메뉴 건너뛰기




Volumn 281, Issue , 2015, Pages 32-42

Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice

Author keywords

Alzheimer's disease; Behavioral deficit; Cerebral amyloidosis; Hesperidin; Neuro inflammation; Transgenic mouse model

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; HESPERIDIN; TRANSFORMING GROWTH FACTOR BETA; PRESENILIN 1;

EID: 84920876906     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2014.12.012     Document Type: Article
Times cited : (76)

References (58)
  • 1
    • 0032717524 scopus 로고    scopus 로고
    • Anti-inflammatory activity of diosmin and hesperidin in rat colitis induced by TNBS
    • Crespo M.E., Galvez J., Cruz T., Ocete M.A., Zarzuelo A. Anti-inflammatory activity of diosmin and hesperidin in rat colitis induced by TNBS. Planta Med 1999, 65:651-653.
    • (1999) Planta Med , vol.65 , pp. 651-653
    • Crespo, M.E.1    Galvez, J.2    Cruz, T.3    Ocete, M.A.4    Zarzuelo, A.5
  • 2
    • 84885641411 scopus 로고    scopus 로고
    • Neuroprotective effects of hesperidin, a plant flavanone, on rotenone-induced oxidative stress and apoptosis in a cellular model for Parkinson's disease
    • Tamilselvam K., Braidy N., Manivasagam T., Essa M.M., Prasad N.R., Karthikeyan S., et al. Neuroprotective effects of hesperidin, a plant flavanone, on rotenone-induced oxidative stress and apoptosis in a cellular model for Parkinson's disease. Oxid Med Cell Long 2013, 2013:102741.
    • (2013) Oxid Med Cell Long , vol.2013 , pp. 102741
    • Tamilselvam, K.1    Braidy, N.2    Manivasagam, T.3    Essa, M.M.4    Prasad, N.R.5    Karthikeyan, S.6
  • 3
    • 21644479440 scopus 로고    scopus 로고
    • Antioxidant activity of the flavonoid hesperidin in chemical and biological systems
    • Wilmsen P.K., Spada D.S., Salvador M. Antioxidant activity of the flavonoid hesperidin in chemical and biological systems. J Agric Food Chem 2005, 53:4757-4761.
    • (2005) J Agric Food Chem , vol.53 , pp. 4757-4761
    • Wilmsen, P.K.1    Spada, D.S.2    Salvador, M.3
  • 4
    • 68149124472 scopus 로고    scopus 로고
    • Dietary phenolics: chemistry, bioavailability and effects on health
    • Crozier A., Jaganath I.B., Clifford M.N. Dietary phenolics: chemistry, bioavailability and effects on health. Nat Prod Rep 2009, 26:1001-1043.
    • (2009) Nat Prod Rep , vol.26 , pp. 1001-1043
    • Crozier, A.1    Jaganath, I.B.2    Clifford, M.N.3
  • 5
    • 0035667114 scopus 로고    scopus 로고
    • Chemistry and pharmacology of the Citrus bioflavonoid hesperidin
    • Garg A., Garg S., Zaneveld L.J., Singla A.K. Chemistry and pharmacology of the Citrus bioflavonoid hesperidin. Phytother Res 2001, 15:655-669.
    • (2001) Phytother Res , vol.15 , pp. 655-669
    • Garg, A.1    Garg, S.2    Zaneveld, L.J.3    Singla, A.K.4
  • 6
    • 84867231608 scopus 로고    scopus 로고
    • Potential neuroprotective effects of hesperidin on 3-nitropropionic acid-induced neurotoxicity in rats
    • Menze E.T., Tadros M.G., Abdel-Tawab A.M., Khalifa A.E. Potential neuroprotective effects of hesperidin on 3-nitropropionic acid-induced neurotoxicity in rats. Neurotoxicology 2012, 33:1265-1275.
    • (2012) Neurotoxicology , vol.33 , pp. 1265-1275
    • Menze, E.T.1    Tadros, M.G.2    Abdel-Tawab, A.M.3    Khalifa, A.E.4
  • 7
    • 77957130057 scopus 로고    scopus 로고
    • Behavioural symptoms in patients with Alzheimer's disease and their association with cognitive impairment
    • Fernandez M., Gobartt A.L., Balana M., Group C.S. Behavioural symptoms in patients with Alzheimer's disease and their association with cognitive impairment. BMC Neurol 2010, 10:87.
    • (2010) BMC Neurol , vol.10 , pp. 87
    • Fernandez, M.1    Gobartt, A.L.2    Balana, M.3    Group, C.S.4
  • 9
    • 0035139773 scopus 로고    scopus 로고
    • Prevalence and pharmacological management of behavioural and psychological symptoms amongst dementia sufferers living in care environments
    • Margallo-Lana M., Swann A., O'Brien J., Fairbairn A., Reichelt K., Potkins D., et al. Prevalence and pharmacological management of behavioural and psychological symptoms amongst dementia sufferers living in care environments. Int J Geriatr Psychiatry 2001, 16:39-44.
    • (2001) Int J Geriatr Psychiatry , vol.16 , pp. 39-44
    • Margallo-Lana, M.1    Swann, A.2    O'Brien, J.3    Fairbairn, A.4    Reichelt, K.5    Potkins, D.6
  • 10
    • 84875859346 scopus 로고    scopus 로고
    • Agitation and aggression in people with Alzheimer's disease
    • Ballard C., Corbett A. Agitation and aggression in people with Alzheimer's disease. Curr Opin Psychiatry 2013, 26:252-259.
    • (2013) Curr Opin Psychiatry , vol.26 , pp. 252-259
    • Ballard, C.1    Corbett, A.2
  • 11
    • 80053971718 scopus 로고    scopus 로고
    • Current and emerging drug treatment options for Alzheimer's disease: a systematic review
    • Herrmann N., Chau S.A., Kircanski I., Lanctot K.L. Current and emerging drug treatment options for Alzheimer's disease: a systematic review. Drugs 2011, 71:2031-2065.
    • (2011) Drugs , vol.71 , pp. 2031-2065
    • Herrmann, N.1    Chau, S.A.2    Kircanski, I.3    Lanctot, K.L.4
  • 13
    • 0036685522 scopus 로고    scopus 로고
    • Inflammation in neurodegenerative disease - a double-edged sword
    • Wyss-Coray T., Mucke L. Inflammation in neurodegenerative disease - a double-edged sword. Neuron 2002, 35:419-432.
    • (2002) Neuron , vol.35 , pp. 419-432
    • Wyss-Coray, T.1    Mucke, L.2
  • 14
    • 33947525706 scopus 로고    scopus 로고
    • Early-onset subicular microvascular amyloid and neuroinflammation correlate with behavioral deficits in vasculotropic mutant amyloid beta-protein precursor transgenic mice
    • Xu F., Grande A.M., Robinson J.K., Previti M.L., Vasek M., Davis J., et al. Early-onset subicular microvascular amyloid and neuroinflammation correlate with behavioral deficits in vasculotropic mutant amyloid beta-protein precursor transgenic mice. Neuroscience 2007, 146:98-107.
    • (2007) Neuroscience , vol.146 , pp. 98-107
    • Xu, F.1    Grande, A.M.2    Robinson, J.K.3    Previti, M.L.4    Vasek, M.5    Davis, J.6
  • 15
    • 0031914718 scopus 로고    scopus 로고
    • Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
    • Holcomb L., Gordon M.N., McGowan E., Yu X., Benkovic S., Jantzen P., et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 1998, 4:97-100.
    • (1998) Nat Med , vol.4 , pp. 97-100
    • Holcomb, L.1    Gordon, M.N.2    McGowan, E.3    Yu, X.4    Benkovic, S.5    Jantzen, P.6
  • 16
    • 0036174969 scopus 로고    scopus 로고
    • The effects of long-term treatment with metrifonate, a cholinesterase inhibitor, on cholinergic activity, amyloid pathology, and cognitive function in APP and PS1 doubly transgenic mice
    • Liu L., Ikonen S., Heikkinen T., Tapiola T., van Groen T., Tanila H. The effects of long-term treatment with metrifonate, a cholinesterase inhibitor, on cholinergic activity, amyloid pathology, and cognitive function in APP and PS1 doubly transgenic mice. Exp Neurol 2002, 173:196-204.
    • (2002) Exp Neurol , vol.173 , pp. 196-204
    • Liu, L.1    Ikonen, S.2    Heikkinen, T.3    Tapiola, T.4    van Groen, T.5    Tanila, H.6
  • 17
    • 33748988258 scopus 로고    scopus 로고
    • Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
    • Radde R., Bolmont T., Kaeser S.A., Coomaraswamy J., Lindau D., Stoltze L., et al. Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Rep 2006, 7:940-946.
    • (2006) EMBO Rep , vol.7 , pp. 940-946
    • Radde, R.1    Bolmont, T.2    Kaeser, S.A.3    Coomaraswamy, J.4    Lindau, D.5    Stoltze, L.6
  • 18
    • 84891146250 scopus 로고    scopus 로고
    • Oridonin ameliorates neuropathological changes and behavioural deficits in a mouse model of cerebral amyloidosis
    • Zhang Z.Y., Daniels R., Schluesener H.J. Oridonin ameliorates neuropathological changes and behavioural deficits in a mouse model of cerebral amyloidosis. J Cell Mol Med 2013, 17:1566-1576.
    • (2013) J Cell Mol Med , vol.17 , pp. 1566-1576
    • Zhang, Z.Y.1    Daniels, R.2    Schluesener, H.J.3
  • 20
    • 84876167900 scopus 로고    scopus 로고
    • Hesperidin ameliorates immobilization-stress-induced behavioral and biochemical alterations and mitochondrial dysfunction in mice by modulating nitrergic pathway
    • Viswanatha G.L., Shylaja H., Sandeep Rao K.S., Santhosh Kumar V.R., Jagadeesh M. Hesperidin ameliorates immobilization-stress-induced behavioral and biochemical alterations and mitochondrial dysfunction in mice by modulating nitrergic pathway. ISRN Pharmacol 2012, 2012:479570.
    • (2012) ISRN Pharmacol , vol.2012 , pp. 479570
    • Viswanatha, G.L.1    Shylaja, H.2    Sandeep Rao, K.S.3    Santhosh Kumar, V.R.4    Jagadeesh, M.5
  • 21
    • 78149412424 scopus 로고    scopus 로고
    • Age and gene overexpression interact to abolish nesting behavior in Tg2576 amyloid precursor protein (APP) mice
    • Wesson D.W., Wilson D.A. Age and gene overexpression interact to abolish nesting behavior in Tg2576 amyloid precursor protein (APP) mice. Behav Brain Res 2011, 216:408-413.
    • (2011) Behav Brain Res , vol.216 , pp. 408-413
    • Wesson, D.W.1    Wilson, D.A.2
  • 22
    • 33845336461 scopus 로고    scopus 로고
    • Assessing autism-like behavior in mice: variations in social interactions among inbred strains
    • Bolivar V.J., Walters S.R., Phoenix J.L. Assessing autism-like behavior in mice: variations in social interactions among inbred strains. Behav Brain Res 2007, 176:21-26.
    • (2007) Behav Brain Res , vol.176 , pp. 21-26
    • Bolivar, V.J.1    Walters, S.R.2    Phoenix, J.L.3
  • 23
    • 77953452925 scopus 로고    scopus 로고
    • Cuprizone demyelination of the corpus callosum in mice correlates with altered social interaction and impaired bilateral sensorimotor coordination
    • Hibbits N., Pannu R., Wu T.J., Armstrong R.C. Cuprizone demyelination of the corpus callosum in mice correlates with altered social interaction and impaired bilateral sensorimotor coordination. ASN Neuro 2009, 1.
    • (2009) ASN Neuro , pp. 1
    • Hibbits, N.1    Pannu, R.2    Wu, T.J.3    Armstrong, R.C.4
  • 25
    • 49049095051 scopus 로고    scopus 로고
    • In vivo pharmacokinetics of hesperidin are affected by treatment with glucosidase-like BglA protein isolated from yeasts
    • Li Y.M., Li X.M., Li G.M., Du W.C., Zhang J., Li W.X., et al. In vivo pharmacokinetics of hesperidin are affected by treatment with glucosidase-like BglA protein isolated from yeasts. J Agric Food Chem 2008, 56:5550-5557.
    • (2008) J Agric Food Chem , vol.56 , pp. 5550-5557
    • Li, Y.M.1    Li, X.M.2    Li, G.M.3    Du, W.C.4    Zhang, J.5    Li, W.X.6
  • 26
    • 4043153467 scopus 로고    scopus 로고
    • Antiallergic activity of hesperidin is activated by intestinal microflora
    • Lee N.K., Choi S.H., Park S.H., Park E.K., Kim D.H. Antiallergic activity of hesperidin is activated by intestinal microflora. Pharmacology 2004, 71:174-180.
    • (2004) Pharmacology , vol.71 , pp. 174-180
    • Lee, N.K.1    Choi, S.H.2    Park, S.H.3    Park, E.K.4    Kim, D.H.5
  • 28
    • 84874661821 scopus 로고    scopus 로고
    • Oral administration of histone deacetylase inhibitor MS-275 ameliorates neuroinflammation and cerebral amyloidosis and improves behavior in a mouse model
    • Zhang Z.Y., Schluesener H.J. Oral administration of histone deacetylase inhibitor MS-275 ameliorates neuroinflammation and cerebral amyloidosis and improves behavior in a mouse model. J Neuropathol Exp Neurol 2013, 72:178-185.
    • (2013) J Neuropathol Exp Neurol , vol.72 , pp. 178-185
    • Zhang, Z.Y.1    Schluesener, H.J.2
  • 30
    • 70350196372 scopus 로고    scopus 로고
    • Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington's like symptoms in rats: possible role of nitric oxide
    • Kumar P., Kumar A. Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington's like symptoms in rats: possible role of nitric oxide. Behav Brain Res 2010, 206:38-46.
    • (2010) Behav Brain Res , vol.206 , pp. 38-46
    • Kumar, P.1    Kumar, A.2
  • 31
    • 57349151570 scopus 로고    scopus 로고
    • Post-injury baicalein improves histological and functional outcomes and reduces inflammatory cytokines after experimental traumatic brain injury
    • Chen S.F., Hsu C.W., Huang W.H., Wang J.Y. Post-injury baicalein improves histological and functional outcomes and reduces inflammatory cytokines after experimental traumatic brain injury. Br J Pharmacol 2008, 155:1279-1296.
    • (2008) Br J Pharmacol , vol.155 , pp. 1279-1296
    • Chen, S.F.1    Hsu, C.W.2    Huang, W.H.3    Wang, J.Y.4
  • 32
    • 27744584602 scopus 로고    scopus 로고
    • The construct of minor and major depression in Alzheimer's disease
    • Starkstein S.E., Jorge R., Mizrahi R., Robinson R.G. The construct of minor and major depression in Alzheimer's disease. Am J Psychiatry 2005, 162:2086-2093.
    • (2005) Am J Psychiatry , vol.162 , pp. 2086-2093
    • Starkstein, S.E.1    Jorge, R.2    Mizrahi, R.3    Robinson, R.G.4
  • 33
    • 84868115342 scopus 로고    scopus 로고
    • The role of persistent and incident major depression on rate of cognitive deterioration in newly diagnosed Alzheimer's disease patients
    • Spalletta G., Caltagirone C., Girardi P., Gianni W., Casini A.R., Palmer K. The role of persistent and incident major depression on rate of cognitive deterioration in newly diagnosed Alzheimer's disease patients. Psychiatry Res 2012, 198:263-268.
    • (2012) Psychiatry Res , vol.198 , pp. 263-268
    • Spalletta, G.1    Caltagirone, C.2    Girardi, P.3    Gianni, W.4    Casini, A.R.5    Palmer, K.6
  • 34
    • 84876338022 scopus 로고    scopus 로고
    • Impairment of nesting behaviour in 3xTg-AD mice
    • Torres-Lista V., Gimenez-Llort L. Impairment of nesting behaviour in 3xTg-AD mice. Behav Brain Res 2013, 247:153-157.
    • (2013) Behav Brain Res , vol.247 , pp. 153-157
    • Torres-Lista, V.1    Gimenez-Llort, L.2
  • 35
    • 84905454608 scopus 로고    scopus 로고
    • Icariin ameliorates neuropathological changes, TGF-beta1 accumulation and behavioral deficits in a mouse model of cerebral amyloidosis
    • Zhang Z.Y., Li C., Zug C., Schluesener H.J. Icariin ameliorates neuropathological changes, TGF-beta1 accumulation and behavioral deficits in a mouse model of cerebral amyloidosis. PLoS ONE 2014, 9:e104616.
    • (2014) PLoS ONE , vol.9 , pp. e104616
    • Zhang, Z.Y.1    Li, C.2    Zug, C.3    Schluesener, H.J.4
  • 36
    • 61449189852 scopus 로고    scopus 로고
    • Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease
    • Filali M., Lalonde R., Rivest S. Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease. Genes Brain Behav 2009, 8:143-148.
    • (2009) Genes Brain Behav , vol.8 , pp. 143-148
    • Filali, M.1    Lalonde, R.2    Rivest, S.3
  • 37
    • 0034523749 scopus 로고    scopus 로고
    • Neurobehavioral and neuropsychiatric symptoms in Alzheimer's disease: characteristics and treatment
    • Chung J.A., Cummings J.L. Neurobehavioral and neuropsychiatric symptoms in Alzheimer's disease: characteristics and treatment. Neurol Clin 2000, 18:829-846.
    • (2000) Neurol Clin , vol.18 , pp. 829-846
    • Chung, J.A.1    Cummings, J.L.2
  • 39
    • 0035228401 scopus 로고    scopus 로고
    • Recognition memory: what are the roles of the perirhinal cortex and hippocampus
    • Brown M.W., Aggleton J.P. Recognition memory: what are the roles of the perirhinal cortex and hippocampus. Nat Rev Neurosci 2001, 2:51-61.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 51-61
    • Brown, M.W.1    Aggleton, J.P.2
  • 40
    • 80053050815 scopus 로고    scopus 로고
    • Anomalies in social behaviors and exploratory activities in an APPswe/PS1 mouse model of Alzheimer's disease
    • Filali M., Lalonde R., Rivest S. Anomalies in social behaviors and exploratory activities in an APPswe/PS1 mouse model of Alzheimer's disease. Physiol Behav 2011, 104:880-885.
    • (2011) Physiol Behav , vol.104 , pp. 880-885
    • Filali, M.1    Lalonde, R.2    Rivest, S.3
  • 41
    • 84863896457 scopus 로고    scopus 로고
    • The novel multi-target iron chelating-radical scavenging compound M30 possesses beneficial effects on major hallmarks of Alzheimer's disease
    • Kupershmidt L., Amit T., Bar-Am O., Youdim M.B., Weinreb O. The novel multi-target iron chelating-radical scavenging compound M30 possesses beneficial effects on major hallmarks of Alzheimer's disease. Antioxid Redox Signal 2012, 17:860-877.
    • (2012) Antioxid Redox Signal , vol.17 , pp. 860-877
    • Kupershmidt, L.1    Amit, T.2    Bar-Am, O.3    Youdim, M.B.4    Weinreb, O.5
  • 42
    • 84862777666 scopus 로고    scopus 로고
    • ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models
    • Cramer P.E., Cirrito J.R., Wesson D.W., Lee C.Y., Karlo J.C., Zinn A.E., et al. ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models. Science 2012, 335:1503-1506.
    • (2012) Science , vol.335 , pp. 1503-1506
    • Cramer, P.E.1    Cirrito, J.R.2    Wesson, D.W.3    Lee, C.Y.4    Karlo, J.C.5    Zinn, A.E.6
  • 43
    • 84876187514 scopus 로고    scopus 로고
    • Protective effects of hesperidin against amyloid-beta (Abeta) induced neurotoxicity through the voltage dependent anion channel 1 (VDAC1)-mediated mitochondrial apoptotic pathway in PC12 cells
    • Wang D.M., Li S.Q., Zhu X.Y., Wang Y., Wu W.L., Zhang X.J. Protective effects of hesperidin against amyloid-beta (Abeta) induced neurotoxicity through the voltage dependent anion channel 1 (VDAC1)-mediated mitochondrial apoptotic pathway in PC12 cells. Neurochem Res 2013, 38:1034-1044.
    • (2013) Neurochem Res , vol.38 , pp. 1034-1044
    • Wang, D.M.1    Li, S.Q.2    Zhu, X.Y.3    Wang, Y.4    Wu, W.L.5    Zhang, X.J.6
  • 44
    • 0028199826 scopus 로고
    • Pharmacological evaluation of the anti-inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids, duartin and claussequinone, in rats and mice
    • Emim J.A., Oliveira A.B., Lapa A.J. Pharmacological evaluation of the anti-inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids, duartin and claussequinone, in rats and mice. J Pharm Pharmacol 1994, 46:118-122.
    • (1994) J Pharm Pharmacol , vol.46 , pp. 118-122
    • Emim, J.A.1    Oliveira, A.B.2    Lapa, A.J.3
  • 45
    • 34948879632 scopus 로고    scopus 로고
    • Hesperidin inhibits expression of hypoxia inducible factor-1 alpha and inflammatory cytokine production from mast cells
    • Choi I.Y., Kim S.J., Jeong H.J., Park S.H., Song Y.S., Lee J.H., et al. Hesperidin inhibits expression of hypoxia inducible factor-1 alpha and inflammatory cytokine production from mast cells. Mol Cell Biochem 2007, 305:153-161.
    • (2007) Mol Cell Biochem , vol.305 , pp. 153-161
    • Choi, I.Y.1    Kim, S.J.2    Jeong, H.J.3    Park, S.H.4    Song, Y.S.5    Lee, J.H.6
  • 46
    • 0032450909 scopus 로고    scopus 로고
    • TGF-beta receptors-I and -II immunoexpression in Alzheimer's disease: a comparison with aging and progressive supranuclear palsy
    • Lippa C.F., Flanders K.C., Kim E.S., Croul S. TGF-beta receptors-I and -II immunoexpression in Alzheimer's disease: a comparison with aging and progressive supranuclear palsy. Neurobiol Aging 1998, 19:527-533.
    • (1998) Neurobiol Aging , vol.19 , pp. 527-533
    • Lippa, C.F.1    Flanders, K.C.2    Kim, E.S.3    Croul, S.4
  • 47
    • 0034744296 scopus 로고    scopus 로고
    • TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice
    • Wyss-Coray T., Lin C., Yan F., Yu G.Q., Rohde M., McConlogue L., et al. TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. Nat Med 2001, 7:612-618.
    • (2001) Nat Med , vol.7 , pp. 612-618
    • Wyss-Coray, T.1    Lin, C.2    Yan, F.3    Yu, G.Q.4    Rohde, M.5    McConlogue, L.6
  • 48
    • 0027185651 scopus 로고
    • Regulation of beta-amyloid precursor protein isoform mRNAs by transforming growth factor-beta 1 and interleukin-1 beta in astrocytes
    • Gray C.W., Patel A.J. Regulation of beta-amyloid precursor protein isoform mRNAs by transforming growth factor-beta 1 and interleukin-1 beta in astrocytes. Brain Res Mol Brain Res 1993, 19:251-256.
    • (1993) Brain Res Mol Brain Res , vol.19 , pp. 251-256
    • Gray, C.W.1    Patel, A.J.2
  • 49
    • 0038719725 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice
    • Lesne S., Docagne F., Gabriel C., Liot G., Lahiri D.K., Buee L., et al. Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice. J Biol Chem 2003, 278:18408-18418.
    • (2003) J Biol Chem , vol.278 , pp. 18408-18418
    • Lesne, S.1    Docagne, F.2    Gabriel, C.3    Liot, G.4    Lahiri, D.K.5    Buee, L.6
  • 50
    • 0030764732 scopus 로고    scopus 로고
    • Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease
    • Wyss-Coray T., Masliah E., Mallory M., McConlogue L., Johnson-Wood K., Lin C., et al. Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease. Nature 1997, 389:603-606.
    • (1997) Nature , vol.389 , pp. 603-606
    • Wyss-Coray, T.1    Masliah, E.2    Mallory, M.3    McConlogue, L.4    Johnson-Wood, K.5    Lin, C.6
  • 51
    • 0036098247 scopus 로고    scopus 로고
    • Cerebrovascular transforming growth factor-beta contributes to inflammation in the Alzheimer's disease brain
    • Grammas P., Ovase R. Cerebrovascular transforming growth factor-beta contributes to inflammation in the Alzheimer's disease brain. Am J Pathol 2002, 160:1583-1587.
    • (2002) Am J Pathol , vol.160 , pp. 1583-1587
    • Grammas, P.1    Ovase, R.2
  • 52
    • 0033900999 scopus 로고    scopus 로고
    • Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice
    • Wyss-Coray T., Lin C., Sanan D.A., Mucke L., Masliah E. Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice. Am J Pathol 2000, 156:139-150.
    • (2000) Am J Pathol , vol.156 , pp. 139-150
    • Wyss-Coray, T.1    Lin, C.2    Sanan, D.A.3    Mucke, L.4    Masliah, E.5
  • 53
    • 84861473274 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease
    • Tweedie D., Ferguson R.A., Fishman K., Frankola K.A., Van Praag H., Holloway H.W., et al. Tumor necrosis factor-alpha synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease. J Neuroinflamm 2012, 9:106.
    • (2012) J Neuroinflamm , vol.9 , pp. 106
    • Tweedie, D.1    Ferguson, R.A.2    Fishman, K.3    Frankola, K.A.4    Van Praag, H.5    Holloway, H.W.6
  • 54
    • 84859886313 scopus 로고    scopus 로고
    • The citrus flavonoid hesperidin induces p53 and inhibits NF-kappaB activation in order to trigger apoptosis in NALM-6 cells: involvement of PPARgamma-dependent mechanism
    • Ghorbani A., Nazari M., Jeddi-Tehrani M., Zand H. The citrus flavonoid hesperidin induces p53 and inhibits NF-kappaB activation in order to trigger apoptosis in NALM-6 cells: involvement of PPARgamma-dependent mechanism. Eur J Nutr 2012, 51:39-46.
    • (2012) Eur J Nutr , vol.51 , pp. 39-46
    • Ghorbani, A.1    Nazari, M.2    Jeddi-Tehrani, M.3    Zand, H.4
  • 56
    • 84912051590 scopus 로고    scopus 로고
    • Hesperidin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress in a mouse model of Alzheimer's disease
    • Wang D., Liu L., Zhu X., Wu W., Wang Y. Hesperidin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress in a mouse model of Alzheimer's disease. Cell Mol Neurobiol 2014, 34:1209-1221.
    • (2014) Cell Mol Neurobiol , vol.34 , pp. 1209-1221
    • Wang, D.1    Liu, L.2    Zhu, X.3    Wu, W.4    Wang, Y.5
  • 57
    • 84875853369 scopus 로고    scopus 로고
    • Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice
    • Sivilia S., Lorenzini L., Giuliani A., Gusciglio M., Fernandez M., Baldassarro V.A., et al. Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice. BMC Neurosci 2013, 14:44.
    • (2013) BMC Neurosci , vol.14 , pp. 44
    • Sivilia, S.1    Lorenzini, L.2    Giuliani, A.3    Gusciglio, M.4    Fernandez, M.5    Baldassarro, V.A.6
  • 58
    • 84883695970 scopus 로고    scopus 로고
    • Ibuprofen rescues abnormalities in periodontal tissues in conditional presenilin 1 and presenilin 2 double knockout mice
    • Su J., Gu J., Dong Z., Mei B. Ibuprofen rescues abnormalities in periodontal tissues in conditional presenilin 1 and presenilin 2 double knockout mice. Int J Mol Sci 2013, 14:18457-18469.
    • (2013) Int J Mol Sci , vol.14 , pp. 18457-18469
    • Su, J.1    Gu, J.2    Dong, Z.3    Mei, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.