Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Hau, Andrew M ^a   Greenwood, Jeffrey A ^a   Löhr, Christiane V ^a   Serrill, Jeffrey D ^a   Proteau, Philip J ^a   Ganley, Ian G ^b   McPhail, Kerry L ^a   Ishmael, Jane E ^a  

^a OREGON STATE UNIVERSITY   (United States)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; AUTOPHAGY PROTEIN 5; CASPASE 3; CASPASE 7; COIBAMIDE A; DEPSIPEPTIDE; EPIDERMAL GROWTH FACTOR RECEPTOR; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; S6 KINASE; UNCLASSIFIED DRUG; APAF1 PROTEIN, HUMAN; ATG5 PROTEIN, HUMAN; CYTOTOXIN; EIF4EBP1 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; PHOSPHOPROTEIN; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE; ULK1 PROTEIN, HUMAN;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL DEATH; CELL VACUOLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; GLIOMA CELL; HUMAN; HUMAN CELL; MEMBRANE DAMAGE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; ANIMAL; ANTIBODY SPECIFICITY; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; AUTOPHAGY; CASPASE 3; CELL LINE, TUMOR; CYTOTOXINS; DEPSIPEPTIDES; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICROTUBULE-ASSOCIATED PROTEINS; ORGAN SPECIFICITY; PHOSPHOPROTEINS; PROTEIN-SERINE-THREONINE KINASES; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84878787575     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065250     Document Type: Article

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