The p53/HSP70 inhibitor, 2-phenylethynesulfonamide, causes oxidative stress, unfolded protein response and apoptosis in rainbow trout cells

Aquatic Toxicology

Volumn 146, Issue , 2014, Pages 45-51

  Zeng, Fanxing ^a   Tee, Catherine ^a   Liu, Michelle ^a   Sherry, James P ^b   Dixon, Brian ^a   Duncker, Bernard P ^a   Bols, Niels C ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

^b ENVIRONMENT CANADA   (Canada)

Author keywords

2 Phenylethynesulfonamide; Apoptosis; ER stress; Pifithrin ; ROS; Unfolded protein response

Indexed keywords

ACETYLCYSTEINE; CHAPERONE; DNA; HEAT SHOCK PROTEIN 70; LIPOCORTIN 5; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

ANTIOXIDANT; APOPTOSIS; EXPERIMENTAL STUDY; INHIBITION; MITOCHONDRION; OXIDATION; PHYSIOLOGICAL RESPONSE; PROTEIN; SALMONID;

APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GILL; HOMEOSTASIS; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; RAINBOW TROUT; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING;

MAMMALIA; ONCORHYNCHUS MYKISS;

2-PHENYLETHYNESULFONAMIDE; APOPTOSIS; BINDING IMMUNOGLOBULIN PROTEIN; BIP; ENDOPLASMIC RETICULUM; ER; ER STRESS; HEAT SHOCK PROTEIN70; HSP70; PIFITHRIN-Μ; ROS; UNFOLDED PROTEIN RESPONSE;

ACETYLCYSTEINE; ANIMALS; APOPTOSIS; CELL LINE; HSP70 HEAT-SHOCK PROTEINS; ONCORHYNCHUS MYKISS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SULFONAMIDES; TUMOR SUPPRESSOR PROTEIN P53; UNFOLDED PROTEIN RESPONSE; WATER POLLUTANTS, CHEMICAL;

EID: 84888083058     PISSN: 0166445X     EISSN: 18791514     Source Type: Journal    
DOI: 10.1016/j.aquatox.2013.10.026     Document Type: Article

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