메뉴 건너뛰기




Volumn 20, Issue 1, 2007, Pages 60-68

Phosphodiesterase (PDE) 7 in inflammatory cells from patients with asthma and COPD

Author keywords

Asthma; COPD; Lymphocyte; Neutrophil; PDE 4; PDE 7; Phosphodiesterase

Indexed keywords

4 [5 [3 HYDROXYCYCLOHEXYLIMINO] 4 METHYL 4,5 DIHYDRO[1,3,4]THIADIAZOL 2 YL]BENZAMIDE; CHROMOGENIC SUBSTRATE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; LEUKOCYTE ELASTASE; MESSENGER RNA; PF 0332040; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IVA; PHOSPHODIESTERASE IVB; PHOSPHODIESTERASE IVC; PHOSPHODIESTERASE IVD; PHOSPHODIESTERASE VII; PHOSPHODIESTERASE VIIA; PHOSPHODIESTERASE VIIB; PHYTOHEMAGGLUTININ; ROLIPRAM; THYMIDINE; TRITIUM; UNCLASSIFIED DRUG;

EID: 33751043887     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2005.11.010     Document Type: Article
Times cited : (31)

References (30)
  • 1
    • 0001747287 scopus 로고    scopus 로고
    • Acute anti-inflammatory effect of the novel phosphodiesterase 4 inhibitor roflumilast on allergen challenge in asthmatics after a single dose
    • Nell H., Louw C., Leichtl S., Rathgeb F., Neuhauser M., and Bardin P.G. Acute anti-inflammatory effect of the novel phosphodiesterase 4 inhibitor roflumilast on allergen challenge in asthmatics after a single dose. Am J Respir Crit Care Med 161 (2000) A200
    • (2000) Am J Respir Crit Care Med , vol.161
    • Nell, H.1    Louw, C.2    Leichtl, S.3    Rathgeb, F.4    Neuhauser, M.5    Bardin, P.G.6
  • 2
    • 0000619359 scopus 로고    scopus 로고
    • Efficacy of once-daily roflumilast, a new orally active, selective phosphodiesterase 4 inhibitor, in chronic obstructive pulmonary disease
    • Leichtl S., Syed J., and Bredenbroker D. Efficacy of once-daily roflumilast, a new orally active, selective phosphodiesterase 4 inhibitor, in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 165 (2002)
    • (2002) Am J Respir Crit Care Med , vol.165
    • Leichtl, S.1    Syed, J.2    Bredenbroker, D.3
  • 3
    • 0033524977 scopus 로고    scopus 로고
    • CD3- and CD28-dependent induction of PDE7 required for T cell activation
    • Li L., Yee C., and Beavo J.A. CD3- and CD28-dependent induction of PDE7 required for T cell activation. Science 283 (1999) 848-849
    • (1999) Science , vol.283 , pp. 848-849
    • Li, L.1    Yee, C.2    Beavo, J.A.3
  • 4
    • 0020410475 scopus 로고
    • Elevated leukocyte cyclic AMP-phosphodiesterase in atopic disease: a possible mechanism for cyclic AMP-agonist hyporesponsiveness
    • Grewe S.R., Chan S.C., and Hanifin J.M. Elevated leukocyte cyclic AMP-phosphodiesterase in atopic disease: a possible mechanism for cyclic AMP-agonist hyporesponsiveness. J Allergy Clin Immunol 70 (1982) 452-457
    • (1982) J Allergy Clin Immunol , vol.70 , pp. 452-457
    • Grewe, S.R.1    Chan, S.C.2    Hanifin, J.M.3
  • 5
    • 0027194175 scopus 로고
    • Immunochemical characterization of the distinct monocyte cyclic AMP-phosphodiesterase from patients with atopic dermatitis
    • Chan S.C., Reifsnyder D., Beavo J.A., and Hanifin J.M. Immunochemical characterization of the distinct monocyte cyclic AMP-phosphodiesterase from patients with atopic dermatitis. J Allergy Clin Immunol 91 (1993) 1179-1188
    • (1993) J Allergy Clin Immunol , vol.91 , pp. 1179-1188
    • Chan, S.C.1    Reifsnyder, D.2    Beavo, J.A.3    Hanifin, J.M.4
  • 7
    • 0033737479 scopus 로고    scopus 로고
    • A biochemical and functional assessment of monocyte phosphodiesterase activity in healthy and asthmatic subjects
    • Landells L.J., Spina D., Souness J.E., O'Connor B.J., and Page C.P. A biochemical and functional assessment of monocyte phosphodiesterase activity in healthy and asthmatic subjects. Pulm Pharmacol Ther 13 (2000) 231-239
    • (2000) Pulm Pharmacol Ther , vol.13 , pp. 231-239
    • Landells, L.J.1    Spina, D.2    Souness, J.E.3    O'Connor, B.J.4    Page, C.P.5
  • 9
    • 0030876492 scopus 로고    scopus 로고
    • Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: a comparative study
    • Gantner F., Tenor H., Gekeler V., Schudt C., Wendel A., and Hatzelmann A. Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: a comparative study. J Allergy Clin Immunol 100 (1997) 527-535
    • (1997) J Allergy Clin Immunol , vol.100 , pp. 527-535
    • Gantner, F.1    Tenor, H.2    Gekeler, V.3    Schudt, C.4    Wendel, A.5    Hatzelmann, A.6
  • 10
    • 0027317131 scopus 로고
    • A new cyclic nucleotide phosphodiesterase isozyme expressed in the T-lymphocyte cell lines
    • Ichimura M., and Kase H. A new cyclic nucleotide phosphodiesterase isozyme expressed in the T-lymphocyte cell lines. Biochem Biophys Res Commun 193 (1993) 985-990
    • (1993) Biochem Biophys Res Commun , vol.193 , pp. 985-990
    • Ichimura, M.1    Kase, H.2
  • 11
    • 0030459832 scopus 로고    scopus 로고
    • Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants
    • Bloom T.J., and Beavo J.A. Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants. Proc Natl Acad Sci USA 93 (1996) 14188-14192
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14188-14192
    • Bloom, T.J.1    Beavo, J.A.2
  • 14
    • 0036277784 scopus 로고    scopus 로고
    • Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors
    • Nakata A., Ogawa K., Sasaki T., Koyama N., Wada K., Kotera J., et al. Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors. Clin Exp Immunol 128 (2002) 460-466
    • (2002) Clin Exp Immunol , vol.128 , pp. 460-466
    • Nakata, A.1    Ogawa, K.2    Sasaki, T.3    Koyama, N.4    Wada, K.5    Kotera, J.6
  • 15
    • 0034944944 scopus 로고    scopus 로고
    • Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects
    • Landells L.J., Szilagy C.M., Jones N.A., Banner K.H., Allen J.M., Doherty A., et al. Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects. Br J Pharmacol 133 (2001) 722-729
    • (2001) Br J Pharmacol , vol.133 , pp. 722-729
    • Landells, L.J.1    Szilagy, C.M.2    Jones, N.A.3    Banner, K.H.4    Allen, J.M.5    Doherty, A.6
  • 16
    • 8544250603 scopus 로고    scopus 로고
    • Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies
    • Vergne F., Bernardelli P., Lorthiois E., Pham N., Proust E., Oliveira C., et al. Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies. Bioorg Med Chem Lett 14 (2004) 4607-4613
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 4607-4613
    • Vergne, F.1    Bernardelli, P.2    Lorthiois, E.3    Pham, N.4    Proust, E.5    Oliveira, C.6
  • 17
    • 8544256308 scopus 로고    scopus 로고
    • Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: metabolism-directed optimization studies towards orally bioavailable derivatives
    • Vergne F., Bernardelli P., Lorthiois E., Pham N., Proust E., Oliveira C., et al. Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: metabolism-directed optimization studies towards orally bioavailable derivatives. Bioorg Med Chem Lett 14 (2004) 4615-4621
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 4615-4621
    • Vergne, F.1    Bernardelli, P.2    Lorthiois, E.3    Pham, N.4    Proust, E.5    Oliveira, C.6
  • 18
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162 (1987) 156-159
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 20
    • 9444228283 scopus 로고    scopus 로고
    • Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes
    • Smith S.J., Cieslinski L.B., Newton R., Donnelly L.E., Fenwick P.S., Nicholson A.G., et al. Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. Mol Pharmacol 66 (2004) 1679-1689
    • (2004) Mol Pharmacol , vol.66 , pp. 1679-1689
    • Smith, S.J.1    Cieslinski, L.B.2    Newton, R.3    Donnelly, L.E.4    Fenwick, P.S.5    Nicholson, A.G.6
  • 21
    • 0029560498 scopus 로고
    • Differential effect of phosphodiesterase 4 inhibitors on the proliferation of human peripheral blood mononuclear cells from normals and subjects with atopic dermatitis
    • Banner K.H., Roberts N.M., and Page C.P. Differential effect of phosphodiesterase 4 inhibitors on the proliferation of human peripheral blood mononuclear cells from normals and subjects with atopic dermatitis. Br J Pharmacol 116 (1995) 3169-3174
    • (1995) Br J Pharmacol , vol.116 , pp. 3169-3174
    • Banner, K.H.1    Roberts, N.M.2    Page, C.P.3
  • 22
    • 0035224418 scopus 로고    scopus 로고
    • PDE4 cAMP-specific phosphodiesterases
    • Houslay M.D. PDE4 cAMP-specific phosphodiesterases. Prog Nucleic Acid Res Mol Biol 69 (2001) 249-315
    • (2001) Prog Nucleic Acid Res Mol Biol , vol.69 , pp. 249-315
    • Houslay, M.D.1
  • 23
    • 0036016114 scopus 로고    scopus 로고
    • Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)
    • MacKenzie S.J., Baillie G.S., McPhee I., MacKenzie C., Seamons R., McSorley T., et al. Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1). Br J Pharmacol 136 (2002) 421-433
    • (2002) Br J Pharmacol , vol.136 , pp. 421-433
    • MacKenzie, S.J.1    Baillie, G.S.2    McPhee, I.3    MacKenzie, C.4    Seamons, R.5    McSorley, T.6
  • 24
    • 3242726932 scopus 로고    scopus 로고
    • Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers
    • Barber R., Baillie G.S., Bergmann R., Shepherd M.C., Sepper R., Houslay M.D., et al. Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers. Am J Physiol Lung Cell Mol Physiol 287 (2004) L332-L343
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287
    • Barber, R.1    Baillie, G.S.2    Bergmann, R.3    Shepherd, M.C.4    Sepper, R.5    Houslay, M.D.6
  • 27
    • 0029165312 scopus 로고
    • PDE isoenzymes as targets for anti-asthma drugs
    • Schudt C., Tenor H., and Hatzelmann A. PDE isoenzymes as targets for anti-asthma drugs. Eur Respir J 8 (1995) 1179-1183
    • (1995) Eur Respir J , vol.8 , pp. 1179-1183
    • Schudt, C.1    Tenor, H.2    Hatzelmann, A.3
  • 28
    • 15144342064 scopus 로고    scopus 로고
    • Effect of rolipram and dibutyryl cyclic AMP on resequestration of cytosolic calcium in FMLP-activated human neutrophils
    • Anderson R., Mahomed A.G., Theron A.J., Ramafi G., and Feldman C. Effect of rolipram and dibutyryl cyclic AMP on resequestration of cytosolic calcium in FMLP-activated human neutrophils. Br J Pharmacol 124 (1998) 547-555
    • (1998) Br J Pharmacol , vol.124 , pp. 547-555
    • Anderson, R.1    Mahomed, A.G.2    Theron, A.J.3    Ramafi, G.4    Feldman, C.5
  • 29
    • 0031911575 scopus 로고    scopus 로고
    • SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions
    • Barnette M.S., Christensen S.B., Essayan D.M., Grous M., Prabhakar U., Rush J.A., et al. SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions. J Pharmacol Exp Ther 284 (1998) 420-426
    • (1998) J Pharmacol Exp Ther , vol.284 , pp. 420-426
    • Barnette, M.S.1    Christensen, S.B.2    Essayan, D.M.3    Grous, M.4    Prabhakar, U.5    Rush, J.A.6
  • 30
    • 11844249945 scopus 로고    scopus 로고
    • The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vitro
    • Jones N.A., Boswell-Smith V., Lever R., and Page C.P. The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vitro. Pulm Pharmacol Ther 18 (2005) 93-101
    • (2005) Pulm Pharmacol Ther , vol.18 , pp. 93-101
    • Jones, N.A.1    Boswell-Smith, V.2    Lever, R.3    Page, C.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.