Mutations in Keap1 are a potential prognostic factor in resected non-small cell lung cancer

Journal of Surgical Oncology

Volumn 101, Issue 6, 2010, Pages 500-506

  Takahashi, Tsuyoshi ^a   Sonobe, Makoto ^a   Menju, Toshi ^a   Nakayama, E I ^a   Mino, Nobuya ^a   Iwakiri, Shotaro ^a   Nagai, Shinjiro ^a   Sato, Kiyoshi ^a   Miyahara, R Y O ^a   Okubo, Kenichi ^a   Hirata, Toshiki ^a   Date, Hiroshi ^a   Wada, Hiromi ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b Wada Clinic   (Japan)

Author keywords

Disease free survival rate; Kelch like ECH associated protein 1 (Keap1); Mutation; Non small cell lung cancer (NSCLC); Prognosis

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; OXIDOREDUCTASE; PACLITAXEL; TRANSCRIPTION FACTOR NRF2;

ADJUVANT THERAPY; ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER SURGERY; CANCER SURVIVAL; CANCER TISSUE; DISEASE FREE SURVIVAL; DISEASE SEVERITY; DNA SEQUENCE; FEMALE; GENE EXPRESSION PROFILING; GENE MUTATION; HUMAN; HUMAN TISSUE; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; LUNG RESECTION; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SURVIVAL RATE; SURVIVAL TIME; WILD TYPE;

AGED; AGED, 80 AND OVER; BASE SEQUENCE; CARCINOMA, NON-SMALL-CELL LUNG; DISEASE-FREE SURVIVAL; DNA, COMPLEMENTARY; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; MUTATION; PROGNOSIS; RETROSPECTIVE STUDIES; SMOKING; SURVIVAL RATE;

EID: 77950823830     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.21520     Document Type: Article

References (30)

1. Itoh K, Ishii T, Wakabayashi N, et al.: Regulatory mechanism of cellular response to oxidative stress. Free Radic Res 1999;31:319-324. (Pubitemid 29452857)
2. Motohashi H, Yamamoto M: Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 2004;10:549-557. (Pubitemid 39433824)
3. Itoh K, Wakabayashi N, Katoh Y, et al.: Keap1 represses nuclear activation of antioxidant responsive elements by nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 1999;13:76-86. (Pubitemid 29045117)
4. Nguyen T, Huang HC, Pickett CB: Transcriptional regulation of the antioxidant response element. J Biol Chem 2000;275:15466-15473.
5. Eggler AL, Liu G, Pezzuto JM, et al.: Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proc Natl Acad Sci 2005;102:10070-10075. (Pubitemid 41023327)
6. Nguyen T, Sherratt PJ, Nioi P, et al.: Nrf2 contorls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1. J Biol Chem 2005;280:32485-32492. (Pubitemid 41361861)
7. Motohashi H, Katsuoka F, Engel JD, et al.: Small Maf proteins serve as transcriptional factors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway. Proc Natl Acad Sci 2004;101:6379-6384. (Pubitemid 38585982)
8. Yamamoto T, Suzuki T, Kobayashi A, et al.: Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity. Mol Cell Biol 2008;28:2758-2770. (Pubitemid 351542373)
9. Padmanabhan B, Tong KI, Kobayashi A, et al.: Structural insights into the similar modes of Nrf2 transcription factor recognition by the cytoplasmic repressor Keap1. J Synchrotron Radiat 2008;15:273-276. (Pubitemid 351571020)
10. Zhang DD, Hannink M: Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol 2003;23:8137-8151.
11. Zhang DD, Lo SC, Cross JV, et al.: Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol 2004;24:10941-10953.
12. Kobayashi A, Kang MI, Okawa H, et al.: Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 2004;24:7130-7139. (Pubitemid 39014439)
13. Kobayashi A, Kang MI, Watai Y, et al.: Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol Cell Biol 2006;26:221-229.
14. Cullinan SB, Gordan JD, Jin J, et al.: The Keap1-BTB protein is an adaptor that bridges Nrf2 to an Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase. Mol Cell Biol 2004;24:8477-8486. (Pubitemid 39245070)
15. Furukawa M, Xiong Y: BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Mol Cell Biol 2005;25:162-171. (Pubitemid 40039808)
16. Hong F, Sekhar KR, Freeman ML, et al.: Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation. J Biol Chem 2005;280:31768-31775. (Pubitemid 41291926)
17. Itoh K, Chiba T, Takahashi S, et al.: An Nrf2/small Maf hetrodimer mediates the induction of phase II detoxifying enzyme gene through antioxidant response elements. Biochem Biophys Res Commun 1997;236:313-322. (Pubitemid 27373291)
18. Rangasamy T, Cho CY, Thimmulappa RK, et al.: Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest 2004;114:1248-1259. (Pubitemid 40385296)
19. Thimmulappa RK, Mai KH, Srisuma S, et al.: Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res 2002;62:5196-5203. (Pubitemid 35033454)
20. Jaiswal AK: Regulation of gene encoding NAD(P)H:-quinine oxidoreductases. Free Radic Biol Med 2000;29:254-262.
21. Maher JM, Dieter MZ, Aleksunes LM, et al.: Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology 2007;46:1597-1610.
22. Vollrath V,Wielandt AM, Iruretagoyena M, et al.: Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene. Biochem J 2006;395:599-609.
23. Jonathan MM, Dieter MZ, Aleksunes LM, et al.: Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology 2007;46:1597-1610.
24. Singh A, Misra V, Thimmulappa RK, et al.: Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Med 2006;3:e420.
25. Ohta T, Iijima K, Miyamoto M, et al.: Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. Cancer Res 2008;68:1303-1309. (Pubitemid 351346836)
26. Singh A, Boldin-Adamsky S, Thimmulappa RK, et al.: RNAimediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small-cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy. Cancer Res 2008;68:7975-7984.
27. Wang XJ, Sun Z, Villeneuve NF, et al.: Nrf2 enhances resistance of cancer cell to chemotherapeutic drugs, the dark side of Nrf2. Carcinogenesis 2008;29:1235-1243. (Pubitemid 351958704)
28. Filipits M, Haddad V, Schmid K, et al.: Multidrug resistance proteins do not predict benefit of adjuvant chemotherapy in patients with completely resected non-small cell lung cancer: International adjuvant lung cancer trial biologic program. Clin Cancer Res 2007;13:3892-3898. (Pubitemid 47037596)
29. Ushijima R, Takayama K, Izumi M, et al.: Immunohistochemical expression of MRP2 and clinical resistance to platinum-based chemotherapy in small cell lung cancer. Anticancer Res 2007;27:4351-4358.
30. Padmanabhan B, Tong KI, Ohta T, et al.: et al. Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol Cell 2006;21:689-700.