B.S., and Elizondo-Fournier M. An obligate role for oxygen in the early stages of glutamate-induced, delayed neuronal death. J. Neurosci. 15 (1995) 7071-7078
13. El-Abhar H.S., Abdallah M., and Saleh S. Gastroprotective activity of Nigella sativa oil and its constituent, thymoquinone, against gastric mucosal injury induced by ischaemia-reperfusion in rats. J. Ethnopharmacol. 84 (2003) 251-258
14. El-Dakhakhny M., Mady N.I., and Halim M.A. Nigella sativa L. protects against induced hepatotoxicity and improves serum lipid profile in rats. Arzneimittelforsch 50 (2000) 832-836
15. El Daly E.S. Protective effect of cysteine and vitamin E, Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in rats. J. Pharm. Bel. 53 (1998) 87-95
16. Fernandez J., Perez-Alvarez J.A., and Fernandez-lopez J.A. Thiobarbituric acid test for monitoring lipid oxidation in meat. Food Chem. 99 (1997) 345-353
17. Fisher M. Stroke Therapy. second ed. (2001), Butter worth-Heinemann pp. 25-50
18. Gilgun-Sherki Y., Rosenbaum Z., Melamed E., and Offen D. Antioxidant therapy in acute central nervous system injury: current state. Pharm. Rev. 54 (2002) 271-284
19. Hassan M., and El-Dakhakhny M. Effect of some Nigella sativa constituents on chemical carcinogenesis in hamster cheek pouch. J. Egypt. Soci. Pharmacol. Exp. Ther. 11 (1992) 675-677
20. Houghton P.I., Zarka R., De las Heras B., and Hoult J.R.S. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med. 61 (1995) 33-36
21. Hsieh C.L., Chang C.H., Chiang S.Y., Li T.C., Tang N.Y., Pon C.Z., Hsieh C.T., and Lin J.G. Anticonvulsive and free radical scavenging activities of vanillyl alcohol in ferric chloride-induced epileptic seizures in Sprague-Dawley rats. Life Sci. 67 (2000) 1185-1195
22. Hsieh C.L., Chiang S.Y., Cheng K.S., Lin Y.H., Tang N.Y., Lee C.J., Pon C.Z., and Hsieh C.T. Anticonvulsive and free radical scavenging activities of Gastrodia elata Bl in kainic acid-treated rats. Am. J. Chin. Med. 29 (2001) 331-341
23. Kanter M., Coskun O., and Budancamanak M. Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats. World J. Gastroenterol. 11 (2005) 6684-6688
24. Kanter M., Coskun O., Kalayci M., Buyukbas S., and Cagavi F. Neuroprotective effects of Nigella sativa on experimental spinal cord injury in rats. Hum. Exp. Toxicol. 25 (2006) 127-133
25. Kaptanoglu E., Solaroglu I., Surucu H.S., Akbiyik F., and Beskonakli E. Blockade of sodium channels by phenytoin protects ultrastructure and attenuates lipid peroxidation in experimental spinal cord injury. Acta Neurochir. (Wien) 147 (2005) 405-412
26. Khanna T., Zaidi F.A., and Dandiya P.C. CNS and analgesic studies on Nigella sativa. Fitoterapia 5 (1993) 407-410
27. Lampley Jr. E.C., Mishra O.P., Graham E., and Delivoria-Papadopoulos M. Neuroprotective effect of phenytoin against in utero hypoxic brain injury in fetal guinea pigs. Neurosci. Lett. 186 (1995) 192-196
28. Love S. Oxidative stress in brain ischemia. Brain Pathol. 9 (1999) 119-131
29. Mahgoub A.A. Thymoquinone protects against experimental colitis in rats. Toxicol. Lett. 143 (2003) 133-143
30. Mahmood M.S., Gilani A.H., Khwaja A., Rashid A., and Ashfaq M.K. The in vitro effect of aqueous extract of Nigella sativa seeds on nitric oxide production. Phytother. Res. 17 (2003) 921-924
31. Mansour M.A., Ginawi O.T., El-Hadiyah T., El-Khatib A.S., Al-Shabanah O.A., and Al-Sawaf H.A. Effects of volatile oil constituents of Nigella sativa on carbon tetrachloride-induced hepatotoxicity in mice: evidence for antioxidant effects of thymoquinone. Res. Commun. Mol. Pathol. Pharmacol. 110 (2001) 239-251
32. Mansour M.A., Nagi M.N., El-Khatib A.S., and Al-Bekairi A.M. Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action. Cell Biochem. Funct. 20 (2002) 143-151
33. Mutabagani A., and El-Mahdi S.M. A study of the anti-inflammatory activity of Nigella sativa L. and thymoquinone in rats. Saudi Pharmacol. J. 5 (1997) 110-113
34. Nagi M.N., Alam K., Badary O.A., al-Shabanah O.A., al-Sawaf H.A., and al-Bekairi A.M. Thymoquinone protects against carbon tetrachloride hepatotoxicity in mice via an antioxidant mechanism. Biochem. Mol. Biol. Int. 47 (1999) 153-159
35. Nair S.C., Salomi M.J., Panikkar B., and Panikkar K.P. Modulatory effects of Crocus sativus and Nigella sativa extracts on cisplatininduced toxicity in mice. J. Ethnopharmacol. 31 (1991) 16-20
36. Nickavar B., Mojab F., Javidnia K., and Amoli M.A. Chemical composition of the fixed and volatile oils of Nigella sativa L. from Iran. Z. Naturforsch [C] 58 (2003) 629-631
37. Paradis V., Mathurin P., Kollinger M., Imbert-Bismut F., Charlotte F., Piton A., Opolon P., Holstege A., Poynard T., and Bedossa P. In situ detection of lipid peroxidation in chronic hepatitis C: correlation with pathological features. J. Clin. Pathol. 50 (1997) 401-406
38. Parvardeh S., and Fatehi M. Effects of thymoquinone, the major constituent of Nigella sativa seeds, on the contractile responses of rat vas deferens. Pharmac. Biol. 41 (2003) 616-621
39. Patel M., Day B.J., Crapo J.D., Fridovich I., and McNamara J.O. Requirement for superoxide in excitotoxic cell death. Neuron 16 (1996) 345-355
40. Pulsinelli W.A., and Brierley J.B. A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke 10 (1979) 267-272
41. Pulsinelli W.A., and Buchan A.M. The four-vessel occlusion rat model: method for complete occlusion of vertebral arteries and control of collateral circulation. Stroke 19 (1988) 913-914
42. Salomi N.J., Nair S.C., and Panikkar L.R. Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis. Cancer Lett. 63 (1991) 41-46
43. Salomi N.J., Nair S.C., Jayawardhanan K.K., Varghese C.D., and Panikkar L.R. Anti-tumor principles from Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice. Nutr. Cancer 16 (1992) 67-72
44. Streck E.L., Vieira P.S., Wannmacher C.M.D., Dutra-Filho C.S., Wajner M., and Wyse A.T.S. In vitro effect of homocysteine on some parameters of oxidative stress in rat hippocampus. Metab. Brain Dis. 18 (2003) 147-154
45. Sun, A.Y., Chen, Y.M., 1998. Oxidative stress and neurodegenerative disorders. J. Biomed. Sci. 401-414.
46. Turkdogan M.K., Agaoglu Z., Yener Z., Sekeroglu R., Akkan H.A., and Avci M.E. The role of antioxidant vitamins (C and E), selenium and Nigella sativa in the prevention of liver fibrosis and cirrhosis in rabbits, new hopes. Dtscch. Tierarzt. Wschr. 108 (2000) 71-73
47. Wang X.W., Zhang J.L., Zhou C.M., Wang X.F., Liu W.J., and Zhang K.J. Anti-lipid peroxidation and protective effects of phenytoin sodium on ischemic myocardium of mice. Zhongguo Yao Li Xue Bao 13 (1992) 531-534
48. Werz M.A., and Macdonald R.L. Dynorphin reduces voltage-dependent calcium conductance of mouse dorsal root ganglion neurons. Neuropeptides 5 (1984) 253-256
49. Werz M.A., and Macdonald R.L. Dynorphin and neoendorphin peptides decrease dorsal root ganglion neuron calcium-dependent action potential duration. J. Pharmacol. Exp. Ther. 234 (1985) 49-56
50. White B.C., Sullivan J.M., DeGracia D.J., O'Neil B.J., Neumar R.W., Grossman L.I., Rafols J.A., and Krause G.S. Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J. Neuro. Sci. 179 (2000) 1-33
51. Worthen D.R., Ghosheh O.A., and Crooks P.A. The in vitro anti-tumor activity of some crude and purified components of blackseed Nigella sativa L. Anticancer Res. 18 (1998) 1527-1532