Structural models of ligand-gated ion channels: Sites of action for anesthetics and ethanol

Alcoholism: Clinical and Experimental Research

Volumn 38, Issue 3, 2014, Pages 595-603

  Olsen, Richard W ^a   Li, Guo Dong ^a   Wallner, Martin ^a   Trudell, James R ^b   Bertaccini, Edward J ^b   Lindahl, Erik ^c   Miller, Keith W ^d   Alkana, Ronald L ^e   Davies, Daryl L ^e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

ELIC; Ethanol sites of action; GLIC; GluCl pentameric ion channels; Loop 2

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; ANESTHETIC AGENT; AZIRIDINE; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; BROMOFORM; CYSTEINE; ETOMIDATE; FLUMAZENIL; GLYCINE RECEPTOR; INHALATION ANESTHETIC AGENT; KETAMINE; LIGAND GATED ION CHANNEL; NEUROTRANSMITTER RECEPTOR; NICOTINIC RECEPTOR; PROPOFOL; STEROID; THIOL DERIVATIVE; THIOL REAGENT;

AFFINITY LABELING; ALCOHOLISM; BINDING SITE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ELECTRON MICROSCOPY; IN VITRO STUDY; INVERTEBRATE; LIGAND BINDING; LIPID BILAYER; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; REVIEW; SITE DIRECTED MUTAGENESIS; VOLTAGE CLAMP TECHNIQUE;

ELIC; ETHANOL SITES OF ACTION; GABAA RECEPTORS; GLIC; GLUCL PENTAMERIC ION CHANNELS; LOOP 2;

AMINO ACID SEQUENCE; ANESTHETICS; ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CYSTEINE LOOP LIGAND-GATED ION CHANNEL RECEPTORS; ETHANOL; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE;

EID: 84896316287     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12283     Document Type: Review

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