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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 1, 2014, Pages 249-253

Design, synthesis and evaluation of dual pharmacology β2- adrenoceptor agonists and PDE4 inhibitors

(6) Huang, Ling a Shan, Wenjun c Zhou, Qi a Xie, Jiaxing b Lai, Kefang b Li, Xingshu a

a SUN YAT SEN UNIVERSITY (China)

b GUANGZHOU MEDICAL UNIVERSITY (China)

c Jiangsu Hansoh Pharmaceutical Research Institute Co Ltd (China)

Author keywords

2 Adrenoceptor agonist; Bronchodilator; Chronic obstructive pulmonary disease (COPD); PDE4 inhibitor

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; ISOPRENALINE; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM; 4 (3,4 DIMETHOXYPHENYL) 4A,5,8,8A TETRAHYDRO 2H PHTHALAZIN 1 ONE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CILOMILAST; N ALKYL PHTHALAZINONE; ROFLUMILAST; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENANTIOMER; GENE EXPRESSION; GUINEA PIG; HUMAN; HYDROGENATION; HYDROLYSIS; IC 50; IN VITRO STUDY; NONHUMAN; PHARMACOPHORE; STEREOISOMERISM; CONCENTRATION CAMP; CONTROLLED STUDY; EC50; ENZYME ASSAY; HYBRID; NEUTROPHIL;

BRONCHODILATOR; CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD); PDE4 INHIBITOR; Β(2)-ADRENOCEPTOR AGONIST;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ETHANOLAMINES; HUMANS; MOLECULAR STRUCTURE; PHOSPHODIESTERASE 4 INHIBITORS; PHTHALAZINES; RECEPTORS, ADRENERGIC, BETA-2; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84891492695 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.11.028 Document Type: Article

Times cited : (19)

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