Cuprizone demyelination of the corpus callosum in mice correlates with altered social interaction and impaired bilateral sensorimotor coordination

ASN Neuro

Volumn 1, Issue 3, 2009, Pages 153-164

  Hibbits, Norah ^a   Pannu, Ravinder ^a   Wu, T John ^a   Armstrong, Regina C ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Corpus callosum; Cuprizone; Demyelination; Remyelination; Rodent behaviour; Wheel activity

Indexed keywords

CUPRIZONE;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CEREBELLUM; CONTROLLED STUDY; CORPUS CALLOSUM; DEMYELINATION; HEMISPHERE; HIPPOCAMPUS; MALE; MOTOR COORDINATION; MOUSE; NONHUMAN; REMYELINIZATION; SENSORIMOTOR FUNCTION; SOCIAL INTERACTION;

EID: 77953452925     PISSN: None     EISSN: 17590914     Source Type: Journal    
DOI: 10.1042/AN20090032     Document Type: Article

References (40)

1. Adamo AM, Paez PM, Escobar Cabrera OE, Wolfson M, Franco PG, Pasquini JM, Soto EF (2006) Remyelination after cuprizone-induced demyelination in the rat is stimulated by apotransferrin. Exp Neurol 198:519-529.
2. Alexander AL, Lee JE, Lazar M, Boudos R, DuBray MB, Oakes TR, Miller JN, Lu J, Jeong EK, McMahon WM, Bigler ED, Lainhart JE (2007) Diffusion tensor imaging of the corpus callosum in autism. Neuroimage 34:61-73.
3. Anstey KJ, Mack HA, Christensen H, Li SC, Reglade-Meslin C, Maller J, Kumar R, Dear K, Easteal S, Sachdev P (2007) Corpus callosum size, reaction time speed and variability in mild cognitive disorders and in a normative sample. Neuropsychologia 45:1911-1920.
4. Armstrong RC, Le TQ, Frost EE, Borke RC, Vana AC (2002) Absence of fibroblast growth factor 2 promotes oligodendroglial repopulation of demyelinated white matter. J Neurosci 22:8574-8585.
5. Armstrong RC, Le TQ, Flint NC, Vana AC, Zhou YX (2006) Endogenous cell repair of chronic demyelination. J Neuropathol Exp Neurol 65:245-256.
6. Badaruddin DH, Andrews GL, Bolte S, Schilmoeller KJ, Schilmoeller G, Paul LK, Brown WS (2007) Social and behavioral problems of children with agenesis of the corpus callosum. Child Psychiatry Hum Dev 38:287-302.
7. Bando Y, Takakusaki K, Ito S, Terayama R, Kashiwayanagi M, Yoshida S (2008) Differential changes in axonal conduction following CNS demyelination in two mouse models. Eur J Neurosci 28:1731-1742.
8. Bolivar VJ, Walters SR, Phoenix JL (2007) Assessing autism-like behavior in mice: variations in social interactions among inbred strains. Behav Brain Res 176:21-26.
9. Bonzano L, Tacchino A, Roccatagliata L, Abbruzzese G, Mancardi GL, Bove M (2008) Callosal contributions to simultaneous bimanual finger movements. J Neurosci 28:3227-3233.
10. Cody H, Pelphrey K, Piven J (2002) Structural and functional magnetic resonance imaging of autism. Int J Dev Neurosci 20:421-438.
11. Decker L, Picard-Riera N, Lachapelle F, Baron-Van Evercooren A (2002) Growth factor treatment promotes mobilization of young but not aged adult subventricular zone precursors in response to demyelination. J Neurosci Res 69:763-771.
12. Devinsky O, Laff R (2003) Callosal lesions and behavior: history and modern concepts. Epilepsy Behav 4:607-617.
13. Fairless AH, Dow HC, Toledo MM, Malkus KA, Edelmann M, Li H, Talbot K, Arnold SE, Abel T, Brodkin ES (2008) Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strain. Brain Res 1230:211-217.
14. Franco-Pons N, Torrente M, Colomina MT, Vilella E (2007) Behavioral deficits in the cuprizone-induced murine model of demyelination/remyelination. Toxicol Lett 169:205-213.
15. Friederici AD, von Cramon DY, Kotz SA (2007) Role of the corpus callosum in speech comprehension: interfacing syntax and prosody. Neuron 53:135-145.
16. Gadea M, Espert R (2009) A comparison of the effects for sustained versus shifted attention on dichotic listening performance. Laterality 14:315-328.
17. Gean-Marton AD, Vezina LG, Marton KI, Stimac GK, Peyster RG, Taveras JM, Davis KR (1991) Abnormal corpus callosum: a sensitive and specific indicator of multiple sclerosis. Radiology 180:215-221.
18. Gensert JM, Goldman JE (1997) Endogenous progenitors remyelinate demyelinated axons in the adult CNS. Neuron 19:197-203.
19. Groebe A, Clarner T, Baumgartner W, Dang J, Beyer C, Kipp M (2009) Cuprizone treatment induces distinct demyelination, astrocytosis, and microglia cell invasion or proliferation in the mouse cerebellum. Cerebellum, doi:10.1007/s12311-009-0099-3
20. Gudi V, Moharregh-Khiabani D, Skripuletz T, Koutsoudaki PN, Kotsian A, Skuljec J, Trebst C, Stangel M (2009) Regional differences between grey and white matter in cuprizone induced demyelination. Brain Res 1283:127-138.
21. Hiremath MM, Saito Y, Knapp GW, Ting JP, Suzuki K, Matsushima GK (1998) Microglial/macrophage accumulation during cuprizone-induced demyelination in C57BL/6 mice. J Neuroimmunol 92:38-49.
22. Hoffmann K, Lindner M, Groticke I, Stangel M, Loscher W (2008) Epileptic seizures and hippocampal damage after cuprizone-induced demyelination in C57BL/6 mice. Exp Neurol 210:308-321.
23. Jean I, Lavialle C, Barthelaix-Pouplard A, Fressinaud C (2003) Neurotrophin-3 specifically increases mature oligodendrocyte population and enhances remyelination after chemical demyelination of adult rat CNS. Brain Res 972:110-118.
24. Kennerley SW, Diedrichsen J, Hazeltine E, Semjen A, Ivry RB (2002) Callosotomy patients exhibit temporal uncoupling during continuous bimanual movements. Nat Neurosci 5:376-381.
25. Koutsoudaki PN, Skripuletz T, Gudi V, Moharregh-Khiabani D, Hildebrandt H, Trebst C, Stangel M (2009) Demyelination of the hippocampus is prominent in the cuprizone model. Neurosci Lett 451:83-88.
26. Liebetanz D, Merkler D (2006) Effects of commissural de- and remyelination on motor skill behaviour in the cuprizone mouse model of multiple sclerosis. Exp Neurol 202:217-224.
27. Lindner M, Heine S, Haastert K, Garde N, Fokuhl J, Linsmeier F, Grothe C, Baumgartner W, Stangel M (2008) Sequential myelin protein expression during remyelination reveals fast and efficient repair after central nervous system demyelination. Neuropathol Appl Neurobiol 34:105-114.
28. Martola J, Stawiarz L, Fredrikson S, Hillert J, Bergstrom J, Flodmark O, Kristoffersen Wiberg M (2007) Progression of non-age-related callosal brain atrophy in multiple sclerosis: a 9-year longitudinal MRI study representing four decades of disease development. J Neurol Neurosurg Psychiatry 78:375-380.
29. Mason JL, Langaman C, Morell P, Suzuki K, Matsushima GK (2001) Episodic demyelination and subsequent remyelination within the murine central nervous system: changes in axonal calibre. Neuropathol Appl Neurobiol 27:50-58.
30. Matsushima GK, Morell P (2001) The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system. Brain Pathol 11:107-116.
31. Muetzel RL, Collins PF, Mueller BA, Schissel MA, Lim KO, Luciana M (2008) The development of corpus callosum microstructure and associations with bimanual task performance in healthy adolescents. Neuroimage 39:1918-1925.
32. Nicolson R, Szatmari P (2003) Genetic and neurodevelopmental influences in autistic disorder. Can J Psychiatry 48:526-537.
33. Norkute A, Hieble A, Braun A, Johann S, Clarner T, Baumgartner W, Beyer C, Kipp M (2009) Cuprizone treatment induces demyelination and astrocytosis in the mouse hippocampus. J Neurosci Res 87:1343-1355.
34. Paul LK, Brown WS, Adolphs R, Tyszka JM, Richards LJ, Mukherjee P, Sherr EH (2007) Agenesis of the corpus callosum: genetic, developmental and functional aspects of connectivity. Nat Rev Neurosci 8:287-299.
35. Schalomon PM, Wahlsten D (2002) Wheel running behavior is impaired by both surgical section and genetic absence of the mouse corpus callosum. Brain Res Bull 57:27-33.
36. Skripuletz T, Lindner M, Kotsiari A, Garde N, Fokuhl J, Linsmeier F, Trebst C, Stangel M (2008) Cortical demyelination is prominent in the murine cuprizone model and is strain-dependent. Am J Pathol 172:1053-1061.
37. Skripuletz T, Bussmann JH, Gudi V, Koutsoudaki PN, Pul R, Moharregh-Khiabani D, Lindner M, Stangel M (2009) Cerebellar cortical demyelination in the murine cuprizone model. Brain Pathol, doi:10.1111/j.1750- 3639.2009.00271.x
38. Song SK, Yoshino J, Le TQ, Lin SJ, Sun SW, Cross AH, Armstrong RC (2005) Demyelination increases radial diffusivity in corpus callosum of mouse brain. Neuroimage 26:132-140.
39. Tiwari-Woodruff SK, Crawford DK, Song B, Sofroniew MV, Mangiardi M (2009) A critical window: functional recovery of callosal axons following demyelination. J Neurochem 108 (Suppl 1):65.
40. Xu H, Yang HJ, Zhang Y, Clough R, Browning R, Li XM (2009) Behavioral and neurobiological changes in C57BL/6 mice exposed to cuprizone. Behav Neurosci 123:418-429.