The comparative pharmacokinetics of modified-release and immediate-release paracetamol in a simulated overdose model

EMA - Emergency Medicine Australasia

Volumn 22, Issue 6, 2010, Pages 548-555

  Chiew, Angela ^a   Day, Peter ^b   Salonikas, Chris ^b   Naidoo, Daya ^b   Graudins, Andis ^c   Thomas, Rebecca ^b  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b New South Wales Government   (Australia)

^c MONASH UNIVERSITY   (Australia)

Author keywords

Metabolites; Modified release; Overdose; Paracetamol; Pharmacokinetics

Indexed keywords

CYSTEINE; GLUCURONIDE; PANADOL EXTEND; PARACETAMOL; SULFATE; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DOSAGE FORM COMPARISON; DRUG HALF LIFE; DRUG METABOLISM; DRUG OVERDOSE; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TIME TO MAXIMUM PLASMA CONCENTRATION;

ACETAMINOPHEN; ADULT; ANALGESICS, NON-NARCOTIC; AREA UNDER CURVE; AUSTRALIA; CROSS-OVER STUDIES; DELAYED-ACTION PREPARATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HALF-LIFE; HUMANS; LONGITUDINAL STUDIES; MALE; MAXIMUM TOLERATED DOSE; MIDDLE AGED; MODELS, BIOLOGICAL; NONPRESCRIPTION DRUGS; PRESCRIPTION DRUG MISUSE;

EID: 78650357833     PISSN: 17426731     EISSN: 17426723     Source Type: Journal    
DOI: 10.1111/j.1742-6723.2010.01354.x     Document Type: Article

References (14)

1. Buckley NA, Eddleston M. Paracetamol (Acetaminophen) poisoning. Clin. Evid. 2005; 14: 1738-44.
2. GlaxoSmithKline. Panadol Extend Product Information. 2002.
3. Prescott LF, Illingworth RN, Critchley JA, Stewart MJ, Adam RD, Proudfoot AT. Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning. Br. Med. J. 1979; 2 (6198): 1097-100.
4. Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985) [see comments]. N. Engl. J. Med. 1988; 319 (24): 1557-62.
5. Rumack BH, Matthew H. Acetaminophen poisoning and toxicity. Pediatrics 1975; 55: 871-6.
6. Daly FFS, Fountain J, Graudins A, Murray L, Buckley N. Consensus statement: New guidelines for the management of paracetamol (Acetaminophen) Poisoning in Australia and New Zealand - Explanation and elaboration. Med. J. Aust. 2008; 188: 296-301.
7. Tan C, Graudins A. Comparative pharmacokinetics of Panadol Extend and immediate-release paracetamol in a simulated overdose model. Emerg. Med. Australas. 2006; 18: 398-403.
8. Gelotte CK, Auiler JF, Lynch JM, Temple AR, Slattery JT. Disposition of acetaminophen at 4, 6, and 8g/day for 3days in healthy young adults. Clin. Pharmacol. Ther. 2007; 81: 840-8.
9. Prescott LF. Drug conjugation in clinical toxicology. Biochem. Soc. Trans. 1984; 12: 96-9.
10. Bacon TH, Hole JG, North M, Burnett I. Analgesic efficacy of susteined release paracetamol in patients with osteoarthritis of the knee. Br. J. Clin. Pharmacol. 2002; 53: 629-36.
11. Halcomb SE, Sivilotti MLA, Goklaney A, Mullins ME. Pharmacokinetics effects of diphenhydramine or oxycodone in simulated acetaminophen overdose. Acad. Emerg. Med. 2005; 12: 169-72.
12. Roberts DM, Buckley NA. Prolonged absorption and delayed peak paracetamol concentration following poisoning with extended-release formulation. Med. J. Aust. 2008; 188: 310-11.
13. Graudins A, Chiew A, Chan BS. Overdose with modified-release paracetamol results in delayed and prolonged absorption of paracetamol: a case series. Intern. Med. J. 2010; 40: 72-6.
14. Graudins A, Pham H, Day P, Salonikas C, Naidoo D, Chan BS. Early presentation following overdose of modified-release paracetamol (Panadol Osteo) with biphasic and prolonged paracetamol absorption. N. Z. Med. J. 2009; 122 (1300): 64-71.