Phosphodiesterase inhibitors. Part 5: Hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 1, 2013, Pages 375-381

  Ochiai, Koji ^a   Takita, Satoshi ^a   Kojima, Akihiko ^a   Eiraku, Tomohiko ^a   Iwase, Kazuhiko ^a   Kishi, Tetsuya ^a   Ohinata, Akira ^a   Yageta, Yuichi ^a   Yasue, Tokutaro ^a   Adams, David R ^b   Kohno, Yasushi ^a  

^a KYORIN PHARMACEUTICAL CO LTD   (Japan)

^b HERIOT WATT UNIVERSITY   (United Kingdom)

Author keywords

Asthma; COPD; Dual PDE3 4 inhibitor; Inhaled administration; Phosphodiesterase (PDE)

Indexed keywords

4,5 DIHYDRO 6 [4 (1H IMIDAZOL 1 YL)PHENYL] 5 METHYL 3(2H) PYRIDAZINONE; 6 ARYL 4,5 DIHYDROPYRIDAZIN 3 (2H) ONE; AROMATIC COMPOUND; HISTAMINE; KCA 1490; PHOSPHODIESTERASE III; PHOSPHODIESTERASE III INHIBITOR; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; PYRAZOLOPYRIDINE; PYRIDAZINONE DERIVATIVE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ALKYLATION; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRONCHODILATATION; BRONCHOSPASM; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; GUINEA PIG; IC 50; IN VIVO STUDY; NONHUMAN; RING OPENING;

ADMINISTRATION, INHALATION; ANIMALS; ANTI-INFLAMMATORY AGENTS; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHODILATOR AGENTS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DRUG DESIGN; LEUKOCYTES; PHOSPHODIESTERASE 3 INHIBITORS; PHOSPHODIESTERASE 4 INHIBITORS; PROTEIN BINDING; PYRIDAZINES; PYRIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870991478     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.121     Document Type: Article

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