Age-dependent increase of heme oxygenase-1 gene expression in the liver mediated by NFκB

Mechanisms of Ageing and Development

Volumn 114, Issue 1, 2000, Pages 49-60

  Lavrovsky, Yan ^a   Song, Chung S ^a   Chatterjee, Bandana ^a,b   Roy, Arun K ^a  

^a Univ Texas Hlth Sci Ctr 7703 F ^*  (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

Aging; Heme oxygenase 1; Nuclear factor B; Reactive oxidative species; Transcriptional regulation

Indexed keywords

HEME OXYGENASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; REACTIVE OXYGEN METABOLITE;

AGE; AGING; ANIMAL CELL; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; ENZYME INDUCTION; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LIVER; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

ANIMALS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HUMANS; ISOENZYMES; LIVER; MEMBRANE PROTEINS; NF-KAPPA B; PROMOTER REGIONS (GENETICS); RATS; RATS, INBRED F344; TUMOR CELLS, CULTURED;

EID: 0034701113     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(00)00087-7     Document Type: Article

References (43)

1. Abraham N.G., Lavrovsky Y., Schwartzman M.L. et al. Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity. Proc. Natl. Acad. Sci. USA. 92:1995;6798-6802.
2. Barlow C., Dennery P.A., Shigenaga M.K. et al. Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs. Proc. Natl. Acad. Sci. USA. 96:1999;9915-9919.
3. Bergeron M., Ferriero D.M., Sharp F.R. Developmental expression of heme oxygenase-1 (HSP32) in rat brain: an immunocytochemical study. Brain Res. Dev. Brain Res. 105:1998;181-194.
4. Berlett B.S., Stadtman E.R. Protein oxidation in aging, disease and oxidative stress. J. Biol. Chem. 272:1997;20313-20316.
5. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
6. Dennery P.A., Spitz D.R., Yang G. et al. Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2. J. Clin. Invest. 101:1998;1001-1011.
7. Dore S., Takahashi M., Ferris C.D. et al. Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury. Proc. Natl. Acad. Sci. USA. 96:1999;2445-2450.
8. Eisenstein R.S., Garcia-Mayol D., Pettingell W., Munro H.N. Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron. Proc. Natl. Acad. Sci. USA. 88:1991;688-692.
9. Fogg S., Agarwal A., Nick H.S., Visner G.A. Iron regulates hyperoxia-dependent human heme oxygenase 1 gene expression in pulmonary endothelial cells. Am. J. Respir. Cell Mol. Biol. 20:1999;797-804.
10. Harman D. The aging process. Proc. Natl. Acad. Sci. USA. 78:1981;7124-7128.
11. Helenius M., Hanninen M., Lehtinen S.K., Salminen A. Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NFκB transcription factor in mouse cardiac muscle. J. Mol. Cell Cardiol. 28:1996;487-498.
12. Iijima N., Tamada Y., Hayashi S. et al. Expanded expression of heme oxygenase-1 (HO-1) in the hypothalamic median eminence of aged as compared with young rats: an immunocytochemical study (In process citation). Neurosci. Lett. 271:1999;113-116.
13. Ishii N., Fujii M., Hartman P.S. et al. A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes. Nature. 394:1998;694-697.
14. Khan A.U., Wilson T. Reactive oxygen species as cellular messengers. Chem. Biol. 2:1995;437-445.
15. Kurata S., Matsumoto M., Nakajima H. Transcriptional control of the heme oxygenase gene in mouse M1 cells during their TPA-induced differentiation into macrophages. J. Cell Biochem. 62:1996;314-324.
16. Lavrovsky Y., Schwartzman M.L., Levere R.D., Kappas A., Abraham N.G. Identification of binding sites for transcription factors NFκB and AP-2 in the promoter region of the human heme oxygenase 1 gene. Proc. Natl. Acad. Sci. USA. 91:1994;5987-5991.
17. Lavrovsky Y., Drummond G.S., Abraham N.G. Downregulation of the human heme oxygenase gene by glucocorticoids and identification of 56b regulatory elements. Biochem. Biophys. Res. Commun. 218:1996;759-765.
18. Li N., Karin M. Is NFκB the sensor of oxidative stress? FASEB. J. 13:1999;1137-1143.
19. Maines M.D. The heme oxygenase system: a regulator of second messenger gases. Annu. Rev. Pharmacol. Toxicol. 37:1997;517-554.
20. McCoubrey W.K., Huang T.J., Maines M.D. Heme oxygenase-2 is a hemoprotein and binds heme through heme regulatory motifs that are not involved in heme catalysis. J. Biol. Chem. 272:1997;12568-12574.
21. Mireles L.C., Lum M.A., Dennery P.A. Antioxidant and cytotoxic effects of bilirubin on neonatal erythrocytes. Pediatr. Res. 45:1999;355-362.
22. Muller J.M., Rupec R.A., Baeuerle P.A. Study of gene regulation by NFκB and AP-1 in response to reactive oxygen intermediates. Methods. 11:1997;301-312.
23. Ni A., Chao L., Chao J. Transcription factor nuclear factor κB regulates the inducible expression of the human B1 receptor gene in inflammation. J. Biol. Chem. 273:1998;2784-2791.
24. Oliver C.N., Ahn B.W., Moerman E.J., Goldstein S., Stadtman E.R. Age-related changes in oxidized proteins. J. Biol. Chem. 262:1987;5488-5491.
25. Orr W.C., Sohal R.S. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science. 263:1994;1128-1130.
26. Poss K.D., Tonegawa S. Reduced stress defense in heme oxygenase 1-deficient cells. Proc. Natl. Acad. Sci. USA. 94:1997;10925-10930.
27. Poynter M.E., Daynes R.A. Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor κB signaling and reduces inflammatory cytokine production in aging. J. Biol. Chem. 273:1998;32833-32841.
28. Rahman A., Anwar K.N., True A.L., Malik A.B. Thrombin-induced p65 homodimer binding to downstream NFκB site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion. J. Immunol. 162:1999;5466-5476.
29. Reeve V.E., Tyrrell R.M. Heme oxygenase induction mediates the photoimmunoprotective activity of UVA radiation in the mouse (In process citation). Proc. Natl. Acad. Sci. USA. 96:1999;9317-9321.
30. Roy A.K. Transcription factors and aging. Mol. Med. 3:1997;496-504.
31. Shibahara S., Sato M., Muller R.M., Yoshida T. Structural organization of the human heme oxygenase gene and the function of its promoter. Eur. J. Biochem. 179:1989;557-563.
32. Sohal R.S Beal M.F., Howell N., Bodis-Wollner I. Mitochondria and Free Radicals in Neurodenerative Diseases. 1997;91-100 Wiley-Liss Inc, New York.
33. Song C.S., Her S., Slomczynska M. et al. A distal activation domain is critical in the regulation of the rat androgen receptor gene promoter. Biochem. J. 294(3):1993;779-784.
34. Stadtman E.R. Protein oxidation and aging. Science. 257:1992;1220-1224.
35. Stocker R., Yamamoto Y., McDonagh A.F., Glazer A.N., Ames B.N. Bilirubin is an antioxidant of possible physiological importance. Science. 235:1987;1043-1046.
36. Supakar P.C., Jung M.H., Song C.S., Chatterjee B., Roy A.K. Nuclear factor κB functions as a negative regulator for the rat androgen receptor gene and NFκB activity increases during the age- dependent desensitization of the liver. J. Biol. Chem. 270:1995;837-842.
37. Suttner D.M., Sridhar K., Lee C.S. et al. Protective effects of transient HO-1 overexpression on susceptibility to oxygen toxicity in lung cells. Am. J. Physiol. 276:1999;L443-L451.
38. Toliver-Kinsky T., Papaconstantinou J., Perez-Polo J.R. Age-associated alterations in hippocampal and basal forebrain nuclear factor κB activity. J. Neurosci. Res. 48:1997;580-587.
39. Tyrrell R.M., Applegate L.A., Tromvoukis Y. The proximal promoter region of the human heme oxygenase gene contains elements involved in stimulation of transcriptional activity by a variety of agents including oxidants. Carcinogenesis. 14:1993;761-765.
40. Verma I.M., Stevenson J. IκB kinase: beginning, not the end. Proc. Natl. Acad. Sci. USA. 94:1997;11758-11760.
41. Walter R., Sierra F. Changes in hepatic DNA binding proteins as a function of age in rats (published erratum, J. Gerontol. A Biol. Sci. Med. Sci. 1998 May;53(3):B172). J. Gerontol. A Biol. Sci. Med. Sci. 53:1998;B102-B110.
42. Wu R.L., Chen T.T., Sun T.T. Functional importance of an Sp1 and an NFκB-related nuclear protein in a keratinocyte-specific promoter of rabbit K3 keratin gene. J. Biol. Chem. 269:1994;28450-28459.
43. Yamada N., Yamaya M., Okinaga S. et al. Protective Effects of Heme Oxygenase-1 against Oxidant-Induced Injury in the Cultured Human Tracheal Epithelium. Am. J. Respir. Cell. Mol. Biol. 21:1999;428-435.