Introduction to pharmacokinetics in clinical toxicology

Methods in Molecular Biology

Volumn 929, Issue , 2012, Pages 289-312

  Vajjah, Pavan ^a,b   Isbister, Geoffrey K ^c   Duffull, Stephen B ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b CERTARA UK LIMITED   (United Kingdom)

^c UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

Clearance; Clinical toxicology; Compartmental models; Disposition; Input; Pharmacokinetics; Volume of distribution

Indexed keywords

AMITRIPTYLINE; ANTICONVULSIVE AGENT; CARBAMAZEPINE; CETIRIZINE; CLARITHROMYCIN; CODEINE; CYCLOSPORIN; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DABIGATRAN ETEXILATE; DIGOXIN; DISULFIRAM; DRUG METABOLITE; FEXOFENADINE; GLIBENCLAMIDE; HYDROXYZINE; IRON; LITHIUM; METHOTREXATE; MORPHINE; MULTIDRUG RESISTANCE PROTEIN; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NORTRIPTYLINE; PARACETAMOL; SALICYLIC ACID DERIVATIVE; TERBUTALINE; THEOPHYLLINE; TRICYCLIC ANTIDEPRESSANT AGENT; UNINDEXED DRUG;

ARTICLE; CENTRAL NERVOUS SYSTEM DEPRESSION; CHEMICAL STRUCTURE; COMA; CONCENTRATION RESPONSE; CONFUSION; CREATININE CLEARANCE; DRUG ABSORPTION; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG EFFECT; DRUG ELIMINATION; DRUG EXCRETION; DRUG EXPOSURE; DRUG HALF LIFE; DRUG METABOLISM; DRUG RESPONSE; DRUG SOLUBILITY; GASTROINTESTINAL TRACT; GLOMERULUS FILTRATION; HEART OUTPUT; HUMAN; KIDNEY CLEARANCE; KIDNEY TUBULE ABSORPTION; LIPOPHILICITY; LIVER METABOLISM; MATHEMATICAL MODEL; MEDICAL DECISION MAKING; PHYSICAL CHEMISTRY; PLASMA PROTEIN BINDING; PRACTICE GUIDELINE; PRIORITY JOURNAL; QT PROLONGATION; RISK ASSESSMENT;

EID: 84934441541     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-50-2_12     Document Type: Article

References (36)

1. Dawson AH, Whyte IM (2001) Therapeutic drug monitoring in drug overdose. Br J Clin Pharmacol 52(Suppl 1):97S-102S
2. Isbister GK (2010) How do we use drug concentration data to improve the treatment of overdose patients? Ther Drug Monit 32:300-304
3. Isbister GK, Friberg LE, Duuull SB (2006) Application of pharmacokineticpharmacodynamic modelling in management of QT abnormalities after citalopram overdose. Intensive Care Med 32:1060-1065
4. Friberg LE, Isbister GK, Duuull SB (2006) Pharmacokinetic-pharmacodynamic modelling ofQTinterval prolongation following citalopram overdoses. Br J Clin Pharmacol 61:177-190
5. Martinez MN, Amidon GL (2002) A mechanistic approach to understanding the factors affecting drug absorption: a review of fundamentals. J Clin Pharmacol 42:620-643
6. Lin JH, Chiba M, Baillie TA (1999) Is the role of the small intestine in first-pass metabolism overemphasized? Pharmacol Rev 51:135-158
7. Hoppu K, Koskimies O, Holmberg C, Hirvisalo EL (1991) Evidence for pre-hepatic metabolism of oral cyclosporine in children. Br J Clin Pharmacol 32:477-481
8. Pacifici GM, Eligi M, Giuliani L (1993) (+) and (-) terbutaline are sulphated at a higher rate in human intestine than in liver. Eur J Clin Pharmacol 45:483-487
9. Tanigawara Y, Okamura N, Hirai M, Yasuhara M, Ueda K, Kioka N, Komano T, Hori R (1992) Transport of digoxin by human Pglycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1). J Pharmacol Exp Ther 263:840-845
10. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB (1999) OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos 27:866-871
11. Lindenberg M, Kopp S, Dressman JB (2004) Classification of orally administered drugs on the World Health Organization Model list of Essential Medicines according to the biopharmaceutics classification system. Eur J Pharm Biopharm 58:265-278
12. Friberg LE, Isbister GK, Hackett LP, Duull SB (2005) The population pharmacokinetics of citalopram after deliberate self-poisoning: a Bayesian approach. J Pharmacokinet Pharmacodyn 32:571-605
13. Isbister GK, Friberg LE, Hackett LP, Duuull SB (2007) Pharmacokinetics of quetiapine in overdose and the effect of activated charcoal. Clin Pharmacol Ther 81:821-827
14. Kumar VV, Oscarsson S, Friberg LE, Isbister GK, Hackett LP, Duuull SB (2009) The effect of decontamination procedures on the pharmacokinetics of venlafaxine in overdose. Clin Pharmacol Ther 86:403-410
15. Buckley NA, Dawson AH, Reith DA (1995) Controlled release drugs in overdose: clinical considerations. Drug Saf 12:73-84
16. Brahmi N, Kouraichi N, Thabet H, Amamou M (2006) Influence of activated charcoal on the pharmacokinetics and the clinical features of carbamazepine poisoning. Am J Emerg Med 24:440-443
17. Hulten BA, Heath A, Knudsen K, Nyberg G, Starmark JE, Martensson E (1992) Severe amitriptyline overdose: relationship between toxicokinetics and toxicodynamics. J Toxicol Clin Toxicol 30:171-179
18. Hulten BA, Heath A, Knudsen K, Nyberg G, Svensson C, Martensson E (1992) Amitriptyline and amitriptyline metabolites in blood and cerebrospinal fluid following human overdose. J Toxicol Clin Toxicol 30:181-201
19. Meineke I, Schmidt W, Nottrott M, Schroder T, Hellige G, Gundert-Remy U (1997) Modelling of non-linear pharmacokinetics in sheep after short-term infusion of cardiotoxic doses of imipramine. Pharmacol Toxicol 80:266-271
20. Waring WS (2006) Management of lithium toxicity. Toxicol Rev 25:221-230
21. Sproule BA, Hardy BG, Shulman KI (2000) Differential pharmacokinetics of lithium in elderly patients. Drugs Aging 16:165-177
22. Balit CR, Daly FFS, Little M, Murray L (2006) Oral methotrexate overdose. Clin Toxicol 44:1
23. Sanford M, Plosker GL (2008) Dabigatran etexilate. Drugs 68:1699-1709
24. Goldblum R (1993) Therapy of rheumatoid arthritis with mycophenolate mofetil. Clin Exp Rheumatol 11(Suppl 8):S117-S119
25. Watson CP, Vernich L, Chipman M, Reed K (1998) Nortriptyline versus amitriptyline in postherpetic neuralgia: a randomized trial. Neurology 51:1166-1171
26. Tashkin DP, Brik A, Gong H Jr (1987) Cetirizine inhibition of histamine-induced bronchospasm. Ann Allergy 59:49-52
27. Manyike PT, Kharasch ED, Kalhorn TF, Slattery JT (2000) Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation. Clin Pharmacol Ther 67:275-282
28. Schmidt LE, Dalhoff K, Poulsen HE (2002) Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity. Hepatology 35:876-882
29. Thummel KE, Slattery JT, Ro H, Chien JY, Nelson SD, Lown KE,Watkins PB (2000) Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults. Clin Pharmacol Ther 67:591-599
30. Levy G, Galinsky RE, Lin JH (1982) Pharmacokinetic consequences and toxicologic implications of endogenous cosubstrate depletion. Drug Metab Rev 13:1009-1020
31. Gelotte CK, Auiler JF, Lynch JM, Temple AR, Slattery JT (2007) Disposition of acetaminophen at 4, 6, and 8 g/day for 3 days in healthy young adults. Clin Pharmacol Ther 81:840-848
32. Tirona RG, Kim RB (2002) Pharmacogenomics of organic anion-transporting polypeptides (OATP). Adv Drug Deliv Rev 54:1343-1352
33. Levy G, Tsuchiya T (1972) Salicylate accumulation kinetics in man.NEngl J Med 287:430-432
34. Done AK (1960) Salicylate intoxication. Significance of measurements of salicylate in blood in cases of acute ingestion. Pediatrics 26:800-807
35. Cumming G, Dukes DC, Widdowson G (1964) Alkaline diuresis in treatment of aspirin poisoning. Br Med J 2:1033-1036
36. Rosenzweig P, Canal M, Patat A, Bergougnan L, Zieleniuk I, Bianchetti G (2002) A review of the pharmacokinetics, tolerability and pharmacodynamics of amisulpride in healthy volunteers. Hum Psychopharmacol 17:1-13