Identification of cinnamic acid derivatives as novel antagonists of the prokaryotic proton-gated ion channel GLIC

Journal of Medicinal Chemistry

Volumn 56, Issue 11, 2013, Pages 4619-4630

  Prevost, Marie S ^a,b,c   Delarue Cochin, Sandrine ^d,e   Marteaux, Justine ^d,e   Colas, Claire ^a,b   Van Renterghem, Catherine ^a,b   Blondel, Arnaud ^a,b   Malliavin, Thérèse ^a,b   Corringer, Pierre Jean ^a,b   Joseph, Delphine ^d,e  

^a INSTITUT PASTEUR   (France)

^b CNRS   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d UNIVERSITÉ PARIS SACLAY   (France)

^e UNIVERSITÉ PARIS SUD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 PHENYLALLYLIDENE)MALONIC ACID; 2 BENZYLIDENEMALONIC ACID; 3 (3,4 DIHYDROXYPHENYL) N ETHYLACRYLAMIDE; 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; 3 (3,4 DIHYDROXYPHENYL)PROPANOIC ACID; 4 (3 HYDROXYPROP 1 ENYL)BENZENE 1,2 DIOL; CINNAMIC ACID DERIVATIVE; ETHYL 3 (3,4 DIHYDROXYPHENYL)ACRYLATE; LIGAND GATED ION CHANNEL; METHYL 3 (3,4 DIHYDROXYPHENYL)ACRYLATE; N METHOXYCINNAMAMIDE; UNCLASSIFIED DRUG;

AMINO ACID COMPOSITION; ARTICLE; BINDING SITE; DRUG IDENTIFICATION; MOLECULAR DOCKING; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

ANIMALS; BACTERIAL PROTEINS; BINDING SITES; CAFFEIC ACIDS; CINNAMATES; COMPUTER SIMULATION; CYANOBACTERIA; DATABASES, FACTUAL; FEMALE; HYDROGEN-ION CONCENTRATION; LIGAND-GATED ION CHANNELS; MODELS, MOLECULAR; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN MULTIMERIZATION; PROTONS; STEREOISOMERISM; XENOPUS;

EID: 84879036155     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400374q     Document Type: Article

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