Hybrids consisting of the pharmacophores of salmeterol and roflumilast or phthalazinone: Dual β2-adrenoceptor agonists-PDE4 inhibitors for the treatment of COPD

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 5, 2013, Pages 1548-1552

  Liu, Anqiu ^a   Huang, Ling ^a   Wang, Zhiren ^a   Luo, Zonghua ^a   Mao, Fei ^a   Shan, Wenjun ^a   Xie, Jiaxing ^b   Lai, Kefang ^b   Li, Xingshu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

2 Adrenoceptor agonist; Bronchodilator; COPD; PDE4 inhibitor

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; PHOSPHODIESTERASE IV; ROFLUMILAST; SALMETEROL;

ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; DRUG DESIGN; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HUMAN;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ALBUTEROL; AMINOPYRIDINES; BENZAMIDES; BRONCHODILATOR AGENTS; CYCLOPROPANES; HUMANS; PHOSPHODIESTERASE 4 INHIBITORS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

EID: 84873731719     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.11.058     Document Type: Article

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