Crystallographic studies of pharmacological sites in pentameric ligand-gated ion channels

Biochimica et Biophysica Acta - General Subjects

Volumn 1850, Issue 3, 2015, Pages 511-523

  Sauguet, Ludovic ^a   Shahsavar, Azadeh ^a,b   Delarue, Marc ^a  

^a INSTITUT PASTEUR   (France)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Allostery; Binding sites; Crystallography; Ligand gated ion channels; Neurotransmitters

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINE BINDING PROTEIN; ALCOHOL; ANESTHETIC AGENT; BENZODIAZEPINE DERIVATIVE; BINDING PROTEIN; ION TRANSPORT AFFECTING AGENT; LIGAND GATED ION CHANNEL; LIPID; OPEN CHANNEL PORE BLOCKER; PENTAMERIC LIGAND GATED ION CHANNEL; UNCLASSIFIED DRUG; LIGAND;

ALLOSTERISM; ARTICLE; CHANNEL GATING; CRYSTALLIZATION; DRUG BINDING SITE; DRUG MECHANISM; EXTRACELLULAR DOMAIN; GEOMETRY; HUMAN; ICOSAHEDRON; ION TRANSPORT; LIGAND BINDING; MODULATION; MOLECULAR BIOLOGY; NONHUMAN; ORTHOSTERIC BINDING SITE; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION; TRANSMEMBRANE DOMAIN; X RAY CRYSTALLOGRAPHY; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

BACTERIA (MICROORGANISMS);

ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; LIGAND-GATED ION CHANNELS; LIGANDS; MODELS, MOLECULAR; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY;

EID: 84921029711     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2014.05.007     Document Type: Review

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