Toll-like receptor 4 knockout protects against isoproterenol-induced cardiac fibrosis: The role of autophagy

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 20, Issue 1, 2015, Pages 84-92

  Dong, Rui Qing ^a   Wang, Ze Feng ^a   Zhao, Can ^a   Gu, Hai Rong ^a   Hu, Zhuo Wei ^b   Xie, Jing ^b   Wu, Yong Quan ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Cardiac fibroblasts; Cardiac fibrosis; Rapamycin; Toll like receptor 4; Utophagy

Indexed keywords

BECLIN 1; COLLAGEN TYPE 3; ISOPRENALINE; RAPAMYCIN; TOLL LIKE RECEPTOR 4; CARDIOTONIC AGENT; TLR4 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL ACTIVATION; CONTROLLED STUDY; DOWN REGULATION; ECHOCARDIOGRAPHY; FIBROBLAST; GENE INACTIVATION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE FIBROSIS; HEART PROTECTION; MALE; MOUSE; NONHUMAN; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DEFICIENCY; DRUG EFFECTS; FIBROSIS; HEART DISEASES; KNOCKOUT MOUSE; PATHOLOGY; PHYSIOLOGY;

ANIMALS; AUTOPHAGY; CARDIOTONIC AGENTS; FIBROSIS; HEART DISEASES; ISOPROTERENOL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; TOLL-LIKE RECEPTOR 4;

EID: 84916614181     PISSN: 10742484     EISSN: 19404034     Source Type: Journal    
DOI: 10.1177/1074248414539564     Document Type: Article

References (31)

1. Xu XF, Dai HP. Rapamycin in fibrotic diseases: beneficial or detrimental agent? Chin Med J. 2013;126(7):1364-1369.
2. Ni HM, Williams J, Yang H, Shi YH, Fan J, Ding WX. Targeting autophagy for the treatment of liver diseases. Pharmacol Res. 2012;66(6):463-474.
3. Buss SJ, Muenz S, Riffel JH, et al. Beneficial effects of mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction. J Am Coll Cardiol. 2009;54(25): 2435-2446.
4. Baum J, Duffy HS. Fibroblasts and myofibroblasts: what are we talking about? J Cardiovasc Pharmacol. 2011;57(4):376-379.
5. Turner NA. Therapeutic regulation of cardiac fibroblast function: targeting stress-activated protein kinase pathways. Future Cardiol. 2011;7(5):673-691.
6. Levine B, Yoshimori T, Deretic V. Autophagy in Infection and Immunity. Berlin, Heidelberg: Springer; 2009.
7. Nemchenko A, Chiong M, Turer A, Lavandero S, Hill JA. Autophagy as a therapeutic target in cardiovascular disease. J Mol Cell Cardiol. 2011;51(4):584-593.
8. Nakai A, Yamaguchi O, Takeda T, et al. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med. 2007;13(5):619-624.
9. Ma Y, Zhang X, Bao H, et al. Toll-like receptor (tlr) 2 and tlr4 differentially regulate doxorubicin induced cardiomyopathy in mice. PLoS One. 2012;7(7):e40763.
10. Liu YY, Cai WF, Yang HZ, et al. Bacillus calmette-guerin and tlr4 agonist prevent cardiovascular hypertrophy and fibrosis by regulating immune microenvironment. J Immunol. 2008; 180(11):7349-7357.
11. Moghimpour Bijani F, Vallejo JG, Rezaei N. Toll-like receptor signaling pathways in cardiovascular diseases: challenges and opportunities. Int Rev Immunol. 2012;31(5):379-395.
12. Timmers L, Sluijter JP, van Keulen JK, et al. Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction. Circ Res. 2008;102(2): 257-264.
13. Topkara VK, Evans S, Zhang W, et al. Therapeutic targeting of innate immunity in the failing heart. J Mol Cell Cardiol. 2011; 51(4):594-599.
14. Gonzalez A, Ravassa S, Beaumont J, Lopez B, Diez J. New targets to treat the structural remodeling of the myocardium. J Am Coll Cardiol. 2011;58(18):1833-1843.
15. van Nieuwenhoven FA, Turner NA. The role of cardiac fibroblasts in the transition from inflammation to fibrosis following myocardial infarction. Vascul Pharmacol. 2013;58(3):182-188.
16. Chen W, Frangogiannis NG. Fibroblasts in post-infarction inflammation and cardiac repair. Biochim Biophys Acta. 2013;1833(4):945-953.
17. Harrison DE, Strong R, Sharp ZD, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009;460(7253):392-395.
18. Respress JL, Wehrens XH. Transthoracic echocardiography in mice. J Vis Exp. 2010;(39). pii: 1738.
19. Mi S, Li Z, Yang HZ, et al. Blocking il-17a promotes the resolution of pulmonary inflammation and fibrosis via tgf-β1-dependent andindependent mechanisms. J Immunol. 2011;187(6):3003-3014.
20. Heldin CH, Miyazono K, Ten Dijke P. Tgf-β signalling from cell membrane to nucleus through smad proteins. Nature. 1997;390(6659):465-471.
21. Ottaviano FG, Yee KO. Communication signals between cardiac fibroblasts and cardiac myocytes. J Cardiovascul Pharmacol. 2011;57(5):513-521.
22. Russell RC, Tian Y, Yuan H, et al. Ulk1 induces autophagy by phosphorylating beclin-1 and activating vps34 lipid kinase. Nat Cell Biol. 2013;15(7):741-750.
23. Benjamin IJ, Jalil JE, Tan L, Cho K, Weber KT, Clark WA. Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis. Circ Res. 1989;65(3):657-670.
24. Mann DL. The emerging role of innate immunity in the heart and vascular system: for whom the cell tolls. Circ Res. 2011;108(9):1133-1145.
25. Weber KT, Sun Y, Bhattacharya SK, Ahokas RA, Gerling IC. Myofibroblast-mediated mechanisms of pathological remodelling of the heart. Nat Rev Cardiol. 2012;10(1):15-26.
26. Nishida K, Yamaguchi O, Otsu K. Crosstalk between autophagy and apoptosis in heart disease. Circ Res. 2008;103(4):343-351.
27. Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol. 2007;8(9):741-752.
28. Wencker D, Chandra M, Nguyen K, et al. A mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Invest. 2003;111(10):1497-1504.
29. Takemura G, Kanoh M, Minatoguchi S, Fujiwara H. Cardiomyocyte apoptosis in the failing heart - a critical review from definition and classification of cell death. Int J Cardiol. 2013;167(6):2373-2386.
30. Thoen LF, Guimaraes EL, Dolle L, et al. A role for autophagy during hepatic stellate cell activation. J Hepatol. 2011;55(6):1353-1360.
31. Mizushima N, Levine B. Autophagy in mammalian development and differentiation. Nat Cell Biol. 2010;12(9):823-830.