Genotoxicity of urethane dimethacrylate, a tooth restoration component

Toxicology in Vitro

Volumn 24, Issue 3, 2010, Pages 854-862

  Poplawski, Tomasz ^a   Loba, Katarzyna ^a   Pawlowska, Elzbieta ^b   Szczepanska, Joanna ^b   Blasiak, Janusz ^a  

^a UNIVERSITY OF LODZ   (Poland)

^b MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Apoptosis; Cell cycle; Comet assay; DNA damage; DNA repair; UDMA; Urethane dimethacrylate

Indexed keywords

ASCORBIC ACID; CHITOSAN; METHACRYLIC ACID DERIVATIVE; PLASMID DNA; UNCLASSIFIED DRUG; URETHANE DIMETHACRYLATE;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DENTAL SURGERY; DNA DAMAGE; DNA REPAIR; GENOTOXICITY; HUMAN; HUMAN CELL; LYMPHOCYTE; OXIDATIVE STRESS;

ADULT; ANTIOXIDANTS; APOPTOSIS; ASCORBIC ACID; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; CHITOSAN; COMET ASSAY; DENTAL RESTORATION, PERMANENT; DNA; DNA DAMAGE; DNA REPAIR; ELECTROPHORESIS, GEL, PULSED-FIELD; HUMANS; LYMPHOCYTES; MALE; MUTAGENS; OXIDATIVE STRESS; PLASMIDS; URETHANE; YOUNG ADULT;

EID: 77649182948     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.12.004     Document Type: Article

References (49)

1. Al-Hiyasat A.S., Darmani H., and Milhem M.M. Cytotoxicity evaluation of dental resin composites and their flowable derivatives. Clinical Oral Investigation 9 (2005) 21-25
2. Asmussen A.P. Mechanical properties of heat treated restorative resins for use in the inlay/onlay technique. European Journal of Oral Sciences 98 (1990) 564-567
3. Beatty M.L.S., Moore B.K., Phillips R.W., and Roberts T.A. Effect of crosslinking agent content, monomer functionality, and repeat unit chemistry on properties of unfilled resins. Journal of Biomedical Materials Research 27 (1993) 403-413
4. Bouillaguet S., Wataha J.C., Hanks C.T., Ciucchi B., and Holz J. In vitro cytotoxicity and dentin permeability of HEMA. Journal of Endodontics 22 (1996) 244-248
5. Burrows C.J., and Muller J.G. Oxidative nucleobase modifications leading to strand scission. Chemical Reviews 98 (1998) 1109-1151
6. Cetinguc A., Olmez S., and Vural N. HEMA diffusion from dentin bonding agents in young and old primary molars in vitro. Dental Materials 23 (2007) 302-307
7. Collins A.R., Duthie S.J., and Dobson V.L. Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA. Carcinogenesis 14 (1993) 1733-1735
8. David-Cordonnier M.H., Laval J., and O'Neill P. Clustered DNA damage, influence on damage excision by XRS5 nuclear extracts and Escherichia coli Nth and Fpg proteins. The Journal of Biological Chemistry 275 (2000) 11865-11873
9. Eckhardt A., Gerstmayr N., Hiller K.A., Bolay C., Waha C., Spagnuolo G., Camargo C., Schmalz G., and Schweikl H. TEGDMA-induced oxidative DNA damage and activation of ATM and MAP kinases. Biomaterials 30 (2009) 2006-2014
10. Ferracane J.L. Hygroscopic and hydrolytic effects in dental polymer networks. Dental Materials 22 (2006) 211-222
11. Foray N., Arlett C.F., and Malaise E.P. Underestimation of the small residual damage when measuring DNA double-strand breaks (DSB): is the repair of radiation-induced DSB complete?. International Journal of Radiation Biology 75 (1999) 1589-1595
12. Geurtsen W. Substances released from dental resin composites and glass ionomer cements. European Journal of Oral Sciences 106 (1998) 687-695
13. Graves R., Laval J., and Pegg A.E. Sequence specificity of DNA repair by Escherichia coli Fpg protein. Carcinogenesis 13 (1992) 1455-1459
14. Houtgraaf J.H., Versmissen J., and van der Giessen W.J. A concise review of DNA damage checkpoints and repair in mammalian cells. Cardiovascular Revascularization Medicine 7 (2006) 165-172
15. Jontell M., Hanks C.T., Bratel J., and Bergenholtz G. Effects of unpolymerized resin components on the function of accessory cells derived from the rat incisor pulp. Journal of Dental Research 74 (1995) 1162-1167
16. Kainthla R., and Zewail-Foote M. Oxidative DNA damage following photoexcitation of daunomycin: direct role of oxygen. Journal of Photochemistry and Photobiology 198 (2008) 200-204
17. Klaude M., Eriksson S., Nygren J., and Ahnstrom G. The comet assay: mechanisms and technical considerations. Mutation Research 363 (1996) 89-96
18. Kleinsasser N.H., Schmid K., Sassen A.W., Harreus U.A., Staudenmaier R., Folwaczny M., Glas J., and Reichl F.X. Cytotoxic and genotoxic effects of resin monomers in human salivary gland tissue and lymphocytes as assessed by the single cell microgel electrophoresis (comet) assay. Biomaterials 27 (2006) 1762-1770
19. Kleinsasser N.H., Wallner B.C., Harreus U.A., Kleinjung T., Folwaczny M., Hickel R., Kehe K., and Reichl F.X. Genotoxicity and cytotoxicity of dental materials in human lymphocytes as assessed by the single cell microgel electrophoresis (comet) assay. Journal of Dentistry 32 (2004) 229-234
20. Krokan H.E., Standal R., and Slupphaug G. DNA glycosylases in the base excision repair of DNA. Biochemical Journal 325 Pt. 1 (1997) 1-16
21. Lee D.H., Lim B.S., Lee Y.K., Ahn S.J., and Yang H.C. Involvement of oxidative stress in mutagenicity and apoptosis caused by dental resin monomers in cell cultures. Dental Materials 22 (2006) 1086-1092
22. Stanislawski M.L., Bourd K., Soheili-Majd E., Goldberg M., and Périanin A. TEGDMA-induced toxicity in human fibroblasts is associated with early and drastic glutathione depletion with subsequent production of oxygen reactive species. Journal of Biomedical Materials Research 66A (2003) 476-482
23. Li Q., Laval J., and Ludlum D. Fpg protein releases a ring-opened N-7 guanine adduct from DNA that has been modified by sulfur mustard. Carcinogenesis 18 (1997) 1035-1038
24. Liu H.T., Li W.M., Xu G., Li X.Y., Bai X.F., Wei P., Yu C., and Du Y.G. Chitosan oligosaccharides attenuate hydrogen peroxide-induced stress injury in human umbilical vein endothelial cells. Pharmacological Research 59 (2009) 167-175
25. Mohsen N.M., Craig R.G., and Hanks C.T. Cytotoxicity of urethane dimethacrylate composites before and after aging and leaching. Journal of Biomedical Materials Research 39 (1998) 252-260
26. Nassiri M.R., Hanks C.T., Cameron M.J., Strawn S.E., and Craig R.G. Application of flow cytometry to determine the cytotoxicity of urethane dimethacrylate in human cells. Journal of Biomedical Materials Research 28 (1994) 153-158
27. Nocca G., Martorana G.E., De Sole P., De Palma F., Callà C., Corsale P., Antenucci M., Gambarini G., Chimenti C., Giardina B., and Lupi A. Effects of 1,4-butanediol dimethacrylate and urethane dimethacrylate on HL-60 cell metabolism. European Journal of Oral Science 117 (2009) 175-181
28. Noda M., Wataha J.C., Kaga M., Lockwood P.E., Volkmann K.R., and Sano H. Components of dentinal adhesives modulate heat shock protein 72 expression in heat-stressed THP-1 human monocytes at sublethal concentrations. Journal of Dental Research 81 (2002) 265-269
29. Polydorou O., König A., Hellwig E., and Kümmerer K. Uthethane dimethacrylate: a molecule that may cause confusion in dental research. Journal of Biomedical Materials Research. Part B, Applied Biomaterials 91 (2009) 1-4
30. Polydorou O., Konig A., Hellwig E., and Kummerer K. Long-term release of monomers from modern dental-composite materials. European Journal of Oral Sciences 117 (2009) 68-75
31. Poplawski T., Pawlowska E., Wisniewska-Jarosinska M., Ksiazek D., Wozniak K., Szczepanska J., and Blasiak J. Cytotoxicity and genotoxicity of glycidyl methacrylate. Chemico Biological Interactions 180 (2009) 69-70
32. Ratanasathien S., Wataha J.C., Hanks C.T., and Dennison J.B. Cytotoxic interactive effects of dentin bonding components on mouse fibroblasts. Journal of Dental Research 74 (1995) 1602-1606
33. Reichl F.X., Durner J., Hickel R., Spahl W., Kehe K., Walther U., Gempel K., Liebl B., Kunzelmann K.H., and Hume W. Uptake, clearance and metabolism of TEGDMA in guinea pigs. Dental Materials 18 (2002) 581-589
34. Reichl F.X., Esters M., Simon S., Seiss M., Kehe K., Kleinsasser N., Folwaczny M., Glas J., and Hickel R. Cell death effects of resin-based dental material compounds and mercurials in human gingival fibroblasts. Archives of Toxicology 80 (2006) 370-377
35. Saito I., Nakamura T., Nakatani K., Yoshioka Y., Yamaguchi K., and Sugiyama H. Mapping of the hot spots for DNA damage by one-electron oxidation: efficacy of GG doublets and GGG triplets as a trap in long-range hole migration. Journal of American Chemical Society 120 (1998) 12686-12687
36. Santerre J.P., Shajii L., and Leung B.W. Relation of dental composite formulations to their degradation and the release of hydrolyzed polymeric-resin-derived products. Critical Reviews in Oral Biology 12 (2001) 136-151
37. Schweikl H., Hiller K.A., Eckhardt A., Bolay C., Spagnuolo G., Stempfl T., and Schmalz G. Differential gene expression involved in oxidative stress response caused by triethylene glycol dimethacrylate. Biomaterials 29 (2008) 1377-1387
38. Schweikl H., Schmalz G., and Rackebrandt K. The mutagenic activity of unpolymerized resin monomers in Salmonella typhimurium and V79 cells. Mutation Research 415 (1998) 119-130
39. Schweikl H., Schmalz G., and Spruss T. The induction of micronuclei in vitro by unpolymerized resin monomers. Journal of Dental Research 80 (2001) 1615-1620
40. Schweikl H., Spagnuolo G., and Schmalz G. Genetic and cellular toxicology of dental resin monomers. Journal of Dental Research 85 (2006) 870-877
41. Singh N.P., McCoy M.T., Tice R.R., and Schneider E.L. A simple technique for quantification of low levels of DNA damage in individual cells. Experimental Cell Research 17 (1988) 84-191
42. Singh N.P., and Stephens R.E. Microgel electrophoresis: sensitivity, mechanisms, and DNA electrostretching. Mutation Research 383 (1997) 167-175
43. Spahl W., Budzikiewicz H., and Geurtsen W. Determination of leachable components from four commercial dental composites by gas and liquid chromatography/mass spectrometry. Journal of Dentistry 26 (1998) 137-145
44. Steenken S., and Jovanovic S. How easily oxidizable is DNA? One-electron reduction potentials of adenosine and guanosine radicals in aqueous solution. Journal of American Chemical Society 119 (1997) 617-618
45. Sugiyama H., and Saito I. Theoretical studies of GG-specific photocleavage of DNA via electron transfer: significant lowering of ionization potential and 5′-localization of HOMO of stacked GG bases in B-form DNA. Journal of American Chemical Society 118 (1996) 7063-7068
46. Tice R.R., Agurell E., Anderson D., Burlinson B., Hartmann A., Kobayashi H., Miyamae Y., Rojas E., Ryu J.C., and Sasaki Y.F. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environmental and Molecular Mutagenesis 35 (2000) 206-221
47. Tudek B., Van Zeeland A.A., Kusmierek J.T., and Laval J. Activity of Escherichia coli DNA-glycosylases on DNA damaged by methylating and ethylating agents and influence of 3-substituted adenine derivatives. Mutation Research 407 (1998) 169-176
48. Walther U.I., Siagian I.I., Walther S.C., Reichl F.X., and Hickel R. Antioxidative vitamins decrease cytotoxicity of HEMA and TEGDMA in cultured cell lines. Archives of Oral Biology 49 (2004) 125-131
49. Yoshii E. Cytotoxic effects of acrylates and methacrylates: relationships of monomer structures and cytotoxicity. Journal of Biomedical Materials Research 37 (1997) 517-524