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Volumn 74, Issue 17, 2014, Pages 1983-1992

Phosphodiesterase inhibitors for chronic obstructive pulmonary disease: What does the future hold?

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; MUSCARINIC RECEPTOR BLOCKING AGENT; PHOSPHODIESTERASE III INHIBITOR; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; PHOSPHODIESTERASE VII INHIBITOR; PHOSPHODIESTERASE INHIBITORS;

EID: 84922079549     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.1007/s40265-014-0303-8     Document Type: Article
Times cited : (28)

References (83)
  • 1
    • 79960928267 scopus 로고    scopus 로고
    • Phosphodiesterase inhibitors in the treatment of inflammatory diseases
    • 1:CAS:528:DC%2BC38XhsFChsLfF 21695650
    • Page CP, Spina D. Phosphodiesterase inhibitors in the treatment of inflammatory diseases. Handb Exp Pharmacol. 2011;204:391-414.
    • (2011) Handb Exp Pharmacol , vol.204 , pp. 391-414
    • Page, C.P.1    Spina, D.2
  • 2
    • 0344513958 scopus 로고    scopus 로고
    • Phosphodiesterase-4 inhibitors in the treatment of inflammatory lung disease
    • 1:CAS:528:DC%2BD2cXpsVSg 14636078
    • Spina D. Phosphodiesterase-4 inhibitors in the treatment of inflammatory lung disease. Drugs. 2003;63:2575-94.
    • (2003) Drugs , vol.63 , pp. 2575-2594
    • Spina, D.1
  • 3
    • 3142517968 scopus 로고    scopus 로고
    • Association between chronic obstructive pulmonary disease and systemic inflammation: A systematic review and a metaanalysis
    • 1:STN:280:DC%2BD2czkslSjsQ%3D%3D 1747070 15223864
    • Gan WQ, Man SF, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a metaanalysis. Thorax. 2004;59:574-8.
    • (2004) Thorax , vol.59 , pp. 574-578
    • Gan, W.Q.1    Man, S.F.2    Senthilselvan, A.3    Sin, D.D.4
  • 4
    • 84893811262 scopus 로고    scopus 로고
    • How phosphodiesterase 4 inhibitors work in patients with chronic obstructive pulmonary disease of the severe, bronchitic, frequent exacerbator phenotype
    • 24507847
    • Giembycz MA, Newton R. How phosphodiesterase 4 inhibitors work in patients with chronic obstructive pulmonary disease of the severe, bronchitic, frequent exacerbator phenotype. Clin Chest Med. 2014;35:203-17.
    • (2014) Clin Chest Med , vol.35 , pp. 203-217
    • Giembycz, M.A.1    Newton, R.2
  • 5
    • 84856219643 scopus 로고    scopus 로고
    • European Medicines Agency Last accessed 28 May 2014
    • European Medicines Agency. Daxas - Roflumilast. http://www.ema.europa.eu/docs/en-GB/document-library/Summary-of-opinion-Initial-authorisation/human/001179/WC500089626.pdf. Last accessed 28 May 2014.
    • Daxas - Roflumilast
  • 7
    • 34147214922 scopus 로고    scopus 로고
    • Global Initiative for Chronic Obstructive Lung Disease 2014. Global Initiative for Chronic Obstructive Lung Disease Last accessed 9 June 2014
    • Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of COPD. 2014. Global Initiative for Chronic Obstructive Lung Disease. http://www.goldcopd.org/Guidelines/guidelines-resources.html. Last accessed 9 June 2014.
    • Global Strategy for the Diagnosis, Management, and Prevention of COPD
  • 8
    • 84899792562 scopus 로고    scopus 로고
    • Phosphodiesterase 4 inhibitors for chronic obstructive pulmonary disease
    • Chong J, Leung B, Poole P. Phosphodiesterase 4 inhibitors for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2013;11:CD002309.
    • (2013) Cochrane Database Syst Rev , vol.11 , pp. CD002309
    • Chong, J.1    Leung, B.2    Poole, P.3
  • 9
    • 84892445790 scopus 로고    scopus 로고
    • Efficacy and safety of roflumilast in patients with stable chronic obstructive pulmonary disease: A meta-analysis
    • 1:CAS:528:DC%2BC3sXmvF2iurY%3D 23624309
    • Yan JH, Gu WJ, Pan L. Efficacy and safety of roflumilast in patients with stable chronic obstructive pulmonary disease: a meta-analysis. Pulm Pharmacol Ther. 2014;27:83-9.
    • (2014) Pulm Pharmacol Ther , vol.27 , pp. 83-89
    • Yan, J.H.1    Gu, W.J.2    Pan, L.3
  • 10
    • 84877589288 scopus 로고    scopus 로고
    • Efficacy of roflumilast in the chronic obstructive pulmonary disease frequent exacerbator phenotype
    • 1:CAS:528:DC%2BC3sXosFCgurg%3D 23117188
    • Wedzicha JA, Rabe KF, Martinez FJ, et al. Efficacy of roflumilast in the chronic obstructive pulmonary disease frequent exacerbator phenotype. Chest. 2013;143:1302-11.
    • (2013) Chest , vol.143 , pp. 1302-1311
    • Wedzicha, J.A.1    Rabe, K.F.2    Martinez, F.J.3
  • 11
    • 79251588730 scopus 로고    scopus 로고
    • Reduction of exacerbations by the PDE4 inhibitor roflumilast - The importance of defining different subsets of patients with COPD
    • 1:CAS:528:DC%2BC3MXis1SgsLk%3D 3040135 21272339
    • Rennard SI, Calverley PM, Goehring UM, Bredenbröker D, Martinez FJ. Reduction of exacerbations by the PDE4 inhibitor roflumilast - the importance of defining different subsets of patients with COPD. Respir Res. 2011;12:18.
    • (2011) Respir Res , vol.12 , pp. 18
    • Rennard, S.I.1    Calverley, P.M.2    Goehring, U.M.3    Bredenbröker, D.4    Martinez, F.J.5
  • 12
    • 84893727688 scopus 로고    scopus 로고
    • Pooled subpopulation analyses of the effects of roflumilast on exacerbations and lung function in COPD
    • 24120253
    • Hanania NA, Calverley PM, Dransfield MT, et al. Pooled subpopulation analyses of the effects of roflumilast on exacerbations and lung function in COPD. Respir Med. 2014;108:366-75.
    • (2014) Respir Med , vol.108 , pp. 366-375
    • Hanania, N.A.1    Calverley, P.M.2    Dransfield, M.T.3
  • 13
    • 84860473468 scopus 로고    scopus 로고
    • Physiological effects of roflumilast at rest and during exercise in COPD
    • 21965226
    • O'Donnell DE, Bredenbröker D, Brose M, et al. Physiological effects of roflumilast at rest and during exercise in COPD. Eur Respir J. 2012;39:1104-12.
    • (2012) Eur Respir J , vol.39 , pp. 1104-1112
    • O'Donnell, D.E.1    Bredenbröker, D.2    Brose, M.3
  • 14
    • 33645526100 scopus 로고    scopus 로고
    • Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease
    • 16565429
    • O'Donnell DE. Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006;3:180-4.
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 180-184
    • O'Donnell, D.E.1
  • 15
    • 84903273716 scopus 로고    scopus 로고
    • Does roflumilast improve dyspnea in patients with chronic obstructive pulmonary disease? A meta-analysis
    • 3755693 23991297
    • Pan L, Guo YZ, Zhang B, Yan JH. Does roflumilast improve dyspnea in patients with chronic obstructive pulmonary disease? A meta-analysis. J Thorac Dis. 2013;5:422-9.
    • (2013) J Thorac Dis , vol.5 , pp. 422-429
    • Pan, L.1    Guo, Y.Z.2    Zhang, B.3    Yan, J.H.4
  • 16
    • 84887909801 scopus 로고    scopus 로고
    • Mechanisms and impact of the frequent exacerbator phenotype in chronic obstructive pulmonary disease
    • 3750926 23945277
    • Wedzicha JA, Brill SE, Allinson JP, Donaldson GC. Mechanisms and impact of the frequent exacerbator phenotype in chronic obstructive pulmonary disease. BMC Med. 2013;11:181.
    • (2013) BMC Med , vol.11 , pp. 181
    • Wedzicha, J.A.1    Brill, S.E.2    Allinson, J.P.3    Donaldson, G.C.4
  • 17
    • 77956689733 scopus 로고    scopus 로고
    • Susceptibility to exacerbation in chronic obstructive pulmonary disease
    • 1:CAS:528:DC%2BC3cXhtFOltLzF
    • Hurst JR, Vestbo J, Anzueto A, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Eng J Med. 2010;363:1128-38.
    • (2010) N Eng J Med , vol.363 , pp. 1128-1138
    • Hurst, J.R.1    Vestbo, J.2    Anzueto, A.3
  • 18
    • 0034018102 scopus 로고    scopus 로고
    • Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations
    • 1:STN:280:DC%2BD3c7gslaltg%3D%3D 1745686 10639527
    • Bhowmik A, Seemungal TA, Sapsford RJ, Wedzicha JA. Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations. Thorax. 2000;55:114-20.
    • (2000) Thorax , vol.55 , pp. 114-120
    • Bhowmik, A.1    Seemungal, T.A.2    Sapsford, R.J.3    Wedzicha, J.A.4
  • 19
    • 27144526596 scopus 로고    scopus 로고
    • Airway and systemic inflammation and decline in lung function in patients with COPD
    • 16236847
    • Donaldson GC, Seemungal TA, Patel IS, et al. Airway and systemic inflammation and decline in lung function in patients with COPD. Chest. 2005;128:1995-2004.
    • (2005) Chest , vol.128 , pp. 1995-2004
    • Donaldson, G.C.1    Seemungal, T.A.2    Patel, I.S.3
  • 20
    • 80051757118 scopus 로고    scopus 로고
    • Pharmacotherapeutic approaches to preventing acute exacerbations of chronic obstructive pulmonary disease
    • 1:CAS:528:DC%2BC3MXht1yitLzM 21816992
    • Han MK, Martinez FJ. Pharmacotherapeutic approaches to preventing acute exacerbations of chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2011;8:356-62.
    • (2011) Proc Am Thorac Soc , vol.8 , pp. 356-362
    • Han, M.K.1    Martinez, F.J.2
  • 21
    • 36749063803 scopus 로고    scopus 로고
    • Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD
    • 2094292 17573446
    • Grootendorst DC, Gauw SA, Verhoosel RM, et al. Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD. Thorax. 2007;62:1081-7.
    • (2007) Thorax , vol.62 , pp. 1081-1087
    • Grootendorst, D.C.1    Gauw, S.A.2    Verhoosel, R.M.3
  • 22
    • 84922080678 scopus 로고    scopus 로고
    • Anti-inflammatory effects of dexamethasone, roflumilast N-oxide, formoterol and their combinations in human neutrophils from healthy and chronic obstructive pulmonary disease patients [abstract]
    • Milara J, Lluch J, Cano P, et al. Anti-inflammatory effects of dexamethasone, roflumilast N-oxide, formoterol and their combinations in human neutrophils from healthy and chronic obstructive pulmonary disease patients [abstract]. Am J Respir Crit Care Med. 2014;189:A2746.
    • (2014) Am J Respir Crit Care Med , vol.189 , pp. 2746
    • Milara, J.1    Lluch, J.2    Cano, P.3
  • 23
    • 33644784718 scopus 로고    scopus 로고
    • Corticosteroids: The drugs to beat
    • 1:CAS:528:DC%2BD28XitVKgsr0%3D 16436275
    • Barnes PJ. Corticosteroids: the drugs to beat. Eur J Pharmacol. 2006;533:2-14.
    • (2006) Eur J Pharmacol , vol.533 , pp. 2-14
    • Barnes, P.J.1
  • 25
    • 84905578194 scopus 로고    scopus 로고
    • Roflumilast N-oxide reverses corticosteroid resistance in neutrophils from patients with chronic obstructive pulmonary disease
    • 1:CAS:528:DC%2BC2cXkslWht7s%3D 24636089
    • Milara J, Lluch J, Almudever P, et al. Roflumilast N-oxide reverses corticosteroid resistance in neutrophils from patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2014;134:314-22.
    • (2014) J Allergy Clin Immunol , vol.134 , pp. 314-322
    • Milara, J.1    Lluch, J.2    Almudever, P.3
  • 26
    • 79960906296 scopus 로고    scopus 로고
    • Harnessing the clinical efficacy of phosphodiesterase 4 inhibitors in inflammatory lung diseases: Dual-selective phosphodiesterase inhibitors and novel combination therapies
    • 1:CAS:528:DC%2BC38XhsFChsb7N 21695651
    • Giembycz MA, Newton R. Harnessing the clinical efficacy of phosphodiesterase 4 inhibitors in inflammatory lung diseases: dual-selective phosphodiesterase inhibitors and novel combination therapies. Handb Exp Pharmacol. 2011;204:415-46.
    • (2011) Handb Exp Pharmacol , vol.204 , pp. 415-446
    • Giembycz, M.A.1    Newton, R.2
  • 27
    • 84922080156 scopus 로고    scopus 로고
    • Additive anti-inflammatory effect of glucocorticoids and PDE4 inhibitors on COPD CD8 cells [abstract]
    • Grundy S, Plumb J, Kaur M, et al. Additive anti-inflammatory effect of glucocorticoids and PDE4 inhibitors on COPD CD8 cells [abstract]. Eur Respir J. 2014;44(suppl):P1515.
    • (2014) Eur Respir J , vol.44 , pp. 1515
    • Grundy, S.1    Plumb, J.2    Kaur, M.3
  • 28
    • 84922079841 scopus 로고    scopus 로고
    • Roflumilast added to triple therapy in severe COPD patients with frequent exacerbations: Efficacy and tolerability [abstract]
    • Muñoz-Esquerre M, Diez-Ferrer M, Montón C, et al. Roflumilast added to triple therapy in severe COPD patients with frequent exacerbations: efficacy and tolerability [abstract]. Eur Respir J. 2014;44(suppl):P560.
    • (2014) Eur Respir J , vol.44 , pp. 560
    • Muñoz-Esquerre, M.1    Diez-Ferrer, M.2    Montón, C.3
  • 29
    • 84922080676 scopus 로고    scopus 로고
    • A double blind placebo controlled study to assess the effect of roflumilast in addition to LABA/LAMA/ICS treatment in COPD patients using novel biomarkers [abstract]
    • De Backer J, Vos W, Van Holsbeke C, et al. A double blind placebo controlled study to assess the effect of roflumilast in addition to LABA/LAMA/ICS treatment in COPD patients using novel biomarkers [abstract]. Eur Respir J. 2014;44(suppl):4670.
    • (2014) Eur Respir J , vol.44 , pp. 4670
    • De Backer, J.1    Vos, W.2    Van Holsbeke, C.3
  • 30
    • 84890686350 scopus 로고    scopus 로고
    • Roflumilast: The new orally active, selective phophodiesterase-4 inhibitor, for the treatment of COPD
    • 1:CAS:528:DC%2BC3sXhvFSltL%2FJ 24032576
    • Tashkin DP. Roflumilast: the new orally active, selective phophodiesterase-4 inhibitor, for the treatment of COPD. Expert Opin Pharmacother. 2014;15:85-96.
    • (2014) Expert Opin Pharmacother , vol.15 , pp. 85-96
    • Tashkin, D.P.1
  • 31
    • 52949140176 scopus 로고    scopus 로고
    • PDE4 inhibitors: Current status
    • 1:CAS:528:DC%2BD1cXhtFKkurbM 2567892 18660825
    • Spina D. PDE4 inhibitors: current status. Br J Pharmacol. 2008;155:308-15.
    • (2008) Br J Pharmacol , vol.155 , pp. 308-315
    • Spina, D.1
  • 32
    • 84862290893 scopus 로고    scopus 로고
    • Selective PDE inhibitors as novel treatments for respiratory diseases
    • 1:CAS:528:DC%2BC38Xltl2kurg%3D 22497841
    • Page CP, Spina D. Selective PDE inhibitors as novel treatments for respiratory diseases. Curr Opin Pharmacol. 2012;12:275-86.
    • (2012) Curr Opin Pharmacol , vol.12 , pp. 275-286
    • Page, C.P.1    Spina, D.2
  • 33
    • 84868699494 scopus 로고    scopus 로고
    • Tetomilast: New promise for phosphodiesterase-4 inhibitors?
    • 1:CAS:528:DC%2BC38Xhs1Cks7zL 23043390
    • Bickston SJ, Snider KR, Kappus MR. Tetomilast: new promise for phosphodiesterase-4 inhibitors? Expert Opin Investig Drugs. 2012;21:1845-9.
    • (2012) Expert Opin Investig Drugs , vol.21 , pp. 1845-1849
    • Bickston, S.J.1    Snider, K.R.2    Kappus, M.R.3
  • 36
    • 28244488701 scopus 로고    scopus 로고
    • AWD-12-281 (inhaled) (elbion/GlaxoSmithKline)
    • 1:CAS:528:DC%2BD2MXht1Kku7vM 16312137
    • Gutke HJ, Guse JH, Khobzaoui M, et al. AWD-12-281 (inhaled) (elbion/GlaxoSmithKline). Curr Opin Investig Drugs. 2005;6:1149-58.
    • (2005) Curr Opin Investig Drugs , vol.6 , pp. 1149-1158
    • Gutke, H.J.1    Guse, J.H.2    Khobzaoui, M.3
  • 37
    • 35948942231 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, parallel group, six-week study of the efficacy and safety of tofimilast dry powder for inhalation (DPI) in adults with COPD [abstract]
    • Danto S, Wei GC, Gill J. A randomized, double-blind, placebo-controlled, parallel group, six-week study of the efficacy and safety of tofimilast dry powder for inhalation (DPI) in adults with COPD [abstract]. Am J Respir Crit Care Med. 2007;175:A131.
    • (2007) Am J Respir Crit Care Med , vol.175 , pp. 131
    • Danto, S.1    Wei, G.C.2    Gill, J.3
  • 38
    • 66749187721 scopus 로고    scopus 로고
    • A controlled trial of 6-weeks' treatment with a novel inhaled phosphodiesterase type-4 inhibitor in COPD
    • 1:CAS:528:DC%2BD1MXmtFahtb4%3D 19213793
    • Vestbo J, Tan L, Atkinson G, Ward J. A controlled trial of 6-weeks' treatment with a novel inhaled phosphodiesterase type-4 inhibitor in COPD. Eur Respir J. 2009;33:1039-44.
    • (2009) Eur Respir J , vol.33 , pp. 1039-1044
    • Vestbo, J.1    Tan, L.2    Atkinson, G.3    Ward, J.4
  • 39
    • 79955803729 scopus 로고    scopus 로고
    • Anti-asthmatic effect of ASP3258, a novel phosphodiesterase 4 inhibitor
    • 1:CAS:528:DC%2BC3MXlvVCjurg%3D 21315169
    • Kobayashi M, Kubo S, Iwata M, et al. Anti-asthmatic effect of ASP3258, a novel phosphodiesterase 4 inhibitor. Int Immunopharmacol. 2011;11:732-9.
    • (2011) Int Immunopharmacol , vol.11 , pp. 732-739
    • Kobayashi, M.1    Kubo, S.2    Iwata, M.3
  • 40
    • 79953687195 scopus 로고    scopus 로고
    • Pharmacology of SCH900182, a potent, selective inhibitor of PDE4 for inhaled administration [abstract]
    • Chapman RW, House A, Richard J, et al. Pharmacology of SCH900182, a potent, selective inhibitor of PDE4 for inhaled administration [abstract]. Am J Respir Crit Care Med. 2010;181:A5671.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 5671
    • Chapman, R.W.1    House, A.2    Richard, J.3
  • 41
    • 84861341040 scopus 로고    scopus 로고
    • Discovery of a novel orally active PDE-4 inhibitor effective in an ovalbumin induced asthma murine model
    • 1:CAS:528:DC%2BC38XmvFKntbY%3D 22554769
    • Kwak HJ, Nam JY, Song JS, et al. Discovery of a novel orally active PDE-4 inhibitor effective in an ovalbumin induced asthma murine model. Eur J Pharmacol. 2012;685:141-8.
    • (2012) Eur J Pharmacol , vol.685 , pp. 141-148
    • Kwak, H.J.1    Nam, J.Y.2    Song, J.S.3
  • 42
    • 80053374565 scopus 로고    scopus 로고
    • NCS 613, a potent and specific PDE4 inhibitor, displays antiinflammatory effects on human lung tissues
    • 1:CAS:528:DC%2BC3MXhtlersbnM 21784969
    • Yougbare I, Morin C, Senouvo FY, et al. NCS 613, a potent and specific PDE4 inhibitor, displays antiinflammatory effects on human lung tissues. Am J Physiol Lung Cell Mol Physiol. 2011;301:L441-50.
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.301 , pp. 441-L450
    • Yougbare, I.1    Morin, C.2    Senouvo, F.Y.3
  • 43
    • 79953012235 scopus 로고    scopus 로고
    • In vivo characterization of GSK256066, a high-affinity inhaled phosphodiesterase 4 inhibitor
    • 1:CAS:528:DC%2BC3MXktVGqur0%3D 21205924
    • Nials AT, Tralau-Stewart CJ, Gascoigne MH, et al. In vivo characterization of GSK256066, a high-affinity inhaled phosphodiesterase 4 inhibitor. J Pharmacol Exp Ther. 2011;337:137-44.
    • (2011) J Pharmacol Exp Ther , vol.337 , pp. 137-144
    • Nials, A.T.1    Tralau-Stewart, C.J.2    Gascoigne, M.H.3
  • 44
    • 84942098053 scopus 로고    scopus 로고
    • GlaxoSmithKline February Last accessed 14 March 2014.
    • GlaxoSmithKline. Product development pipeline 2013. February 2013. http://www.gsk.com/content/dam/gsk/globals/documents/pdf/GSK%202013%20Pipeline.pdf. Last accessed 14 March 2014.
    • (2013) Product Development Pipeline 2013
  • 45
    • 84894049174 scopus 로고    scopus 로고
    • A novel class of benzoic acid ester derivatives as potent PDE4 inhibitors for inhaled administration in the treatment of respiratory diseases
    • 1:CAS:528:DC%2BC2cXkvFGltA%3D%3D 24400806
    • Armani E, Amari G, Rizzi A, et al. A novel class of benzoic acid ester derivatives as potent PDE4 inhibitors for inhaled administration in the treatment of respiratory diseases. J Med Chem. 2014;57:793-816.
    • (2014) J Med Chem , vol.57 , pp. 793-816
    • Armani, E.1    Amari, G.2    Rizzi, A.3
  • 47
    • 84922060317 scopus 로고    scopus 로고
    • CHF6001 is a novel highly potent and selective phosphodiesterase 4 (PDE4) inhibitor with a robust in vitro anti-inflammatory profile [abstract]
    • Moretto N, Caruso P, Marchini G, et al. CHF6001 is a novel highly potent and selective phosphodiesterase 4 (PDE4) inhibitor with a robust in vitro anti-inflammatory profile [abstract]. Am J Respir Crit Care Med. 2014;189:A6725.
    • (2014) Am J Respir Crit Care Med , vol.189 , pp. 6725
    • Moretto, N.1    Caruso, P.2    Marchini, G.3
  • 48
    • 84922079954 scopus 로고    scopus 로고
    • Reduction in systemic inflammation by the PDE4 inhibitor roflumilast in patients with COPD [abstract]
    • Marquez-Martin E, Ortega Ruiz F, Campano E, et al. Reduction in systemic inflammation by the PDE4 inhibitor roflumilast in patients with COPD [abstract]. Eur Respir J 2014;44 (suppl):P926.
    • (2014) Eur Respir J , vol.44 , pp. P926
    • Marquez-Martin, E.1    Ortega Ruiz, F.2    Campano, E.3
  • 49
    • 84897443197 scopus 로고    scopus 로고
    • Advances in targeting cyclic nucleotide phosphodiesterases
    • 1:CAS:528:DC%2BC2cXltFOiu7s%3D 4155750 24687066
    • Maurice DH, Ke H, Ahmad F, et al. Advances in targeting cyclic nucleotide phosphodiesterases. Nat Rev Drug Discov. 2014;13:290-314.
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 290-314
    • Maurice, D.H.1    Ke, H.2    Ahmad, F.3
  • 50
    • 84905667274 scopus 로고    scopus 로고
    • Bifunctional drugs for the treatment of asthma and chronic obstructive pulmonary disease
    • 1:CAS:528:DC%2BC2cXhs1yitb%2FL 24696121
    • Page C, Cazzola M. Bifunctional drugs for the treatment of asthma and chronic obstructive pulmonary disease. Eur Respir J. 2014;44:475-82.
    • (2014) Eur Respir J , vol.44 , pp. 475-482
    • Page, C.1    Cazzola, M.2
  • 51
    • 33646924049 scopus 로고    scopus 로고
    • Are phosphodiesterase inhibitors just more theophylline?
    • 1:CAS:528:DC%2BD28XlsVaqt7g%3D 16750981
    • Boswell-Smith V, Cazzola M, Page CP. Are phosphodiesterase inhibitors just more theophylline? J Allergy Clin Immunol. 2006;117:1237-43.
    • (2006) J Allergy Clin Immunol , vol.117 , pp. 1237-1243
    • Boswell-Smith, V.1    Cazzola, M.2    Page, C.P.3
  • 52
    • 33644811309 scopus 로고    scopus 로고
    • Phosphodiesterase inhibitors in airways disease
    • 1:CAS:528:DC%2BD28XitVKhu7o%3D
    • Chung FK. Phosphodiesterase inhibitors in airways disease. Eur J Pharmacol. 2006;533:110-7.
    • (2006) Eur J Pharmacol , vol.533 , pp. 110-117
    • Chung, F.K.1
  • 53
    • 0026497719 scopus 로고
    • Trials of the bronchodilator activity of the isoenzyme-selective phosphodiesterase inhibitor AH 21-132 in healthy volunteers during a methacholine challenge test
    • 1:CAS:528:DyaK3sXlt1ajsg%3D%3D 1381455 1493085
    • Foster RW, Rakshi K, Carpenter JR, Small RC. Trials of the bronchodilator activity of the isoenzyme-selective phosphodiesterase inhibitor AH 21-132 in healthy volunteers during a methacholine challenge test. Br J Clin Pharmacol. 1992;34:527-34.
    • (1992) Br J Clin Pharmacol , vol.34 , pp. 527-534
    • Foster, R.W.1    Rakshi, K.2    Carpenter, J.R.3    Small, R.C.4
  • 54
    • 84870991478 scopus 로고    scopus 로고
    • Phosphodiesterase inhibitors. Part 5: Hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration
    • 1:CAS:528:DC%2BC38XhslKntbnK 23200255
    • Ochiai K, Takita S, Kojima A, et al. Phosphodiesterase inhibitors. Part 5: hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration. Bioorg Med Chem Lett. 2013;23:375-81.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 375-381
    • Ochiai, K.1    Takita, S.2    Kojima, A.3
  • 55
    • 33745939122 scopus 로고    scopus 로고
    • The pharmacology of two novel long-acting phosphodiesterase 3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-Aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6-diisopropylphenoxy)-9,10-dimethoxy-4Hpyrimido[6,1-a]isoquinolin-4-one]
    • 1:CAS:528:DC%2BD28XnslOlt7w%3D 16682455
    • Boswell-Smith V, Spina D, Oxford AW, et al. The pharmacology of two novel long-acting phosphodiesterase 3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6-diisopropylphenoxy)-9,10-dimethoxy-4Hpyrimido[6,1-a]isoquinolin-4-one]. J Pharmacol Exp Ther. 2006;318:840-8.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 840-848
    • Boswell-Smith, V.1    Spina, D.2    Oxford, A.W.3
  • 56
    • 84882399041 scopus 로고    scopus 로고
    • Effect of the mixed phosphodiesterase 3/4 inhibitor RPL554 on human isolated bronchial smooth muscle tone
    • 1:CAS:528:DC%2BC3sXhtlCmtbnJ 23766543
    • Calzetta L, Page CP, Spina D, et al. Effect of the mixed phosphodiesterase 3/4 inhibitor RPL554 on human isolated bronchial smooth muscle tone. J Pharmacol Exp Ther. 2013;346:414-23.
    • (2013) J Pharmacol Exp Ther , vol.346 , pp. 414-423
    • Calzetta, L.1    Page, C.P.2    Spina, D.3
  • 57
    • 84887115924 scopus 로고    scopus 로고
    • Efficacy and safety of RPL 554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: Findings from four clinical trials
    • 1:CAS:528:DC%2BC2cXhsFCmsro%3D 24429275
    • Franciosi LG, Diamant Z, Banner KH, et al. Efficacy and safety of RPL 554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials. Lancet Respir Med. 2013;1:714-27.
    • (2013) Lancet Respir Med , vol.1 , pp. 714-727
    • Franciosi, L.G.1    Diamant, Z.2    Banner, K.H.3
  • 58
    • 84887086305 scopus 로고    scopus 로고
    • Dual PDE3/4 inhibition: A novel approach to airway disease?
    • 24429260
    • Wedzicha JA. Dual PDE3/4 inhibition: a novel approach to airway disease? Lancet Respir Med. 2013;1:669-70.
    • (2013) Lancet Respir Med , vol.1 , pp. 669-670
    • Wedzicha, J.A.1
  • 59
    • 84897959610 scopus 로고    scopus 로고
    • Dual PDE3/4 and PDE4 inhibitors: Novel treatments for COPD and other inflammatory airway diseases
    • 1:CAS:528:DC%2BC2cXlvVSitL4%3D 24517491
    • Abbott-Banner KH, Page CP. Dual PDE3/4 and PDE4 inhibitors: novel treatments for COPD and other inflammatory airway diseases. Basic Clin Pharmacol Toxicol. 2014;114:365-76.
    • (2014) Basic Clin Pharmacol Toxicol , vol.114 , pp. 365-376
    • Abbott-Banner, K.H.1    Page, C.P.2
  • 60
    • 33751043887 scopus 로고    scopus 로고
    • Phosphodiesterase (PDE) 7 in inflammatory cells from patients with asthma and COPD
    • 1:CAS:528:DC%2BD28XhtFOhs7jJ 16427796
    • Jones NA, Leport M, Holand T, et al. Phosphodiesterase (PDE) 7 in inflammatory cells from patients with asthma and COPD. Pulm Pharmacol Ther. 2007;20:60-8.
    • (2007) Pulm Pharmacol Ther , vol.20 , pp. 60-68
    • Jones, N.A.1    Leport, M.2    Holand, T.3
  • 61
    • 84877940204 scopus 로고    scopus 로고
    • New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurological and inflammatory disorders
    • 1:CAS:528:DC%2BC3sXotFynsLc%3D 23570245
    • Safavi M, Baeeri M, Abdollahi M. New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurological and inflammatory disorders. Expert Opin Drug Discov. 2013;8:733-51.
    • (2013) Expert Opin Drug Discov , vol.8 , pp. 733-751
    • Safavi, M.1    Baeeri, M.2    Abdollahi, M.3
  • 62
    • 9444228283 scopus 로고    scopus 로고
    • Discovery of BRL 50481 [3-(N, N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: In vitro studies in human monocytes, lung macrophages, and CD8+T-lymphocytes
    • 1:CAS:528:DC%2BD2cXhtVOit7jE 15371556
    • Smith SJ, Cieslinski LB, Newton R, et al. Discovery of BRL 50481 [3-(N, N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+T-lymphocytes. Mol Pharmacol. 2004;66:1679-89.
    • (2004) Mol Pharmacol , vol.66 , pp. 1679-1689
    • Smith, S.J.1    Cieslinski, L.B.2    Newton, R.3
  • 63
    • 70249093993 scopus 로고    scopus 로고
    • A multi-target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice
    • 2696437 19457265
    • Fortin M, D'Anjou H, Higgins ME, et al. A multi-target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice. Respir Res. 2009;10:39.
    • (2009) Respir Res , vol.10 , pp. 39
    • Fortin, M.1    D'Anjou, H.2    Higgins, M.E.3
  • 64
    • 84899797831 scopus 로고    scopus 로고
    • Cyclic nucleotide-based therapeutics for chronic obstructive pulmonary disease
    • 1:CAS:528:DC%2BC2cXhtVSlt7jP 24810285
    • Giembycz MA, Maurice DH. Cyclic nucleotide-based therapeutics for chronic obstructive pulmonary disease. Curr Opin Pharmacol. 2014;16:89-107.
    • (2014) Curr Opin Pharmacol , vol.16 , pp. 89-107
    • Giembycz, M.A.1    Maurice, D.H.2
  • 65
    • 70349338939 scopus 로고    scopus 로고
    • Emerging oligonucleotide therapies for asthma and chronic obstructive pulmonary disease
    • 1:CAS:528:DC%2BD1MXhtFCisLnK 19715448
    • Seguin RM, Ferrari N. Emerging oligonucleotide therapies for asthma and chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2009;18:1505-17.
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 1505-1517
    • Seguin, R.M.1    Ferrari, N.2
  • 66
    • 0034881183 scopus 로고    scopus 로고
    • Does sildenafil also improve breathing?
    • 1:STN:280:DC%2BD3MvgtVertA%3D%3D 11451855
    • Charan NB. Does sildenafil also improve breathing? Chest. 2001;120:305-6.
    • (2001) Chest , vol.120 , pp. 305-306
    • Charan, N.B.1
  • 67
    • 1642493925 scopus 로고    scopus 로고
    • Effect of phosphodiesterase-5 inhibitor, sildenafil (Viagra), in animal models of airways disease
    • 14597480
    • Toward TJ, Smith N, Broadley KJ. Effect of phosphodiesterase-5 inhibitor, sildenafil (Viagra), in animal models of airways disease. Am J Respir Crit Care Med. 2004;169:227-34.
    • (2004) Am J Respir Crit Care Med , vol.169 , pp. 227-234
    • Toward, T.J.1    Smith, N.2    Broadley, K.J.3
  • 68
    • 18744393466 scopus 로고    scopus 로고
    • Life after PDE4: Overcoming adverse events with dual-specificity phosphodiesterase inhibitors
    • 1:CAS:528:DC%2BD2MXktlejtLY%3D 15907909
    • Giembycz MA. Life after PDE4: overcoming adverse events with dual-specificity phosphodiesterase inhibitors. Curr Opin Pharmacol. 2005;5:238-44.
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 238-244
    • Giembycz, M.A.1
  • 69
    • 0042311379 scopus 로고    scopus 로고
    • Therapeutic potential of a new phosphodiesterase inhibitor in acute lung injury
    • 1:CAS:528:DC%2BD3sXmsFGisbg%3D 12882446
    • Rocco PR, Momesso DP, Figueira RC, et al. Therapeutic potential of a new phosphodiesterase inhibitor in acute lung injury. Eur Respir J. 2003;22:20-7.
    • (2003) Eur Respir J , vol.22 , pp. 20-27
    • Rocco, P.R.1    Momesso, D.P.2    Figueira, R.C.3
  • 70
    • 84922080674 scopus 로고    scopus 로고
    • Therapy with a new phosphodiesterase 4 and 5 inhibitor in experimental elastase-induced emphysema [abstract]
    • Guimaraes IH, Padilha GDA, Lopes-Pacheco M, et al. Therapy with a new phosphodiesterase 4 and 5 inhibitor in experimental elastase-induced emphysema [abstract]. Am J Respir Crit Care Med. 2014;189:A6557.
    • (2014) Am J Respir Crit Care Med , vol.189 , pp. 6557
    • Guimaraes, I.H.1    Padilha, G.D.A.2    Lopes-Pacheco, M.3
  • 71
    • 33646249634 scopus 로고    scopus 로고
    • Protective effects of phosphodiesterase inhibitors on lung function and remodeling in a murine model of chronic asthma
    • 1:CAS:528:DC%2BD28XivVWhurg%3D 16470317
    • Campos HS, Xisto DG, Oliveira MB, et al. Protective effects of phosphodiesterase inhibitors on lung function and remodeling in a murine model of chronic asthma. Braz J Med Biol Res. 2006;39:283-7.
    • (2006) Braz J Med Biol Res , vol.39 , pp. 283-287
    • Campos, H.S.1    Xisto, D.G.2    Oliveira, M.B.3
  • 72
    • 84883397197 scopus 로고    scopus 로고
    • Sildenafil to improve respiratory rehabilitation outcomes in COPD: A controlled trial
    • 1:CAS:528:DC%2BC3sXhslWnsbzJ 23429918
    • Blanco I, Santos S, Gea J, et al. Sildenafil to improve respiratory rehabilitation outcomes in COPD: a controlled trial. Eur Respir J. 2013;42:982-92.
    • (2013) Eur Respir J , vol.42 , pp. 982-992
    • Blanco, I.1    Santos, S.2    Gea, J.3
  • 73
    • 82255162733 scopus 로고    scopus 로고
    • PDE1 isozymes, key regulators of pathological vascular remodeling
    • 1:CAS:528:DC%2BC3MXhsFegtr7P 3225597 21962439
    • Chan S, Yan C. PDE1 isozymes, key regulators of pathological vascular remodeling. Curr Opin Pharmacol. 2011;11:720-4.
    • (2011) Curr Opin Pharmacol , vol.11 , pp. 720-724
    • Chan, S.1    Yan, C.2
  • 74
    • 67651163869 scopus 로고    scopus 로고
    • Effects of KF19514, a phosphodiesterase 4 and 1 inhibitor, on bronchial inflammation and remodeling in a murine model of chronic asthma
    • 19390238
    • Kita T, Fujimura M, Myou S, et al. Effects of KF19514, a phosphodiesterase 4 and 1 inhibitor, on bronchial inflammation and remodeling in a murine model of chronic asthma. Allergol Int. 2009;58:267-75.
    • (2009) Allergol Int , vol.58 , pp. 267-275
    • Kita, T.1    Fujimura, M.2    Myou, S.3
  • 75
    • 84896474573 scopus 로고    scopus 로고
    • The in vitro pharmacology of GS-5759, a novel bifunctional phosphodiesterase 4 inhibitor and long acting β2-adrenoceptor agonist
    • 24513870
    • Tannheimer SL, Sorensen EA, Cui Z-H, et al. The in vitro pharmacology of GS-5759, a novel bifunctional phosphodiesterase 4 inhibitor and long acting β2-adrenoceptor agonist. J Pharmacol Exp Ther. 2014;349:85-93.
    • (2014) J Pharmacol Exp Ther , vol.349 , pp. 85-93
    • Tannheimer, S.L.1    Sorensen, E.A.2    Cui, Z.-H.3
  • 76
    • 84873731719 scopus 로고    scopus 로고
    • Hybrids consisting of the pharmacophores of salmeterol and roflumilast or phthalazinone: Dual β2-adrenoceptor agonists-PDE4 inhibitors for the treatment of COPD
    • 1:CAS:528:DC%2BC3sXhvVGgtLg%3D 23375225
    • Liu A, Huang L, Wang Z, et al. Hybrids consisting of the pharmacophores of salmeterol and roflumilast or phthalazinone: dual β2-adrenoceptor agonists-PDE4 inhibitors for the treatment of COPD. Bioorg Med Chem Lett. 2013;23:1548-52.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 1548-1552
    • Liu, A.1    Huang, L.2    Wang, Z.3
  • 77
    • 84891492695 scopus 로고    scopus 로고
    • Design, synthesis and evaluation of dual pharmacology β2-adrenoceptor agonists and PDE4 inhibitors
    • 1:CAS:528:DC%2BC3sXhvFWrsbnL 24300734
    • Huang L, Shan W, Zhou Q, et al. Design, synthesis and evaluation of dual pharmacology β2-adrenoceptor agonists and PDE4 inhibitors. Bioorg Med Chem Lett. 2014;24:249-53.
    • (2014) Bioorg Med Chem Lett , vol.24 , pp. 249-253
    • Huang, L.1    Shan, W.2    Zhou, Q.3
  • 78
    • 84866765937 scopus 로고    scopus 로고
    • Bifunctional compounds for the treatment of COPD
    • 1:CAS:528:DC%2BC38Xhs1eju7vP
    • Phillips G, Salmon M. Bifunctional compounds for the treatment of COPD. Ann Rep Med Chem. 2012;47:209-22.
    • (2012) Ann Rep Med Chem , vol.47 , pp. 209-222
    • Phillips, G.1    Salmon, M.2
  • 79
    • 33144462084 scopus 로고    scopus 로고
    • First dual M3 antagonists-PDE4 inhibitors: Synthesis and SAR of 4,6-diaminopyrimidine derivatives
    • 1:CAS:528:DC%2BD28XhvVyrtbs%3D 16439121
    • Provins L, Christophe B, Danhaive P, et al. First dual M3 antagonists-PDE4 inhibitors: synthesis and SAR of 4,6-diaminopyrimidine derivatives. Bioorg Med Chem Lett. 2006;16:1834-9.
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 1834-1839
    • Provins, L.1    Christophe, B.2    Danhaive, P.3
  • 80
    • 34247892403 scopus 로고    scopus 로고
    • Dual M3 antagonists-PDE4 inhibitors. Part 2: Synthesis and SAR of 3-substituted azetidinyl derivatives
    • 1:CAS:528:DC%2BD2sXlt1Kjurc%3D 17398090
    • Provins L, Christophe B, Danhaive P, et al. Dual M3 antagonists-PDE4 inhibitors. Part 2: synthesis and SAR of 3-substituted azetidinyl derivatives. Bioorg Med Chem Lett. 2007;17:3077-80.
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 3077-3080
    • Provins, L.1    Christophe, B.2    Danhaive, P.3
  • 81
    • 84857080656 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: Benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments
    • 1:CAS:528:DC%2BC38Xis1Ohtb8%3D 3372715 22014080
    • Keravis T, Lugnier C. Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments. Br J Pharmacol. 2012;165:1288-305.
    • (2012) Br J Pharmacol , vol.165 , pp. 1288-1305
    • Keravis, T.1    Lugnier, C.2
  • 82
    • 84900821143 scopus 로고    scopus 로고
    • Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides
    • 1:CAS:528:DC%2BC2cXosVyhtr8%3D
    • Lomas O, Zaccolo M. Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides. Physiology (Bethesda). 2014;29:141-9.
    • (2014) Physiology (Bethesda) , vol.29 , pp. 141-149
    • Lomas, O.1    Zaccolo, M.2
  • 83
    • 84855998675 scopus 로고    scopus 로고
    • AKAPs: The architectural underpinnings of local cAMP signaling
    • 1:CAS:528:DC%2BC38XhtFGhtrY%3D 3168680 21600214
    • Kritzer MD, Li J, Dodge-Kafka K, Kapiloff MS. AKAPs: the architectural underpinnings of local cAMP signaling. J Mol Cell Cardiol. 2012;52:351-8.
    • (2012) J Mol Cell Cardiol , vol.52 , pp. 351-358
    • Kritzer, M.D.1    Li, J.2    Dodge-Kafka, K.3    Kapiloff, M.S.4


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