A novel carbohydrate derived compound FCP5 causes DNA strand breaks and oxidative modifications of DNA bases in cancer cells

Chemico-Biological Interactions

Volumn 227, Issue , 2015, Pages 77-88

  Czubatka, Anna ^a   Sarnik, Joanna ^a   Lucent, Del ^b   Blasiak, Janusz ^a   Witczak, Zbigniew J ^b   Poplawski, Tomasz ^a  

^a UNIVERSITY OF LODZ   (Poland)

^b WILKES UNIVERSITY   (United States)

Author keywords

1,5 Anhydro 6 deoxy methane sulfamido D glucitol; Comet assay; DNA damage; DNA repair; Functional carb pharmacophores; Genotoxicity

Indexed keywords

1,5 ANHYDRO 6 DEOXY METHANE SULFAMIDO DEXTRO GLUCITOL; ADENOSINE; CARBOHYDRATE; THYMINE; UNCLASSIFIED DRUG; 1,5-ANHYDRO-6-DEOXYMETHANESULFAMIDOGLUCITOL; DNA; SORBITOL; SULFONAMIDE;

A549 CELL LINE; APOPTOSIS; ARTICLE; ASSAY; BASE PAIRING; BINDING KINETICS; CANCER CELL LINE; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION ASSAY; DNA MODIFICATION; DNA REPAIR; DNA REPAIR ENZYME ASSAY; DNA SEQUENCE; DNA STRAND BREAKAGE; DRUG DESIGN; FEMALE; HELA CELL LINE; HUMAN; HUMAN CELL; LOVO CELL LINE; MCF 7 CELL LINE; MOLECULAR DOCKING; PLASMID RELAXATION ASSAY; ANALOGS AND DERIVATIVES; BINDING SITE; CHEMISTRY; CONFORMATION; DOUBLE STRANDED DNA BREAK; DRUG EFFECTS; DRUG SCREENING; METABOLISM; OXIDATIVE STRESS; TUMOR CELL LINE;

APOPTOSIS; BINDING SITES; CARBOHYDRATES; CELL LINE, TUMOR; DNA; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; MCF-7 CELLS; MOLECULAR DOCKING SIMULATION; NUCLEIC ACID CONFORMATION; OXIDATIVE STRESS; SORBITOL; SULFONAMIDES;

EID: 84921327792     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2014.12.023     Document Type: Article

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