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Volumn 57, Issue 2, 2015, Pages 273-289

Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling

Author keywords

[No Author keywords available]

Indexed keywords

ATR PROTEIN; CHECKPOINT KINASE 2; FUNGAL ENZYME; HISTONE H2A; MEC1 KINASE; PHOSPHATASE; PHOSPHOTRANSFERASE; PP4 PHOSPHATASE; PPH3 PROTEIN; PROTEIN DDC2; PSY2 PROTEIN; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; LCD1 PROTEIN, S CEREVISIAE; MEC1 PROTEIN, S CEREVISIAE; NUCLEAR PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PPH3 PROTEIN, S CEREVISIAE; PROTEIN SERINE THREONINE KINASE; PSY2 PROTEIN, S CEREVISIAE; RAD53 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

EID: 84921551742     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2014.11.016     Document Type: Article
Times cited : (52)

References (62)
  • 4
    • 73549116091 scopus 로고    scopus 로고
    • Dephosphorylation of gamma H2A by Glc7/protein phosphatase 1 promotes recovery from inhibition of DNA replication
    • Bazzi M., Mantiero D., Trovesi C., Lucchini G., Longhese M.P. Dephosphorylation of gamma H2A by Glc7/protein phosphatase 1 promotes recovery from inhibition of DNA replication. Mol. Cell. Biol. 2010, 30:131-145.
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 131-145
    • Bazzi, M.1    Mantiero, D.2    Trovesi, C.3    Lucchini, G.4    Longhese, M.P.5
  • 5
    • 0030479885 scopus 로고    scopus 로고
    • The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast
    • Brush G.S., Morrow D.M., Hieter P., Kelly T.J. The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast. Proc. Natl. Acad. Sci. USA 1996, 93:15075-15080.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 15075-15080
    • Brush, G.S.1    Morrow, D.M.2    Hieter, P.3    Kelly, T.J.4
  • 6
    • 77951219621 scopus 로고    scopus 로고
    • A proteome-wide analysis of kinase-substrate network in the DNA damage response
    • Chen S.H., Albuquerque C.P., Liang J., Suhandynata R.T., Zhou H. A proteome-wide analysis of kinase-substrate network in the DNA damage response. J.Biol. Chem. 2010, 285:12803-12812.
    • (2010) J.Biol. Chem. , vol.285 , pp. 12803-12812
    • Chen, S.H.1    Albuquerque, C.P.2    Liang, J.3    Suhandynata, R.T.4    Zhou, H.5
  • 8
    • 47749141560 scopus 로고    scopus 로고
    • ATR: an essential regulator of genome integrity
    • Cimprich K.A., Cortez D. ATR: an essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol. 2008, 9:616-627.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 616-627
    • Cimprich, K.A.1    Cortez, D.2
  • 9
    • 33645799075 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling
    • Clerici M., Mantiero D., Lucchini G., Longhese M.P. The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling. EMBO Rep. 2006, 7:212-218.
    • (2006) EMBO Rep. , vol.7 , pp. 212-218
    • Clerici, M.1    Mantiero, D.2    Lucchini, G.3    Longhese, M.P.4
  • 10
    • 29144486147 scopus 로고    scopus 로고
    • Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations
    • Cobb J.A., Schleker T., Rojas V., Bjergbaek L., Tercero J.A., Gasser S.M. Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations. Genes Dev. 2005, 19:3055-3069.
    • (2005) Genes Dev. , vol.19 , pp. 3055-3069
    • Cobb, J.A.1    Schleker, T.2    Rojas, V.3    Bjergbaek, L.4    Tercero, J.A.5    Gasser, S.M.6
  • 11
    • 33747367151 scopus 로고    scopus 로고
    • A strategy for extracting and analyzing large-scale quantitative epistatic interaction data
    • Collins S.R., Schuldiner M., Krogan N.J., Weissman J.S. A strategy for extracting and analyzing large-scale quantitative epistatic interaction data. Genome Biol. 2006, 7:R63.
    • (2006) Genome Biol. , vol.7 , pp. R63
    • Collins, S.R.1    Schuldiner, M.2    Krogan, N.J.3    Weissman, J.S.4
  • 13
    • 0034700511 scopus 로고    scopus 로고
    • A role for Saccharomyces cerevisiae histone H2A in DNA repair
    • Downs J.A., Lowndes N.F., Jackson S.P. A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature 2000, 408:1001-1004.
    • (2000) Nature , vol.408 , pp. 1001-1004
    • Downs, J.A.1    Lowndes, N.F.2    Jackson, S.P.3
  • 14
    • 77957861306 scopus 로고    scopus 로고
    • A Mec1- and PP4-dependent checkpoint couples centromere pairing to meiotic recombination
    • Falk J.E., Chan A.C., Hoffmann E., Hochwagen A. A Mec1- and PP4-dependent checkpoint couples centromere pairing to meiotic recombination. Dev. Cell 2010, 19:599-611.
    • (2010) Dev. Cell , vol.19 , pp. 599-611
    • Falk, J.E.1    Chan, A.C.2    Hoffmann, E.3    Hochwagen, A.4
  • 15
    • 84876373036 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae F-box protein Dia2 is a mediator of S-phase checkpoint recovery from DNA damage
    • Fong C.M., Arumugam A., Koepp D.M. The Saccharomyces cerevisiae F-box protein Dia2 is a mediator of S-phase checkpoint recovery from DNA damage. Genetics 2013, 193:483-499.
    • (2013) Genetics , vol.193 , pp. 483-499
    • Fong, C.M.1    Arumugam, A.2    Koepp, D.M.3
  • 16
    • 77956833348 scopus 로고    scopus 로고
    • Phosphatases in the cellular response to DNA damage
    • Freeman A.K., Monteiro A.N. Phosphatases in the cellular response to DNA damage. Cell Commun. Signal. 2010, 8:27.
    • (2010) Cell Commun. Signal. , vol.8 , pp. 27
    • Freeman, A.K.1    Monteiro, A.N.2
  • 22
    • 38149030719 scopus 로고    scopus 로고
    • Phosphatases, DNA damage checkpoints and checkpoint deactivation
    • Heideker J., Lis E.T., Romesberg F.E. Phosphatases, DNA damage checkpoints and checkpoint deactivation. Cell Cycle 2007, 6:3058-3064.
    • (2007) Cell Cycle , vol.6 , pp. 3058-3064
    • Heideker, J.1    Lis, E.T.2    Romesberg, F.E.3
  • 23
    • 84922479562 scopus 로고    scopus 로고
    • Analyzing DNA replication checkpoint in budding yeast
    • Hustedt N., Shimada K. Analyzing DNA replication checkpoint in budding yeast. Methods Mol. Biol. 2014, 1170:321-341.
    • (2014) Methods Mol. Biol. , vol.1170 , pp. 321-341
    • Hustedt, N.1    Shimada, K.2
  • 24
    • 84884156068 scopus 로고    scopus 로고
    • Replication checkpoint: tuning and coordination of replication forks in s phase
    • Hustedt N., Gasser S.M., Shimada K. Replication checkpoint: tuning and coordination of replication forks in s phase. Genes (Basel). 2013, 4:388-434.
    • (2013) Genes (Basel). , vol.4 , pp. 388-434
    • Hustedt, N.1    Gasser, S.M.2    Shimada, K.3
  • 26
    • 0033621392 scopus 로고    scopus 로고
    • Substrate specificities and identification of putative substrates of ATM kinase family members
    • Kim S.T., Lim D.S., Canman C.E., Kastan M.B. Substrate specificities and identification of putative substrates of ATM kinase family members. J.Biol. Chem. 1999, 274:37538-37543.
    • (1999) J.Biol. Chem. , vol.274 , pp. 37538-37543
    • Kim, S.T.1    Lim, D.S.2    Canman, C.E.3    Kastan, M.B.4
  • 27
    • 78751486419 scopus 로고    scopus 로고
    • Protein phosphatases pph3, ptc2, and ptc3 play redundant roles in DNA double-strand break repair by homologous recombination
    • Kim J.A., Hicks W.M., Li J., Tay S.Y., Haber J.E. Protein phosphatases pph3, ptc2, and ptc3 play redundant roles in DNA double-strand break repair by homologous recombination. Mol. Cell. Biol. 2011, 31:507-516.
    • (2011) Mol. Cell. Biol. , vol.31 , pp. 507-516
    • Kim, J.A.1    Hicks, W.M.2    Li, J.3    Tay, S.Y.4    Haber, J.E.5
  • 28
    • 77949267720 scopus 로고    scopus 로고
    • A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination
    • Lee D.H., Pan Y., Kanner S., Sung P., Borowiec J.A., Chowdhury D. A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination. Nat. Struct. Mol. Biol. 2010, 17:365-372.
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 365-372
    • Lee, D.H.1    Pan, Y.2    Kanner, S.3    Sung, P.4    Borowiec, J.A.5    Chowdhury, D.6
  • 29
    • 84861185981 scopus 로고    scopus 로고
    • Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response
    • Lee D.H., Goodarzi A.A., Adelmant G.O., Pan Y., Jeggo P.A., Marto J.A., Chowdhury D. Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response. EMBO J. 2012, 31:2403-2415.
    • (2012) EMBO J. , vol.31 , pp. 2403-2415
    • Lee, D.H.1    Goodarzi, A.A.2    Adelmant, G.O.3    Pan, Y.4    Jeggo, P.A.5    Marto, J.A.6    Chowdhury, D.7
  • 32
    • 4544281398 scopus 로고    scopus 로고
    • Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins
    • Lisby M., Barlow J.H., Burgess R.C., Rothstein R. Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell 2004, 118:699-713.
    • (2004) Cell , vol.118 , pp. 699-713
    • Lisby, M.1    Barlow, J.H.2    Burgess, R.C.3    Rothstein, R.4
  • 34
    • 84892461284 scopus 로고    scopus 로고
    • Psy2 targets the PP4 family phosphatase Pph3 to dephosphorylate Mth1 and repress glucose transporter gene expression
    • Ma H., Han B.K., Guaderrama M., Aslanian A., Yates J.R., Hunter T., Wittenberg C. Psy2 targets the PP4 family phosphatase Pph3 to dephosphorylate Mth1 and repress glucose transporter gene expression. Mol. Cell. Biol. 2014, 34:452-463.
    • (2014) Mol. Cell. Biol. , vol.34 , pp. 452-463
    • Ma, H.1    Han, B.K.2    Guaderrama, M.3    Aslanian, A.4    Yates, J.R.5    Hunter, T.6    Wittenberg, C.7
  • 35
    • 33746429958 scopus 로고    scopus 로고
    • Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
    • Mailand N., Bekker-Jensen S., Bartek J., Lukas J. Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol. Cell 2006, 23:307-318.
    • (2006) Mol. Cell , vol.23 , pp. 307-318
    • Mailand, N.1    Bekker-Jensen, S.2    Bartek, J.3    Lukas, J.4
  • 36
    • 44849093460 scopus 로고    scopus 로고
    • TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
    • Mordes D.A., Glick G.G., Zhao R., Cortez D. TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev. 2008, 22:1478-1489.
    • (2008) Genes Dev. , vol.22 , pp. 1478-1489
    • Mordes, D.A.1    Glick, G.G.2    Zhao, R.3    Cortez, D.4
  • 37
    • 53249100305 scopus 로고    scopus 로고
    • PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint
    • Nakada S., Chen G.I., Gingras A.C., Durocher D. PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint. EMBO Rep. 2008, 9:1019-1026.
    • (2008) EMBO Rep. , vol.9 , pp. 1019-1026
    • Nakada, S.1    Chen, G.I.2    Gingras, A.C.3    Durocher, D.4
  • 38
    • 80051678503 scopus 로고    scopus 로고
    • Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase
    • Nam E.A., Zhao R., Glick G.G., Bansbach C.E., Friedman D.B., Cortez D. Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase. J.Biol. Chem. 2011, 286:28707-28714.
    • (2011) J.Biol. Chem. , vol.286 , pp. 28707-28714
    • Nam, E.A.1    Zhao, R.2    Glick, G.G.3    Bansbach, C.E.4    Friedman, D.B.5    Cortez, D.6
  • 39
    • 34547196917 scopus 로고    scopus 로고
    • Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage
    • O'Neill B.M., Szyjka S.J., Lis E.T., Bailey A.O., Yates J.R., Aparicio O.M., Romesberg F.E. Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage. Proc. Natl. Acad. Sci. USA 2007, 104:9290-9295.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 9290-9295
    • O'Neill, B.M.1    Szyjka, S.J.2    Lis, E.T.3    Bailey, A.O.4    Yates, J.R.5    Aparicio, O.M.6    Romesberg, F.E.7
  • 40
    • 84871787877 scopus 로고    scopus 로고
    • DNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9
    • Ohouo P.Y., Bastos de Oliveira F.M., Liu Y., Ma C.J., Smolka M.B. DNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9. Nature 2013, 493:120-124.
    • (2013) Nature , vol.493 , pp. 120-124
    • Ohouo, P.Y.1    Bastos de Oliveira, F.M.2    Liu, Y.3    Ma, C.J.4    Smolka, M.B.5
  • 41
    • 0038506000 scopus 로고    scopus 로고
    • Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53
    • Osborn A.J., Elledge S.J. Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev. 2003, 17:1755-1767.
    • (2003) Genes Dev. , vol.17 , pp. 1755-1767
    • Osborn, A.J.1    Elledge, S.J.2
  • 42
    • 0034663809 scopus 로고    scopus 로고
    • The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast
    • Paciotti V., Clerici M., Lucchini G., Longhese M.P. The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast. Genes Dev. 2000, 14:2046-2059.
    • (2000) Genes Dev. , vol.14 , pp. 2046-2059
    • Paciotti, V.1    Clerici, M.2    Lucchini, G.3    Longhese, M.P.4
  • 43
    • 0035019655 scopus 로고    scopus 로고
    • Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathway
    • Paciotti V., Clerici M., Scotti M., Lucchini G., Longhese M.P. Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathway. Mol. Cell. Biol. 2001, 21:3913-3925.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3913-3925
    • Paciotti, V.1    Clerici, M.2    Scotti, M.3    Lucchini, G.4    Longhese, M.P.5
  • 44
    • 41649111513 scopus 로고    scopus 로고
    • The Ino80 chromatin-remodeling enzyme regulates replisome function and stability
    • Papamichos-Chronakis M., Peterson C.L. The Ino80 chromatin-remodeling enzyme regulates replisome function and stability. Nat. Struct. Mol. Biol. 2008, 15:338-345.
    • (2008) Nat. Struct. Mol. Biol. , vol.15 , pp. 338-345
    • Papamichos-Chronakis, M.1    Peterson, C.L.2
  • 45
    • 0030920723 scopus 로고    scopus 로고
    • ORC-dependent and origin-specific initiation of DNA replication at defined foci in isolated yeast nuclei
    • Pasero P., Braguglia D., Gasser S.M. ORC-dependent and origin-specific initiation of DNA replication at defined foci in isolated yeast nuclei. Genes Dev. 1997, 11:1504-1518.
    • (1997) Genes Dev. , vol.11 , pp. 1504-1518
    • Pasero, P.1    Braguglia, D.2    Gasser, S.M.3
  • 47
    • 34548417621 scopus 로고    scopus 로고
    • Fluorescent protein FRET: the good, the bad and the ugly
    • Piston D.W., Kremers G.J. Fluorescent protein FRET: the good, the bad and the ugly. Trends Biochem. Sci. 2007, 32:407-414.
    • (2007) Trends Biochem. Sci. , vol.32 , pp. 407-414
    • Piston, D.W.1    Kremers, G.J.2
  • 48
    • 0037115462 scopus 로고    scopus 로고
    • ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase
    • Shimada K., Pasero P., Gasser S.M. ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase. Genes Dev. 2002, 16:3236-3252.
    • (2002) Genes Dev. , vol.16 , pp. 3236-3252
    • Shimada, K.1    Pasero, P.2    Gasser, S.M.3
  • 49
  • 50
    • 34547499407 scopus 로고    scopus 로고
    • Proteome-wide identification of invivo targets of DNA damage checkpoint kinases
    • Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proteome-wide identification of invivo targets of DNA damage checkpoint kinases. Proc. Natl. Acad. Sci. USA 2007, 104:10364-10369.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 10364-10369
    • Smolka, M.B.1    Albuquerque, C.P.2    Chen, S.H.3    Zhou, H.4
  • 53
    • 0038730929 scopus 로고    scopus 로고
    • A central role for DNAreplication forks in checkpoint activation and response
    • Tercero J.A., Longhese M.P., Diffley J.F. A central role for DNAreplication forks in checkpoint activation and response. Mol. Cell 2003, 11:1323-1336.
    • (2003) Mol. Cell , vol.11 , pp. 1323-1336
    • Tercero, J.A.1    Longhese, M.P.2    Diffley, J.F.3
  • 54
    • 47749088951 scopus 로고    scopus 로고
    • Distinct phosphatases mediate the deactivation of the DNA damage checkpoint kinase Rad53
    • Travesa A., Duch A., Quintana D.G. Distinct phosphatases mediate the deactivation of the DNA damage checkpoint kinase Rad53. J.Biol. Chem. 2008, 283:17123-17130.
    • (2008) J.Biol. Chem. , vol.283 , pp. 17123-17130
    • Travesa, A.1    Duch, A.2    Quintana, D.G.3
  • 55
    • 10944233962 scopus 로고    scopus 로고
    • Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair
    • van Attikum H., Fritsch O., Hohn B., Gasser S.M. Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair. Cell 2004, 119:777-788.
    • (2004) Cell , vol.119 , pp. 777-788
    • van Attikum, H.1    Fritsch, O.2    Hohn, B.3    Gasser, S.M.4
  • 56
    • 14244253120 scopus 로고    scopus 로고
    • Specific interactions of PP2A and PP2A-like phosphatases with the yeast PTPA homologues, Ypa1 and Ypa2
    • Van Hoof C., Martens E., Longin S., Jordens J., Stevens I., Janssens V., Goris J. Specific interactions of PP2A and PP2A-like phosphatases with the yeast PTPA homologues, Ypa1 and Ypa2. Biochem. J. 2005, 386:93-102.
    • (2005) Biochem. J. , vol.386 , pp. 93-102
    • Van Hoof, C.1    Martens, E.2    Longin, S.3    Jordens, J.4    Stevens, I.5    Janssens, V.6    Goris, J.7
  • 58
    • 84872480220 scopus 로고    scopus 로고
    • Rfa2 is specifically dephosphorylated by Pph3 in Candida albicans
    • Wang H., Gao J., Wong A.H., Hu K., Li W., Wang Y., Sang J. Rfa2 is specifically dephosphorylated by Pph3 in Candida albicans. Biochem. J. 2013, 449:673-681.
    • (2013) Biochem. J. , vol.449 , pp. 673-681
    • Wang, H.1    Gao, J.2    Wong, A.H.3    Hu, K.4    Li, W.5    Wang, Y.6    Sang, J.7
  • 60
    • 77649116452 scopus 로고    scopus 로고
    • De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks
    • Zhang W., Durocher D. De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks. Genes Dev. 2010, 24:502-515.
    • (2010) Genes Dev. , vol.24 , pp. 502-515
    • Zhang, W.1    Durocher, D.2
  • 61
    • 0032161269 scopus 로고    scopus 로고
    • A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools
    • Zhao X., Muller E.G., Rothstein R. A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol. Cell 1998, 2:329-340.
    • (1998) Mol. Cell , vol.2 , pp. 329-340
    • Zhao, X.1    Muller, E.G.2    Rothstein, R.3
  • 62
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou L., Elledge S.J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003, 300:1542-1548.
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2


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