TLR4 activity is required in the resolution of pulmonary inflammation and fibrosis after acute and chronic lung injury

American Journal of Pathology

Volumn 180, Issue 1, 2012, Pages 275-292

  Yang, Hong Zhen ^a   Wang, Jia Ping ^a   Mi, Su ^a   Liu, Han Zhi ^a   Cui, Bing ^a   Yan, Hui Min ^a   Yan, Jun ^a   Li, Zhe ^a   Liu, Hong ^a   Hua, Fang ^a   Lu, Wange ^b   Hu, Zhuo Wei ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; BLEOMYCIN; RAPAMYCIN; SILICON DIOXIDE; TOLL LIKE RECEPTOR 4;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CHRONIC INFLAMMATION; CHRONIC LUNG INJURY; CONTROLLED STUDY; LUNG FIBROSIS; LUNG FUNCTION; LUNG INJURY; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ACUTE LUNG INJURY; ANIMALS; APOPTOSIS; AUTOPHAGY; IDIOPATHIC PULMONARY FIBROSIS; LUNG INJURY; MAP KINASE SIGNALING SYSTEM; MICE; PNEUMONIA; TOLL-LIKE RECEPTOR 4;

EID: 83455230751     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.09.019     Document Type: Article

References (51)

1. J. Rosenbloom, S.V. Castro, S.A. Jimenez Narrative review: fibrotic diseases: cellular and molecular mechanisms and novel therapies Ann Intern Med 152 2010 159 166
2. R.M. du Bois Strategies for treating idiopathic pulmonary fibrosis Nat Rev Drug Discov 9 2010 129 140
3. J.A. de Andrade, V.J. Thannickal Innovative approaches to the therapy of fibrosis Curr Opin Rheumatol 21 2009 649 655
4. R.C. Boucher Idiopathic pulmonary fibrosisa sticky business N Engl J Med 364 2011 1560 1561
5. A. Datta, C.J. Scotton, R.C. Chambers Novel therapeutic approaches for pulmonary fibrosis Br J Pharmacol 163 2011 141 172
6. M.A. Perazella, G.S. Markowitz Drug-induced acute interstitial nephritis Nat Rev Nephrol 6 2010 461 470
7. D.A. Zisman, M. Schwarz, K.J. Anstrom, H.R. Collard, K.R. Flaherty, G.W. Hunninghake A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosis N Engl J Med 363 2010 620 628
8. R.M. Strieter, B. Mehrad New mechanisms of pulmonary fibrosis Chest 136 2009 1364 1370
9. M. Delgado, S. Singh, S. De Haro, S. Master, M. Ponpuak, C. Dinkins, W. Ornatowski, I. Vergne, V. Deretic Autophagy and pattern recognition receptors in innate immunity Immunol Rev 227 2009 189 202
10. T.A. Wynn Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases J Clin Invest 117 2007 524 529 (Pubitemid 46348506)
11. H.Z. Yang, B. Cui, H.Z. Liu, Z.R. Chen, H.M. Yan, F. Hua, Z.W. Hu Targeting TLR2 attenuates pulmonary inflammation and fibrosis by reversion of suppressive immune microenvironment J Immunol 182 2009 692 702
12. A.S. Williams, S.Y. Leung, P. Nath, N.M. Khorasani, P. Bhavsar, R. Issa, J.A. Mitchell, I.M. Adcock, K.F. Chung Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia J Appl Physiol 103 2007 1189 1195 (Pubitemid 47610420)
13. Y. Imai, K. Kuba, G.G. Neely, R. Yaghubian-Malhami, T. Perkmann, G. van Loo, M. Ermolaeva, R. Veldhuizen, Y.H. Leung, H. Wang, H. Liu, Y. Sun, M. Pasparakis, M. Kopf, C. Mech, S. Bavari, J.S. Peiris, A.S. Slutsky, S. Akira, M. Hultqvist, R. Holmdahl, J. Nicholls, C. Jiang, C.J. Binder, J.M. Penninger Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury Cell 133 2008 235 249 (Pubitemid 351512299)
14. E. Seki, S. De Minicis, C.H. Osterreicher, J. Kluwe, Y. Osawa, D.A. Brenner, R.F. Schwabe TLR4 enhances TGF-β signaling and hepatic fibrosis Nat Med 13 2007 1324 1332 (Pubitemid 350073596)
15. L. Timmers, J.P. Sluijter, J.K. van Keulen, I.E. Hoefer, M.G. Nederhoff, M.J. Goumans, P.A. Doevendans, C.J. van Echteld, J.A. Joles, P.H. Quax, J.J. Piek, G. Pasterkamp, D.P. de Kleijn Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction Circ Res 102 2008 257 264 (Pubitemid 351674064)
16. Y.Y. Liu, W.F. Cai, H.Z. Yang, B. Cui, Z.R. Chen, H.Z. Liu, J. Yan, W. Jin, H.M. Yan, B.M. Xin, B. Yuan, F. Hua, Z.W. Hu Bacillus Calmette-Guerin and TLR4 agonist prevent cardiovascular hypertrophy and fibrosis by regulating immune microenvironment J Immunol 180 2008 7349 7357
17. H.Z. Yang, B. Cui, H.Z. Liu, S. Mi, J. Yan, H.M. Yan, F. Hua, H. Lin, W.F. Cai, W.J. Xie, X.X. Lv, X.X. Wang, B.M. Xin, Q.M. Zhan, Z.W. Hu Blocking TLR2 activity attenuates pulmonary metastases of tumor PLoS ONE 4 2009 e6520
18. A. Moeller, K. Ask, D. Warburton, J. Gauldie, M. Kolb The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis Int J Biochem Cell Biol 40 2008 362 382 (Pubitemid 351249887)
19. J.A. Vanoirbeek, M. Rinaldi, V. De Vooght, S. Haenen, S. Bobic, G. Gayan-Ramirez, P.H. Hoet, E. Verbeken, M. Decramer, B. Nemery, W. Janssens Noninvasive and invasive pulmonary function in mouse models of obstructive and restrictive respiratory diseases Am J Respir Cell Mol Biol 42 2009 96 104
20. S. Shofer, C. Badea, Y. Qi, E. Potts, W.M. Foster, G.A. Johnson A micro-CT analysis of murine lung recruitment in bleomycin-induced lung injury J Appl Physiol 105 2008 669 677
21. C. Traidl-Hoffmann, V. Mariani, H. Hochrein, K. Karg, H. Wagner, J. Ring, M.J. Mueller, T. Jakob, H. Behrendt Pollen-associated phytoprostanes inhibit dendritic cell interleukin-12 production and augment T helper type 2 cell polarization J Exp Med 201 2005 627 636
22. A. Hamacher-Brady, N.R. Brady, S.E. Logue, M.R. Sayen, M. Jinno, L.A. Kirshenbaum, R.A. Gottlieb, A.B. Gustafsson Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy Cell Death Differ 14 2007 146 157 (Pubitemid 44911902)
23. K. Atabai, S. Jame, N. Azhar, A. Kuo, M. Lam, W. McKleroy, G. Dehart, S. Rahman, D.D. Xia, A.C. Melton, P. Wolters, C.L. Emson, S.M. Turner, Z. Werb, D. Sheppard Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages J Clin Invest 119 2009 3713 3722
24. J.X. Chen, A. Stinnett Critical role of the NADPH oxidase subunit p47phox on vascular TLR expression and neointimal lesion formation in high-fat diet-induced obesity Lab Invest 88 2008 1316 1328
25. Y. Xu, C. Jagannath, X.D. Liu, A. Sharafkhaneh, K.E. Kolodziejska, N.T. Eissa Toll-like receptor 4 is a sensor for autophagy associated with innate immunity Immunity 27 2007 135 144 (Pubitemid 47089027)
26. V.I. Korolchuk, S. Saiki, M. Lichtenberg, F.H. Siddiqi, E.A. Roberts, S. Imarisio, L. Jahreiss, S. Sarkar, M. Futter, F.M. Menzies, C.J. O'Kane, V. Deretic, D.C. Rubinsztein Lysosomal positioning coordinates cellular nutrient responses Nat Cell Biol 13 2011 453 460
27. M. Salazar, A. Carracedo, I.J. Salanueva, S. Hernandez-Tiedra, M. Lorente, A. Egia, P. Vazquez, C. Blazquez, S. Torres, S. Garcia, J. Nowak, G.M. Fimia, M. Piacentini, F. Cecconi, P.P. Pandolfi, L. Gonzalez-Feria, J.L. Iovanna, M. Guzman, P. Boya, G. Velasco Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells J Clin Invest 119 2009 1359 1372
28. M. Chhikara, S. Wang, S.J. Kern, G.A. Ferreyra, J.J. Barb, P.J. Munson, R.L. Danner Carbon monoxide blocks lipopolysaccharide-induced gene expression by interfering with proximal TLR4 to NF-kappaB signal transduction in human monocytes PLoS ONE 4 2009 e8139
29. O. Mungunsukh, A.J. Griffin, Y.H. Lee, R.M. Day Bleomycin induces the extrinsic apoptotic pathway in pulmonary endothelial cells Am J Physiol Lung Cell Mol Physiol 298 2010 L696 L703
30. K.W. Kim, M. Hwang, L. Moretti, J.J. Jaboin, Y.I. Cha, B. Lu Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer Autophagy 4 2008 659 668
31. C.N. Serhan, S.D. Brain, C.D. Buckley, D.W. Gilroy, C. Haslett, L.A. O'Neill, M. Perretti, A.G. Rossi, J.L. Wallace Resolution of inflammation: state of the art, definitions and terms FASEB J 21 2007 325 332 (Pubitemid 46213480)
32. H. Zhao, S.W. Leu, L. Shi, R. Dedaj, G. Zhao, H.G. Garg, L. Shen, E. Lien, K.A. Fitzgerald, A. Shiedlin, H. Shen, D.A. Quinn, C.A. Hales TLR4 is a negative regulator in noninfectious lung inflammation J Immunol 184 2010 5308 5314
33. J.C. Canale-Zambrano, M.L. Auger, C.K. Haston Toll-like receptor-4 genotype influences the survival of cystic fibrosis mice Am J Physiol Gastrointest Liver Physiol 299 2010 G381 G390
34. G. John, A.O. Yildirim, B.K. Rubin, D.C. Gruenert, M.O. Henke TLR-4-mediated innate immunity is reduced in cystic fibrosis airway cells Am J Respir Cell Mol Biol 42 2010 424 431
35. A. Lembo, M. Pelletier, R. Iyer, M. Timko, J.C. Dudda, T.E. West, C.B. Wilson, A.M. Hajjar, S.J. Skerrett Administration of a synthetic TLR4 agonist protects mice from pneumonic tularemia J Immunol 180 2008 7574 7581
36. S. Gariboldi, M. Palazzo, L. Zanobbio, S. Selleri, M. Sommariva, L. Sfondrini, S. Cavicchini, A. Balsari, C. Rumio Low molecular weight hyaluronic acid increases the self-defense of skin epithelium by induction of beta-defensin 2 via TLR2 and TLR4 J Immunol 181 2008 2103 2110
37. D. Jiang, J. Liang, P.W. Noble Hyaluronan in tissue injury and repair Annu Rev Cell Dev Biol 23 2007 435 461
38. X. Zhang, P. Shan, G. Jiang, L. Cohn, P.J. Lee Toll-like receptor 4 deficiency causes pulmonary emphysema J Clin Invest 116 2006 3050 3059 (Pubitemid 44684490)
39. T. Luedde, C. Trautwein A molecular link between inflammation and fibrogenesis: the bacterial microflora influences hepatic fibrosis via toll-like receptor 4-dependent modification of transforming growth factor-beta signaling in hepatic stellate cells Hepatology 47 2008 1089 1091 (Pubitemid 351449700)
40. Z. He, Y. Zhu, H. Jiang Inhibiting toll-like receptor 4 signaling ameliorates pulmonary fibrosis during acute lung injury induced by lipopolysaccharide: an experimental study Respir Res 10 2009 126
41. M.T. Campbell, K.L. Hile, H. Zhang, H. Asanuma, B.A. Vanderbrink, R.R. Rink, K.K. Meldrum Toll-Like receptor 4: a novel signaling pathway during renal fibrogenesis J Surg Res 156 2009 1 9
42. V.J. Thannickal, J. Roman Challenges in translating preclinical studies to effective drug therapies in idiopathic pulmonary fibrosis Am J Respir Crit Care Med 181 2010 532 533
43. M.A. Sanjuan, C.P. Dillon, S.W. Tait, S. Moshiach, F. Dorsey, S. Connell, M. Komatsu, K. Tanaka, J.L. Cleveland, S. Withoff, D.R. Green Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis Nature 450 2007 1253 1257
44. T.A. Wynn Fibrotic disease and the T(H)1/T(H)2 paradigm Nat Rev Immunol 4 2004 583 594
45. S. Mi, Z. Li, H.Z. Yang, H. Liu, J.P. Wang, Y.G. Ma, X.X. Wang, H.Z. Liu, W. Sun, Z.W. Hu Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and -independent mechanisms J Immunol 187 2011 3003 3014
46. A. Luciani, V.R. Villella, S. Esposito, N. Brunetti-Pierri, D.L. Medina, C. Settembre, M. Gavina, V. Raia, A. Ballabio, L. Maiuri Cystic fibrosis: a disorder with defective autophagy Autophagy 7 2010 104 106
47. A. Luciani, V.R. Villella, S. Esposito, N. Brunetti-Pierri, D. Medina, C. Settembre, M. Gavina, L. Pulze, I. Giardino, M. Pettoello-Mantovani, M. D'Apolito, S. Guido, E. Masliah, B. Spencer, S. Quaratino, V. Raia, A. Ballabio, L. Maiuri Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition Nat Cell Biol 12 2010 863 875
48. T. Hidvegi, M. Ewing, P. Hale, C. Dippold, C. Beckett, C. Kemp, N. Maurice, A. Mukherjee, C. Goldbach, S. Watkins, G. Michalopoulos, D.H. Perlmutter An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis Science 329 2010 229 232
49. R.N. Sifers Medicine Clearing conformational disease Science 329 2010 154 155
50. D. Bouros Interferon gamma for idiopathic pulmonary fibrosis Lancet 374 2009 180 182
51. T.E. King Jr, C. Albera, W.Z. Bradford, U. Costabel, P. Hormel, L. Lancaster, P.W. Noble, S.A. Sahn, J. Szwarcberg, M. Thomeer, D. Valeyre, R.M. du Bois Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial Lancet 374 2009 222 228