The citrus flavonoid hesperidin induces p53 and inhibits NF-κB activation in order to trigger apoptosis in NALM-6 cells: Involvement of PPARγ-dependent mechanism

European Journal of Nutrition

Volumn 51, Issue 1, 2012, Pages 39-46

  Ghorbani, Asghar ^a   Nazari, Maryam ^a   Jeddi Tehrani, Mahmood ^b   Zand, Hamid ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b AVICENNA RESEARCH INSTITUTE   (Iran)

Author keywords

Hesperidin; Ikappa B; NF kappaB; P53; PPAR gamma

Indexed keywords

CASPASE; CASPASE 3; CASPASE 9; HESPERIDIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; X LINKED INHIBITOR OF APOPTOSIS;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BIOACCUMULATION; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; UPREGULATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CITRUS; FRUIT; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HESPERIDIN; HUMANS; I-KAPPA B PROTEINS; NEOPLASM PROTEINS; NF-KAPPA B; PHOSPHORYLATION; PPAR GAMMA; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA, MESSENGER; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53;

CITRUS;

EID: 84859886313     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-011-0187-2     Document Type: Article

References (35)

1. Ou S (2002) Pharmacological action of hesperidin. Zhong Yao Cai 25(7):531-533
2. Benavente-Garcia O, Castillo J (2008) Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. J Agric Food Chem 56(15):6185-6205
3. Park HJ, Kim MJ, Ha E, Chung JH (2008) Apoptotic effect of hesperidin through caspase3 activation in human colon cancer cells, SNU-C4. Phytomedicine 15(1-2):147-151 (Pubitemid 350297903)
4. Patil JR, Chidambara Murthy KN, Jayaprakasha GK, Chetti MB, Patil BS (2009) Bioactive compounds from Mexican lime (Citrus aurantifolia) juice induce apoptosis in human pancreatic cells. J Agric Food Chem 57(22):10933-10942
5. Salam NK, Huang TH, Kota BP, Kim MS, Li Y, Hibbs DE (2008) Novel PPAR-gamma agonists identified from a natural product library: a virtual screening, induced-fit docking and biological assay study. Chem Biol Drug Des 71(1):57-70
6. Vanden Heuvel JP (1999) Peroxisome proliferator-activated receptors (PPARS) and carcinogenesis. Toxicol Sci 47(1):1-8
7. Hihi AK, Michalik L, Wahli W (2002) PPARs: transcriptional effectors of fatty acids and their derivatives. Cell Mol Life Sci 59(5):790-798 (Pubitemid 34628240)
8. Ondrey F (2009) Peroxisome proliferator-activated receptor gamma pathway targeting in carcinogenesis: implications for chemoprevention. Clin Cancer Res 15(1):2-8
9. Agarwal ML, Agarwal A, Taylor WR, Stark GR (1995) p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc Natl Acad Sci USA 92(18):8493-8497
10. Boland MP (2001) DNA damage signalling and NF-kappaB: implications for survival and death in mammalian cells. Biochem Soc Trans 29(Pt 6):674-678 (Pubitemid 33131758)
11. Weston VJ, Austen B, Wei W, Marston E, Alvi A, Lawson S, Darbyshire PJ, Griffiths M, Hill F, Mann JR, Moss PA, Taylor AM, Stankovic T (2004) Apoptotic resistance to ionizing radiation in pediatric B-precursor acute lymphoblastic leukemia frequently involves increased NF-kappaB survival pathway signaling. Blood 104(5):1465-1473 (Pubitemid 39166526)
12. Burns TF, El-Deiry WS (1999) The p53 pathway and apoptosis. J Cell Physiol 181(2):231-239 (Pubitemid 29463638)
13. Leesnitzer LM, Parks DJ, Bledsoe RK, Cobb JE, Collins JL, Consler TG, Davis RG, Hull-Ryde EA, Lenhard JM, Patel L, Plunket KD, Shenk JL, Stimmel JB, Therapontos C, Willson TM, Blanchard SG (2002) Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662. Biochemistry 41(21):6640-6650 (Pubitemid 34547354)
14. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65(1-2):55-63 (Pubitemid 14203433)
15. Hawkins CJ, Vaux DL (1997) The role of the Bcl-2 family of apoptosis regulatory proteins in the immune system. Semin Immunol 9(1):25-33 (Pubitemid 27166009)
16. Yang YL, Li XM (2000) The IAP family: endogenous caspase inhibitors with multiple biological activities. Cell Res 10(3):169-177
17. Hampel JK, Brownrigg LM, Vignarajah D, Croft KD, Dharmarajan AM, Bentel JM, Puddey IB, Yeap BB (2006) Differential modulation of cell cycle, apoptosis and PPARgamma2 gene expression by PPARgamma agonists ciglitazone and 9-hydroxyoctadecadienoic acid in monocytic cells. Prostaglandins Leukot Essent Fatty Acids 74(5):283-293
18. Bonofiglio D, Aquila S, Catalano S, Gabriele S, Belmonte M, Middea E, Qi H, Morelli C, Gentile M, Maggiolini M, Ando S (2006) Peroxisome proliferator-activated receptor-gamma activates p53 gene promoter binding to the nuclear factor-kappaB sequence in human MCF7 breast cancer cells. Mol Endocrinol 20(12):3083-3092 (Pubitemid 44833557)
19. Karin M, Ben-Neriah Y (2000) Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol 18:621-663 (Pubitemid 30365393)
20. Zhou M, Gu L, Zhu N, Woods WG, Findley HW (2003) Transfection of a dominant-negative mutant NF-kB inhibitor (IkBm) represses p53-dependent apoptosis in acute lymphoblastic leukemia cells: interaction of IkBm and p53. Oncogene 22(50):8137-8144 (Pubitemid 37487304)
21. Beecher GR (2003) Overview of dietary flavonoids: nomenclature, occurrence and intake. J Nutr 133(10):3248S-3254S (Pubitemid 37222252)
22. Fresco P, Borges F, Diniz C, Marques MP (2006) New insights on the anticancer properties of dietary polyphenols. Med Res Rev 26(6):747-766 (Pubitemid 44735552)
23. Shinjyo T, Kurosawa H, Miyagi J, Ohama K, Masuda M, Nagasaki A, Matsui H, Inaba T, Furukawa Y, Takasu N (2008) Ras-mediated up-regulation of survivin expression in cytokinedependent murine pro-B lymphocytic cells. Tohoku J Exp Med 216(1):25-34
24. Sarkar FH, Li Y, Wang Z, Kong D (2009) Cellular signaling perturbation by natural products. Cell Signal 21(11):1541-1547
25. Xu L, Zhang L, Bertucci AM, Pope RM, Datta SK (2008) Apigenin, a dietary flavonoid, sensitizes human T cells for activationinduced cell death by inhibiting PKB/Akt and NF-kappaB activation pathway. Immunol Lett 121(1):74-83
26. Khan N, Afaq F, Syed DN, Mukhtar H (2008) Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells. Carcinogenesis 29(5):1049-1056 (Pubitemid 351982251)
27. Li Y, Wang Z, Kong D, Li R, Sarkar SH, Sarkar FH (2008) Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells. J Biol Chem 283(41):27707-27716
28. Gaetano C, Colussi C, Capogrossi MC (2007) PEDF, PPAR-gamma, p53: deadly circuits arise when worlds collide. Cardiovasc Res 76(2):195-196 (Pubitemid 350198602)
29. Ho TC, Chen SL, Yang YC, Liao CL, Cheng HC, Tsao YP (2007) PEDF induces p53-mediated apoptosis through PPAR gamma signaling in human umbilical vein endothelial cells. Cardiovasc Res 76(2):213-223
30. Sarkar FH, Li Y (2008) NF-kappaB: a potential target for cancer chemoprevention and therapy. Front Biosci 13:2950-2959 (Pubitemid 351589211)
31. Horie R, Watanabe T, Umezawa K (2006) Blocking NF-kappaB as a potential strategy to treat adult T-cell leukemia/lymphoma. Drug News Perspect 19(4):201-209 (Pubitemid 44431062)
32. Bremner P, Heinrich M (2002) Natural products as targeted modulators of the nuclear factor-kappaB pathway. J Pharm Pharmacol 54(4):453-472 (Pubitemid 34308488)
33. Ringseis R, Gahler S, Eder K (2008) Conjugated linoleic acid isomers inhibit platelet-derived growth factor-induced NF-kappaB transactivation and collagen formation in human vascular smooth muscle cells. Eur J Nutr 47(2):59-67
34. Ohga S, Shikata K, Yozai K, Okada S, Ogawa D, Usui H, Wada J, Shikata Y, Makino H (2007) Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-kappaB activation. Am J Physiol Renal Physiol 292(4):F1141-F1150 (Pubitemid 46578056)
35. Eligini S, Banfi C, Brambilla M, Camera M, Barbieri SS, Poma F, Tremoli E, Colli S (2002) 15-deoxy-delta12, 14-prostaglandin J2 inhibits tissue factor expression in human macrophages and endothelial cells: evidence for ERK1/2 signaling pathway blockade. Thromb Haemost 88(3):524-532 (Pubitemid 35021614)