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Volumn 10, Issue 11, 2014, Pages 3165-3174

Engineering better immunotherapies via RNA interference

Author keywords

Cancer vaccine; Gene silencing; Immunotherapy; RNA interference; T cell therapy; Targeted therapies

Indexed keywords

CANCER VACCINE; DENDRITIC CELL VACCINE; DNA VACCINE; INDOLEAMINE 2,3 DIOXYGENASE; SMALL INTERFERING RNA;

EID: 84921734612     PISSN: 21645515     EISSN: 2164554X     Source Type: Journal    
DOI: 10.4161/hv.29754     Document Type: Article
Times cited : (19)

References (75)
  • 1
    • 77958454596 scopus 로고    scopus 로고
    • Designing vaccines based on biology of human dendritic cell subsets
    • PMID:21029958
    • Palucka K, Banchereau J, Mellman I. Designing vaccines based on biology of human dendritic cell subsets. Immunity 2010; 33:464-78; PMID:21029958; http://dx.doi.org/10.1016/j.immuni.2010.10.007
    • (2010) Immunity , vol.33 , pp. 464-478
    • Palucka, K.1    Banchereau, J.2    Mellman, I.3
  • 2
    • 77349124883 scopus 로고    scopus 로고
    • Origin and development of dendritic cells
    • Liu K, Nussenzweig MC. Origin and development of dendritic cells. Immunol Rev 2010; 234:45-54.
    • (2010) Immunol Rev , vol.234 , pp. 45-54
    • Liu, K.1    Nussenzweig, M.C.2
  • 3
    • 2442585121 scopus 로고    scopus 로고
    • Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity
    • PMID:15122199
    • Chen L. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol 2004; 4:336-47; PMID:15122199; http://dx.doi.org/10.1038/nri1349
    • (2004) Nat Rev Immunol , vol.4 , pp. 336-347
    • Chen, L.1
  • 4
    • 0027087331 scopus 로고
    • Costimulation of T lymphocytes: The role of CD28, CTLA-4, and B7BB1 in interleukin-2 production and immunotherapy
    • PMID:1335362
    • Schwartz RH. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7BB1 in interleukin-2 production and immunotherapy. Cell 1992; 71:1065-8; PMID:1335362; http://dx.doi.org/10.1016/S0092-8674(05)80055-8
    • (1992) Cell , vol.71 , pp. 1065-1068
    • Schwartz, R.H.1
  • 5
    • 70350433514 scopus 로고    scopus 로고
    • Interaction between PD-1 and PD-L-1 promote tolerance by blocking the TCR-induced stop signal
    • PMID:19783989
    • Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA. Interaction between PD-1 and PD-L-1 promote tolerance by blocking the TCR-induced stop signal. Nat Immunol 2009; 10:1185-92; PMID:19783989; http://dx.doi.org/10.1038/ni.1790
    • (2009) Nat Immunol , vol.10 , pp. 1185-1192
    • Fife, B.T.1    Pauken, K.E.2    Eagar, T.N.3    Obu, T.4    Wu, J.5    Tang, Q.6    Azuma, M.7    Krummel, M.F.8    Bluestone, J.A.9
  • 7
    • 34248173331 scopus 로고    scopus 로고
    • Indolamine 2,3-dioxygenase and tumor-induced tolerance
    • PMID:17476344
    • Munn DH, Mellor AL. Indolamine 2,3-dioxygenase and tumor-induced tolerance. J Clin Invest 2007; 17:1147-54; PMID:17476344; http://dx.doi.org/10.1172/JCI31178
    • (2007) J Clin Invest , vol.17 , pp. 1147-1154
    • Munn, D.H.1    Mellor, A.L.2
  • 8
    • 0035313447 scopus 로고    scopus 로고
    • Regulatory activity of autocrine IL-10 on dendritic cell functions
    • PMID:11254683
    • Corinti S, Albanesis C, la Salsa A, Pastore S, Girolomoni G. Regulatory activity of autocrine IL-10 on dendritic cell functions. J Immunol 2001; 166:4312-20; PMID:11254683; http://dx.doi.org/10.4049/jimmunol.166.7.4312
    • (2001) J Immunol , vol.166 , pp. 4312-4320
    • Corinti, S.1    Albanesis, C.2    La Salsa, A.3    Pastore, S.4    Girolomoni, G.5
  • 9
    • 84857784900 scopus 로고    scopus 로고
    • Progress toward in vivo use of siRNAs-II
    • PMID:22186795
    • Rettig GR, Behlke MA. Progress toward in vivo use of siRNAs-II. Mol Ther 2012; 20:483-512; PMID:22186795; http://dx.doi.org/10.1038/mt.2011.263
    • (2012) Mol Ther , vol.20 , pp. 483-512
    • Rettig, G.R.1    Behlke, M.A.2
  • 10
    • 80052627990 scopus 로고    scopus 로고
    • Current progress of siRNAshRNA therapeutics in clinical trials
    • PMID:21744502
    • Burnett JC, Rossi JJ, Tiemann K. Current progress of siRNAshRNA therapeutics in clinical trials. Biotechnol J 2011; 6:1130-46; PMID:21744502; http://dx.doi.org/10.1002/biot.201100054
    • (2011) Biotechnol J , vol.6 , pp. 1130-1146
    • Burnett, J.C.1    Rossi, J.J.2    Tiemann, K.3
  • 11
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • PMID:15372042
    • Ambros V. The functions of animal microRNAs. Nature 2004; 431:350-5; PMID:15372042; http://dx.doi.org/10.1038/nature02871
    • (2004) Nature , vol.431 , pp. 350-355
    • Ambros, V.1
  • 12
    • 0042971652 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells
    • PMID:12615891
    • Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol 2003; 21:685-711; PMID:12615891; http://dx.doi.org/10.1146/annurev.immunol.21.120601.141040
    • (2003) Annu Rev Immunol , vol.21 , pp. 685-711
    • Steinman, R.M.1    Hawiger, D.2    Nussenzweig, M.C.3
  • 13
    • 0031908807 scopus 로고    scopus 로고
    • TGF-beta knockout and dominant negative receptor transgenic mice
    • PMID:9525700
    • Letterio JJ, Bottinger EP. TGF-beta knockout and dominant negative receptor transgenic mice. Miner Electrolyte Metab 1998; 24:161; PMID:9525700; http://dx.doi.org/10.1159/000057365
    • (1998) Miner Electrolyte Metab , vol.24 , pp. 161
    • Letterio, J.J.1    Bottinger, E.P.2
  • 14
    • 0033520467 scopus 로고    scopus 로고
    • SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality
    • PMID:10490100
    • Marine JC. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 1999; 98:609-16; PMID:10490100; http://dx.doi.org/10.1016/S0092-8674(00)80048-3
    • (1999) Cell , vol.98 , pp. 609-616
    • Marine, J.C.1
  • 15
    • 23844529169 scopus 로고    scopus 로고
    • Establishment of NOD-Pdc1- mice as efficient animal model of type I diabetes
    • PMID:16087865
    • Wang J, Yoshida T, Nakaki F, Hiai H, Okazaki T, Honjo T. Establishment of NOD-Pdc1- mice as efficient animal model of type I diabetes. Proc Acad Sci USA 2005; 102:11823-8; PMID:16087865; http://dx.doi.org/10.1073/pnas.0505497102
    • (2005) Proc Acad Sci USA , vol.102 , pp. 11823-11828
    • Wang, J.1    Yoshida, T.2    Nakaki, F.3    Hiai, H.4    Okazaki, T.5    Honjo, T.6
  • 16
    • 5044220930 scopus 로고    scopus 로고
    • IDO expression by dendritic cells: Tolerance and tryptophan catabolism
    • PMID:15459668
    • Munn DH, Mellor AL. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 2004; 4:762-74; PMID:15459668; http://dx.doi.org/10.1038/nri1457
    • (2004) Nat Rev Immunol , vol.4 , pp. 762-774
    • Munn, D.H.1    Mellor, A.L.2
  • 19
    • 37849028844 scopus 로고    scopus 로고
    • Impaired expression of indoleamine 2, 3-dioxygenase in monocyte-derived dendritic cells in response to Toll-like receptor-78 ligands
    • PMID: 17725606
    • Furset G, Floisand Y, Sioud M. Impaired expression of indoleamine 2, 3-dioxygenase in monocyte-derived dendritic cells in response to Toll-like receptor-78 ligands. Immunology 2007; 123:263-71; PMID: 17725606
    • (2007) Immunology , vol.123 , pp. 263-271
    • Furset, G.1    Floisand, Y.2    Sioud, M.3
  • 21
    • 68249159577 scopus 로고    scopus 로고
    • Modulation of dendritic cell maturation and function with mono- and bifunctional small interfering RNAs targeting indoleamine 2,3-dioxygenase
    • PMID:19740345
    • Flatekval GF, Sioud M. Modulation of dendritic cell maturation and function with mono- and bifunctional small interfering RNAs targeting indoleamine 2,3-dioxygenase. Immunology 2009; 128:e837-48; PMID:19740345; http://dx.doi.org/10.1111/j.1365-2567.2009.03093.x
    • (2009) Immunology , vol.128 , pp. e837-e848
    • Flatekval, G.F.1    Sioud, M.2
  • 23
    • 84879682811 scopus 로고    scopus 로고
    • Silencing of indoleamine 2,3-dioxygenase in dendritic cell cancer vaccines: Evaluation in vitro and in cancer patients
    • PMID:23620105
    • Sioud M, Saeboe-Larssen S, Hetland TE, Kaern J, Mobergslien A, Kvalheim G. Silencing of indoleamine 2,3-dioxygenase in dendritic cell cancer vaccines: evaluation in vitro and in cancer patients. Int J Oncol 2013; 43:280-8; PMID:23620105
    • (2013) Int J Oncol , vol.43 , pp. 280-288
    • Sioud, M.1    Saeboe-Larssen, S.2    Hetland, T.E.3    Kaern, J.4    Mobergslien, A.5    Kvalheim, G.6
  • 24
    • 0036133166 scopus 로고    scopus 로고
    • mRNA-based electrotransfection of human dendritic cells and induction of cytotoxic T lymphocyte responses against the telomerase catalytic subunit (hTERT)
    • PMID:11730854
    • Sæbo-Larsen S, Fossberg E, Gaudernack G. mRNA-based electrotransfection of human dendritic cells and induction of cytotoxic T lymphocyte responses against the telomerase catalytic subunit (hTERT). J Immunol Methods 2002; 259:191-203; PMID:11730854; http://dx.doi.org/10.1016/S0022-1759(01)00506-3
    • (2002) J Immunol Methods , vol.259 , pp. 191-203
    • Sæbo-Larsen, S.1    Fossberg, E.2    Gaudernack, G.3
  • 25
    • 23744456224 scopus 로고    scopus 로고
    • Epithelial ovarian cancer: A review of current management
    • PMID:16149282
    • Guppy AE, Nathan PD, Rustin GJ. Epithelial ovarian cancer: a review of current management. Clin Oncol (R Coll Radiol) 2005;17:399-411; PMID:16149282; http://dx.doi.org/10.1016/j.clon.2005.05.009
    • (2005) Clin Oncol (R Coll Radiol) , vol.17 , pp. 399-411
    • Guppy, A.E.1    Nathan, P.D.2    Rustin, G.J.3
  • 26
    • 0346121599 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling and immunity
    • PMID:14639467
    • Kubo M, Handa T, Yoshimura A. Suppressors of cytokine signaling and immunity. Nat Immunol 2003; 4:1169-76; PMID:14639467; http://dx.doi.org/10.1038/ni1012
    • (2003) Nat Immunol , vol.4 , pp. 1169-1176
    • Kubo, M.1    Handa, T.2    Yoshimura, A.3
  • 27
    • 11144254962 scopus 로고    scopus 로고
    • Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity
    • PMID:15558048
    • Shen L, Evel-Kabler K, Strube R, Chen SY. Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity. Nat Biotechnol 2004; 22:1546-52; PMID:15558048; http://dx.doi.org/10.1038/nbt1035
    • (2004) Nat Biotechnol , vol.22 , pp. 1546-1552
    • Shen, L.1    Evel-Kabler, K.2    Strube, R.3    Chen, S.Y.4
  • 28
    • 32044433541 scopus 로고    scopus 로고
    • An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cells
    • PMID:16381597
    • Song XT, Evel-Kabler, K, Rollins L, Aldrich M, Gao F, Huang XF, Chen SY. An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cells. PLoS Med 3:e11; PMID:16381597; http://dx.doi.org/10.1371/journal.pmed.0030011
    • PLoS Med , vol.3 , pp. e11
    • Song, X.T.1    Evel-Kabler, K.2    Rollins, L.3    Aldrich, M.4    Gao, F.5    Huang, X.F.6    Chen, S.Y.7
  • 29
    • 77957744000 scopus 로고    scopus 로고
    • STAT3 silencing in dendritic cells by siRNA polyplexes encapsulated in PLGA nanoparticles for the modulation of anticancer immune response
    • PMID:20804176
    • Alshamsan A, Haddadi A, Hamdy S, Samuel J, El-Kadi AO, Uluda-g H, Lavasanifar A. STAT3 silencing in dendritic cells by siRNA polyplexes encapsulated in PLGA nanoparticles for the modulation of anticancer immune response. Molec Pharmaceut 2010; 7:1643-54; PMID:20804176; http://dx.doi.org/10.1021/mp100067u
    • (2010) Molec Pharmaceut , vol.7 , pp. 1643-1654
    • Alshamsan, A.1    Haddadi, A.2    Hamdy, S.3    Samuel, J.4    El-Kadi, A.O.5    Uludaʇ, H.6    Lavasanifar, A.7
  • 30
    • 84869221970 scopus 로고    scopus 로고
    • In situ vaccination with CD204 gene-silenced dendritic cell, not unmodified dendritic cell, enhances radiation therapy
    • 2331-39; PMID:22896667
    • Guo C, Yi H, Yu X, Zuo D, Qian J, Yang G, Foster BA, Subjeck JR, Sun X, Mikkelsen RB, Fisher PB, Wang XY. In situ vaccination with CD204 gene-silenced dendritic cell, not unmodified dendritic cell, enhances radiation therapy. Mol Cancer Ther 2012; 11:2012; 2331-39; PMID:22896667; http://dx.doi.org/10.1158/1535-7163.MCT-12-0164
    • (2012) Mol Cancer Ther , vol.11 , pp. 2012
    • Guo, C.1    Yi, H.2    Yu, X.3    Zuo, D.4    Qian, J.5    Yang, G.6    Foster, B.A.7    Subjeck, J.R.8    Sun, X.9    Mikkelsen, R.B.10    Fisher, P.B.11    Wang, X.Y.12
  • 32
    • 79952775415 scopus 로고    scopus 로고
    • Clinical development of mAbs to block the PD1 pathway as an immunotherapy for cancer
    • PMID:21154117
    • Kline J, Gajewski TF. Clinical development of mAbs to block the PD1 pathway as an immunotherapy for cancer. Curr Opin Investig Drugs 2011; 11:1354-9; PMID:21154117
    • (2011) Curr Opin Investig Drugs , vol.11 , pp. 1354-1359
    • Kline, J.1    Gajewski, T.F.2
  • 33
    • 84874107823 scopus 로고    scopus 로고
    • Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation
    • PMID:22903385
    • Hobo W, Novobrantseva TI, Fredrix H, Wong J, Milstein S, Epstein-Barash H, Liu J, Schaap N, van der Voort R, Dolstra H. Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation. Cancer Immunol Immunother 2013; 62:285-97; PMID:22903385; http://dx.doi.org/10.1007/s00262-012-1334-1
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 285-297
    • Hobo, W.1    Novobrantseva, T.I.2    Fredrix, H.3    Wong, J.4    Milstein, S.5    Epstein-Barash, H.6    Liu, J.7    Schaap, N.8    Van Der Voort, R.9    Dolstra, H.10
  • 34
    • 67349258025 scopus 로고    scopus 로고
    • Turning "sweet" on immunity: Galectin-glycan interactions in immune tolerance and inflammation
    • PMID:19365409
    • Rabinovich GA, Toscano MA. Turning "sweet" on immunity: galectin-glycan interactions in immune tolerance and inflammation. Nat Rev Immunol 2009; 9:338-52; PMID:19365409; http://dx.doi.org/10.1038/nri2536
    • (2009) Nat Rev Immunol , vol.9 , pp. 338-352
    • Rabinovich, G.A.1    Toscano, M.A.2
  • 35
    • 33749556658 scopus 로고    scopus 로고
    • Galectin 1: A small protein with major functions
    • PMID:16840800
    • Camby I, Le Mercier M, Lefranc F, Kiss R. Galectin 1: a small protein with major functions. Glycobiology 2006; 16:137-57; PMID:16840800; http://dx.doi.org/10.1093/glycob/cwl025
    • (2006) Glycobiology , vol.16 , pp. 137-157
    • Camby, I.1    Le Mercier, M.2    Lefranc, F.3    Kiss, R.4
  • 36
    • 67649795958 scopus 로고    scopus 로고
    • Galectin-3 regulates T-cell functions
    • Hsu DK, Chen HY, Liu FT. Galectin-3 regulates T-cell functions. Immunol Rev 2009; 230, 114-27.
    • (2009) Immunol Rev , vol.230 , pp. 114-127
    • Hsu, D.K.1    Chen, H.Y.2    Liu, F.T.3
  • 37
    • 84857824210 scopus 로고    scopus 로고
    • Galectin-1 and -3 gene silencing in immature and mature dendritic cells enhances T cell activation and interferon-g production
    • PMID:22167721Z
    • Mobergslien A, Sioud M. Galectin-1 and -3 gene silencing in immature and mature dendritic cells enhances T cell activation and interferon-g production. J Leucocyte Biol 2012; 91:461-7; PMID:22167721Z; http://dx.doi.org/10.1189/jlb.0711361
    • (2012) J Leucocyte Biol , vol.91 , pp. 461-467
    • Mobergslien, A.1    Sioud, M.2
  • 38
    • 0029855923 scopus 로고    scopus 로고
    • Tuning of activation threshold explains flexibility in the selection and development of T cells in the thymus
    • PMID:8962126
    • Grossman Z, Singer A. Tuning of activation threshold explains flexibility in the selection and development of T cells in the thymus. Proc Acad Sci USA 1996; 93:14747-52; PMID:8962126; http://dx.doi.org/10.1073/pnas.93.25.14747
    • (1996) Proc Acad Sci USA , vol.93 , pp. 14747-14752
    • Grossman, Z.1    Singer, A.2
  • 39
    • 33751511117 scopus 로고    scopus 로고
    • Gene expression analysis in blood cells in response to umpdified and 2'-modified siRNAs reveals TLR-dependent and independent effects
    • PMID:17054988
    • Cekaite L, Furset G, Hvig E, Sioud M. Gene expression analysis in blood cells in response to umpdified and 2'-modified siRNAs reveals TLR-dependent and independent effects. J Mol Biol 2007; 365:90-108; PMID:17054988; http://dx.doi.org/10.1016/j.jmb.2006.09.034
    • (2007) J Mol Biol , vol.365 , pp. 90-108
    • Cekaite, L.1    Furset, G.2    Hvig, E.3    Sioud, M.4
  • 40
    • 0035887771 scopus 로고    scopus 로고
    • Cytokines regulates the capacity of CD8 alpha (+) and CD8 alpha (-) dendritic cells to prime Th1Th2 cells in vivo
    • PMID:11591758
    • Maldonado-Lopz R, Maliszewski C, Urbain J, Moser M. Cytokines regulates the capacity of CD8 alpha (+) and CD8 alpha (-) dendritic cells to prime Th1Th2 cells in vivo. J Immunol 2001; 167:4345-50; PMID:11591758; http://dx.doi.org/10.4049/jimmunol.167.8.4345
    • (2001) J Immunol , vol.167 , pp. 4345-4350
    • Maldonado-Lopz, R.1    Maliszewski, C.2    Urbain, J.3    Moser, M.4
  • 41
    • 0030826825 scopus 로고    scopus 로고
    • IL-10 prevents the generation of dendritic cells from CD14+ blood monocytes, promotes the differentiation to mature macrophages and stimulates endocytosis of FITC-dextran
    • PMID:9286381
    • Allavena P, Piemonti L, Longoni D, Bernasconi S, Stoppacciaro A, Ruco L, Mantovani A. IL-10 prevents the generation of dendritic cells from CD14+ blood monocytes, promotes the differentiation to mature macrophages and stimulates endocytosis of FITC-dextran. Avd Exp Med Biol 1997; 417:323-9; PMID:9286381; http://dx.doi.org/10.1007/978-1-4757-9966-8-53
    • (1997) Avd Exp Med Biol , vol.417 , pp. 323-329
    • Allavena, P.1    Piemonti, L.2    Longoni, D.3    Bernasconi, S.4    Stoppacciaro, A.5    Ruco, L.6    Mantovani, A.7
  • 42
    • 18044365415 scopus 로고    scopus 로고
    • Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization
    • PMID:15854645
    • Sioud M. Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization. J Mol Biol 2005; 348:1079-10; PMID:15854645; http://dx.doi.org/10.1016/j.jmb.2005.03.013
    • (2005) J Mol Biol , vol.348 , pp. 1079-1110
    • Sioud, M.1
  • 44
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • PMID:15778705
    • Judge AD, Sood V, Shaw JR, Fang D, McClintock K, MacLachlan I. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol 2005; 23:457-62; PMID:15778705; http://dx.doi.org/10.1038/nbt1081
    • (2005) Nat Biotechnol , vol.23 , pp. 457-462
    • Judge, A.D.1    Sood, V.2    Shaw, J.R.3    Fang, D.4    McClintock, K.5    MacLachlan, I.6
  • 45
    • 33845298010 scopus 로고    scopus 로고
    • Design of bifunctional siRNAs: Combining immunostimulation and gene-silencing in one single siRNA molecule
    • PMID:17150189
    • Furset G, Sioud M. Design of bifunctional siRNAs: combining immunostimulation and gene-silencing in one single siRNA molecule. Biochem Biophys Res Comm 2007; 352:642-9; PMID:17150189; http://dx.doi.org/10.1016/j.bbrc.2006.11.059
    • (2007) Biochem Biophys Res Comm , vol.352 , pp. 642-649
    • Furset, G.1    Sioud, M.2
  • 46
    • 77953448832 scopus 로고    scopus 로고
    • Dendritic cells loaded with tumor antigens and a dual immunostimulatory and anti-interleukin 10-specific small interference RNA prime T lymphocytes against leukemic cells
    • PMID:19956385
    • Iversen PO, Semaeva E, Sorensen DR, Wiig H, Sioud M. Dendritic cells loaded with tumor antigens and a dual immunostimulatory and anti-interleukin 10-specific small interference RNA prime T lymphocytes against leukemic cells. Transl Oncol 2009; 2:242-6; PMID:19956385; http://dx.doi.org/10.1593/tlo.09154
    • (2009) Transl Oncol , vol.2 , pp. 242-246
    • Iversen, P.O.1    Semaeva, E.2    Sorensen, D.R.3    Wiig, H.4    Sioud, M.5
  • 47
    • 84899489828 scopus 로고    scopus 로고
    • The effect of combined IL10 siRNA and CpG ODN as pathogen-mimicking microparticles on Th1Th2 cytokine balance in dendritic cells and protective immunity against B cell lymphoma
    • PMID:24720881
    • Pradhan P, Qin H, Leleux JA, Gwak D, Sakamaki I, Kwak LW, Roy K. The effect of combined IL10 siRNA and CpG ODN as pathogen-mimicking microparticles on Th1Th2 cytokine balance in dendritic cells and protective immunity against B cell lymphoma. Biomaterials 2014; 35:5491-504; PMID:24720881; http://dx.doi.org/10.1016/j.biomaterials.2014.03.039
    • (2014) Biomaterials , vol.35 , pp. 5491-5504
    • Pradhan, P.1    Qin, H.2    Leleux, J.A.3    Gwak, D.4    Sakamaki, I.5    Kwak, L.W.6    Roy, K.7
  • 48
    • 39149144795 scopus 로고    scopus 로고
    • Scilencing of endogenous IL-10 in human dendritic cells leads to the generation of an improved CTL response against human melanoma associated antigenic epitope, MART-127-35
    • PMID:18249038
    • Chhabra A, Chakraborty NG, Mukherji B. Scilencing of endogenous IL-10 in human dendritic cells leads to the generation of an improved CTL response against human melanoma associated antigenic epitope, MART-127-35. Clin Immunol 2008; 126:251-9; PMID:18249038; http://dx.doi.org/10.1016/j.clim.2007.11.011
    • (2008) Clin Immunol , vol.126 , pp. 251-259
    • Chhabra, A.1    Chakraborty, N.G.2    Mukherji, B.3
  • 49
    • 84877962587 scopus 로고    scopus 로고
    • Targeting the cytosolic innate immune receptors RIG-1 and MDA5 effectively counteracts cancer cell heterogeneity in glioblastoma
    • PMID:23390110
    • Glas M, Coch C, Trageser D, Dassler J, Simon M, Koch P. Targeting the cytosolic innate immune receptors RIG-1 and MDA5 effectively counteracts cancer cell heterogeneity in glioblastoma. Stem Cells 2013; 31:1064-74; PMID:23390110; http://dx.doi.org/10.1002/stem.1350
    • (2013) Stem Cells , vol.31 , pp. 1064-1074
    • Glas, M.1    Coch, C.2    Trageser, D.3    Dassler, J.4    Simon, M.5    Koch, P.6
  • 50
    • 77954372029 scopus 로고    scopus 로고
    • Targeted activation of RNA helicase retinoic acid-inducible gene-1 induces proimmunogenic apoptosis of human ovarian cancer cells
    • PMID:20551064
    • Kübler K, Gehrke N, Riemann S, Böhnert V, Zillinger T, Hartmann E, Pölcher M, Rudlowski C, Kuhn W, Hartmann G, Barchet W. Targeted activation of RNA helicase retinoic acid-inducible gene-1 induces proimmunogenic apoptosis of human ovarian cancer cells. Cancer Res 2010; 70:5293-304; PMID:20551064; http://dx.doi.org/10.1158/0008-5472.CAN-10-0825
    • (2010) Cancer Res , vol.70 , pp. 5293-5304
    • Kübler, K.1    Gehrke, N.2    Riemann, S.3    Böhnert, V.4    Zillinger, T.5    Hartmann, E.6    Pölcher, M.7    Rudlowski, C.8    Kuhn, W.9    Hartmann, G.10    Barchet, W.11
  • 52
    • 77953720628 scopus 로고    scopus 로고
    • In situ regulation of DC subsets and T cells mediated tumor regression in mice
    • PMID:20368186
    • Ali OA, Emerich D, Dranoff G, Mooney DJ. In situ regulation of DC subsets and T cells mediated tumor regression in mice. Sci Transl Med 2009; 8:8-19; PMID:20368186; http://dx.doi.org/10.1126/scitranslmed.3000359
    • (2009) Sci Transl Med , vol.8 , pp. 8-19
    • Ali, O.A.1    Emerich, D.2    Dranoff, G.3    Mooney, D.J.4
  • 53
    • 0037122011 scopus 로고    scopus 로고
    • Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on manor histocompatibility complex class I products and peripheral CD8+ T cell tolerance
    • PMID:12486105
    • Bonifaz L, Bonnyay D, Mahnke K, Rivera M, Nussenzweig MC, Steinman RM. Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on manor histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J Exp Med 2002; 196:1627-38; PMID:12486105; http://dx.doi.org/10.1084/jem.20021598
    • (2002) J Exp Med , vol.196 , pp. 1627-1638
    • Bonifaz, L.1    Bonnyay, D.2    Mahnke, K.3    Rivera, M.4    Nussenzweig, M.C.5    Steinman, R.M.6
  • 55
    • 33747362405 scopus 로고    scopus 로고
    • Targeting antigens to dendritic cells in vivo
    • PMID:16920498
    • Tacken PJ, Torensma R, Figdor CG. Targeting antigens to dendritic cells in vivo. Immunobiology 2006; 211:599-608; PMID:16920498; http://dx.doi.org/10.1016/j.imbio.2006.05.021
    • (2006) Immunobiology , vol.211 , pp. 599-608
    • Tacken, P.J.1    Torensma, R.2    Figdor, C.G.3
  • 56
    • 23744481998 scopus 로고    scopus 로고
    • Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody
    • PMID:15878980
    • Tacken PJ, de Vries IJ, Gijzen K, Joosten B, Wu D, Rother RP, Faas SJ, Punt CJ, Torensma R, Adema GJ, Figdor CG. Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody. Blood 2005; 106:1278-85; PMID:15878980; http://dx.doi.org/10.1182/blood-2005-01-0318
    • (2005) Blood , vol.106 , pp. 1278-1285
    • Tacken, P.J.1    De Vries, I.J.2    Gijzen, K.3    Joosten, B.4    Wu, D.5    Rother, R.P.6    Faas, S.J.7    Punt, C.J.8    Torensma, R.9    Adema, G.J.10    Figdor, C.G.11
  • 57
    • 84881127984 scopus 로고    scopus 로고
    • A novel peptide carrier for efficient targeting of antigens and nucleic acids to dendritic cells
    • PMID:23671272
    • Sioud M, Skorstad G, Mobergslien A, Sæboe-Larssen S. A novel peptide carrier for efficient targeting of antigens and nucleic acids to dendritic cells. FASEB J 2013; 27:3272-83; PMID:23671272; http://dx.doi.org/10.1096/fj.12-224758
    • (2013) FASEB J , vol.27 , pp. 3272-3283
    • Sioud, M.1    Skorstad, G.2    Mobergslien, A.3    Sæboe-Larssen, S.4
  • 58
    • 84891769689 scopus 로고    scopus 로고
    • Leukemia cell-targeted STAT3 silencing and TLR9-triggering generate systemic antitumor immunity
    • PMID:24169824
    • Hossain DM, Dos Santos C, Zhang Q, Kozlowska A, Liu H, Gao C, Moreira D, Swiderski P, Jozwiak A, Kline J, et al. Leukemia cell-targeted STAT3 silencing and TLR9-triggering generate systemic antitumor immunity. Blood 2014; 123:15-25; PMID:24169824; http://dx.doi.org/10.1182/blood-2013-07-517987
    • (2014) Blood , vol.123 , pp. 15-25
    • Hossain, D.M.1    Dos Santos, C.2    Zhang, Q.3    Kozlowska, A.4    Liu, H.5    Gao, C.6    Moreira, D.7    Swiderski, P.8    Jozwiak, A.9    Kline, J.10
  • 59
    • 84877257306 scopus 로고    scopus 로고
    • T-cell tolerance in cancer
    • PMID:23638746
    • Nurieva R, Wang J, Sahoo A. T-cell tolerance in cancer. Immunotherapy 2013; 5:513-31; PMID:23638746; http://dx.doi.org/10.2217/imt.13.33
    • (2013) Immunotherapy , vol.5 , pp. 513-531
    • Nurieva, R.1    Wang, J.2    Sahoo, A.3
  • 60
    • 34249868241 scopus 로고    scopus 로고
    • Adoptive T cell therapy for cancer in the clinic
    • PMID:17549249
    • June,CH. Adoptive T cell therapy for cancer in the clinic. J. Clin Invest 2007; 117:1466-76; PMID:17549249; http://dx.doi.org/10.1172/JCI32446
    • (2007) J. Clin Invest , vol.117 , pp. 1466-1476
    • June, C.H.1
  • 61
    • 41149097574 scopus 로고    scopus 로고
    • Adoptive cell transfer: A clinical path to effective cancer immunotherapy
    • PMID:18354418
    • Rosenberg SA., Restifo, NP, Yang JC, Morgan RA, Dudley ME. Adoptive cell transfer: a clinical path to effective cancer immunotherapy. Nat Rev Cancer 2008; 8:299-30; PMID:18354418; http://dx.doi.org/10.1038/nrc2355
    • (2008) Nat Rev Cancer , vol.8 , pp. 299-330
    • Rosenberg, S.A.1    Restifo, N.P.2    Yang, J.C.3    Morgan, R.A.4    Dudley, M.E.5
  • 63
    • 38849093957 scopus 로고    scopus 로고
    • Role of STAT3 in CD4+ CD25 +FOXP3+ regulatory lymphocyte generation: Implication in graft-versus-host disease and antitumor immunity
    • PMID:18025205
    • Pallandre JR, Brillard E, Créhange G, Radlovic A, Remy-Martin JP, Saas P, Rohrlich PS, Pivot X, Ling X, et al. Role of STAT3 in CD4+ CD25 +FOXP3+ regulatory lymphocyte generation: implication in graft-versus-host disease and antitumor immunity. J Immunol 2007; 179:7593-604; PMID:18025205; http://dx.doi.org/10.4049/jimmunol.179.11.7593
    • (2007) J Immunol , vol.179 , pp. 7593-7604
    • Pallandre, J.R.1    Brillard, E.2    Créhange, G.3    Radlovic, A.4    Remy-Martin, J.P.5    Saas, P.6    Rohrlich, P.S.7    Pivot, X.8    Ling, X.9
  • 64
    • 79953747618 scopus 로고    scopus 로고
    • T cell treatment with small interfering RNA for suppressor of cytokine signaling 3 modulates allergic airway responses in a murine model of asthma
    • PMID:20508071
    • Moriwaki A, Inoue H, Nakano T, Matsunaga Y, Matsuno Y, Matsumoto T, Fukuyama S, Kan-O K, Matsumoto K, Tsuda-Eguchi M, et al. T cell treatment with small interfering RNA for suppressor of cytokine signaling 3 modulates allergic airway responses in a murine model of asthma. Am J Respir Cell Mol Biol 2011; 44:448-55; PMID:20508071; http://dx.doi.org/10.1165/rcmb.2009-0051OC
    • (2011) Am J Respir Cell Mol Biol , vol.44 , pp. 448-455
    • Moriwaki, A.1    Inoue, H.2    Nakano, T.3    Matsunaga, Y.4    Matsuno, Y.5    Matsumoto, T.6    Fukuyama, S.7    Kan-O, K.8    Matsumoto, K.9    Tsuda-Eguchi, M.10
  • 65
    • 84872784967 scopus 로고    scopus 로고
    • Regulating naive and memory CD8 T cell homeostasis - A role for protein tyrosine phosphatases
    • PMID:22458809
    • Pike KA, Tremblay ML. Regulating naive and memory CD8 T cell homeostasis - a role for protein tyrosine phosphatases. FEBS J 2013; 280:432-44; PMID:22458809; http://dx.doi.org/10.1111/j.1742-4658.2012.08587.x
    • (2013) FEBS J , vol.280 , pp. 432-444
    • Pike, K.A.1    Tremblay, M.L.2
  • 66
    • 4143137360 scopus 로고    scopus 로고
    • Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction
    • PMID:15308098
    • Jeon MS, Atfield A, Venuprasad K, Krawczyk C, Sarao R, Elly C, Yang C, Arya S, Bachmaier K, et al. Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity 2004; 21:167-77; PMID:15308098; http://dx.doi.org/10.1016/j.immuni.2004.07.013
    • (2004) Immunity , vol.21 , pp. 167-177
    • Jeon, M.S.1    Atfield, A.2    Venuprasad, K.3    Krawczyk, C.4    Sarao, R.5    Elly, C.6    Yang, C.7    Arya, S.8    Bachmaier, K.9
  • 68
    • 84864797384 scopus 로고    scopus 로고
    • Abrogation of Src homology region 2 domain-containing phosphatase 1 in tumor-specific T cells improves efficacy of adoptive immunotherapy by enhancing the effector function and accumulation of short-lived effector T cells in vivo
    • PMID:22798667
    • Stromnes IM, Fowler C, Casamina CC, Georgopolos CM, McAfee MS, Schmitt TM, Tan X, Kim TD, Choi I, Blattman JN, et al. Abrogation of Src homology region 2 domain-containing phosphatase 1 in tumor-specific T cells improves efficacy of adoptive immunotherapy by enhancing the effector function and accumulation of short-lived effector T cells in vivo. J Immunol 2012; 189:1812-25; PMID:22798667; http://dx.doi.org/10.4049/jimmunol.1200552
    • (2012) J Immunol , vol.189 , pp. 1812-1825
    • Stromnes, I.M.1    Fowler, C.2    Casamina, C.C.3    Georgopolos, C.M.4    McAfee, M.S.5    Schmitt, T.M.6    Tan, X.7    Kim, T.D.8    Choi, I.9    Blattman, J.N.10
  • 69
    • 33845941583 scopus 로고    scopus 로고
    • Loss of Src homology region 2 domain-containing protein tyrosine phosphatase-1 increases CD8+ T cell-APC conjugate formation and is associated with enhanced in vivo CTL function
    • PMID:17182570
    • Sathish JG, Dolton G, Leroy FG, Matthews RJ. Loss of Src homology region 2 domain-containing protein tyrosine phosphatase-1 increases CD8+ T cell-APC conjugate formation and is associated with enhanced in vivo CTL function. J Immunol 2007; 178:330-7; PMID:17182570; http://dx.doi.org/10.4049/jimmunol.178.1.330
    • (2007) J Immunol , vol.178 , pp. 330-337
    • Sathish, J.G.1    Dolton, G.2    Leroy, F.G.3    Matthews, R.J.4
  • 71
    • 84867745292 scopus 로고    scopus 로고
    • Creating genetic resistance to HIV
    • PMID:22985479
    • Burnett JC., Zaia JA, Rossi JJ. Creating genetic resistance to HIV. Curr Opin Immunol 2012; 24, 625-32; PMID:22985479; http://dx.doi.org/10.1016/j.coi.2012.08.013
    • (2012) Curr Opin Immunol , vol.24 , pp. 625-632
    • Burnett, J.C.1    Zaia, J.A.2    Rossi, J.J.3
  • 73
    • 49549117077 scopus 로고    scopus 로고
    • T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice
    • PMID:18691745
    • Kumar P, Ban HS, Kim SS, Wu H, Pearson T, Greiner DL, Laouar A, Yao J, Haridas V, Habiro K, et al. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell 2008; 134:577-86; PMID:18691745; http://dx.doi.org/10.1016/j.cell.2008.06.034
    • (2008) Cell , vol.134 , pp. 577-586
    • Kumar, P.1    Ban, H.S.2    Kim, S.S.3    Wu, H.4    Pearson, T.5    Greiner, D.L.6    Laouar, A.7    Yao, J.8    Haridas, V.9    Habiro, K.10
  • 74
    • 80054843136 scopus 로고    scopus 로고
    • Polymerase II promoter strength determines efficacy of microRNA adapted shRNAs
    • PMID:22031824
    • Lebbink RJ, Lowe M, Chan T, Khine H, Wang X. and McManus MT. Polymerase II promoter strength determines efficacy of microRNA adapted shRNAs. PloS One 2011; 6:e26213-20; PMID:22031824; http://dx.doi.org/10.1371/journal.pone.0026213
    • (2011) PloS One , vol.6 , pp. e26213-e26220
    • Lebbink, R.J.1    Lowe, M.2    Chan, T.3    Khine, H.4    Wang, X.5    McManus, M.T.6
  • 75
    • 84886261520 scopus 로고    scopus 로고
    • Delivery materials for siRNA therapeutics
    • PMID:24150415
    • Kanasty R, Dorkin JR, Vegas A, Anderson D. Delivery materials for siRNA therapeutics. Nat Mat 2013; 12:967-77; PMID:24150415; http://dx.doi.org/10.1038/nmat3765
    • (2013) Nat Mat , vol.12 , pp. 967-977
    • Kanasty, R.1    Dorkin, J.R.2    Vegas, A.3    Anderson, D.4


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