Toll-like receptor 4 signaling augments transforming growth factor-β responses: A novel mechanism for maintaining and amplifying fibrosis in scleroderma

American Journal of Pathology

Volumn 182, Issue 1, 2013, Pages 192-205

  Bhattacharyya, Swati ^a   Kelley, Kathleen ^a   Melichian, Denisa S ^a   Tamaki, Zenshiro ^a   Fang, Feng ^a   Su, Yunyun ^b   Feng, Gilbert ^c   Pope, Richard M ^a   Budinger, G R Scott ^a   Mutlu, Gökhan M ^a   Lafyatis, Robert ^d   Radstake, Timothy ^e   Feghali Bostwick, Carol ^b   Varga, John ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; CD11B ANTIGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 11; COLLAGEN TYPE 2; COLLAGEN TYPE 3; COLLAGEN TYPE 5; COLLAGEN TYPE 8; MICRORNA; SMAD2 PROTEIN; SMAD3 PROTEIN; TENASCIN; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DERMIS; EXTRACELLULAR MATRIX; FEMALE; FIBROBLAST; FIBROGENESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEYDIG CELL; LUNG PARENCHYMA; MALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SCLERODERMA; SIGNAL TRANSDUCTION; SKIN BIOPSY; SKIN DEFECT; SKIN FIBROSIS;

ADULT; AGED; ANIMALS; BIOPSY; BLEOMYCIN; CELLS, CULTURED; COLLAGEN; EXTRACELLULAR MATRIX; FEMALE; FIBROBLASTS; FIBROSIS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; LIGANDS; LUNG; MALE; MICE; MICE, INBRED C3H; MICE, MUTANT STRAINS; MICRORNAS; MIDDLE AGED; SCLERODERMA, SYSTEMIC; SIGNAL TRANSDUCTION; SKIN; TOLL-LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA;

EID: 84871284466     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2012.09.007     Document Type: Article

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