Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 3, 2014, Pages 966-971

  Sauguet, Ludovic ^a   Shahsavar, Azadeh ^a,d   Poitevin, Frédéric ^a   Huon, Christèle ^b   Menny, Anaïs ^b   Nemecz, Àkos ^b   Haouz, Ahmed ^b   Changeux, Jean Pierre ^b,c   Corringer, Pierre Jean ^b   Delarue, Marc ^a  

^a CNRS   (France)

^b INSTITUT PASTEUR   (France)

^c l'alimentation et l'Environnement   (France)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND GATED ION CHANNEL; PENTAMERIC LIGAND GATED ION CHANNEL; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYOPROTECTION; CRYSTAL STRUCTURE; ELECTRON SPIN RESONANCE; ELECTROPHYSIOLOGY; EXTRACELLULAR SPACE; LIGAND BINDING; PH; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

ALLOSTERY; CYS-LOOP RECEPTOR; SIGNAL TRANSDUCTION; X-RAY CRYSTALLOGRAPHY;

ALLOSTERIC SITE; ANIMALS; BINDING SITES; CATIONS; CRYSTALLOGRAPHY, X-RAY; CYANOBACTERIA; ESCHERICHIA COLI; HYDROGEN-ION CONCENTRATION; ION CHANNELS; LIGAND-GATED ION CHANNELS; LIGANDS; MODELS, MOLECULAR; OOCYTES; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; XENOPUS LAEVIS;

EID: 84892910277     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1314997111     Document Type: Article

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