Prediction of dose-hepatotoxic response in humans based on toxicokinetic/toxicodynamic modeling with or without in vivo data: A case study with acetaminophen

Toxicology Letters

Volumn 220, Issue 1, 2013, Pages 26-34

  Péry, Alexandre R R ^a   Brochot, Céline ^a   Zeman, Florence A ^a   Mombelli, Enrico ^a   Desmots, Sophie ^a   Pavan, Manuela ^b   Fioravanzo, Elena ^b   Zaldívar, José Manuel ^c  

^a INSTITUT NATIONAL DE L ENVIRONNEMENT INDUSTRIEL ET DES RISQUES INERIS   (France)

^b S IN Soluzioni Informatiche   (Italy)

^c JOINT RESEARCH CENTRE   (Italy)

Author keywords

Acetaminophen; Liver toxicity; Model calibration; PBPK; Vitro vivo extrapolation

Indexed keywords

PARACETAMOL;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALIBRATION; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; IN VITRO STUDY; KIDNEY CLEARANCE; LIVER TOXICITY; MALE; METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT; TOXICOKINETICS;

ACETAMINOPHEN; ANALGESICS; ANIMAL TESTING ALTERNATIVES; ANIMALS; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; FORECASTING; HUMANS; MALE; MODELS, BIOLOGICAL; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84877330506     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.03.032     Document Type: Article

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