Physiologically based modeling of the pharmacokinetics of acetaminophen and its major metabolites in humans using a Bayesian population approach

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 41, Issue 3, 2016, Pages 267-280

  Zurlinden, Todd J ^a   Reisfeld, Brad ^a  

^a Engineering Research Center and Hydraulics Laboratory   (United States)

Author keywords

Acetaminophen; APAP; Bayesian population; PBPK; Physiologically based pharmacokinetic modeling

Indexed keywords

PARACETAMOL; BIOLOGICAL MARKER;

ARTICLE; BAYES THEOREM; CONCENTRATION RESPONSE; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG STRUCTURE; HEART OUTPUT; HUMAN; PHARMACOKINETIC ASSAY; PHARMACOKINETIC PARAMETERS; RENAL CLEARANCE; STOMACH EMPTYING; TISSUE DISTRIBUTION; VALIDATION STUDY; BIOLOGICAL MODEL; BLOOD; LIVER; METABOLISM;

ACETAMINOPHEN; BAYES THEOREM; BIOMARKERS; HUMANS; LIVER; MODELS, BIOLOGICAL; TISSUE DISTRIBUTION;

EID: 84921947279     PISSN: 03787966     EISSN: 21070180     Source Type: Journal    
DOI: 10.1007/s13318-015-0253-x     Document Type: Article

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