Using artificial microRNA sponges to achieve microRNA loss-of-function in cancer cells

Advanced Drug Delivery Reviews

Volumn 81, Issue , 2015, Pages 117-127

  Tay, Felix Chang ^a   Lim, Jia Kai ^b   Zhu, Haibao ^a   Hin, Lau Cia ^a   Wang, Shu ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

Author keywords

Cancer studies; MiRNA loss of function; MiRNA sponge; Oncogenic and tumor suppressive miRNA; Plasmid and viral delivery

Indexed keywords

BINDING SITES; DISEASES; DNA; GENE EXPRESSION; GENE THERAPY; RATIONAL FUNCTIONS; TUMORS; VECTORS;

ARTIFICIAL MICRORNA; CANCER DEVELOPMENT; CANCER STUDIES; HIGH LEVEL EXPRESSION; MIRNA SPONGE; ONCOGENIC AND TUMOR-SUPPRESSIVE MIRNA; PLASMID AND VIRAL DELIVERY; THERAPEUTIC STRATEGY;

RNA;

MICRORNA; MICRORNA SPONGE; POLYMER; UNCLASSIFIED DRUG; VIRUS VECTOR; MESSENGER RNA;

ANTINEOPLASTIC ACTIVITY; BACULOVIRIDAE; BINDING AFFINITY; BINDING SITE; CANCER CELL; CANCER INHIBITION; DRUG CYTOTOXICITY; DRUG DESIGN; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOSS; GENE VECTOR; HUMAN; LOSS OF FUNCTION MUTATION; NONHUMAN; REVIEW; RNA BINDING; TUMOR SUPPRESSOR GENE; VIRAL GENE DELIVERY SYSTEM; VIRUS IDENTIFICATION; ADMINISTRATION AND DOSAGE; ANIMAL; GENE SILENCING; GENETICS; METABOLISM; NEOPLASMS; PLASMID; PROMOTER REGION;

ANIMALS; BINDING SITES; GENE KNOCKDOWN TECHNIQUES; GENETIC VECTORS; HUMANS; MICRORNAS; NEOPLASMS; PLASMIDS; PROMOTER REGIONS, GENETIC; RNA, MESSENGER;

EID: 84922336562     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2014.05.010     Document Type: Review

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