Anomalies in social behaviors and exploratory activities in an APPswe/PS1 mouse model of Alzheimer's disease

Physiology and Behavior

Volumn 104, Issue 5, 2011, Pages 880-885

  Filali, Mohammed ^a,b   Lalonde, Robert ^c   Rivest, Serge ^a,b  

^a Université Laval   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

^c UNIVERSITÉ DE ROUEN   (France)

Author keywords

Alzheimer's disease; Anxiety like behaviors; Exploratory activity; Social behavior; Social memory; Transgenic mice

Indexed keywords

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; APATHY; ARTICLE; CONTROLLED STUDY; EXPLORATORY BEHAVIOR; HYPERACTIVITY; MALE; MAZE TEST; MOUSE; NONHUMAN; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL; SOCIAL AVOIDANCE BEHAVIOR; SOCIAL BEHAVIOR; SOCIAL INTERACTION; STIMULUS RESPONSE; STRAIN DIFFERENCE; WILD TYPE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANALYSIS OF VARIANCE; ANIMALS; DISEASE MODELS, ANIMAL; EXPLORATORY BEHAVIOR; HUMANS; MALE; MAZE LEARNING; MEMORY DISORDERS; MENTAL DISORDERS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; PRESENILIN-1; SOCIAL BEHAVIOR; SOCIAL ISOLATION;

EID: 80053050815     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2011.05.023     Document Type: Article

References (29)

1. Chung J.A., Cummings J.L. Neurobehavioral and neuropsychiatric symptoms in Alzheimer's disease. Neurol Clin 2000, 18:829-846.
2. Daffner K.R., Scinto L.F.M., Weintraub S., Guinessey J.E., Mesulam M.M. Diminished curiosity in patients with probable Alzheimer's disease as measured by exploratory eye movements. Neurology 1992, 42:320-328.
3. Frisoni G.B., Rozzini L., Gozetti A., Binetti G., Zanetti O., Bianchetti A., et al. Behavioral syndromes in Alzheimer's disease: description and correlates. Dement Geriatr Cogn Disord 1999, 10:130-138.
4. Holthoff V.A., Beuthien-Baumann B., Kalbe E., Ludecke S., Lenz O., Zundorf G., et al. Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or depression. Biol Psychiatry 2005, 57:412-421.
5. Lyketsos C.G., Lopez O., Jones B., Fitzpatrick A.L., Breitner J., DeKosky S. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. JAMA 2002, 288:1475-1483.
6. Deacon R.M., Koros E., Bornemann K.D., Rawlins J.N. Aged Tg2576 mice are impaired on social memory and open field habituation tests. Behav Brain Res 2009, 197:466-468.
7. Heneka M.T., Ramanathan M., Jacobs A.H., Dumitrescu-Ozimek L., Bilkei-Gorzo A., Debeir T., et al. Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice. J Neurosci 2006, 26:1343-1354.
8. Moy S.S., Nadler J.J., Young N.B., Nonneman R.J., Grossman A.W., Murphy D.L., et al. Social approach in genetically engineered mouse lines relevant to autism. Genes Brain Behav 2009, 8:129-142.
9. Riedel G., Kang S.H., Choi D.Y., Platt B. Scopolamine-induced deficits in social memory in mice: reversal by donepezil. Behav Brain Res 2009, 204:217-225.
10. Borchelt D.R., Ratovitski T., van Lare J., Lee M.K., Gonzales V., Jenkins N.A., et al. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 1997, 19:939-945.
11. Marutle A., Unger C., Hellström-Lindahl E., Wang J., Puoliväli J., Tanila H., et al. Elevated levels of Aβ1-40 and Aβ1-42 do not alter the binding sites of nicotinic receptor subtypes in the brain of APPswe and PS1 double transgenic mice. Neurosci Lett 2002, 328:269-272.
12. Wang J., Tanila H., Puoliväli J., Kadish I., van Groen T. Gender differences in the amount and deposition of amyloidβ in APPswe and PS1 double transgenic mice. Neurobiol Dis 2003, 14:318-327.
13. Rogers D.C., Fisher E.M., Brown S.D., Peters J., Hunter A.J., Martin J.E. Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment. Mamm Genome 1997, 8:711-713.
14. SWE. Neurobiol Dis 2003, 12:194-211.
15. Liu L., Ikonen S., Heikkinen T., Tapiola T., van Groen T., Tanila H. The effects of long-term treatment with metrifonate, a cholinesterase inhibitor, on cholinergic activity, amyloid pathology, and cognitive function in APP and PS1 doubly transgenic mice. Exp Neurol 2002, 173:196-204.
16. Puoliväli J., Wang J., Heikkinen T., Heikkilä M., Tapiola T., van Groen T., et al. Hippocampal Aβ42 levels correlate with spatial memory deficit in APP and PS1 double transgenic mice. Neurobiol Dis 2002, 9:339-347.
17. Filali M., Lalonde R., Rivest S. Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer's disease. Neuropharmacology 2011, 60:930-936.
18. Filali M., Lalonde R. Age-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease. Brain Res 2009, 1292:93-99.
19. Filali M., Lalonde R., Rivest S. Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease. Genes Brain Behav 2009, 8:143-148.
20. Bediou B., Ryff I., Mercier B., Milliery M., Hénaff M.A., D'Amato T., et al. Impaired social cognition in mild Alzheimer disease. J Geriatr Psychiatry Neurol 2009, 22:130-140.
21. Deacon R.M.J., Cholerton L.L., Talbot K., Nair-Roberts R.G., Sanderson D.J., Romberg C., et al. Age-dependent and -independent behavioral deficits in Tg2576 mice. Behav Brain Res 2008, 189:126-138.
22. King D.L., Arendash G.W. Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19months. Physiol Behav 2002, 75:627-642.
23. Gil-Bea F.J., Aisa B., Schliebs R., Ramirez M.J. Increase of locomotor activity underlying the behavioral disinhibition in Tg2576 mice. Behav Neurosci 2007, 121:340-344.
24. 695SWE (Tg2576) mice with the Swedish mutation. Brain Res 2003, 977:38-45.
25. Middei S., Daniele S., Caprioli A., Ghirardi O., Ammassari-Teule M. Progressive cognitive decline in a transgenic mouse model of Alzheimer's disease overexpressing mutant hAPPswe. Genes Brain Behav 2006, 5:249-256.
26. Dumont M., Strazielle C., Staufenbiel M., Lalonde R. Spatial learning and exploration of environmental stimuli in 24-month-old female APP23 transgenic mice with the Swedish mutation. Brain Res 2004, 1024:113-121.
27. Senechal Y., Prut L., Kelly P.H., Staufenbiel M., Natt F., Hoyer D., et al. Increased exploratory activity of APP23 mice in a novel environment is reversed by siRNA. Brain Res 2008, 1243:124-133.
28. Hooijmans C.R., Van der Zee C.E., Dederen P.J., Brouwer K.M., Reijmer Y.D., van Groen T., et al. DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice. Neurobiol Dis 2009, 33:482-498.
29. 695SWE/co+PS1/ΔE9 mice with amyloid plaques. Neurosci Lett 2005, 390:87-92.