-
2
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444:860-867.
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
3
-
-
44449118921
-
Fatty acid-binding proteins: Role in metabolic diseases and potential as drug targets
-
Furuhashi M, Hotamisligil GS. Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov. 2008;7:489-503.
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 489-503
-
-
Furuhashi, M.1
Hotamisligil, G.S.2
-
4
-
-
0010626731
-
Adipocyte P2 gene: Developmental expression and homology of 5'-flanking sequences among fat cell-specific genes
-
Hunt CR, Ro JH, Dobson DE, Min HY, Spiegelman BM. Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes. Proc Natl Acad Sci USA. 1986;83:3786-3790.
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 3786-3790
-
-
Hunt, C.R.1
Ro, J.H.2
Dobson, D.E.3
Min, H.Y.4
Spiegelman, B.M.5
-
5
-
-
0034959752
-
Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein e against atherosclerosis
-
Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamisligil GS, Linton MF. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nat Med. 2001;7:699-705.
-
(2001)
Nat Med
, vol.7
, pp. 699-705
-
-
Makowski, L.1
Boord, J.B.2
Maeda, K.3
Babaev, V.R.4
Uysal, K.T.5
Morgan, M.A.6
Parker, R.A.7
Suttles, J.8
Fazio, S.9
Hotamisligil, G.S.10
Linton, M.F.11
-
6
-
-
0029847504
-
Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein
-
Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science. 1996;274:1377-1379.
-
(1996)
Science
, vol.274
, pp. 1377-1379
-
-
Hotamisligil, G.S.1
Johnson, R.S.2
Distel, R.J.3
Ellis, R.4
Papaioannou, V.E.5
Spiegelman, B.M.6
-
7
-
-
0034457430
-
Improved glucose and lipid metabolism in genetically obese mice lacking aP2
-
Uysal KT, Scheja L, Wiesbrock SM, Bonner-Weir S, Hotamisligil GS. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology. 2000;141:3388-3396.
-
(2000)
Endocrinology
, vol.141
, pp. 3388-3396
-
-
Uysal, K.T.1
Scheja, L.2
Wiesbrock, S.M.3
Bonner-Weir, S.4
Hotamisligil, G.S.5
-
8
-
-
0032882081
-
Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/-mice
-
Scheja L, Makowski L, Uysal KT, Wiesbrock SM, Shimshek DR, Meyers DS, Morgan M, Parker RA, Hotamisligil GS. Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/-mice. Diabetes. 1999;48:1987-1994.
-
(1999)
Diabetes
, vol.48
, pp. 1987-1994
-
-
Scheja, L.1
Makowski, L.2
Uysal, K.T.3
Wiesbrock, S.M.4
Shimshek, D.R.5
Meyers, D.S.6
Morgan, M.7
Parker, R.A.8
Hotamisligil, G.S.9
-
9
-
-
0036790535
-
Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia
-
Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2002;22:1686-1691.
-
(2002)
Arterioscler Thromb Vasc Biol
, vol.22
, pp. 1686-1691
-
-
Boord, J.B.1
Maeda, K.2
Makowski, L.3
Babaev, V.R.4
Fazio, S.5
Linton, M.F.6
Hotamisligil, G.S.7
-
10
-
-
34250904186
-
Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2
-
Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature. 2007;447:959-965.
-
(2007)
Nature
, vol.447
, pp. 959-965
-
-
Furuhashi, M.1
Tuncman, G.2
Görgün, C.Z.3
Makowski, L.4
Atsumi, G.5
Vaillancourt, E.6
Kono, K.7
Babaev, V.R.8
Fazio, S.9
Linton, M.F.10
Sulsky, R.11
Robl, J.A.12
Parker, R.A.13
Hotamisligil, G.S.14
-
11
-
-
33646493482
-
A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease
-
Tuncman G, Erbay E, Hom X, De Vivo I, Campos H, Rimm EB, Hotamisligil GS. A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. Proc Natl Acad Sci USA. 2006;103:6970-6975.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 6970-6975
-
-
Tuncman, G.1
Erbay, E.2
Hom, X.3
De Vivo, I.4
Campos, H.5
Rimm, E.B.6
Hotamisligil, G.S.7
-
12
-
-
33644545704
-
Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome
-
Xu A, Wang Y, Xu JY, Stejskal D, Tam S, Zhang J, Wat NM, Wong WK, Lam KS. Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome. Clin Chem. 2006;52:405-413.
-
(2006)
Clin Chem
, vol.52
, pp. 405-413
-
-
Xu, A.1
Wang, Y.2
Xu, J.Y.3
Stejskal, D.4
Tam, S.5
Zhang, J.6
Wat, N.M.7
Wong, W.K.8
Lam, K.S.9
-
13
-
-
34247472138
-
Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: A 5-year prospective study
-
Xu A, Tso AW, Cheung BM, Wang Y, Wat NM, Fong CH, Yeung DC, Janus ED, Sham PC, Lam KS. Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study. Circulation. 2007;115:1537-1543.
-
(2007)
Circulation
, vol.115
, pp. 1537-1543
-
-
Xu, A.1
Tso, A.W.2
Cheung, B.M.3
Wang, Y.4
Wat, N.M.5
Fong, C.H.6
Yeung, D.C.7
Janus, E.D.8
Sham, P.C.9
Lam, K.S.10
-
14
-
-
35148875083
-
Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: A 10-year prospective study in a Chinese cohort
-
Tso AW, Xu A, Sham PC, Wat NM, Wang Y, Fong CH, Cheung BM, Janus ED, Lam KS. Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort. Diabetes Care. 2007;30:2667-2672.
-
(2007)
Diabetes Care
, vol.30
, pp. 2667-2672
-
-
Tso, A.W.1
Xu, A.2
Sham, P.C.3
Wat, N.M.4
Wang, Y.5
Fong, C.H.6
Cheung, B.M.7
Janus, E.D.8
Lam, K.S.9
-
15
-
-
75749108572
-
Fasting serum level of fatty-acid-binding protein 4 positively correlates with metabolic syndrome in patients with coronary artery disease
-
Hsu BG, Chen YC, Lee RP, Lee CC, Lee CJ, Wang JH. Fasting serum level of fatty-acid-binding protein 4 positively correlates with metabolic syndrome in patients with coronary artery disease. Circ J. 2010;74:327-331.
-
(2010)
Circ J
, vol.74
, pp. 327-331
-
-
Hsu, B.G.1
Chen, Y.C.2
Lee, R.P.3
Lee, C.C.4
Lee, C.J.5
Wang, J.H.6
-
16
-
-
34547612970
-
Serum adipocyte fatty acid-binding protein levels were independently associated with carotid atherosclerosis
-
Yeung DC, Xu A, Cheung CW, Wat NM, Yau MH, Fong CH, Chau MT, Lam KS. Serum adipocyte fatty acid-binding protein levels were independently associated with carotid atherosclerosis. Arterioscler Thromb Vasc Biol. 2007;27:1796-1802.
-
(2007)
Arterioscler Thromb Vasc Biol
, vol.27
, pp. 1796-1802
-
-
Yeung, D.C.1
Xu, A.2
Cheung, C.W.3
Wat, N.M.4
Yau, M.H.5
Fong, C.H.6
Chau, M.T.7
Lam, K.S.8
-
17
-
-
80755152323
-
Serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease
-
Furuhashi M, Ishimura S, Ota H, Hayashi M, Nishitani T, Tanaka M, Yoshida H, Shimamoto K, Hotamisligil GS, Miura T. Serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease. PLoS ONE. 2011;6:e27356.
-
(2011)
PLoS ONE
, vol.6
-
-
Furuhashi, M.1
Ishimura, S.2
Ota, H.3
Hayashi, M.4
Nishitani, T.5
Tanaka, M.6
Yoshida, H.7
Shimamoto, K.8
Hotamisligil, G.S.9
Miura, T.10
-
18
-
-
79960490052
-
Adipocyte fatty acid binding protein in atherosclerotic plaques is associated with local vulnerability and is predictive for the occurrence of adverse cardiovascular events
-
Peeters W, de Kleijn DP, Vink A, van de Weg S, Schoneveld AH, Sze SK, van der Spek PJ, de Vries JP, Moll FL, Pasterkamp G. Adipocyte fatty acid binding protein in atherosclerotic plaques is associated with local vulnerability and is predictive for the occurrence of adverse cardiovascular events. Eur Heart J. 2011;32:1758-1768.
-
(2011)
Eur Heart J
, vol.32
, pp. 1758-1768
-
-
Peeters, W.1
De Kleijn, D.P.2
Vink, A.3
Van De Weg, S.4
Schoneveld, A.H.5
Sze, S.K.6
Van Der Spek, P.J.7
De Vries, J.P.8
Moll, F.L.9
Pasterkamp, G.10
-
19
-
-
33646383881
-
Relationship of adiponectin with markers of systemic inflammation, atherogenic dyslipidemia, and heart failure in patients with coronary heart disease
-
von Eynatten M, Hamann A, Twardella D, Nawroth PP, Brenner H, Rothenbacher D. Relationship of adiponectin with markers of systemic inflammation, atherogenic dyslipidemia, and heart failure in patients with coronary heart disease. Clin Chem. 2006;52:853-859.
-
(2006)
Clin Chem
, vol.52
, pp. 853-859
-
-
Von Eynatten, M.1
Hamann, A.2
Twardella, D.3
Nawroth, P.P.4
Brenner, H.5
Rothenbacher, D.6
-
20
-
-
33745965348
-
Lipoprotein-associated phospholipase A2 predicts future cardiovascular events in patients with coronary heart disease independently of traditional risk factors, markers of inflammation, renal function, and hemodynamic stress
-
Koenig W, Twardella D, Brenner H, Rothenbacher D. Lipoprotein-associated phospholipase A2 predicts future cardiovascular events in patients with coronary heart disease independently of traditional risk factors, markers of inflammation, renal function, and hemodynamic stress. Arterioscler Thromb Vasc Biol. 2006;26:1586-1593.
-
(2006)
Arterioscler Thromb Vasc Biol
, vol.26
, pp. 1586-1593
-
-
Koenig, W.1
Twardella, D.2
Brenner, H.3
Rothenbacher, D.4
-
21
-
-
44449095124
-
Atherogenic dyslipidaemia but not total-and high-molecular weight adiponectin are associated with the prognostic outcome in patients with coronary heart disease
-
von Eynatten M, Hamann A, Twardella D, Nawroth PP, Brenner H, Rothenbacher D. Atherogenic dyslipidaemia but not total-and high-molecular weight adiponectin are associated with the prognostic outcome in patients with coronary heart disease. Eur Heart J. 2008;29:1307-1315.
-
(2008)
Eur Heart J
, vol.29
, pp. 1307-1315
-
-
Von Eynatten, M.1
Hamann, A.2
Twardella, D.3
Nawroth, P.P.4
Brenner, H.5
Rothenbacher, D.6
-
22
-
-
33646688394
-
Comparison of circulating adiponectin and proinflammatory markers regarding their association with metabolic syndrome in Japanese men
-
Matsushita K, Yatsuya H, Tamakoshi K, Wada K, Otsuka R, Takefuji S, Sugiura K, Kondo T, Murohara T, Toyoshima H. Comparison of circulating adiponectin and proinflammatory markers regarding their association with metabolic syndrome in Japanese men. Arterioscler Thromb Vasc Biol. 2006;26:871-876.
-
(2006)
Arterioscler Thromb Vasc Biol
, vol.26
, pp. 871-876
-
-
Matsushita, K.1
Yatsuya, H.2
Tamakoshi, K.3
Wada, K.4
Otsuka, R.5
Takefuji, S.6
Sugiura, K.7
Kondo, T.8
Murohara, T.9
Toyoshima, H.10
-
23
-
-
36849008667
-
Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people
-
Qi Q, Yu Z, Ye X, Zhao F, Huang P, Hu FB, Franco OH, Wang J, Li H, Liu Y, Lin X. Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people. J Clin Endocrinol Metab. 2007;92:4827-4834.
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 4827-4834
-
-
Qi, Q.1
Yu, Z.2
Ye, X.3
Zhao, F.4
Huang, P.5
Hu, F.B.6
Franco, O.H.7
Wang, J.8
Li, H.9
Liu, Y.10
Lin, X.11
-
24
-
-
0033552883
-
Atherosclerosis-an inflammatory disease
-
Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med. 1999;340:115-126.
-
(1999)
N Engl J Med
, vol.340
, pp. 115-126
-
-
Ross, R.1
-
25
-
-
46749084688
-
Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice
-
Furuhashi M, Fucho R, Görgün CZ, Tuncman G, Cao H, Hotamisligil GS. Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J Clin Invest. 2008;118:2640-2650.
-
(2008)
J Clin Invest
, vol.118
, pp. 2640-2650
-
-
Furuhashi, M.1
Fucho, R.2
Görgün, C.Z.3
Tuncman, G.4
Cao, H.5
Hotamisligil, G.S.6
-
26
-
-
18244363982
-
Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes
-
Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab. 2005;1:107-119.
-
(2005)
Cell Metab
, vol.1
, pp. 107-119
-
-
Maeda, K.1
Cao, H.2
Kono, K.3
Gorgun, C.Z.4
Furuhashi, M.5
Uysal, K.T.6
Cao, Q.7
Atsumi, G.8
Malone, H.9
Krishnan, B.10
Minokoshi, Y.11
Kahn, B.B.12
Parker, R.A.13
Hotamisligil, G.S.14
-
27
-
-
4544298808
-
Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice
-
Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS. Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation. 2004;110:1492-1498.
-
(2004)
Circulation
, vol.110
, pp. 1492-1498
-
-
Boord, J.B.1
Maeda, K.2
Makowski, L.3
Babaev, V.R.4
Fazio, S.5
Linton, M.F.6
Hotamisligil, G.S.7
-
28
-
-
33746572217
-
Lipid metabolism mediated by adipocyte lipid binding protein (ALBP/aP2) gene expression in human THP-1 macrophages
-
Fu Y, Luo L, Luo N, Garvey WT. Lipid metabolism mediated by adipocyte lipid binding protein (ALBP/aP2) gene expression in human THP-1 macrophages. Atherosclerosis. 2006;188:102-111.
-
(2006)
Atherosclerosis
, vol.188
, pp. 102-111
-
-
Fu, Y.1
Luo, L.2
Luo, N.3
Garvey, W.T.4
-
29
-
-
16844379483
-
The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities
-
Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamisligil GS. The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. J Biol Chem. 2005;280:12888-12895.
-
(2005)
J Biol Chem
, vol.280
, pp. 12888-12895
-
-
Makowski, L.1
Brittingham, K.C.2
Reynolds, J.M.3
Suttles, J.4
Hotamisligil, G.S.5
-
30
-
-
43249118045
-
Long-term interleukin-6 levels and subsequent risk of coronary heart disease: Two new prospective studies and a systematic review
-
Danesh J, Kaptoge S, Mann AG, Sarwar N, Wood A, Angleman SB, Wensley F, Higgins JP, Lennon L, Eiriksdottir G, Rumley A, Whincup PH, Lowe GD, Gudnason V. Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review. PLoS Med. 2008;5:e78.
-
(2008)
PLoS Med
, vol.5
-
-
Danesh, J.1
Kaptoge, S.2
Mann, A.G.3
Sarwar, N.4
Wood, A.5
Angleman, S.B.6
Wensley, F.7
Higgins, J.P.8
Lennon, L.9
Eiriksdottir, G.10
Rumley, A.11
Whincup, P.H.12
Lowe, G.D.13
Gudnason, V.14
-
31
-
-
34247477664
-
Prognostic significance of the Centers for Disease Control/American Heart Association high-sensitivity C-reactive protein cut points for cardiovascular and other outcomes in patients with stable coronary artery disease
-
PEACE Investigators
-
Sabatine MS, Morrow DA, Jablonski KA, Rice MM, Warnica JW, Domanski MJ, Hsia J, Gersh BJ, Rifai N, Ridker PM, Pfeffer MA, Braunwald E. PEACE Investigators. Prognostic significance of the Centers for Disease Control/American Heart Association high-sensitivity C-reactive protein cut points for cardiovascular and other outcomes in patients with stable coronary artery disease. Circulation. 2007;115:1528-1536.
-
(2007)
Circulation
, vol.115
, pp. 1528-1536
-
-
Sabatine, M.S.1
Morrow, D.A.2
Jablonski, K.A.3
Rice, M.M.4
Warnica, J.W.5
Domanski, M.J.6
Hsia, J.7
Gersh, B.J.8
Rifai, N.9
Ridker, P.M.10
Pfeffer, M.A.11
Braunwald, E.12
|