Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels

EMBO Journal

Volumn 32, Issue 5, 2013, Pages 728-741

  Sauguet, Ludovic ^a   Poitevin, Frédéric ^a,b   Murail, Samuel ^c   Van Renterghem, Catherine ^a   Moraga Cid, Gustavo ^a   Malherbe, Laurie ^a   Thompson, Andrew W ^d   Koehl, Patrice ^e   Corringer, Pierre Jean ^a   Baaden, Marc ^c   Delarue, Marc ^a  

^a CNRS   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c INST DE BIOLOGIE PHYSICO CHIMIQUE   (France)

^d SYNCHROTRON SOLEIL   (France)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

crystallography; electrophysiology; ion channels; molecular dynamics; permeation

Indexed keywords

ANION; HYDROXYL GROUP; LIGAND GATED ION CHANNEL; PENTAMERIC LIGAND GATED ION CHANNEL; SERINE; SODIUM ION; THREONINE; UNCLASSIFIED DRUG; WATER;

CALCULATION; CONTROLLED STUDY; CRYSTAL; ELECTROPHYSIOLOGY; HYDROPHOBICITY; HYDROXYLATION; ION TRANSPORT; MOLECULE; PRIORITY JOURNAL; PROTEIN STRUCTURE; REVIEW; SIMULATION; STATIC ELECTRICITY;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; ELECTROPHYSIOLOGY; FEMALE; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; ION CHANNEL GATING; LIGAND-GATED ION CHANNELS; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTATION; OOCYTES; PROTEIN STRUCTURE, QUATERNARY; SERINE; SODIUM; THREONINE; WATER; XENOPUS LAEVIS;

PROKARYOTA;

EID: 84875220675     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2013.17     Document Type: Review

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