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Volumn 17, Issue 1, 2015, Pages

Emerging Roles of Innate Immune Signaling and Toll-Like Receptors in Fibrosis and Systemic Sclerosis

Author keywords

Fibroblast; Fibrosis; Fn EDA; Scleroderma; SSc; Systemic sclerosis; TGF ; Toll like receptor 4

Indexed keywords

BONE MORPHOGENETIC PROTEIN AND ACTIVIN MEMBRANE BOUND INHIBITOR; CELL PROTEIN; CPG OLIGODEOXYNUCLEOTIDE; FIBRONECTIN; HEAT SHOCK PROTEIN; HIGH MOBILITY GROUP B1 PROTEIN; SCLEROPROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; TLR4 PROTEIN, HUMAN;

EID: 84921841338     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-014-0474-z     Document Type: Review
Times cited : (55)

References (80)
  • 1
    • 84655175061 scopus 로고    scopus 로고
    • Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities
    • COI: 1:CAS:528:DC%2BC3MXhs1GlsLv
    • Bhattacharyya S, Wei J, Varga J. Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities. Nat Rev Rheumatol. 2012;8(1):42–54.
    • (2012) Nat Rev Rheumatol , vol.8 , Issue.1 , pp. 42-54
    • Bhattacharyya, S.1    Wei, J.2    Varga, J.3
  • 2
    • 84872338388 scopus 로고    scopus 로고
    • Therapy for fibrotic diseases: nearing the starting line
    • PID: 23303606, This update highlighted evolving understanding of how tissue injury and repair lead to fibrosis and present promising new approaches for diagnosis and treatment of fibrotic disease
    • Friedman SL, Sheppard D, Duffield JS, Violette S. Therapy for fibrotic diseases: nearing the starting line. Sci Transl Med. 2013;5(167):167sr1. This update highlighted evolving understanding of how tissue injury and repair lead to fibrosis and present promising new approaches for diagnosis and treatment of fibrotic diseases.
    • (2013) Sci Transl Med , vol.5 , Issue.167 , pp. 167sr1
    • Friedman, S.L.1    Sheppard, D.2    Duffield, J.S.3    Violette, S.4
  • 3
    • 84899051032 scopus 로고    scopus 로고
    • FibronectinEDA promotes chronic cutaneous fibrosis through toll-like receptor signaling
    • PID: 24739758, This study identifies alternately spliced fibronectin (Fn-EDA) as an endogenous ligand for TLR4 that is markedly elevated in lesional skin in SSc and is responsible for driving persistent myofibroblasts differentiation and progression of fibrosi
    • Bhattacharyya S, Tamaki Z, Wang W, Hinchcliff M, Hoover P, Getsios S, et al. FibronectinEDA promotes chronic cutaneous fibrosis through toll-like receptor signaling. Sci Transl Med. 2014;6(232):232ra50. This study identifies alternately spliced fibronectin (Fn-EDA) as an endogenous ligand for TLR4 that is markedly elevated in lesional skin in SSc and is responsible for driving persistent myofibroblasts differentiation and progression of fibrosis.
    • (2014) Sci Transl Med , vol.6 , Issue.232 , pp. 232ra50
    • Bhattacharyya, S.1    Tamaki, Z.2    Wang, W.3    Hinchcliff, M.4    Hoover, P.5    Getsios, S.6
  • 4
    • 84871284466 scopus 로고    scopus 로고
    • Toll-like receptor 4 signaling augments transforming growth factor-beta responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma
    • COI: 1:CAS:528:DC%2BC3sXhslCgsbw%3D, PID: 2314192
    • Bhattacharyya S, Kelley K, Melichian DS, Tamaki Z, Fang F, Su Y, et al. Toll-like receptor 4 signaling augments transforming growth factor-beta responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma. Am J Pathol. 2013;182(1):192–205.
    • (2013) Am J Pathol , vol.182 , Issue.1 , pp. 192-205
    • Bhattacharyya, S.1    Kelley, K.2    Melichian, D.S.3    Tamaki, Z.4    Fang, F.5    Su, Y.6
  • 5
    • 84881010975 scopus 로고    scopus 로고
    • Fibrosis in systemic sclerosis: common and unique pathobiology
    • PID: 2325981
    • Bhattacharyya S, Wei J, Tourtellotte WG, Hinchcliff M, Gottardi CG, Varga J. Fibrosis in systemic sclerosis: common and unique pathobiology. Fibrogenesis Tissue Repair. 2012;5(Suppl 1 Proceedings of Fibroproliferative disorders: from biochemical analysis to targeted therapiesPetro E Petrides and David Brenner):S18.
    • (2012) Fibrogenesis Tissue Repair , vol.5 , pp. S18
    • Bhattacharyya, S.1    Wei, J.2    Tourtellotte, W.G.3    Hinchcliff, M.4    Gottardi, C.G.5    Varga, J.6
  • 6
    • 67650480995 scopus 로고    scopus 로고
    • Transforming growth factor beta as a therapeutic target in systemic sclerosis
    • COI: 1:CAS:528:DC%2BD1MXktVGrur8%3D, PID: 1933728
    • Varga J, Pasche B. Transforming growth factor beta as a therapeutic target in systemic sclerosis. Nat Rev Rheumatol. 2009;5(4):200–6.
    • (2009) Nat Rev Rheumatol , vol.5 , Issue.4 , pp. 200-206
    • Varga, J.1    Pasche, B.2
  • 7
    • 77955383770 scopus 로고    scopus 로고
    • DAMPening inflammation by modulating TLR signalling
    • Piccinini AM, Midwood KS. DAMPening inflammation by modulating TLR signalling. Mediat Inflamm. 2010;2010.
    • (2010) Mediat Inflamm , pp. 2010
    • Piccinini, A.M.1    Midwood, K.S.2
  • 9
    • 84863940106 scopus 로고    scopus 로고
    • New insights into the mechanisms of innate immune receptor signalling in fibrosis
    • COI: 1:CAS:528:DC%2BC38XhtVyis73I, PID: 2280290
    • Lafyatis R, Farina A. New insights into the mechanisms of innate immune receptor signalling in fibrosis. Open Rheumatol J. 2012;6:72–9.
    • (2012) Open Rheumatol J , vol.6 , pp. 72-79
    • Lafyatis, R.1    Farina, A.2
  • 10
    • 0035524488 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • COI: 1:CAS:528:DC%2BD38XlvF2qu74%3D, PID: 1190582
    • Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol. 2001;1(2):135–45.
    • (2001) Nat Rev Immunol , vol.1 , Issue.2 , pp. 135-145
    • Medzhitov, R.1
  • 11
    • 79956300649 scopus 로고    scopus 로고
    • Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
    • COI: 1:CAS:528:DC%2BC3MXms12rs7w%3D, PID: 2161643
    • Kawai T, Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity. 2011;34(5):637–50.
    • (2011) Immunity , vol.34 , Issue.5 , pp. 637-650
    • Kawai, T.1    Akira, S.2
  • 12
    • 0025774776 scopus 로고
    • Drosophila toll and IL-1 receptor
    • COI: 1:STN:280:DyaK3M3jvV2lsQ%3D%3D, PID: 185196
    • Gay NJ, Keith FJ. Drosophila toll and IL-1 receptor. Nature. 1991;351(6325):355–6.
    • (1991) Nature , vol.351 , Issue.6325 , pp. 355-356
    • Gay, N.J.1    Keith, F.J.2
  • 13
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: update on toll-like receptors
    • COI: 1:CAS:528:DC%2BC3cXkvFSjsrc%3D, PID: 2040485
    • Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on toll-like receptors. Nat Immunol. 2010;11(5):373–84.
    • (2010) Nat Immunol , vol.11 , Issue.5 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 14
    • 84865571191 scopus 로고    scopus 로고
    • TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification
    • COI: 1:CAS:528:DC%2BC38Xht1Grtr7J, PID: 22821982, This study unraveled an unanticipated link between antibiotic resistance and evasion from TLR13 recognition, due to 23S rRNA modifications by methylation, camouflaging bacteria from TLR13 recognitio
    • Oldenburg M, Kruger A, Ferstl R, Kaufmann A, Nees G, Sigmund A, et al. TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification. Science. 2012;337(6098):1111–5. This study unraveled an unanticipated link between antibiotic resistance and evasion from TLR13 recognition, due to 23S rRNA modifications by methylation, camouflaging bacteria from TLR13 recognition.
    • (2012) Science , vol.337 , Issue.6098 , pp. 1111-1115
    • Oldenburg, M.1    Kruger, A.2    Ferstl, R.3    Kaufmann, A.4    Nees, G.5    Sigmund, A.6
  • 15
    • 84872153665 scopus 로고    scopus 로고
    • The first type III domain of fibronectin is associated with the expression of cytokines within the lung tumor microenvironment
    • COI: 1:CAS:528:DC%2BC3MXhsVWju7v
    • Zheng M, Jones DM, Horzempa C, Prasad A, McKeown-Longo PJ. The first type III domain of fibronectin is associated with the expression of cytokines within the lung tumor microenvironment. J Cancer Educ. 2011;2:478–83.
    • (2011) J Cancer Educ , vol.2 , pp. 478-483
    • Zheng, M.1    Jones, D.M.2    Horzempa, C.3    Prasad, A.4    McKeown-Longo, P.J.5
  • 16
    • 84865298775 scopus 로고    scopus 로고
    • Dissecting negative regulation of toll-like receptor signaling
    • COI: 1:CAS:528:DC%2BC38XovVGkur0%3D, PID: 22721918, This review highlighted recent insights into the negative regulation of TLR signaling and innate immunity, underscoring how pathogens can negatively target TLR signaling as a strategy to evade the host immune respons
    • Kondo T, Kawai T, Akira S. Dissecting negative regulation of toll-like receptor signaling. Trends Immunol. 2012;33(9):449–58. This review highlighted recent insights into the negative regulation of TLR signaling and innate immunity, underscoring how pathogens can negatively target TLR signaling as a strategy to evade the host immune response.
    • (2012) Trends Immunol , vol.33 , Issue.9 , pp. 449-458
    • Kondo, T.1    Kawai, T.2    Akira, S.3
  • 17
    • 75649113377 scopus 로고    scopus 로고
    • Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21
    • COI: 1:CAS:528:DC%2BD1MXhsVylsL3O, PID: 1994627
    • Sheedy FJ, Palsson-McDermott E, Hennessy EJ, Martin C, O’Leary JJ, Ruan Q, et al. Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nat Immunol. 2010;11(2):141–7.
    • (2010) Nat Immunol , vol.11 , Issue.2 , pp. 141-147
    • Sheedy, F.J.1    Palsson-McDermott, E.2    Hennessy, E.J.3    Martin, C.4    O’Leary, J.J.5    Ruan, Q.6
  • 18
    • 79960073532 scopus 로고    scopus 로고
    • A trio of microRNAs that control toll-like receptor signalling
    • COI: 1:CAS:528:DC%2BC3MXotlensr8%3D, PID: 2165251
    • Quinn SR, O’Neill LA. A trio of microRNAs that control toll-like receptor signalling. Int Immunol. 2011;23(7):421–5.
    • (2011) Int Immunol , vol.23 , Issue.7 , pp. 421-425
    • Quinn, S.R.1    O’Neill, L.A.2
  • 19
    • 5444223519 scopus 로고    scopus 로고
    • The ubiquitin-modifying enzyme A20 is required for termination of toll-like receptor responses
    • COI: 1:CAS:528:DC%2BD2cXnvFCgsro%3D, PID: 1533408
    • Boone DL, Turer EE, Lee EG, Ahmad RC, Wheeler MT, Tsui C, et al. The ubiquitin-modifying enzyme A20 is required for termination of toll-like receptor responses. Nat Immunol. 2004;5(10):1052–60.
    • (2004) Nat Immunol , vol.5 , Issue.10 , pp. 1052-1060
    • Boone, D.L.1    Turer, E.E.2    Lee, E.G.3    Ahmad, R.C.4    Wheeler, M.T.5    Tsui, C.6
  • 20
    • 3943054838 scopus 로고    scopus 로고
    • De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
    • COI: 1:CAS:528:DC%2BD2cXmt1Gisb8%3D, PID: 1525859
    • Wertz IE, O’Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, et al. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature. 2004;430(7000):694–9.
    • (2004) Nature , vol.430 , Issue.7000 , pp. 694-699
    • Wertz, I.E.1    O’Rourke, K.M.2    Zhou, H.3    Eby, M.4    Aravind, L.5    Seshagiri, S.6
  • 21
    • 84905562455 scopus 로고    scopus 로고
    • Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis
    • PID: 25043000, This study revealed A20 as a novel negative regulator of Nlrp3 inflammasome activation and describe A20myel-KO mice as an experimental model to study the role of inflammasomes in rheumatoid arthriti
    • Vande Walle L, Van Opdenbosch N, Jacques P, Fossoul A, Verheugen E, Vogel P, et al. Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature. 2014;512(7512):69–73. This study revealed A20 as a novel negative regulator of Nlrp3 inflammasome activation and describe A20myel-KO mice as an experimental model to study the role of inflammasomes in rheumatoid arthritis.
    • (2014) Nature , vol.512 , Issue.7512 , pp. 69-73
    • Vande Walle, L.1    Van Opdenbosch, N.2    Jacques, P.3    Fossoul, A.4    Verheugen, E.5    Vogel, P.6
  • 22
    • 20644450101 scopus 로고    scopus 로고
    • Negative regulation of toll-like receptor 4 signaling by the toll-like receptor homolog RP105
    • COI: 1:CAS:528:DC%2BD2MXktlWitrg%3D, PID: 1585200
    • Divanovic S, Trompette A, Atabani SF, Madan R, Golenbock DT, Visintin A, et al. Negative regulation of toll-like receptor 4 signaling by the toll-like receptor homolog RP105. Nat Immunol. 2005;6(6):571–8.
    • (2005) Nat Immunol , vol.6 , Issue.6 , pp. 571-578
    • Divanovic, S.1    Trompette, A.2    Atabani, S.F.3    Madan, R.4    Golenbock, D.T.5    Visintin, A.6
  • 23
    • 34547814263 scopus 로고    scopus 로고
    • Regulation of TLR4 signaling and the host interface with pathogens and danger: the role of RP105
    • COI: 1:CAS:528:DC%2BD2sXos12rtbc%3D, PID: 1747053
    • Divanovic S, Trompette A, Petiniot LK, Allen JL, Flick LM, Belkaid Y, et al. Regulation of TLR4 signaling and the host interface with pathogens and danger: the role of RP105. J Leukoc Biol. 2007;82(2):265–71.
    • (2007) J Leukoc Biol , vol.82 , Issue.2 , pp. 265-271
    • Divanovic, S.1    Trompette, A.2    Petiniot, L.K.3    Allen, J.L.4    Flick, L.M.5    Belkaid, Y.6
  • 24
    • 54949121403 scopus 로고    scopus 로고
    • Toll-like receptor homolog RP105 modulates the antigen-presenting cell function and regulates the development of collagen-induced arthritis
    • PID: 1884749
    • Tada Y, Koarada S, Morito F, Mitamura M, Inoue H, Suematsu R, et al. Toll-like receptor homolog RP105 modulates the antigen-presenting cell function and regulates the development of collagen-induced arthritis. Arthritis Res Ther. 2008;10(5):R121.
    • (2008) Arthritis Res Ther , vol.10 , Issue.5 , pp. R121
    • Tada, Y.1    Koarada, S.2    Morito, F.3    Mitamura, M.4    Inoue, H.5    Suematsu, R.6
  • 25
    • 79960657903 scopus 로고    scopus 로고
    • Negative regulation of signaling by a soluble form of toll-like receptor 9
    • COI: 1:CAS:528:DC%2BC3MXpt1yht78%3D, PID: 2160425
    • Chockalingam A, Cameron JL, Brooks JC, Leifer CA. Negative regulation of signaling by a soluble form of toll-like receptor 9. Eur J Immunol. 2011;41(8):2176–84.
    • (2011) Eur J Immunol , vol.41 , Issue.8 , pp. 2176-2184
    • Chockalingam, A.1    Cameron, J.L.2    Brooks, J.C.3    Leifer, C.A.4
  • 26
    • 84921873680 scopus 로고    scopus 로고
    • Hepatic inflammation and fibrosis: functional links and key pathways
    • Seki E, Schwabe RF. Hepatic inflammation and fibrosis: functional links and key pathways. Hepatology. 2014.
    • (2014) Hepatology
    • Seki, E.1    Schwabe, R.F.2
  • 27
    • 33646347356 scopus 로고    scopus 로고
    • Toll-like receptor signaling in the liver
    • COI: 1:CAS:528:DC%2BD28Xls1Wit7s%3D, PID: 1669775
    • Schwabe RF, Seki E, Brenner DA. Toll-like receptor signaling in the liver. Gastroenterology. 2006;130(6):1886–900.
    • (2006) Gastroenterology , vol.130 , Issue.6 , pp. 1886-1900
    • Schwabe, R.F.1    Seki, E.2    Brenner, D.A.3
  • 28
    • 84896754721 scopus 로고    scopus 로고
    • Transcriptional repression of the transforming growth factor beta (TGF-beta) pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by nuclear factor kappaB (NF-kappaB) p50 enhances TGF-beta signaling in hepatic stellate cells
    • COI: 1:CAS:528:DC%2BC2cXjvVyktrc%3D, PID: 2444880
    • Liu C, Chen X, Yang L, Kisseleva T, Brenner DA, Seki E. Transcriptional repression of the transforming growth factor beta (TGF-beta) pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by nuclear factor kappaB (NF-kappaB) p50 enhances TGF-beta signaling in hepatic stellate cells. J Biol Chem. 2014;289(10):7082–91.
    • (2014) J Biol Chem , vol.289 , Issue.10 , pp. 7082-7091
    • Liu, C.1    Chen, X.2    Yang, L.3    Kisseleva, T.4    Brenner, D.A.5    Seki, E.6
  • 29
    • 35948958955 scopus 로고    scopus 로고
    • TLR4 enhances TGF-beta signaling and hepatic fibrosis
    • COI: 1:CAS:528:DC%2BD2sXht1Kmtr3O, PID: 1795209
    • Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, et al. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med. 2007;13(11):1324–32.
    • (2007) Nat Med , vol.13 , Issue.11 , pp. 1324-1332
    • Seki, E.1    De Minicis, S.2    Osterreicher, C.H.3    Kluwe, J.4    Osawa, Y.5    Brenner, D.A.6
  • 30
    • 13744255589 scopus 로고    scopus 로고
    • Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
    • COI: 1:CAS:528:DC%2BD2MXis1eksw%3D%3D, PID: 1563044
    • Duffield JS, Forbes SJ, Constandinou CM, Clay S, Partolina M, Vuthoori S, et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest. 2005;115(1):56–65.
    • (2005) J Clin Invest , vol.115 , Issue.1 , pp. 56-65
    • Duffield, J.S.1    Forbes, S.J.2    Constandinou, C.M.3    Clay, S.4    Partolina, M.5    Vuthoori, S.6
  • 31
    • 37349108815 scopus 로고    scopus 로고
    • Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis
    • COI: 1:CAS:528:DC%2BD1cXhtlehtLg%3D, PID: 1816635
    • Jeong WI, Park O, Gao B. Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis. Gastroenterology. 2008;134(1):248–58.
    • (2008) Gastroenterology , vol.134 , Issue.1 , pp. 248-258
    • Jeong, W.I.1    Park, O.2    Gao, B.3
  • 32
    • 84905040885 scopus 로고    scopus 로고
    • Review: interstitial lung disease associated with systemic sclerosis and idiopathic pulmonary fibrosis: how similar and distinct?
    • COI: 1:CAS:528:DC%2BC2cXhs1Chs73K, PID: 24838199, This review compared and contrasted the features of SSc-associated interstitial lung disease (ILD) and IPF, with significant implications for diagnosis, evaluation, and managemen
    • Herzog EL, Mathur A, Tager AM, Feghali-Bostwick C, Schneider F, Varga J. Review: interstitial lung disease associated with systemic sclerosis and idiopathic pulmonary fibrosis: how similar and distinct? Arthritis Rheumatol. 2014;66(8):1967–78. This review compared and contrasted the features of SSc-associated interstitial lung disease (ILD) and IPF, with significant implications for diagnosis, evaluation, and management.
    • (2014) Arthritis Rheumatol , vol.66 , Issue.8 , pp. 1967-1978
    • Herzog, E.L.1    Mathur, A.2    Tager, A.M.3    Feghali-Bostwick, C.4    Schneider, F.5    Varga, J.6
  • 33
    • 84901022861 scopus 로고    scopus 로고
    • Revealing the pathogenic and aging-related mechanisms of the enigmatic idiopathic pulmonary fibrosis an integral model
    • COI: 1:CAS:528:DC%2BC2cXhtFSns7fN, PID: 2464168
    • Selman M, Pardo A. Revealing the pathogenic and aging-related mechanisms of the enigmatic idiopathic pulmonary fibrosis an integral model. Am J Respir Crit Care Med. 2014;189(10):1161–72.
    • (2014) Am J Respir Crit Care Med , vol.189 , Issue.10 , pp. 1161-1172
    • Selman, M.1    Pardo, A.2
  • 34
    • 84890478294 scopus 로고    scopus 로고
    • The toll-like receptor 3 L412F polymorphism and disease progression in idiopathic pulmonary fibrosis
    • PID: 24070541, This study identified the role of a single nucleotide polymorphism in TLR3 that impairs TLR3 function and promotes progression of IP
    • O’Dwyer DN, Armstrong ME, Trujillo G, Cooke G, Keane MP, Fallon PG, et al. The toll-like receptor 3 L412F polymorphism and disease progression in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2013;188(12):1442–50. This study identified the role of a single nucleotide polymorphism in TLR3 that impairs TLR3 function and promotes progression of IPF.
    • (2013) Am J Respir Crit Care Med , vol.188 , Issue.12 , pp. 1442-1450
    • O’Dwyer, D.N.1    Armstrong, M.E.2    Trujillo, G.3    Cooke, G.4    Keane, M.P.5    Fallon, P.G.6
  • 35
    • 78349285513 scopus 로고    scopus 로고
    • TLR9 differentiates rapidly from slowly progressing forms of idiopathic pulmonary fibrosis
    • COI: 1:CAS:528:DC%2BC3MXhsFKqtbg%3D, PID: 2106844
    • Trujillo G, Meneghin A, Flaherty KR, Sholl LM, Myers JL, Kazerooni EA, et al. TLR9 differentiates rapidly from slowly progressing forms of idiopathic pulmonary fibrosis. Sci Transl Med. 2010;2(57):57ra82.
    • (2010) Sci Transl Med , vol.2 , Issue.57 , pp. 57ra82
    • Trujillo, G.1    Meneghin, A.2    Flaherty, K.R.3    Sholl, L.M.4    Myers, J.L.5    Kazerooni, E.A.6
  • 36
    • 84880998606 scopus 로고    scopus 로고
    • Aberrant innate immune sensing leads to the rapid progression of idiopathic pulmonary fibrosis
    • PID: 2325967
    • Hogaboam CM, Trujillo G, Martinez FJ. Aberrant innate immune sensing leads to the rapid progression of idiopathic pulmonary fibrosis. Fibrogenesis Tissue Repair. 2012;5(Suppl 1 Proceedings of Fibroproliferative disorders: from biochemical analysis to targeted therapiesPetro E Petrides and David Brenner):S3.
    • (2012) Fibrogenesis Tissue Repair , vol.5 , pp. S3
    • Hogaboam, C.M.1    Trujillo, G.2    Martinez, F.J.3
  • 37
    • 80052373688 scopus 로고    scopus 로고
    • TLR9-induced interferon beta is associated with protection from gammaherpesvirus-induced exacerbation of lung fibrosis
    • COI: 1:CAS:528:DC%2BC3MXhtV2mtbzM, PID: 2181021
    • Luckhardt TR, Coomes SM, Trujillo G, Stoolman JS, Vannella KM, Bhan U, et al. TLR9-induced interferon beta is associated with protection from gammaherpesvirus-induced exacerbation of lung fibrosis. Fibrogenesis Tissue Repair. 2011;4:18.
    • (2011) Fibrogenesis Tissue Repair , vol.4 , pp. 18
    • Luckhardt, T.R.1    Coomes, S.M.2    Trujillo, G.3    Stoolman, J.S.4    Vannella, K.M.5    Bhan, U.6
  • 39
    • 77449153891 scopus 로고    scopus 로고
    • Inhibiting toll-like receptor 4 signaling ameliorates pulmonary fibrosis during acute lung injury induced by lipopolysaccharide: an experimental study
    • PID: 2001795
    • He Z, Zhu Y, Jiang H. Inhibiting toll-like receptor 4 signaling ameliorates pulmonary fibrosis during acute lung injury induced by lipopolysaccharide: an experimental study. Respir Res. 2009;10:126.
    • (2009) Respir Res , vol.10 , pp. 126
    • He, Z.1    Zhu, Y.2    Jiang, H.3
  • 40
    • 77953585588 scopus 로고    scopus 로고
    • Combined Tlr2 and Tlr4 deficiency increases radiation-induced pulmonary fibrosis in mice
    • COI: 1:CAS:528:DC%2BC3cXnvVOks7w%3D, PID: 2061004
    • Paun A, Fox J, Balloy V, Chignard M, Qureshi ST, Haston CK. Combined Tlr2 and Tlr4 deficiency increases radiation-induced pulmonary fibrosis in mice. Int J Radiat Oncol Biol Phys. 2010;77(4):1198–205.
    • (2010) Int J Radiat Oncol Biol Phys , vol.77 , Issue.4 , pp. 1198-1205
    • Paun, A.1    Fox, J.2    Balloy, V.3    Chignard, M.4    Qureshi, S.T.5    Haston, C.K.6
  • 41
    • 30744462300 scopus 로고    scopus 로고
    • Regulation of lung injury and repair by toll-like receptors and hyaluronan
    • COI: 1:CAS:528:DC%2BD2MXhtFOhsLvI, PID: 1624465
    • Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, et al. Regulation of lung injury and repair by toll-like receptors and hyaluronan. Nat Med. 2005;11(11):1173–9.
    • (2005) Nat Med , vol.11 , Issue.11 , pp. 1173-1179
    • Jiang, D.1    Liang, J.2    Fan, J.3    Yu, S.4    Chen, S.5    Luo, Y.6
  • 42
    • 83455230751 scopus 로고    scopus 로고
    • TLR4 activity is required in the resolution of pulmonary inflammation and fibrosis after acute and chronic lung injury
    • COI: 1:CAS:528:DC%2BC38Xhs1Oqur8%3D, PID: 2206222
    • Yang HZ, Wang JP, Mi S, Liu HZ, Cui B, Yan HM, et al. TLR4 activity is required in the resolution of pulmonary inflammation and fibrosis after acute and chronic lung injury. Am J Pathol. 2012;180(1):275–92.
    • (2012) Am J Pathol , vol.180 , Issue.1 , pp. 275-292
    • Yang, H.Z.1    Wang, J.P.2    Mi, S.3    Liu, H.Z.4    Cui, B.5    Yan, H.M.6
  • 43
    • 84902179695 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms in kidney fibrosis
    • COI: 1:CAS:528:DC%2BC2cXpvFaitb0%3D, PID: 2489270
    • Duffield JS. Cellular and molecular mechanisms in kidney fibrosis. J Clin Invest. 2014;124(6):2299–306.
    • (2014) J Clin Invest , vol.124 , Issue.6 , pp. 2299-2306
    • Duffield, J.S.1
  • 44
    • 77955604860 scopus 로고    scopus 로고
    • TLR4 promotes fibrosis but attenuates tubular damage in progressive renal injury
    • COI: 1:CAS:528:DC%2BC3cXhtVyku7zF, PID: 2059568
    • Pulskens WP, Rampanelli E, Teske GJ, Butter LM, Claessen N, Luirink IK, et al. TLR4 promotes fibrosis but attenuates tubular damage in progressive renal injury. J Am Soc Nephrol: JASN. 2010;21(8):1299–308.
    • (2010) J Am Soc Nephrol: JASN , vol.21 , Issue.8 , pp. 1299-1308
    • Pulskens, W.P.1    Rampanelli, E.2    Teske, G.J.3    Butter, L.M.4    Claessen, N.5    Luirink, I.K.6
  • 45
    • 84908316746 scopus 로고    scopus 로고
    • Devaraj S. Global toll-like receptor 4 knockout results in decreased renal inflammation, fibrosis and podocytopathy. J
    • Jialal I, Major AM, Devaraj S. Global toll-like receptor 4 knockout results in decreased renal inflammation, fibrosis and podocytopathy. J. Diabetes Complicat. 2014.
    • (2014) Diabetes Complicat
    • Jialal, I.1    Major, A.M.2
  • 46
    • 79955586970 scopus 로고    scopus 로고
    • Toll-like receptor 4: a novel signaling pathway during renal fibrogenesis
    • COI: 1:CAS:528:DC%2BC3MXlsVCqu7w%3D, PID: 2008926
    • Campbell MT, Hile KL, Zhang H, Asanuma H, Vanderbrink BA, Rink RR, et al. Toll-like receptor 4: a novel signaling pathway during renal fibrogenesis. J Surg Res. 2011;168(1):e61–9.
    • (2011) J Surg Res , vol.168 , Issue.1 , pp. e61-e69
    • Campbell, M.T.1    Hile, K.L.2    Zhang, H.3    Asanuma, H.4    Vanderbrink, B.A.5    Rink, R.R.6
  • 47
    • 77649204540 scopus 로고    scopus 로고
    • Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling
    • COI: 1:CAS:528:DC%2BC3cXhsFyhtLfM, PID: 2003871
    • Wang S, Schmaderer C, Kiss E, Schmidt C, Bonrouhi M, Porubsky S, et al. Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling. Dis Model Mech. 2010;3(1–2):92–103.
    • (2010) Dis Model Mech , vol.3 , Issue.1-2 , pp. 92-103
    • Wang, S.1    Schmaderer, C.2    Kiss, E.3    Schmidt, C.4    Bonrouhi, M.5    Porubsky, S.6
  • 48
    • 79551614815 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction
    • COI: 1:CAS:528:DC%2BC3MXhsFOntrk%3D, PID: 2121990
    • Vilahur G, Juan-Babot O, Pena E, Onate B, Casani L, Badimon L. Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction. J Mol Cell Cardiol. 2011;50(3):522–33.
    • (2011) J Mol Cell Cardiol , vol.50 , Issue.3 , pp. 522-533
    • Vilahur, G.1    Juan-Babot, O.2    Pena, E.3    Onate, B.4    Casani, L.5    Badimon, L.6
  • 49
    • 84876014283 scopus 로고    scopus 로고
    • Recurrent exposure to subclinical lipopolysaccharide increases mortality and induces cardiac fibrosis in mice
    • COI: 1:CAS:528:DC%2BC3sXmsVKqtb0%3D, PID: 2358587
    • Lew WY, Bayna E, Molle ED, Dalton ND, Lai NC, Bhargava V, et al. Recurrent exposure to subclinical lipopolysaccharide increases mortality and induces cardiac fibrosis in mice. PLoS One. 2013;8(4):e61057.
    • (2013) PLoS One , vol.8 , Issue.4 , pp. e61057
    • Lew, W.Y.1    Bayna, E.2    Molle, E.D.3    Dalton, N.D.4    Lai, N.C.5    Bhargava, V.6
  • 50
    • 45549084247 scopus 로고    scopus 로고
    • Toll-like receptor-4 modulates survival by induction of left ventricular remodeling after myocardial infarction in mice
    • COI: 1:CAS:528:DC%2BD1cXltlCrsrk%3D, PID: 1845361
    • Riad A, Jager S, Sobirey M, Escher F, Yaulema-Riss A, Westermann D, et al. Toll-like receptor-4 modulates survival by induction of left ventricular remodeling after myocardial infarction in mice. J Immunol. 2008;180(10):6954–61.
    • (2008) J Immunol , vol.180 , Issue.10 , pp. 6954-6961
    • Riad, A.1    Jager, S.2    Sobirey, M.3    Escher, F.4    Yaulema-Riss, A.5    Westermann, D.6
  • 51
    • 84916614181 scopus 로고    scopus 로고
    • Toll-like receptor 4 knockout protects against isoproterenol-induced cardiac fibrosis: the role of autophagy
    • Dong RQ, Wang ZF, Zhao C, Gu HR, Hu ZW, Xie J, et al. Toll-like receptor 4 knockout protects against isoproterenol-induced cardiac fibrosis: the role of autophagy. J Cardiovasc Pharmacol Ther. 2014.
    • (2014) J Cardiovasc Pharmacol Ther
    • Dong, R.Q.1    Wang, Z.F.2    Zhao, C.3    Gu, H.R.4    Hu, Z.W.5    Xie, J.6
  • 52
    • 84894593288 scopus 로고    scopus 로고
    • Inhibition of Toll-like receptor 2 reduces cardiac fibrosis by attenuating macrophage-mediated inflammation
    • COI: 1:CAS:528:DC%2BC2cXjtVGhsL4%3D, PID: 2425949
    • Wang L, Li YL, Zhang CC, Cui W, Wang X, Xia Y, et al. Inhibition of Toll-like receptor 2 reduces cardiac fibrosis by attenuating macrophage-mediated inflammation. Cardiovasc Res. 2014;101(3):383–92.
    • (2014) Cardiovasc Res , vol.101 , Issue.3 , pp. 383-392
    • Wang, L.1    Li, Y.L.2    Zhang, C.C.3    Cui, W.4    Wang, X.5    Xia, Y.6
  • 53
    • 79955484855 scopus 로고    scopus 로고
    • Innate immune signaling in cardiac ischemia
    • COI: 1:CAS:528:DC%2BC3MXltVKjt70%3D, PID: 2144814
    • Arslan F, de Kleijn DP, Pasterkamp G. Innate immune signaling in cardiac ischemia. Nat Rev Cardiol. 2011;8(5):292–300.
    • (2011) Nat Rev Cardiol , vol.8 , Issue.5 , pp. 292-300
    • Arslan, F.1    de Kleijn, D.P.2    Pasterkamp, G.3
  • 54
    • 84869396139 scopus 로고    scopus 로고
    • Priming with synthetic oligonucleotides attenuates pressure overload-induced inflammation and cardiac hypertrophy in mice
    • COI: 1:CAS:528:DC%2BC38Xhs12mtLfF, PID: 2297700
    • Velten M, Duerr GD, Pessies T, Schild J, Lohner R, Mersmann J, et al. Priming with synthetic oligonucleotides attenuates pressure overload-induced inflammation and cardiac hypertrophy in mice. Cardiovasc Res. 2012;96(3):422–32.
    • (2012) Cardiovasc Res , vol.96 , Issue.3 , pp. 422-432
    • Velten, M.1    Duerr, G.D.2    Pessies, T.3    Schild, J.4    Lohner, R.5    Mersmann, J.6
  • 55
    • 84893840072 scopus 로고    scopus 로고
    • Danger signals in the initiation of the inflammatory response after myocardial infarction
    • de Haan JJ, Smeets MB, Pasterkamp G, Arslan F. Danger signals in the initiation of the inflammatory response after myocardial infarction. Mediat Inflamm. 2013;2013:206039.
    • (2013) Mediat Inflamm , vol.2013 , pp. 206039
    • de Haan, J.J.1    Smeets, M.B.2    Pasterkamp, G.3    Arslan, F.4
  • 56
    • 80052856292 scopus 로고    scopus 로고
    • Upregulation of toll-like receptors (TLRs) 6, 7, and 8 in keloid scars
    • COI: 1:CAS:528:DC%2BC3MXhtFOlsLvF, PID: 2167767
    • Bagabir RA, Syed F, Rautemaa R, McGrouther DA, Paus R, Bayat A. Upregulation of toll-like receptors (TLRs) 6, 7, and 8 in keloid scars. J Investig Dermatol. 2011;131(10):2128–30.
    • (2011) J Investig Dermatol , vol.131 , Issue.10 , pp. 2128-2130
    • Bagabir, R.A.1    Syed, F.2    Rautemaa, R.3    McGrouther, D.A.4    Paus, R.5    Bayat, A.6
  • 57
    • 84862866635 scopus 로고    scopus 로고
    • Gadolinium compounds signaling through TLR4 and TLR7 in normal human macrophages: establishment of a proinflammatory phenotype and implications for the pathogenesis of nephrogenic systemic fibrosis
    • COI: 1:CAS:528:DC%2BC38XovVyrt7c%3D, PID: 2264920
    • Wermuth PJ, Jimenez SA. Gadolinium compounds signaling through TLR4 and TLR7 in normal human macrophages: establishment of a proinflammatory phenotype and implications for the pathogenesis of nephrogenic systemic fibrosis. J Immunol. 2012;189(1):318–27.
    • (2012) J Immunol , vol.189 , Issue.1 , pp. 318-327
    • Wermuth, P.J.1    Jimenez, S.A.2
  • 58
    • 79951786211 scopus 로고    scopus 로고
    • Toll-like receptors expressed by dermal fibroblasts contribute to hypertrophic scarring
    • COI: 1:CAS:528:DC%2BC3MXit1eht7o%3D, PID: 20945369, This study implicates TLR on dermal fibroblasts as contributory to fibrosis in hypertrophic scarrin
    • Wang J, Hori K, Ding J, Huang Y, Kwan P, Ladak A, et al. Toll-like receptors expressed by dermal fibroblasts contribute to hypertrophic scarring. J Cell Physiol. 2011;226(5):1265–73. This study implicates TLR on dermal fibroblasts as contributory to fibrosis in hypertrophic scarring.
    • (2011) J Cell Physiol , vol.226 , Issue.5 , pp. 1265-1273
    • Wang, J.1    Hori, K.2    Ding, J.3    Huang, Y.4    Kwan, P.5    Ladak, A.6
  • 59
    • 84866897878 scopus 로고    scopus 로고
    • The genetics of scleroderma: looking into the postgenomic era
    • COI: 1:CAS:528:DC%2BC38XhsVenu7rF, PID: 2302685
    • Mayes MD. The genetics of scleroderma: looking into the postgenomic era. Curr Opin Rheumatol. 2012;24(6):677–84.
    • (2012) Curr Opin Rheumatol , vol.24 , Issue.6 , pp. 677-684
    • Mayes, M.D.1
  • 60
    • 84872129706 scopus 로고    scopus 로고
    • Genetics of scleroderma: implications for personalized medicine?
    • PID: 23311619, This review highlighted the implication of recent discoveries in SSc genetics for drug development and identification of predictive biomarker
    • Assassi S, Radstake TR, Mayes MD, Martin J. Genetics of scleroderma: implications for personalized medicine? BMC Med. 2013;11:9. This review highlighted the implication of recent discoveries in SSc genetics for drug development and identification of predictive biomarkers.
    • (2013) BMC Med , vol.11 , pp. 9
    • Assassi, S.1    Radstake, T.R.2    Mayes, M.D.3    Martin, J.4
  • 61
    • 84855281875 scopus 로고    scopus 로고
    • A rare polymorphism in the gene for toll-like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediators
    • COI: 1:CAS:528:DC%2BC3MXhs12mtb3L, PID: 2190500
    • Broen JC, Bossini-Castillo L, van Bon L, Vonk MC, Knaapen H, Beretta L, et al. A rare polymorphism in the gene for toll-like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediators. Arthritis Rheum. 2012;64(1):264–71.
    • (2012) Arthritis Rheum , vol.64 , Issue.1 , pp. 264-271
    • Broen, J.C.1    Bossini-Castillo, L.2    van Bon, L.3    Vonk, M.C.4    Knaapen, H.5    Beretta, L.6
  • 62
    • 84886081492 scopus 로고    scopus 로고
    • The role of type 1 interferon in systemic sclerosis
    • PID: 2404676
    • Wu M, Assassi S. The role of type 1 interferon in systemic sclerosis. Front Immunol. 2013;4:266.
    • (2013) Front Immunol , vol.4 , pp. 266
    • Wu, M.1    Assassi, S.2
  • 63
    • 84864447493 scopus 로고    scopus 로고
    • Brief report: candidate gene study in systemic sclerosis identifies a rare and functional variant of the TNFAIP3 locus as a risk factor for polyautoimmunity
    • COI: 1:CAS:528:DC%2BC38XhtV2gtb%2FN, PID: 2248858
    • Koumakis E, Giraud M, Dieude P, Cohignac V, Cuomo G, Airo P, et al. Brief report: candidate gene study in systemic sclerosis identifies a rare and functional variant of the TNFAIP3 locus as a risk factor for polyautoimmunity. Arthritis Rheum. 2012;64(8):2746–52.
    • (2012) Arthritis Rheum , vol.64 , Issue.8 , pp. 2746-2752
    • Koumakis, E.1    Giraud, M.2    Dieude, P.3    Cohignac, V.4    Cuomo, G.5    Airo, P.6
  • 64
    • 84874399330 scopus 로고    scopus 로고
    • Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study
    • COI: 1:CAS:528:DC%2BC3sXnt12rsLk%3D, PID: 2289674
    • Bossini-Castillo L, Martin JE, Broen J, Simeon CP, Beretta L, Gorlova OY, et al. Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study. Ann Rheum Dis. 2013;72(4):602–7.
    • (2013) Ann Rheum Dis , vol.72 , Issue.4 , pp. 602-607
    • Bossini-Castillo, L.1    Martin, J.E.2    Broen, J.3    Simeon, C.P.4    Beretta, L.5    Gorlova, O.Y.6
  • 65
    • 79960934301 scopus 로고    scopus 로고
    • Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis
    • COI: 1:CAS:528:DC%2BC3MXpsFCns74%3D, PID: 2175067
    • Allanore Y, Saad M, Dieude P, Avouac J, Distler JH, Amouyel P, et al. Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis. PLoS Genet. 2011;7(7):e1002091.
    • (2011) PLoS Genet , vol.7 , Issue.7 , pp. e1002091
    • Allanore, Y.1    Saad, M.2    Dieude, P.3    Avouac, J.4    Distler, J.H.5    Amouyel, P.6
  • 66
    • 33745625865 scopus 로고    scopus 로고
    • Signatures of differentially regulated interferon gene expression and vasculotrophism in the peripheral blood cells of systemic sclerosis patients
    • COI: 1:CAS:528:DC%2BD28Xmt1Wkurc%3D, PID: 1641820
    • Tan FK, Zhou X, Mayes MD, Gourh P, Guo X, Marcum C, et al. Signatures of differentially regulated interferon gene expression and vasculotrophism in the peripheral blood cells of systemic sclerosis patients. Rheumatology. 2006;45(6):694–702.
    • (2006) Rheumatology , vol.45 , Issue.6 , pp. 694-702
    • Tan, F.K.1    Zhou, X.2    Mayes, M.D.3    Gourh, P.4    Guo, X.5    Marcum, C.6
  • 67
    • 33947154329 scopus 로고    scopus 로고
    • A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists
    • COI: 1:CAS:528:DC%2BD2sXjs1yks7o%3D, PID: 1732808
    • York MR, Nagai T, Mangini AJ, Lemaire R, van Seventer JM, Lafyatis R. A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists. Arthritis Rheum. 2007;56(3):1010–20.
    • (2007) Arthritis Rheum , vol.56 , Issue.3 , pp. 1010-1020
    • York, M.R.1    Nagai, T.2    Mangini, A.J.3    Lemaire, R.4    van Seventer, J.M.5    Lafyatis, R.6
  • 68
    • 67349269613 scopus 로고    scopus 로고
    • Molecular subtypes of systemic sclerosis in association with anti-centromere antibodies and digital ulcers
    • COI: 1:CAS:528:DC%2BD1MXkvVSru78%3D, PID: 1912985
    • Bos CL, van Baarsen LG, Timmer TC, Overbeek MJ, Basoski NM, Rustenburg F, et al. Molecular subtypes of systemic sclerosis in association with anti-centromere antibodies and digital ulcers. Genes Immun. 2009;10(3):210–8.
    • (2009) Genes Immun , vol.10 , Issue.3 , pp. 210-218
    • Bos, C.L.1    van Baarsen, L.G.2    Timmer, T.C.3    Overbeek, M.J.4    Basoski, N.M.5    Rustenburg, F.6
  • 69
    • 47249144728 scopus 로고    scopus 로고
    • Induction of interferon-alpha by scleroderma sera containing autoantibodies to topoisomerase I: association of higher interferon-alpha activity with lung fibrosis
    • COI: 1:CAS:528:DC%2BD1cXpt1Wrsrs%3D, PID: 1857634
    • Kim D, Peck A, Santer D, Patole P, Schwartz SM, Molitor JA, et al. Induction of interferon-alpha by scleroderma sera containing autoantibodies to topoisomerase I: association of higher interferon-alpha activity with lung fibrosis. Arthritis Rheum. 2008;58(7):2163–73.
    • (2008) Arthritis Rheum , vol.58 , Issue.7 , pp. 2163-2173
    • Kim, D.1    Peck, A.2    Santer, D.3    Patole, P.4    Schwartz, S.M.5    Molitor, J.A.6
  • 70
    • 84880131657 scopus 로고    scopus 로고
    • Toll-like receptor-mediated, enhanced production of profibrotic TIMP-1 in monocytes from patients with systemic sclerosis: role of serum factors
    • COI: 1:CAS:528:DC%2BC2cXjtVemu7o%3D, PID: 2322342
    • Ciechomska M, Huigens CA, Hugle T, Stanly T, Gessner A, Griffiths B, et al. Toll-like receptor-mediated, enhanced production of profibrotic TIMP-1 in monocytes from patients with systemic sclerosis: role of serum factors. Ann Rheum Dis. 2013;72(8):1382–9.
    • (2013) Ann Rheum Dis , vol.72 , Issue.8 , pp. 1382-1389
    • Ciechomska, M.1    Huigens, C.A.2    Hugle, T.3    Stanly, T.4    Gessner, A.5    Griffiths, B.6
  • 71
    • 77955452418 scopus 로고    scopus 로고
    • Distinct evolution of TLR-mediated dendritic cell cytokine secretion in patients with limited and diffuse cutaneous systemic sclerosis
    • PID: 2049820
    • van Bon L, Popa C, Huijbens R, Vonk M, York M, Simms R, et al. Distinct evolution of TLR-mediated dendritic cell cytokine secretion in patients with limited and diffuse cutaneous systemic sclerosis. Ann Rheum Dis. 2010;69(8):1539–47.
    • (2010) Ann Rheum Dis , vol.69 , Issue.8 , pp. 1539-1547
    • van Bon, L.1    Popa, C.2    Huijbens, R.3    Vonk, M.4    York, M.5    Simms, R.6
  • 72
    • 78651068822 scopus 로고    scopus 로고
    • Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts
    • COI: 1:CAS:528:DC%2BC3MXjtVWisr0%3D, PID: 2122358
    • Agarwal SK, Wu M, Livingston CK, Parks DH, Mayes MD, Arnett FC, et al. Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts. Arthritis Res Ther. 2011;13(1):R3.
    • (2011) Arthritis Res Ther , vol.13 , Issue.1 , pp. R3
    • Agarwal, S.K.1    Wu, M.2    Livingston, C.K.3    Parks, D.H.4    Mayes, M.D.5    Arnett, F.C.6
  • 73
    • 84884247600 scopus 로고    scopus 로고
    • A synthetic TLR3 ligand mitigates profibrotic fibroblast responses by inducing autocrine IFN signaling
    • COI: 1:CAS:528:DC%2BC3sXhsVWrsr7P, PID: 2395642
    • Fang F, Ooka K, Sun X, Shah R, Bhattacharyya S, Wei J, et al. A synthetic TLR3 ligand mitigates profibrotic fibroblast responses by inducing autocrine IFN signaling. J Immunol. 2013;191(6):2956–66.
    • (2013) J Immunol , vol.191 , Issue.6 , pp. 2956-2966
    • Fang, F.1    Ooka, K.2    Sun, X.3    Shah, R.4    Bhattacharyya, S.5    Wei, J.6
  • 74
    • 84897060890 scopus 로고    scopus 로고
    • Epstein-Barr virus infection induces aberrant TLR activation pathway and fibroblast-myofibroblast conversion in scleroderma
    • COI: 1:CAS:528:DC%2BC3sXhslKmsbnP, PID: 24129067, These findings demonstrated that EBV infection in mesenchymal, endothelial, and immune cells in the skin of SSc patients may underlie fibrotic and vascular complications mediated via TLR signalin
    • Farina A, Cirone M, York M, Lenna S, Padilla C, McLaughlin S, et al. Epstein-Barr virus infection induces aberrant TLR activation pathway and fibroblast-myofibroblast conversion in scleroderma. J Investig Dermatol. 2014;134(4):954–64. These findings demonstrated that EBV infection in mesenchymal, endothelial, and immune cells in the skin of SSc patients may underlie fibrotic and vascular complications mediated via TLR signaling.
    • (2014) J Investig Dermatol , vol.134 , Issue.4 , pp. 954-964
    • Farina, A.1    Cirone, M.2    York, M.3    Lenna, S.4    Padilla, C.5    McLaughlin, S.6
  • 75
    • 77957940944 scopus 로고    scopus 로고
    • Poly(I:C) drives type I IFN- and TGFbeta-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis
    • COI: 1:CAS:528:DC%2BC3cXht1yjsrnL, PID: 2061377
    • Farina GA, York MR, Di Marzio M, Collins CA, Meller S, Homey B, et al. Poly(I:C) drives type I IFN- and TGFbeta-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis. J Investig Dermatol. 2010;130(11):2583–93.
    • (2010) J Investig Dermatol , vol.130 , Issue.11 , pp. 2583-2593
    • Farina, G.A.1    York, M.R.2    Di Marzio, M.3    Collins, C.A.4    Meller, S.5    Homey, B.6
  • 76
    • 84905247530 scopus 로고    scopus 로고
    • Chronic toll-like receptor 4 stimulation in skin induces inflammation, macrophage activation, transforming growth factor beta signature gene expression, and fibrosis
    • PID: 24984848, This study showed how chronic TLR4 activation in the skin cells can enhance TGF-β signaling in mice, providing a potential mechanism for TLR4/myeloid differentiation factor 88 (MyD88)-dependent fibrosi
    • Stifano G, Affandi AJ, Mathes AL, Rice LM, Nakerakanti S, Nazari B, et al. Chronic toll-like receptor 4 stimulation in skin induces inflammation, macrophage activation, transforming growth factor beta signature gene expression, and fibrosis. Arthritis Res Ther. 2014;16(4):R136. This study showed how chronic TLR4 activation in the skin cells can enhance TGF-β signaling in mice, providing a potential mechanism for TLR4/myeloid differentiation factor 88 (MyD88)-dependent fibrosis.
    • (2014) Arthritis Res Ther , vol.16 , Issue.4 , pp. R136
    • Stifano, G.1    Affandi, A.J.2    Mathes, A.L.3    Rice, L.M.4    Nakerakanti, S.5    Nazari, B.6
  • 77
    • 57349109321 scopus 로고    scopus 로고
    • Antifibroblast antibodies in systemic sclerosis induce fibroblasts to produce profibrotic chemokines, with partial exploitation of toll-like receptor 4
    • COI: 1:CAS:528:DC%2BD1MXmt1yltw%3D%3D, PID: 1903550
    • Fineschi S, Goffin L, Rezzonico R, Cozzi F, Dayer JM, Meroni PL, et al. Antifibroblast antibodies in systemic sclerosis induce fibroblasts to produce profibrotic chemokines, with partial exploitation of toll-like receptor 4. Arthritis Rheum. 2008;58(12):3913–23.
    • (2008) Arthritis Rheum , vol.58 , Issue.12 , pp. 3913-3923
    • Fineschi, S.1    Goffin, L.2    Rezzonico, R.3    Cozzi, F.4    Dayer, J.M.5    Meroni, P.L.6
  • 79
    • 50249176028 scopus 로고    scopus 로고
    • New insights into form and function of fibronectin splice variants
    • COI: 1:CAS:528:DC%2BD1cXhtFSrtbbI, PID: 1868011
    • White ES, Baralle FE, Muro AF. New insights into form and function of fibronectin splice variants. J Pathol. 2008;216(1):1–14.
    • (2008) J Pathol , vol.216 , Issue.1 , pp. 1-14
    • White, E.S.1    Baralle, F.E.2    Muro, A.F.3
  • 80
    • 84877577557 scopus 로고    scopus 로고
    • Toll-like receptors as therapeutic targets for autoimmune connective tissue diseases
    • COI: 1:CAS:528:DC%2BC3sXlvVCqsbc%3D, PID: 23531543, This review highlighted modulating TLR signaling as an important strategy for the treatment of connective tissue disease
    • Li J, Wang X, Zhang F, Yin H. Toll-like receptors as therapeutic targets for autoimmune connective tissue diseases. Pharmacol Ther. 2013;138(3):441–51. This review highlighted modulating TLR signaling as an important strategy for the treatment of connective tissue diseases.
    • (2013) Pharmacol Ther , vol.138 , Issue.3 , pp. 441-451
    • Li, J.1    Wang, X.2    Zhang, F.3    Yin, H.4


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