BCR/ABL downregulates DNA-PKCS-dependent and upregulates backup non-homologous end joining in leukemic cells

Molecular Biology Reports

Volumn 37, Issue 5, 2010, Pages 2309-2315

  Poplawski, Tomasz ^a   Blasiak, Janusz ^a  

^a UNIVERSITY OF LODZ   (Poland)

Author keywords

BCR ABL; Non homologous DNA end joining; STI571

Indexed keywords

BCR ABL PROTEIN; DOUBLE STRANDED DNA; ETOPOSIDE; PROTEIN KINASE; SOBUZOXANE; WORTMANNIN;

ARTICLE; CANCER CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; GENETIC STABILITY; HUMAN; HUMAN CELL; INCUBATION TIME; KINETICS; LEUKEMIA CELL; MOLECULAR MECHANICS; NONHOMOLOGOUS DNA END JOINING; PROTEIN EXPRESSION; PULSED FIELD GEL ELECTROPHORESIS; RESTRICTION MAPPING; UPREGULATION;

ANDROSTADIENES; CELL LINE, TUMOR; CELL SURVIVAL; COMET ASSAY; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; DOWN-REGULATION; ETOPOSIDE; FUSION PROTEINS, BCR-ABL; HUMANS; LEUKEMIA; NUCLEAR PROTEINS; PIPERAZINES; RECOMBINATION, GENETIC; TIME FACTORS; UP-REGULATION;

EID: 77955658191     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-009-9730-0     Document Type: Article

References (23)

1. I Majsterek J Blasiak W Mlynarski G Hoser T Skorski 2002 Does the bcr/abl-mediated increase in the efficacy of DNA repair play a role in the drug resistance of cancer cells? Cell Biol Int 26 363 370 10.1006/cbir.2002.0865 1:CAS:528:DC%2BD38Xjt12qtbw%3D 11991666
2. I Majsterek A Slupianek J Blasiak 2003 TEL-fusion oncogenic tyrosine kinases determine leukemic cells response to idarubicin Anticancer Drugs 14 625 631 10.1097/00001813-200309000-00007 1:CAS:528:DC%2BD3sXntlKjtr4%3D 14501384 (Pubitemid 37297262)
3. I Majsterek A Slupianek G Hoser T Skorski J Blasiak 2004 ABL-fusion oncoproteins activate multi-pathway of DNA repair: role in drug resistance? Biochimie 86 53 65 10.1016/j.biochi.2003.10.008 1:CAS:528:DC%2BD2cXhsV2rsLs%3D 14987801 (Pubitemid 38264279)
4. A Slupianek G Hoser I Majsterek A Bronisz M Malecki J Blasiak R Fishel T Skorski 2002 Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis Mol Cell Biol 22 4189 4201 10.1128/MCB.22.12.4189- 4201.2002 1:CAS:528:DC%2BD38XktlSmu70%3D 12024032 (Pubitemid 34556589)
5. P Ahnesorg P Smith SP Jackson 2006 XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining Cell 27 301 313 10.1016/j.cell.2005.12.031 (Pubitemid 43121979)
6. L Chen K Trujillo P Sung AE Tomkinson 2000 Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase J Biol Chem 275 26196 26205 10.1074/jbc.M000491200 1:CAS:528:DC%2BD3cXmt1Oksb8%3D 10854421
7. HL Hsu SM Yannone DJ Chen 2002 Defining interactions between DNA-PK and ligase IV/XRCC4 DNA Repair 1 225 235 10.1016/S1568-7864(01)00018-0 1:CAS:528:DC%2BD38XhvVWitL8%3D 12509254 (Pubitemid 34465484)
8. Q Ding YV Reddy W Wang T Woods P Douglas DA Ramsden SP Lees-Miller K Meek 2003 Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair Mol Cell Biol 23 5836 5848 10.1128/MCB.23.16.5836-5848.2003 1:CAS:528:DC%2BD3sXmt1SrtLc%3D 12897153 (Pubitemid 36951345)
9. N Adachi S Iiizumi S So H Koyama 2004 Genetic evidence for involvement of two distinct nonhomologous end-joining pathways in repair of topoisomerase II-mediated DNA damage Biochem Biophys Res Commun 318 856 861 10.1016/j.bbrc.2004.04.099 1:CAS:528:DC%2BD2cXktV2mtLs%3D 15147950 (Pubitemid 38625852)
10. H Wang AR Perrault Y Takeda W Qin H Wang G Iliakis 2003 Biochemical evidence for Ku-independent backup pathways of NHEJ Nucleic Acids Res 31 5377 5388 10.1093/nar/gkg728 1:CAS:528:DC%2BD3sXntVKhu7o%3D 12954774 (Pubitemid 37441906)
11. E Deutsch A Dugray BA Karim E Marangoni L Maggiorella S Vaganay R Kacher SD Rasy F Eschwege W Vainchenker AG Turhan J Bourhis 2001 BCR-ABL down-regulates the DNA repair protein DNA-PKcs Blood 97 2084 2090 10.1182/blood.V97.7.2084 1:CAS:528:DC%2BD3MXjvFCqs7s%3D 11264175 (Pubitemid 32239090)
12. C Gambacorti-Passerini P Coutre L Mologni M Fanelli C Bertazzoli E Marchesi M Di Nicola A Biondi GM Corneo D Belotti E Pogliani NB Lydon 1997 Inhibition of the ABL kinase activity blocks the proliferation of BCR/ABL+ leukemic cells and induces apoptosis Blood Cells Mol Dis 23 380 394 10.1006/bcmd.1997.0155 1:CAS:528:DyaK1cXhsF2gtro%3D 9446752 (Pubitemid 28123720)
13. M Gupta M Abdel-Megeed Y Hoki G Kohlhagen K Paull Y Pommier 1995 Eukaryotic DNA topoisomerases mediated DNA cleavage induced by a new inhibitor: NSC 665517 Mol Pharmacol 48 658 665 1:CAS:528:DyaK2MXovFajs7g%3D 7476891
14. N Adachi S Iiizumi H Koyama 2005 Evidence for a role of vertebrate Rad52 in the repair of topoisomerase II-mediated DNA damage DNA Cell Biol 24 388 393 10.1089/dna.2005.24.388 1:CAS:528:DC%2BD2MXkvVahsrk%3D 15941391 (Pubitemid 40840347)
15. K Caldecott G Banks P Jeggo 1990 DNA double-strand break repair pathways and cellular tolerance to inhibitors of topoisomerase II Cancer Res 50 5778 5783 1:CAS:528:DyaK3cXmt1ChsLw%3D 2168280
16. A Czechowska T Poplawski J Drzewoski J Blasiak 2005 Imatinib (STI571) induces DNA damage in BCR/ABL-expressing leukemic cells but not in normal lymphocytes Chem Biol Interact 152 139 150 10.1016/j.cbi.2005.03.002 1:CAS:528:DC%2BD2MXjsVGksr0%3D 15840387 (Pubitemid 40517151)
17. E Pastwa T Poplawski A Czechowska M Malinowski J Blasiak 2005 Non-homologous DNA end joining repair in normal and leukemic cells depends on the substrate ends Z Naturforsch 60 493 500 1:CAS:528:DC%2BD2MXotFeisbk%3D
18. H Wang B Rosidi R Perrault M Wang L Zhang F Windhofer G Iliakis 2005 DNA ligase III as a candidate component of backup pathways of nonhomologous end joining Cancer Res 65 4020 4030 10.1158/0008-5472.CAN-04-3055 1:CAS:528:DC%2BD2MXktlSmsLs%3D 15899791 (Pubitemid 40775638)
19. R Perrault H Wang M Wang B Rosidi G Iliakis 2004 Backup pathways of NHEJ are suppressed by DNA-PK J Cell Biochem 92 781 794 10.1002/jcb.20104 1:CAS:528:DC%2BD2cXlslenu78%3D 15211575 (Pubitemid 44264268)
20. N Adachi T Ishino Y Ishii S Takeda H Koyama 2001 DNA ligase IV-deficient cells are more resistant to ionizing radiation in the absence of Ku70: implications for DNA double-strand break repair Proc Natl Acad Sci USA 98 12109 12113 10.1073/pnas.201271098 1:CAS:528:DC%2BD3MXns1CjsLc%3D 11593023 (Pubitemid 32959835)
21. N Adachi H Suzuki S Iiizumi H Koyama 2003 Hypersensitivity of nonhomologous DNA end-joining mutants to VP-16 and ICRF-193: implications for the repair of topoisomerase II-mediated DNA damage J Biol Chem 278 35897 35902 10.1074/jbc.M306500200 1:CAS:528:DC%2BD3sXnt1aqtL0%3D 12842886 (Pubitemid 37139907)
22. MO Nowicki R Falinski M Koptyra A Slupianek T Stoklosa E Gloc M Nieborowska-Skorska J Blasiak T Skorski 2004 BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand break Blood 104 3746 3753 10.1182/blood-2004-05-1941 1:CAS:528: DC%2BD2cXhtVGltb3N 15304390 (Pubitemid 39564453)
23. A Sallmyr AE Tomkinson FV Rassool 2008 Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks Blood 112 1413 1423 10.1182/blood-2007-07-104257 1:CAS:528:DC%2BD1cXpvVOktbw%3D 18524993