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Volumn 893-894, Issue , 2012, Pages 162-167
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Simultaneous quantitative determination of paracetamol and its glucuronide conjugate in human plasma and urine by liquid chromatography coupled to electrospray tandem mass spectrometry: Application to a clinical pharmacokinetic study
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Author keywords
Human plasma and urine; LC MS MS; Paracetamol; Paracetamol glucuronide; Pharmacokinetic
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Indexed keywords
ANALYTES;
BIOLOGICAL MATRIXES;
CLINICAL PHARMACOKINETICS;
CONCENTRATION RANGES;
ELECTROSPRAY TANDEM MASS SPECTROMETRY;
EXTRACTION RECOVERY;
GLUCURONIDES;
HPLC-MS/MS;
HUMAN PLASMAS;
ISOCRATIC ELUTION;
LC-MS/MS;
LIQUID CHROMATOGRAPHY COUPLED TO TANDEM MASS SPECTROMETRY;
MOBILE PHASE;
MULTIPLE-REACTION MONITORING MODES;
PARACETAMOL;
PLASMA SAMPLES;
POSITIVE ELECTROSPRAY IONIZATION;
PROPYLENE GLYCOLS;
QUANTITATIVE DETERMINATIONS;
RAPID METHOD;
SIMULTANEOUS DETERMINATIONS;
TRIPLE QUADRUPOLE;
URINE SAMPLE;
ACETONITRILE;
CHROMATOGRAPHY;
ELECTROSPRAY IONIZATION;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
MASS SPECTROMETRY;
PHARMACOKINETICS;
PLASMA (HUMAN);
BODY FLUIDS;
PARACETAMOL;
PARACETAMOL GLUCURONIDE;
ACCURACY;
ADULT;
ARTICLE;
BLOOD SAMPLING;
DRUG BLOOD LEVEL;
DRUG HALF LIFE;
DRUG STABILITY;
DRUG URINE LEVEL;
ELECTROSPRAY MASS SPECTROMETRY;
ELUTION;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
HUMAN;
HUMAN EXPERIMENT;
MAXIMUM PLASMA CONCENTRATION;
NORMAL HUMAN;
PLASMA CONCENTRATION-TIME CURVE;
PRIORITY JOURNAL;
QUANTITATIVE ANALYSIS;
TANDEM MASS SPECTROMETRY;
TIME TO MAXIMUM PLASMA CONCENTRATION;
URINALYSIS;
ACETAMINOPHEN;
ADULT;
CHROMATOGRAPHY, LIQUID;
HUMANS;
LINEAR MODELS;
REPRODUCIBILITY OF RESULTS;
SENSITIVITY AND SPECIFICITY;
SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;
TANDEM MASS SPECTROMETRY;
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EID: 84862782107
PISSN: 15700232
EISSN: 1873376X
Source Type: Journal
DOI: 10.1016/j.jchromb.2012.02.027 Document Type: Article |
Times cited : (31)
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References (23)
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