Flexible stoichiometry and asymmetry of the PIDDosome core complex by heteronuclear NMR spectroscopy and mass spectrometry

Journal of Molecular Biology

Volumn 427, Issue 4, 2015, Pages 737-752

  Nematollahi, Lily A ^a   Garza Garcia, Acely ^a   Bechara, Chérine ^b   Esposito, Diego ^a   Morgner, Nina ^b   Robinson, Carol V ^b   Driscoll, Paul C ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

death domain; ILV labeling; protein complex; spectral complexity; TROSY NMR

Indexed keywords

CASPASE 2; CRADD PROTEIN; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; P53 INDUCED DEATH DOMAIN PROTEIN; PROTEIN; UNCLASSIFIED DRUG; CRADD PROTEIN, HUMAN; MULTIPROTEIN COMPLEX; PIDD PROTEIN, HUMAN;

AMINO ACID SEQUENCE; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DISSOCIATION; ELECTROSPRAY MASS SPECTROMETRY; GEL PERMEATION CHROMATOGRAPHY; HETERONUCLEAR NUCLEAR MAGNETIC RESONANCE; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HUMAN; MASS SPECTROMETRY; MOLECULAR WEIGHT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; STOICHIOMETRY; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PROTEIN TERTIARY STRUCTURE; ULTRASTRUCTURE; X RAY CRYSTALLOGRAPHY;

ISLA VISTA VIRUS;

AMINO ACID SEQUENCE; CRADD SIGNALING ADAPTOR PROTEIN; CRYSTALLOGRAPHY, X-RAY; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; HUMANS; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84922348019     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2014.11.021     Document Type: Article

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