Functional inhibition of β-catenin-mediated Wnt signaling by intracellular VHH antibodies

mAbs

Volumn 7, Issue 1, 2015, Pages 180-191

  Newnham, Laura E ^a   Wright, Michael J ^a   Holdsworth, Gill ^a   Kostarelos, Kostas ^b   Robinson, Martyn K ^a   Rabbitts, Terence H ^c   Lawson, Alastair D ^a  

^a UCB Group   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Antibody; Intrabody; Phage display; VHH; Wnt; catenin

Indexed keywords

ALANINE; BETA CATENIN; LUCIFERASE; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; VHH ANTIBODY; WNT PROTEIN; COMPLEMENTARITY DETERMINING REGION; CTNNB1 PROTEIN, HUMAN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANIMAL EXPERIMENT; ARTICLE; BIOASSAY; CELL FUNCTION; CELL SURFACE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE LIBRARY; GENE SEQUENCE; HEK293 CELL LINE; HUMAN; HUMAN CELL; MALE; MEDIATOR; NONHUMAN; PHAGE DISPLAY; PHAGEMID; PROTEIN EXPRESSION; REPORTER GENE; TRANSCRIPTION INITIATION; WNT SIGNALING PATHWAY; ANTAGONISTS AND INHIBITORS; ANTIBODY COMBINING SITE; BIOSYNTHESIS; GENETICS; METABOLISM;

BETA CATENIN; BINDING SITES, ANTIBODY; COMPLEMENTARITY DETERMINING REGIONS; HEK293 CELLS; HUMANS; SINGLE-CHAIN ANTIBODIES; WNT SIGNALING PATHWAY;

EID: 84921328055     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/19420862.2015.989023     Document Type: Article

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