Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E2P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump

Biochimica et Biophysica Acta - Biomembranes

Volumn 1808, Issue 10, 2011, Pages 2413-2420

  Mahmmoud, Yasser A ^a   Christensen, S Brøgger ^b  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Anthroyl ouabain; Linoleic acid; Na,K ATPase; Nigella Sativa; Oleic acid; Ouabain affinity

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; ANTHROYLOUABAIN; CARDIAC GLYCOSIDE; GAMMA LINOLENIC ACID; LINOLEIC ACID; OLEIC ACID; OUABAIN; POTASSIUM ION; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; BLACK CUMIN; CONTROLLED STUDY; ENZYME CONFORMATION; ENZYME STABILITY; HYDROLYSIS; PRIORITY JOURNAL; PROTEIN INTERACTION; REGULATORY MECHANISM;

ANIMALS; CARDIAC GLYCOSIDES; LINOLEIC ACID; NIGELLA SATIVA; OLEIC ACID; PROTEIN CONFORMATION; SODIUM-POTASSIUM-EXCHANGING ATPASE; SWINE;

NIGELLA SATIVA; STROPHANTHUS GRATUS; SUIDAE;

EID: 79960655137     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2011.06.025     Document Type: Article

References (50)

1. W. Kühlbrandt Biology, structure and mechanism of P-type ATPases Nat. Rev. 5 2004 282 295 (Pubitemid 38480609)
2. J.H. Kaplan Na,K-ATPase Ann. Rev. Biochem. 71 2002 511 535
3. J.M. Shin, K. Munson, O. Vagin, and G. Sachs The gastric HK-ATPase: structure, function, and inhibition Pflugers Arch. 457 2009 609 622
4. D.J. Newman, and G.M. Cragg Natural products as sources of new drugs over the last 25 years J. Nat. Prod. 70 2007 461 477 (Pubitemid 46595760)
5. I. Prassas, and E.P. Diamandis Novel therapeutic applications of cardiac glycosides Nat. Rev. Drug Discov. 7 2008 926 935
6. L. Yatime, M.J. Buch-Pedersen, M. Musgaard, J.P. Morth, A.M.L. Winther, B.P. Pedersen, C. Olesen, J.P. Andersen, B. Vilsen, B. Schiott, M.G. Palmgren, J.V. Møller, P. Nissen, and N. Fedosova P-type ATPases as drug targets: tools for medicine and science Biochim. Biophys. Acta 1787 2009 207 220
7. S.B. Christensen, D.M. Skytte, S.R. Denmeade, C. Dionne, J.V. Moller, P. Nissen, and J.T.A. Isaacs Trojan horse in drug development: targeting of thapsigargins towards prostate cancer cells Anticancer Agents Med. Chem. 9 2009 276 294
8. B.H. Ali, and G. Blunden Pharmacological and toxicological properties of Nigella sativa Phytother. Res. 17 2003 299 305 (Pubitemid 36565330)
9. 2+-ATPase J. Biol. Chem. 283 2008 21418 21426
10. +-ATPase inhibitors from acute volume-expanded hog plasma J. Biol. Chem. 260 1985 9672 9677 (Pubitemid 16245396)
11. S. Terés, G. Barceló-Coblijn, M. Benet, R. Álvarez, R. Bressani, and J.E. Halver Escribá, oleic acid content is responsible for the reduction in blood pressure induced by olive oil Proc. Natl. Acad. Sci. USA 105 2008 13811 13816
12. I. Dostanic-Larson, J.W. Van Huysse, J.N. Lorenz, and J.B. Lingrel The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation Proc. Natl. Acad. Sci. USA 102 2005 15845 15850 (Pubitemid 41552830)
13. I. Klodos, M. Esmann, and R.L. Post Large-scale preparation of sodium-potassium ATPase from kidney outer medulla Kidney Int. 62 2002 2097 2100 (Pubitemid 35366163)
14. E.S. Baginsky, P.P. Foa, and B. Zak Micro determination of inorganic phosphate, phospholipids, and total phosphate in biological materials Clin. Chim. Acta 13 1967 326 332
15. L. Ernster, and O. Lindberg Determination of organic phosphorus compounds by phosphate analysis Methods Biochem. Anal. 3 1956 1 22
16. + occlusion, and inhibition of hydrolytic activity Br. J. Pharmacol. 245 2005 236 245 (Pubitemid 40756528)
17. M. Shani, R. Goldschleger, and S.J. Karlish Rb occlusion in renal Na,K-ATPase characterized with a simple manual assay Biochim. Biophys. Acta 904 1987 13 21
18. P.A.G. Fortes Anthroylouabain: a specific fluorescent probe for the cardiac glycoside receptor of the Na,K-ATPase Biochemistry 16 1977 531 540 (Pubitemid 8036389)
19. Y.A. Mahmmoud Curcumin is a lipid-dependent inhibitor of the Na,K-ATPase that likely interacts at the protein-lipid interface Biochim. Biophys. Acta 1808 2011 466 473
20. K. Ahmed, and B.S. Thomas The effects of long chain fatty acids on sodium potassium ion stimulated adenosine triphosphatase of rat brain J. Biol. Chem. 246 1971 103 109
21. A.C. Swann Free fatty acids and (Na+, K+)-ATPase: effects on cation regulation, enzyme conformation, and interactions with ethanol Arch. Biochem. Biophys. 233 1984 354 361 (Pubitemid 14015613)
22. N. Farman Na, K-pump expression and distribution in the nephron Miner. Electrolyte Metab. 22 1996 272 278
23. L. Segall, L.K. Lane, and R. Blostein New insights into the role of the N terminus in conformational transitions of the Na,K-ATPase J. Biol. Chem. 277 2002 35202 35209
24. A.G. Therien, and R. Blostein K(+)/Na(+) antagonism at cytoplasmic sites of Na(+)-K(+)-ATPase: a tissue-specific mechanism of sodium pump regulation Am. J. Physiol. 277 1999 C891 C898
25. R.P. Garay, and P.J. Garrahan The interaction of sodium and potassium with the sodium pump in red cells J. Physiol. 231 1973 297 325
26. A. Yoda, and S. Yoda Interacion between ouabain and the phosphorylated intermediate of Na,K-ATPase Mol. Pharmacol. 22 1982 700 705 (Pubitemid 13201829)
27. B. Forbush III Cardiotonic steroid binding to Na,K-ATPase Curr. Topics Memb. Transport 19 1983 167 201
28. R.L. Post, G. Toda, and F.N. Rogers Phosphorylation by inorganic phosphate of sodium plus potassium ion transport adenosine triphosphatase J. Biol. Chem. 250 1975 691 701
29. N.U. Fedosova, F. Cornelius, and I. Klodos E2P phosphoforms of Na,K-ATPase. I. Comparosin of phosphointermediates formed from ATP and Pi by their reactivity toward hydroxylamine and vanadate Biochemistry 37 1998 13634 13642 (Pubitemid 28455538)
30. F. Cornelius, N.U. Fedosova, and I. Klodos E2P phosphoforms of Na,K-ATPase. II. Interaction of substrate and cation-binding sites in Pi phosphorylation of Na,K-ATPase Biochemistry 37 1998 16686 16696 (Pubitemid 28543929)
31. A. Askari, W.H. Huang, and P.W. McCormick Na, K-dependent adenosine triphosphatase. Regulation of inorganic phosphate, magnesium ions, and calcium ion interactions with the enzyme J. Biol. Chem. 258 1983 3453 3460 (Pubitemid 13055758)
32. K. Taniguchi, K. Suzuku, and S. Iida Conformational change accompanying transition of ADP-sensitive phosphoenzyme to potassium-sensitive phosphoenzyme of (Na+, K+)-ATPase modified with N-[p-(2-benzimidazolyl)phenyl]maleimide J. Biol. Chem. 257 1982 10159 10667
33. J.C. Skou The Na,K-pump Meth. Enzymol. 156 1988 1 25
34. Y.A. Mahmmoud, G. Cramb, A.B. Maunsbach, C.P. Cutler, L. Meischke, and F. Cornelius Regulation of Na,K-ATPase by PLMS, the phospholemman-like protein from shark: molecular cloning, sequence, expression, cellular distribution, and functional effects of PLMS J. Biol. Chem. 278 2003 37427 37438 (Pubitemid 37175263)
35. M. Liang, J. Tian, L. Liu, S. Pierre, J. Liu, J.I. Shapiro, and Z. Xie Identification of a pool of non-pumping Na/K-ATPase J. Biol. Chem. 282 2007 10585 10593 (Pubitemid 47093457)
36. Y. Chen, T. Cai, H. Wang, Z. Li, E. Loreaux, J.B. Lingrel, and Z. Xie Regulation of intracellular cholesterol distribution by Na/K-ATPase J. Biol. Chem. 284 2009 14881 14890
37. Z. Li, T. Cai, J. Tian, J.X. Xie, X. Zhao, L. Liu, J.I. Shapiro, and Z. Xie NKAtide, a Na/K-ATPase derived peptide Src inhibitor, antagonizes ouabain activated signal transduction in cultured cells J. Biol. Chem. 284 2009 21066 21076
38. H. Ogawa, T. Shinoda, F. Cornelius, and C. Toyoshima Crystal structure of the sodium-potassium pump (Na,K-ATPase) with bound potassium and ouabain Proc. Natl. Acad. Sci. USA 106 2009 13742 13747
39. L.C. Cantley Jr., L.G. Cantley, and L. Josephson A characterization of vanadate interaction with the Na,K-ATPase. Mechanistic and regulatory implications J. Biol. Chem. 253 1978 7361 7368 (Pubitemid 9045220)
40. J.D. Robinson, and R.W. Mercer Vanadate binding to the Na,K-ATPase J. Bioenerg. Biomemb. 13 1981 205 218
41. + J. Biol. Chem. 262 1987 110 115 (Pubitemid 17235639)
42. G. Liu, Z. Xie, N.N. Modyanov, and A. Askari Restoration of phosphorylation capacity to the dormant half of the α-subunits of Na,K-ATPase FEBS Lett. 390 1996 323 326 (Pubitemid 26248969)
43. R.J. Clarke, and D.J. Kane Two gears of pumping by the sodium pump Biophys. J. 93 2007 4187 4196 (Pubitemid 350294467)
44. G. Ustun, L. Kent, N. Cekin, and H. Civelekoglu Investigation of the technological properties of Nigella sativa (Black cumin) seed oil J. Am. Oil Chem. Soc. 67 1990 958 960
45. A. Benzaria, N. Meskini, M. Dubois, M. Croset, G. Némoz, M. Lagarde, and A.F. Prigent Effect of dietary argan oil on fatty acid composition, proliferation, and phospholipase D activity in rat myocytes Nutrition 22 2006 628 637
46. S.J. Tucker, and T. Baukrowitz How highly charged anionic lipids bind and regulate ion channels J. Gen. Physiol. 131 2008 431 438 (Pubitemid 351620100)
47. A.G. Lee The effects of lipids on channel function J. Biol. 8 2009 86
48. G.M. Reaven, C.B. Hollenbeck, C.Y. Jeng, M.S. Wu, and Y.D. Chen Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM Diabetes 37 1988 1020 1024 (Pubitemid 19033579)
49. G. Paolisso, P. Gualdiero, D. Manzella, M.R. Rizzo, M.R. Tagliamonte, A. Gambardella, M. Verza, S. Gentile, M. Varricchio, and F. D'Onofrio Association of fasting plasma free fatty acid concentration and frequency of ventricular premature complexes in nonischemic non-insulin-dependent diabetic patients Am. J. Cardiol. 80 1997 932 937 (Pubitemid 27459171)
50. J.B. Lingrel The physiological significance of the cardiotonic steroid/ouabain-binding site of the Na,K-ATPase Annu. Rev. Physiol. 72 2010 395 412