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Volumn 28, Issue 1, 2015, Pages 14-29

Etiologic field effect: Reappraisal of the field effect concept in cancer predisposition and progression

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BREAST CARCINOMA; CANCER GROWTH; CANCER SUSCEPTIBILITY; CARCINOGENESIS; COLORECTAL CANCER; ENVIRONMENTAL EXPOSURE; EPIGENETICS; ETIOLOGIC FIELD EFFECT; GENOMICS; METABOLOMICS; PROTEOMICS; TRANSCRIPTOMICS; TUMOR MICROENVIRONMENT; ANIMAL; DISEASE COURSE; HUMAN; NEOPLASMS; PATHOLOGY;

EID: 84920643243     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2014.81     Document Type: Article
Times cited : (165)

References (245)
  • 1
    • 84860214990 scopus 로고    scopus 로고
    • Intra-tumor heterogeneity: A looking glass for cancer
    • Marusyk A, Almendro V, Polyak K. Intra-tumor heterogeneity: a looking glass for cancer. Nat Rev Cancer 2012;12:323-334.
    • (2012) Nat Rev Cancer , vol.12 , pp. 323-334
    • Marusyk, A.1    Almendro, V.2    Polyak, K.3
  • 2
    • 77954938591 scopus 로고    scopus 로고
    • Future of personalized medicine in oncology: A systems biology approach
    • Gonzalez-Angulo AM, Hennessy BT, Mills GB. Future of personalized medicine in oncology: a systems biology approach. J Clin Oncol 2010;28: 2777-2783.
    • (2010) J Clin Oncol , vol.28 , pp. 2777-2783
    • Gonzalez-Angulo, A.M.1    Hennessy, B.T.2    Mills, G.B.3
  • 3
    • 82555191051 scopus 로고    scopus 로고
    • Cancer immunology-analysis of host and tumor factors for personalized medicine
    • Ogino S, Galon J, Fuchs CS, et al. Cancer immunology-analysis of host and tumor factors for personalized medicine. Nat Rev Clin Oncol 2011;8:711-719.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 711-719
    • Ogino, S.1    Galon, J.2    Fuchs, C.S.3
  • 4
    • 84863989936 scopus 로고    scopus 로고
    • A bacterial driver-passenger model for colorectal cancer: Beyond the usual suspects
    • Tjalsma H, Boleij A, Marchesi JR, et al. A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects. Nat Rev Microbiol 2012;10: 575-582.
    • (2012) Nat Rev Microbiol , vol.10 , pp. 575-582
    • Tjalsma, H.1    Boleij, A.2    Marchesi, J.R.3
  • 5
    • 80053144962 scopus 로고    scopus 로고
    • A decade of exploring the cancer epigenome-biological and translational implications
    • Baylin SB, Jones PA. A decade of exploring the cancer epigenome-biological and translational implications. Nat Rev Cancer 2011;11:726-734.
    • (2011) Nat Rev Cancer , vol.11 , pp. 726-734
    • Baylin, S.B.1    Jones, P.A.2
  • 6
    • 84875417532 scopus 로고    scopus 로고
    • Current perspective on the global and United States cancer burden attributable to lifestyle and environmental risk factors
    • Schottenfeld D, Beebe-Dimmer JL, Buffler PA, et al. Current perspective on the global and United States cancer burden attributable to lifestyle and environmental risk factors. Annu Rev Public Health 2013; 34:97-117.
    • (2013) Annu Rev Public Health , vol.34 , pp. 97-117
    • Schottenfeld, D.1    Beebe-Dimmer, J.L.2    Buffler, P.A.3
  • 8
    • 80052333832 scopus 로고    scopus 로고
    • Genetics, genomics, and cancer risk assessment: State of the art and future directions in the era of personalized medicine
    • Weitzel JN, Blazer KR, Macdonald DJ, et al. Genetics, genomics, and cancer risk assessment: state of the art and future directions in the era of personalized medicine. CA Cancer J Clin 2011;61:327-359.
    • (2011) CA Cancer J Clin , vol.61 , pp. 327-359
    • Weitzel, J.N.1    Blazer, K.R.2    MacDonald, D.J.3
  • 9
    • 84864631878 scopus 로고    scopus 로고
    • Hotspot oncomutations: Implications for personalized cancer treatment
    • Myers MB, Wang Y, McKim KL, et al. Hotspot oncomutations: implications for personalized cancer treatment. Expert Rev Mol Diagn 2012;12:603-620.
    • (2012) Expert Rev Mol Diagn , vol.12 , pp. 603-620
    • Myers, M.B.1    Wang, Y.2    McKim, K.L.3
  • 10
    • 84880712727 scopus 로고    scopus 로고
    • Clinical advances in molecular biomarkers for cancer diagnosis and therapy
    • Sethi S, Ali S, Phillip PA, et al. Clinical advances in molecular biomarkers for cancer diagnosis and therapy. Int J Mol Sci 2013;14:14771-14784.
    • (2013) Int J Mol Sci , vol.14 , pp. 14771-14784
    • Sethi, S.1    Ali, S.2    Phillip, P.A.3
  • 11
    • 78651056338 scopus 로고
    • Field cancerization in oral stratified squamous epithelium; Clinical implications of multicentric origin
    • Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer 1953;6:963-968.
    • (1953) Cancer , vol.6 , pp. 963-968
    • Slaughter, D.P.1    Southwick, H.W.2    Smejkal, W.3
  • 12
    • 67650496219 scopus 로고    scopus 로고
    • Cancer prevention: From 1727 to milestones of the past 100 years
    • Lippman SM, Hawk ET. Cancer prevention: from 1727 to milestones of the past 100 years. Cancer Res 2009;69:5269-5284.
    • (2009) Cancer Res , vol.69 , pp. 5269-5284
    • Lippman, S.M.1    Hawk, E.T.2
  • 13
    • 64749109723 scopus 로고    scopus 로고
    • Multifocal lung cancers-clonality vs field cancerization and does it matter?
    • Gazdar AF, Minna JD. Multifocal lung cancers-clonality vs field cancerization and does it matter? J Natl Cancer Inst 2009;101:541-543.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 541-543
    • Gazdar, A.F.1    Minna, J.D.2
  • 14
    • 25144474539 scopus 로고    scopus 로고
    • DNA methylation, field effects, and colorectal cancer
    • Giovannucci E, Ogino S. DNA methylation, field effects, and colorectal cancer. J Natl Cancer Inst 2005;97:1317-1319.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1317-1319
    • Giovannucci, E.1    Ogino, S.2
  • 15
    • 34047190317 scopus 로고    scopus 로고
    • Epigenetic field for cancerization
    • Ushijima T. Epigenetic field for cancerization. J Biochem Mol Biol 2007;40:142-150.
    • (2007) J Biochem Mol Biol , vol.40 , pp. 142-150
    • Ushijima, T.1
  • 17
    • 73349132626 scopus 로고    scopus 로고
    • Field effect in cancer-an update
    • Chai H, Brown RE. Field effect in cancer-an update. Ann Clin Lab Sci 2009;39:331-337.
    • (2009) Ann Clin Lab Sci , vol.39 , pp. 331-337
    • Chai, H.1    Brown, R.E.2
  • 18
    • 84862259579 scopus 로고    scopus 로고
    • DNA methylation and field cancerization
    • Ramachandran K, Singal R. DNA methylation and field cancerization. Epigenomics 2012;4:243-245.
    • (2012) Epigenomics , vol.4 , pp. 243-245
    • Ramachandran, K.1    Singal, R.2
  • 20
    • 39149138136 scopus 로고    scopus 로고
    • A macrophage gene expression signature defines a field effect in the lung tumor microenvironment
    • Stearman RS, Dwyer-Nield L, Grady MC, et al. A macrophage gene expression signature defines a field effect in the lung tumor microenvironment. Cancer Res 2008;68:34-43.
    • (2008) Cancer Res , vol.68 , pp. 34-43
    • Stearman, R.S.1    Dwyer-Nield, L.2    Grady, M.C.3
  • 21
    • 77954162846 scopus 로고    scopus 로고
    • Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells
    • Martinez-Outschoorn UE, Balliet RM, Rivadeneira DB, et al. Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells. Cell Cycle 2010;9:3256-3276.
    • (2010) Cell Cycle , vol.9 , pp. 3256-3276
    • Martinez-Outschoorn, U.E.1    Balliet, R.M.2    Rivadeneira, D.B.3
  • 22
    • 77953361444 scopus 로고    scopus 로고
    • Could stroma contribute to field cancerization?
    • Ge L, MengW, Zhou H, et al. Could stroma contribute to field cancerization? Med Hypotheses 2010;75: 26-31.
    • (2010) Med Hypotheses , vol.75 , pp. 26-31
    • Ge, L.1    Meng, W.2    Zhou, H.3
  • 23
    • 84861971342 scopus 로고    scopus 로고
    • Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling
    • Hu B, Castillo E, Harewood L, et al. Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell 2012;149: 1207-1220.
    • (2012) Cell , vol.149 , pp. 1207-1220
    • Hu, B.1    Castillo, E.2    Harewood, L.3
  • 24
    • 84861971346 scopus 로고    scopus 로고
    • Field cancerization: Something new under the sun
    • Vanharanta S, Massague J. Field cancerization: something new under the sun. Cell 2012;149:1179-1181.
    • (2012) Cell , vol.149 , pp. 1179-1181
    • Vanharanta, S.1    Massague, J.2
  • 25
    • 84861186736 scopus 로고    scopus 로고
    • Jekyll and Hyde: The role of the microenvironment on the progression of cancer
    • Allen M, Louise Jones J. Jekyll and Hyde: the role of the microenvironment on the progression of cancer. J Pathol 2011;223:162-176.
    • (2011) J Pathol , vol.223 , pp. 162-176
    • Allen, M.1    Louise Jones, J.2
  • 26
    • 84892444009 scopus 로고    scopus 로고
    • The association of immune cell infiltration and prognosis in colorectal cancer
    • Palmqvist R, Wikberg ML, Ling A, et al. The association of immune cell infiltration and prognosis in colorectal cancer. Curr Colorectal Cancer Rep 2013;9:372-379.
    • (2013) Curr Colorectal Cancer Rep , vol.9 , pp. 372-379
    • Palmqvist, R.1    Wikberg, M.L.2    Ling, A.3
  • 27
    • 84890280907 scopus 로고    scopus 로고
    • Towards the introduction of the Immunoscore in the classification of malignant tumors
    • Galon J, Mlecnik B, Bindea G, et al. Towards the introduction of the Immunoscore in the classification of malignant tumors. J Pathol 2014;232:199-209.
    • (2014) J Pathol , vol.232 , pp. 199-209
    • Galon, J.1    Mlecnik, B.2    Bindea, G.3
  • 28
    • 70350225838 scopus 로고    scopus 로고
    • Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype
    • Ogino S, Nosho K, Irahara N, et al. Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype. Clin Cancer Res 2009;15: 6412-6420.
    • (2009) Clin Cancer Res , vol.15 , pp. 6412-6420
    • Ogino, S.1    Nosho, K.2    Irahara, N.3
  • 29
    • 78349277576 scopus 로고    scopus 로고
    • Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer and prognosis: Cohort study and literature review
    • Nosho K, Baba Y, Tanaka N, et al. Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer and prognosis: cohort study and literature review. J Pathol 2010;222:350-366.
    • (2010) J Pathol , vol.222 , pp. 350-366
    • Nosho, K.1    Baba, Y.2    Tanaka, N.3
  • 30
    • 79955622234 scopus 로고    scopus 로고
    • Colorectal cancer prognosis depends on T-cell infiltration and molecular characteristics of the tumor
    • Dahlin AM, Henriksson ML, Van Guelpen B, et al. Colorectal cancer prognosis depends on T-cell infiltration and molecular characteristics of the tumor. Mod Pathol 2011;24:671-682.
    • (2011) Mod Pathol , vol.24 , pp. 671-682
    • Dahlin, A.M.1    Henriksson, M.L.2    Van Guelpen, B.3
  • 31
    • 84858800620 scopus 로고    scopus 로고
    • The immune contexture in human tumours: Impact on clinical outcome
    • Fridman WH, Pages F, Sautes-Fridman C, et al. The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer 2012;12:298-306.
    • (2012) Nat Rev Cancer , vol.12 , pp. 298-306
    • Fridman, W.H.1    Pages, F.2    Sautes-Fridman, C.3
  • 32
    • 84867504992 scopus 로고    scopus 로고
    • The distribution of macrophages with a m1 or m2 phenotype in relation to prognosis and the molecular characteristics of colorectal cancer
    • Edin S, Wikberg ML, Dahlin AM, et al. The distribution of macrophages with a m1 or m2 phenotype in relation to prognosis and the molecular characteristics of colorectal cancer. PloS One 2012;7:e47045.
    • (2012) PloS One , vol.7 , pp. e47045
    • Edin, S.1    Wikberg, M.L.2    Dahlin, A.M.3
  • 33
    • 77949772292 scopus 로고    scopus 로고
    • Gene-environment-wide association studies: Emerging approaches
    • Thomas D. Gene-environment-wide association studies: emerging approaches. Nat Rev Genet 2010;11: 259-272.
    • (2010) Nat Rev Genet , vol.11 , pp. 259-272
    • Thomas, D.1
  • 34
    • 84862208611 scopus 로고    scopus 로고
    • Physical activity, biomarkers, and disease outcomes in cancer survivors: A systematic review
    • Ballard-Barbash R, Friedenreich CM, Courneya KS, et al. Physical activity, biomarkers, and disease outcomes in cancer survivors: a systematic review. J Natl Cancer Inst 2012;104:815-840.
    • (2012) J Natl Cancer Inst , vol.104 , pp. 815-840
    • Ballard-Barbash, R.1    Friedenreich, C.M.2    Courneya, K.S.3
  • 35
    • 85047687568 scopus 로고    scopus 로고
    • The role of body mass index, physical activity, and diet in colorectal cancer recurrence and survival: A review of the literature
    • Vrieling A, Kampman E. The role of body mass index, physical activity, and diet in colorectal cancer recurrence and survival: a review of the literature. Am J Clin Nutr 2010;92:471-490.
    • (2010) Am J Clin Nutr , vol.92 , pp. 471-490
    • Vrieling, A.1    Kampman, E.2
  • 36
    • 0037446974 scopus 로고    scopus 로고
    • A genetic explanation of Slaughter's concept of field cancerization: Evidence and clinical implications
    • Braakhuis BJM, Tabor MP, Kummer JA, et al. A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications. Cancer Res 2003;63:1727-1730.
    • (2003) Cancer Res , vol.63 , pp. 1727-1730
    • Braakhuis, B.J.M.1    Tabor, M.P.2    Kummer, J.A.3
  • 37
    • 70350212955 scopus 로고    scopus 로고
    • Mammary field cancerization: Molecular evidence and clinical importance
    • Heaphy CM, Griffith JK, Bisoffi M. Mammary field cancerization: molecular evidence and clinical importance. Breast Cancer Res Treat 2009;118:229-239.
    • (2009) Breast Cancer Res Treat , vol.118 , pp. 229-239
    • Heaphy, C.M.1    Griffith, J.K.2    Bisoffi, M.3
  • 38
    • 0030772811 scopus 로고    scopus 로고
    • Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis
    • Franklin WA, Gazdar AF, Haney J, et al. Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis. J Clin Invest 1997;100:2133-2137.
    • (1997) J Clin Invest , vol.100 , pp. 2133-2137
    • Franklin, W.A.1    Gazdar, A.F.2    Haney, J.3
  • 39
    • 0033214611 scopus 로고    scopus 로고
    • P53-mutant clones and field effects in Barrett's esophagus
    • Prevo LJ, Sanchez CA, Galipeau PC, et al. p53-mutant clones and field effects in Barrett's esophagus. Cancer Res 1999;59:4784-4787.
    • (1999) Cancer Res , vol.59 , pp. 4784-4787
    • Prevo, L.J.1    Sanchez, C.A.2    Galipeau, P.C.3
  • 40
    • 0036605097 scopus 로고    scopus 로고
    • Molecular evidence of a common clonal origin and subsequent divergent clonal evolution in vulval intraepithelial neoplasia, vulval squamous cell carcinoma and lymph node metastases
    • Rosenthal AN, Ryan A, Hopster D, et al. Molecular evidence of a common clonal origin and subsequent divergent clonal evolution in vulval intraepithelial neoplasia, vulval squamous cell carcinoma and lymph node metastases. Int J Cancer 2002;99:549-554.
    • (2002) Int J Cancer , vol.99 , pp. 549-554
    • Rosenthal, A.N.1    Ryan, A.2    Hopster, D.3
  • 41
    • 0032927128 scopus 로고    scopus 로고
    • Monoclonality and surface lesion-specific microsatellite alterations in premalignant and malignant neoplasia of uterine cervix: A local field effect of genomic instability and clonal evolution
    • Chu TY, Shen CY, Lee HS, et al. Monoclonality and surface lesion-specific microsatellite alterations in premalignant and malignant neoplasia of uterine cervix: a local field effect of genomic instability and clonal evolution. Genes Chromosomes Cancer 1999;24:127-134.
    • (1999) Genes Chromosomes Cancer , vol.24 , pp. 127-134
    • Chu, T.Y.1    Shen, C.Y.2    Lee, H.S.3
  • 42
    • 33646504142 scopus 로고    scopus 로고
    • Telomere DNA content and allelic imbalance demonstrate field cancerization in histologically normal tissue adjacent to breast tumors
    • Heaphy CM, Bisoffi M, Fordyce CA, et al. Telomere DNA content and allelic imbalance demonstrate field cancerization in histologically normal tissue adjacent to breast tumors. Int J Cancer 2006;119:108-116.
    • (2006) Int J Cancer , vol.119 , pp. 108-116
    • Heaphy, C.M.1    Bisoffi, M.2    Fordyce, C.A.3
  • 43
    • 0032535274 scopus 로고    scopus 로고
    • Clonal and chronological genetic analysis of multifocal cancers of the bladder and upper urinary tract
    • Takahashi T, Habuchi T, Kakehi Y, et al. Clonal and chronological genetic analysis of multifocal cancers of the bladder and upper urinary tract. Cancer Res 1998;58:5835-5841.
    • (1998) Cancer Res , vol.58 , pp. 5835-5841
    • Takahashi, T.1    Habuchi, T.2    Kakehi, Y.3
  • 44
    • 58349086191 scopus 로고    scopus 로고
    • Carcinomas of the pancreas, gallbladder, extrahepatic bile ducts, and ampulla of vater share a field for carcinogenesis: A population-based study
    • Henson DE, Schwartz AM, Nsouli H, et al. Carcinomas of the pancreas, gallbladder, extrahepatic bile ducts, and ampulla of vater share a field for carcinogenesis: a population-based study. Arch Pathol Lab Med 2009;133:67-71.
    • (2009) Arch Pathol Lab Med , vol.133 , pp. 67-71
    • Henson, D.E.1    Schwartz, A.M.2    Nsouli, H.3
  • 45
    • 33845864987 scopus 로고    scopus 로고
    • Field cancerization' in the urothelium of the bladder
    • Davidson DD, Cheng L. 'Field cancerization' in the urothelium of the bladder. Anal Quant Cytol Histol 2006;28:337-338.
    • (2006) Anal Quant Cytol Histol , vol.28 , pp. 337-338
    • Davidson, D.D.1    Cheng, L.2
  • 46
    • 25144518262 scopus 로고    scopus 로고
    • MGMT promoter methylation and field defect in sporadic colorectal cancer
    • Shen L, Kondo Y, Rosner GL, et al. MGMT promoter methylation and field defect in sporadic colorectal cancer. J Natl Cancer Inst 2005;97:1330-1338.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1330-1338
    • Shen, L.1    Kondo, Y.2    Rosner, G.L.3
  • 47
    • 0035328527 scopus 로고    scopus 로고
    • Accelerated agerelated CpG island methylation in ulcerative colitis
    • Issa JP, Ahuja N, Toyota M, et al. Accelerated agerelated CpG island methylation in ulcerative colitis. Cancer Res 2001;61:3573-3577.
    • (2001) Cancer Res , vol.61 , pp. 3573-3577
    • Issa, J.P.1    Ahuja, N.2    Toyota, M.3
  • 48
    • 0034665332 scopus 로고    scopus 로고
    • Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma
    • Eads CA, Lord RV, Kurumboor SK, et al. Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma. Cancer Res 2000;60:5021-5026.
    • (2000) Cancer Res , vol.60 , pp. 5021-5026
    • Eads, C.A.1    Lord, R.V.2    Kurumboor, S.K.3
  • 49
    • 17744394862 scopus 로고    scopus 로고
    • Hypermethylation at 9q32-33 tumour suppressor region is age-related in normal urothelium and an early and frequent alteration in bladder cancer
    • Habuchi T, Takahashi T, Kakinuma H, et al. Hypermethylation at 9q32-33 tumour suppressor region is age-related in normal urothelium and an early and frequent alteration in bladder cancer. Oncogene 2001;20:531-537.
    • (2001) Oncogene , vol.20 , pp. 531-537
    • Habuchi, T.1    Takahashi, T.2    Kakinuma, H.3
  • 50
    • 4143132121 scopus 로고    scopus 로고
    • Promoter hypermethylation of resected bronchial margins: A field defect of changes?
    • Guo M, House MG, Hooker C, et al. Promoter hypermethylation of resected bronchial margins: a field defect of changes? Clin Cancer Res 2004;10: 5131-5136.
    • (2004) Clin Cancer Res , vol.10 , pp. 5131-5136
    • Guo, M.1    House, M.G.2    Hooker, C.3
  • 51
    • 33845333815 scopus 로고    scopus 로고
    • Mapping geographic zones of cancer risk with epigenetic biomarkers in normal breast tissue
    • Yan PS, Venkataramu C, Ibrahim A, et al. Mapping geographic zones of cancer risk with epigenetic biomarkers in normal breast tissue. Clin Cancer Res 2006;12:6626-6636.
    • (2006) Clin Cancer Res , vol.12 , pp. 6626-6636
    • Yan, P.S.1    Venkataramu, C.2    Ibrahim, A.3
  • 52
    • 84870552726 scopus 로고    scopus 로고
    • DNA demethylation in normal colon tissue predicts predisposition to multiple cancers
    • Kamiyama H, Suzuki K, Maeda T, et al. DNA demethylation in normal colon tissue predicts predisposition to multiple cancers. Oncogene 2012;31: 5029-5037.
    • (2012) Oncogene , vol.31 , pp. 5029-5037
    • Kamiyama, H.1    Suzuki, K.2    Maeda, T.3
  • 53
    • 84876921470 scopus 로고    scopus 로고
    • FHL1 on chromosome X is a single-hit gastrointestinal tumor-suppressor gene and contributes to the formation of an epigenetic field defect
    • Asada K, Ando T, Niwa T, et al. FHL1 on chromosome X is a single-hit gastrointestinal tumor-suppressor gene and contributes to the formation of an epigenetic field defect. Oncogene 2013;32:2140-2149.
    • (2013) Oncogene , vol.32 , pp. 2140-2149
    • Asada, K.1    Ando, T.2    Niwa, T.3
  • 54
    • 84876458283 scopus 로고    scopus 로고
    • LINE-1 hypomethylation in noncancerous esophageal mucosae is associated with smoking history
    • Shigaki H, Baba Y, Watanabe M, et al. LINE-1 hypomethylation in noncancerous esophageal mucosae is associated with smoking history. Ann Surg Oncol 2012;19:4238-4243.
    • (2012) Ann Surg Oncol , vol.19 , pp. 4238-4243
    • Shigaki, H.1    Baba, Y.2    Watanabe, M.3
  • 55
    • 84892842111 scopus 로고    scopus 로고
    • The topography of DNA methylation in the non-neoplastic colonic mucosa surrounding colorectal cancers
    • Subramaniam MM, Loh M, Chan JY, et al. The topography of DNA methylation in the non-neoplastic colonic mucosa surrounding colorectal cancers. Mol Carcinog 2013;53:98-108.
    • (2013) Mol Carcinog , vol.53 , pp. 98-108
    • Subramaniam, M.M.1    Loh, M.2    Chan, J.Y.3
  • 56
    • 84866690207 scopus 로고    scopus 로고
    • Dysregulation of MicroRNAs in colonic field carcinogenesis: Implications for screening
    • Kunte DP, Delacruz M, Wali RK, et al. Dysregulation of MicroRNAs in colonic field carcinogenesis: implications for screening. PloS One 2012;7:e45591.
    • (2012) PloS One , vol.7 , pp. e45591
    • Kunte, D.P.1    Delacruz, M.2    Wali, R.K.3
  • 57
    • 84869808619 scopus 로고    scopus 로고
    • Epigenetics of colorectal cancer
    • Goel A, Boland CR. Epigenetics of colorectal cancer. Gastroenterology 2012;143:1442-60e1.
    • (2012) Gastroenterology , vol.143 , pp. 1442-60e1
    • Goel, A.1    Boland, C.R.2
  • 58
    • 16444376397 scopus 로고    scopus 로고
    • The hydra phenomenon of cancer: Why tumors recur locally after microscopically complete resection
    • Hockel A, Dornhofer N. The hydra phenomenon of cancer: why tumors recur locally after microscopically complete resection. Cancer Res. 2005;65:2997-3002.
    • (2005) Cancer Res , vol.65 , pp. 2997-3002
    • Hockel, A.1    Dornhofer, N.2
  • 59
    • 77952987104 scopus 로고    scopus 로고
    • Airway PI3K pathway activation is an early and reversible event in lung cancer development
    • Gustafson AM, Soldi R, Anderlind C, et al. Airway PI3K pathway activation is an early and reversible event in lung cancer development. Sci Transl Med 2010;2:26ra5.
    • (2010) Sci Transl Med , vol.2 , pp. 26ra5
    • Gustafson, A.M.1    Soldi, R.2    Anderlind, C.3
  • 60
    • 70349199854 scopus 로고    scopus 로고
    • Molecular determinants of tumor recurrence in the urinary bladder
    • Cheng L, Zhang S, Davidson DD, et al. Molecular determinants of tumor recurrence in the urinary bladder. Future Oncol 2009;5:843-857.
    • (2009) Future Oncol , vol.5 , pp. 843-857
    • Cheng, L.1    Zhang, S.2    Davidson, D.D.3
  • 61
    • 61749088394 scopus 로고    scopus 로고
    • The field of tissue injury in the lung and airway
    • Steiling K, Ryan J, Brody JS, et al. The field of tissue injury in the lung and airway. Cancer Prev Res (Phila) 2008;1:396-403.
    • (2008) Cancer Prev Res (Phila) , vol.1 , pp. 396-403
    • Steiling, K.1    Ryan, J.2    Brody, J.S.3
  • 62
    • 0033396361 scopus 로고    scopus 로고
    • Surrogate anatomic/functional sites for evaluating cancer risk: An extension of the field effect
    • Kopelovich L, Henson DE, Gazdar AF, et al. Surrogate anatomic/functional sites for evaluating cancer risk: an extension of the field effect. Clin Cancer Res 1999;5:3899-3905.
    • (1999) Clin Cancer Res , vol.5 , pp. 3899-3905
    • Kopelovich, L.1    Henson, D.E.2    Gazdar, A.F.3
  • 63
    • 25144513898 scopus 로고    scopus 로고
    • Molecular evidence supporting field effect in urothelial carcinogenesis
    • Jones TD, Wang M, Eble JN, et al. Molecular evidence supporting field effect in urothelial carcinogenesis. Clin Cancer Res 2005;11:6512-6519.
    • (2005) Clin Cancer Res , vol.11 , pp. 6512-6519
    • Jones, T.D.1    Wang, M.2    Eble, J.N.3
  • 65
    • 33746277763 scopus 로고    scopus 로고
    • Epigenetic profiling of synchronous colorectal neoplasias by quantitative DNA methylation analysis
    • Ogino S, Brahmandam M, Kawasaki T, et al. Epigenetic profiling of synchronous colorectal neoplasias by quantitative DNA methylation analysis. Mod Pathol 2006;19:1083-1090.
    • (2006) Mod Pathol , vol.19 , pp. 1083-1090
    • Ogino, S.1    Brahmandam, M.2    Kawasaki, T.3
  • 66
    • 84862001313 scopus 로고    scopus 로고
    • Molecular profiling of synchronous and metachronous cancers of the pancreas reveal molecular mimicry between samples from the same patient
    • Talbott VA, Yeo CJ, Brody JR, et al. Molecular profiling of synchronous and metachronous cancers of the pancreas reveal molecular mimicry between samples from the same patient. J Surg Res 2012;176: 154-158.
    • (2012) J Surg Res , vol.176 , pp. 154-158
    • Talbott, V.A.1    Yeo, C.J.2    Brody, J.R.3
  • 67
    • 70350092402 scopus 로고    scopus 로고
    • A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers
    • e3
    • Nosho K, Kure S, Irahara N, et al. A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers. Gastroenterology 2009;137:1609-1620; e3.
    • (2009) Gastroenterology , vol.137 , pp. 1609-1620
    • Nosho, K.1    Kure, S.2    Irahara, N.3
  • 68
    • 70449698521 scopus 로고    scopus 로고
    • Concordant DNA methylation in synchronous colorectal carcinomas
    • Konishi K, Shen L, Jelinek J, et al. Concordant DNA methylation in synchronous colorectal carcinomas. Cancer Prev Res (Phila Pa) 2009;2:814-822.
    • (2009) Cancer Prev Res (Phila Pa) , vol.2 , pp. 814-822
    • Konishi, K.1    Shen, L.2    Jelinek, J.3
  • 69
    • 77649288717 scopus 로고    scopus 로고
    • Aberrant gene promoter methylation associated with sporadic multiple colorectal cancer
    • Gonzalo V, Lozano JJ, Munoz J, et al. Aberrant gene promoter methylation associated with sporadic multiple colorectal cancer. PloS One 2010;5: e8777.
    • (2010) PloS One , vol.5 , pp. e8777
    • Gonzalo, V.1    Lozano, J.J.2    Munoz, J.3
  • 70
    • 84857952066 scopus 로고    scopus 로고
    • Clinicopathologic and molecular characteristics of synchronous colorectal cancers: Heterogeneity of clinical outcome depending on microsatellite instability status of individual tumors
    • Bae JM, Cho NY, Kim TY, et al. Clinicopathologic and molecular characteristics of synchronous colorectal cancers: heterogeneity of clinical outcome depending on microsatellite instability status of individual tumors. Dis Colon Rectum 2012;55:181-190.
    • (2012) Dis Colon Rectum , vol.55 , pp. 181-190
    • Bae, J.M.1    Cho, N.Y.2    Kim, T.Y.3
  • 71
    • 79959745909 scopus 로고    scopus 로고
    • A strategy for distinguishing optimal cancer subtypes
    • Begg CB. A strategy for distinguishing optimal cancer subtypes. Int J Cancer 2011;129:931-937.
    • (2011) Int J Cancer , vol.129 , pp. 931-937
    • Begg, C.B.1
  • 72
    • 23044461420 scopus 로고    scopus 로고
    • Hormone receptor status of a contralateral breast cancer is independent of the receptor status of the first primary in patients not receiving adjuvant tamoxifen
    • Arpino G, Weiss HL, Clark GM, et al. Hormone receptor status of a contralateral breast cancer is independent of the receptor status of the first primary in patients not receiving adjuvant tamoxifen. J Clin Oncol 2005;23:4687-4694.
    • (2005) J Clin Oncol , vol.23 , pp. 4687-4694
    • Arpino, G.1    Weiss, H.L.2    Clark, G.M.3
  • 74
    • 1842833558 scopus 로고    scopus 로고
    • Estrogen receptor status of primary breast cancer is predictive of estrogen receptor status of contralateral breast cancer
    • Swain SM, Wilson JW, Mamounas EP, et al. Estrogen receptor status of primary breast cancer is predictive of estrogen receptor status of contralateral breast cancer. J Natl Cancer Inst 2004;96:516-523.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 516-523
    • Swain, S.M.1    Wilson, J.W.2    Mamounas, E.P.3
  • 76
    • 74849124623 scopus 로고    scopus 로고
    • Tumor marker phenotype concordance in second primary breast cancer California 1999-2004
    • Brown M, Bauer K, Pare M. Tumor marker phenotype concordance in second primary breast cancer, California, 1999-2004. Breast Cancer Res Treat 2010;120: 217-227.
    • (2010) Breast Cancer Res Treat , vol.120 , pp. 217-227
    • Brown, M.1    Bauer, K.2    Pare, M.3
  • 77
    • 84882262026 scopus 로고    scopus 로고
    • Similarities of molecular genetic changes in synchronous and metachronous colorectal cancers are limited and related to the cancers' proximities to each other
    • Zauber P, Huang J, Sabbath-Solitare M, et al. Similarities of molecular genetic changes in synchronous and metachronous colorectal cancers are limited and related to the cancers' proximities to each other. J Mol Diagn 2013;15:652-660.
    • (2013) J Mol Diagn , vol.15 , pp. 652-660
    • Zauber, P.1    Huang, J.2    Sabbath-Solitare, M.3
  • 78
    • 80051680291 scopus 로고    scopus 로고
    • A continuum model for tumour suppression
    • Berger AH, Knudson AG, Pandolfi PP. A continuum model for tumour suppression. Nature 2011;476: 163-169.
    • (2011) Nature , vol.476 , pp. 163-169
    • Berger, A.H.1    Knudson, A.G.2    Pandolfi, P.P.3
  • 79
    • 84860605783 scopus 로고    scopus 로고
    • Colorectal and other cancer risks for carriers and noncarriers from families with a DNA mismatch repair gene mutation: A prospective cohort study
    • Win AK, Young JP, Lindor NM, et al. Colorectal and other cancer risks for carriers and noncarriers from families with a DNA mismatch repair gene mutation: a prospective cohort study. J Clin Oncol 2012;30:958-964.
    • (2012) J Clin Oncol , vol.30 , pp. 958-964
    • Win, A.K.1    Young, J.P.2    Lindor, N.M.3
  • 80
    • 84866658167 scopus 로고    scopus 로고
    • Risks of primary extracolonic cancers following colorectal cancer in Lynch syndrome
    • Win AK, Lindor NM, Young JP, et al. Risks of primary extracolonic cancers following colorectal cancer in Lynch syndrome. J Natl Cancer Inst 2012;104: 1363-1372.
    • (2012) J Natl Cancer Inst , vol.104 , pp. 1363-1372
    • Win, A.K.1    Lindor, N.M.2    Young, J.P.3
  • 81
    • 0034644185 scopus 로고    scopus 로고
    • Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland
    • Lichtenstein P, Holm NV, Verkasalo PK, et al. Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 2000;343:78-85.
    • (2000) N Engl J Med , vol.343 , pp. 78-85
    • Lichtenstein, P.1    Holm, N.V.2    Verkasalo, P.K.3
  • 82
    • 77049105158 scopus 로고    scopus 로고
    • Beyond genomewide association studies: Genetic heterogeneity and individual predisposition to cancer
    • Galvan A, Ioannidis JP, Dragani TA. Beyond genomewide association studies: genetic heterogeneity and individual predisposition to cancer. Trends Genet 2010;26:132-141.
    • (2010) Trends Genet , vol.26 , pp. 132-141
    • Galvan, A.1    Ioannidis, J.P.2    Dragani, T.A.3
  • 83
    • 76749121394 scopus 로고    scopus 로고
    • Increased risk of colon cancer associated with a genetic polymorphism of SMAD7
    • Slattery ML, Herrick J, Curtin K, et al. Increased risk of colon cancer associated with a genetic polymorphism of SMAD7. Cancer Res 2010;70:1479-1485.
    • (2010) Cancer Res , vol.70 , pp. 1479-1485
    • Slattery, M.L.1    Herrick, J.2    Curtin, K.3
  • 84
    • 84873542162 scopus 로고    scopus 로고
    • Phenotypic and tumor molecular characterization of colorectal cancer in relation to a susceptibility SMAD7 variant associated with survival
    • Garcia-Albeniz X, Nan H, Valeri L, et al. Phenotypic and tumor molecular characterization of colorectal cancer in relation to a susceptibility SMAD7 variant associated with survival. Carcinogenesis 2013;34: 292-298.
    • (2013) Carcinogenesis , vol.34 , pp. 292-298
    • Garcia-Albeniz, X.1    Nan, H.2    Valeri, L.3
  • 85
    • 34948886186 scopus 로고    scopus 로고
    • MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer
    • Ogino S, Hazra A, Tranah GJ, et al. MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer. Carcinogenesis 2007;28:1985-1990.
    • (2007) Carcinogenesis , vol.28 , pp. 1985-1990
    • Ogino, S.1    Hazra, A.2    Tranah, G.J.3
  • 86
    • 71149121511 scopus 로고    scopus 로고
    • MGMT methylation is associated primarily with the germline C4T SNP (rs16906252) in colorectal cancer and normal colonic mucosa
    • Hawkins NJ, Lee JH, Wong JJ, et al. MGMT methylation is associated primarily with the germline C4T SNP (rs16906252) in colorectal cancer and normal colonic mucosa. Mod Pathol 2009;22:1588-1599.
    • (2009) Mod Pathol , vol.22 , pp. 1588-1599
    • Hawkins, N.J.1    Lee, J.H.2    Wong, J.J.3
  • 87
    • 70449366014 scopus 로고    scopus 로고
    • Detection of MGMT promoter methylation in normal individuals is strongly associated with the T allele of the rs16906252 MGMT promoter single nucleotide polymorphism
    • Candiloro IL, Dobrovic A. Detection of MGMT promoter methylation in normal individuals is strongly associated with the T allele of the rs16906252 MGMT promoter single nucleotide polymorphism. Cancer Prev Res (Phila Pa) 2009;2:862-867.
    • (2009) Cancer Prev Res (Phila Pa) , vol.2 , pp. 862-867
    • Candiloro, I.L.1    Dobrovic, A.2
  • 88
    • 79953323280 scopus 로고    scopus 로고
    • The A/G allele of Rs16906252 predicts for MGMT methylation and is selectively silenced in premalignant lesions from smokers and in lung adenocarcinomas
    • Leng S, Bernauer AM, Hong C, et al. The A/G allele of Rs16906252 predicts for MGMT methylation and is selectively silenced in premalignant lesions from smokers and in lung adenocarcinomas. Clin Cancer Res 2011;17:2014-2023.
    • (2011) Clin Cancer Res , vol.17 , pp. 2014-2023
    • Leng, S.1    Bernauer, A.M.2    Hong, C.3
  • 89
    • 78650953062 scopus 로고    scopus 로고
    • Methylation of MGMT in malignant pleural mesothelioma occurs in a subset of patients and is associated with the T allele of the rs16906252 MGMT promoter SNP
    • Kristensen LS, Nielsen HM, Hager H, et al. Methylation of MGMT in malignant pleural mesothelioma occurs in a subset of patients and is associated with the T allele of the rs16906252 MGMT promoter SNP. Lung Cancer 2011;71:130-136.
    • (2011) Lung Cancer , vol.71 , pp. 130-136
    • Kristensen, L.S.1    Nielsen, H.M.2    Hager, H.3
  • 90
    • 77949928737 scopus 로고    scopus 로고
    • Lifestyle factors and microsatellite instability in colorectal cancer: The evolving field of molecular pathological epidemiology
    • Ogino S, Stampfer M. Lifestyle factors and microsatellite instability in colorectal cancer: the evolving field of molecular pathological epidemiology. J Natl Cancer Inst 2010;102:365-367.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 365-367
    • Ogino, S.1    Stampfer, M.2
  • 91
    • 79851511414 scopus 로고    scopus 로고
    • Molecular pathological epidemiology of colorectal neoplasia: An emerging transdisciplinary and interdisciplinary field
    • Ogino S, Chan AT, Fuchs CS, et al. Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field. Gut 2011;60:397-411.
    • (2011) Gut , vol.60 , pp. 397-411
    • Ogino, S.1    Chan, A.T.2    Fuchs, C.S.3
  • 92
    • 79960123768 scopus 로고    scopus 로고
    • Epigenetic mechanisms and cancer: An interface between the environment and the genome
    • Herceg Z, Vaissiere T. Epigenetic mechanisms and cancer: an interface between the environment and the genome. Epigenetics 2011;6:804-819.
    • (2011) Epigenetics , vol.6 , pp. 804-819
    • Herceg, Z.1    Vaissiere, T.2
  • 93
    • 84856268173 scopus 로고    scopus 로고
    • Long interspersed nuclear element-1 hypomethylation in cancer: Biology and clinical applications
    • Kitkumthorn N, Mutirangura A. Long interspersed nuclear element-1 hypomethylation in cancer: biology and clinical applications. Clin Epigenet 2012;2: 315-330.
    • (2012) Clin Epigenet , vol.2 , pp. 315-330
    • Kitkumthorn, N.1    Mutirangura, A.2
  • 94
    • 84865039717 scopus 로고    scopus 로고
    • Pyrosequencing assay to measure LINE-1 methylation level in esophageal squamous cell carcinoma
    • Iwagami S, Baba Y, Watanabe M, et al. Pyrosequencing assay to measure LINE-1 methylation level in esophageal squamous cell carcinoma. Ann Surg Oncol 2012;19:2726-2732.
    • (2012) Ann Surg Oncol , vol.19 , pp. 2726-2732
    • Iwagami, S.1    Baba, Y.2    Watanabe, M.3
  • 95
    • 63149135457 scopus 로고    scopus 로고
    • Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients
    • Flanagan JM, Munoz-Alegre M, Henderson S, et al. Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients. Hum Mol Genet 2009;18:1332-1342.
    • (2009) Hum Mol Genet , vol.18 , pp. 1332-1342
    • Flanagan, J.M.1    Munoz-Alegre, M.2    Henderson, S.3
  • 96
    • 84870656296 scopus 로고    scopus 로고
    • Is there a link between genome-wide hypomethylation in blood and cancer risk?
    • Brennan K, Flanagan JM. Is there a link between genome-wide hypomethylation in blood and cancer risk? Cancer Prev Res (Phila) 2012;5:1345-1357.
    • (2012) Cancer Prev Res (Phila) , vol.5 , pp. 1345-1357
    • Brennan, K.1    Flanagan, J.M.2
  • 97
    • 13444268381 scopus 로고    scopus 로고
    • Cancer as a complex phenotype: Pattern of cancer distribution within and beyond the nuclear family
    • Amundadottir LT, Thorvaldsson S, Gudbjartsson DF, et al. Cancer as a complex phenotype: pattern of cancer distribution within and beyond the nuclear family. PLoS Med 2004;1:e65.
    • (2004) PLoS Med , vol.1 , pp. e65
    • Amundadottir, L.T.1    Thorvaldsson, S.2    Gudbjartsson, D.F.3
  • 99
    • 34047264801 scopus 로고    scopus 로고
    • Differences in risk factors for breast cancer molecular subtypes in a population-based study
    • Yang XR, Sherman ME, Rimm DL, et al. Differences in risk factors for breast cancer molecular subtypes in a population-based study. Cancer Epidemiol Biomarkers Prev 2007;16:439-443.
    • (2007) Cancer Epidemiol Biomarkers Prev , vol.16 , pp. 439-443
    • Yang, X.R.1    Sherman, M.E.2    Rimm, D.L.3
  • 100
    • 54049127751 scopus 로고    scopus 로고
    • Reproductive and hormonal risk factors for postmenopausal luminal. HER-2-overexpressing, and triple-negative breast cancer
    • Phipps AI, Malone KE, Porter PL, Daling JR, Li CI. Reproductive and hormonal risk factors for postmenopausal luminal, HER-2-overexpressing, and triple-negative breast cancer. Cancer 2008;113: 1521-1526.
    • (2008) Cancer , vol.113 , pp. 1521-1526
    • Phipps, A.I.1    Malone, K.E.2    Porter, P.L.3    Daling, J.R.4    Li, C.I.5
  • 101
    • 66649101370 scopus 로고    scopus 로고
    • Risk factors for triple-negative breast cancer in women under the age of 45 years
    • Dolle JM, Daling JR, White E, et al. Risk factors for triple-negative breast cancer in women under the age of 45 years. Cancer Epidemiol Biomarkers Prev 2009;18:1157-1166.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 1157-1166
    • Dolle, J.M.1    Daling, J.R.2    White, E.3
  • 102
    • 33947117457 scopus 로고    scopus 로고
    • Evidence for heritable predisposition to epigenetic silencing of MLH1
    • Chen H, Taylor NP, Sotamaa KM, et al. Evidence for heritable predisposition to epigenetic silencing of MLH1. Int J Cancer 2007;120:1684-1688.
    • (2007) Int J Cancer , vol.120 , pp. 1684-1688
    • Chen, H.1    Taylor, N.P.2    Sotamaa, K.M.3
  • 103
    • 34047272113 scopus 로고    scopus 로고
    • MLH1-93G4A promoter polymorphism and the risk of microsatellite-unstable colorectal cancer
    • Raptis S, Mrkonjic M, Green RC, et al. MLH1-93G4A promoter polymorphism and the risk of microsatellite-unstable colorectal cancer. J Natl Cancer Inst 2007;99:463-474.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 463-474
    • Raptis, S.1    Mrkonjic, M.2    Green, R.C.3
  • 104
    • 50249098093 scopus 로고    scopus 로고
    • The MLH1-93 G4A promoter polymorphism and genetic and epigenetic alterations in colon cancer
    • Samowitz WS, Curtin K, Wolff RK, et al. The MLH1-93 G4A promoter polymorphism and genetic and epigenetic alterations in colon cancer. Genes Chromosomes Cancer 2008;47:835-844.
    • (2008) Genes Chromosomes Cancer , vol.47 , pp. 835-844
    • Samowitz, W.S.1    Curtin, K.2    Wolff, R.K.3
  • 105
    • 53449086387 scopus 로고    scopus 로고
    • MLH1-93G4A promoter polymorphism and risk of mismatch repair deficient colorectal cancer
    • Allan JM, Shorto J, Adlard J, et al. MLH1-93G4A promoter polymorphism and risk of mismatch repair deficient colorectal cancer. Int J Cancer 2008;123: 2456-2459.
    • (2008) Int J Cancer , vol.123 , pp. 2456-2459
    • Allan, J.M.1    Shorto, J.2    Adlard, J.3
  • 106
    • 66349113849 scopus 로고    scopus 로고
    • Mismatch repair polymorphisms and risk of colon cancer, tumour microsatellite instability and interactions with lifestyle factors
    • Campbell PT, Curtin K, Ulrich CM, et al. Mismatch repair polymorphisms and risk of colon cancer, tumour microsatellite instability and interactions with lifestyle factors. Gut 2009;58:661-667.
    • (2009) Gut , vol.58 , pp. 661-667
    • Campbell, P.T.1    Curtin, K.2    Ulrich, C.M.3
  • 107
    • 2442539281 scopus 로고    scopus 로고
    • The association between methylenetetrahydrofolate reductase polymorphism and promoter methylation in proximal colon cancer
    • Oyama K, Kawakami K, Maeda K, Ishiguro K, Watanabe G. The association between methylenetetrahydrofolate reductase polymorphism and promoter methylation in proximal colon cancer. Anticancer Res 2004;24:649-654.
    • (2004) Anticancer Res , vol.24 , pp. 649-654
    • Oyama, K.1    Kawakami, K.2    Maeda, K.3    Ishiguro, K.4    Watanabe, G.5
  • 108
    • 34548178346 scopus 로고    scopus 로고
    • Genetic polymorphisms in one-carbon metabolism: Associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet
    • Curtin K, Slattery ML, Ulrich CM, et al. Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet. Carcinogenesis 2007;28:1672-1679.
    • (2007) Carcinogenesis , vol.28 , pp. 1672-1679
    • Curtin, K.1    Slattery, M.L.2    Ulrich, C.M.3
  • 109
    • 72749115699 scopus 로고    scopus 로고
    • Genetic variants of methyl metabolizing enzymes and epigenetic regulators: Associations with promoter CpG island hypermethylation in colorectal cancer
    • de Vogel S,Wouters KA, Gottschalk RW, et al. Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer. Cancer Epidemiol Biomarkers Prev 2009;18:3086-3096.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 3086-3096
    • Vogel De Swouters, K.A.1    Gottschalk, R.W.2
  • 110
    • 77949950879 scopus 로고    scopus 로고
    • Dietary folate, alcohol, and B vitamins in relation to LINE-1 hypomethylation in colon cancer
    • Schernhammer ES, Giovannucci E, Kawasaki T, et al. Dietary folate, alcohol, and B vitamins in relation to LINE-1 hypomethylation in colon cancer. Gut 2010; 59:794-799.
    • (2010) Gut , vol.59 , pp. 794-799
    • Schernhammer, E.S.1    Giovannucci, E.2    Kawasaki, T.3
  • 111
    • 77950690337 scopus 로고    scopus 로고
    • Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer
    • Hazra A, Fuchs CS, Kawasaki T, et al. Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer. Cancer Causes Control 2010;21:331-345.
    • (2010) Cancer Causes Control , vol.21 , pp. 331-345
    • Hazra, A.1    Fuchs, C.S.2    Kawasaki, T.3
  • 112
    • 77953293058 scopus 로고    scopus 로고
    • One-carbon metabolism and CpG island methylator phenotype status in incident colorectal cancer: A nested case-referent study
    • Van Guelpen B, Dahlin AM, Hultdin J, et al. One-carbon metabolism and CpG island methylator phenotype status in incident colorectal cancer: a nested case-referent study. Cancer Causes Control 2010;21:557-566.
    • (2010) Cancer Causes Control , vol.21 , pp. 557-566
    • Van Guelpen, B.1    Dahlin, A.M.2    Hultdin, J.3
  • 113
    • 79251540715 scopus 로고    scopus 로고
    • Nutrients in folate-mediated, one-carbon metabolism and the risk of rectal tumors in men and women
    • Curtin K, Samowitz WS, Ulrich CM, et al. Nutrients in folate-mediated, one-carbon metabolism and the risk of rectal tumors in men and women. Nutr Cancer 2011;63:357-366.
    • (2011) Nutr Cancer , vol.63 , pp. 357-366
    • Curtin, K.1    Samowitz, W.S.2    Ulrich, C.M.3
  • 114
    • 79959591185 scopus 로고    scopus 로고
    • B vitamins, methionine and alcohol intake and risk of colon cancer in relation to BRAF mutation and CpG island methylator phenotype (CIMP)
    • Schernhammer ES, Giovannucci E, Baba Y, Fuchs CS, Ogino S. B vitamins, methionine and alcohol intake and risk of colon cancer in relation to BRAF mutation and CpG island methylator phenotype (CIMP). PloS One 2011;6:e21102.
    • (2011) PloS One , vol.6 , pp. e21102
    • Schernhammer, E.S.1    Giovannucci, E.2    Baba, Y.3    Fuchs, C.S.4    Ogino, S.5
  • 115
    • 0034669076 scopus 로고    scopus 로고
    • Associations between cigarette smoking, lifestyle factors, and microsatellite instability in colon tumors
    • Slattery ML, Curtin K, Anderson K, et al. Associations between cigarette smoking, lifestyle factors, and microsatellite instability in colon tumors. J Natl Cancer Inst 2000;92:1831-1836.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1831-1836
    • Slattery, M.L.1    Curtin, K.2    Anderson, K.3
  • 116
    • 13944258085 scopus 로고    scopus 로고
    • Diet, lifestyle, and genomic instability in the north Carolina colon cancer study
    • Satia JA, Keku T, Galanko JA, et al. Diet, lifestyle, and genomic instability in the north Carolina colon cancer study. Cancer Epidemiol Biomarkers Prev 2005;14:429-436.
    • (2005) Cancer Epidemiol Biomarkers Prev , vol.14 , pp. 429-436
    • Satia, J.A.1    Keku, T.2    Galanko, J.A.3
  • 117
    • 57449112521 scopus 로고    scopus 로고
    • Cohort study of fatty acid synthase expression and patient survival in colon cancer
    • Ogino S, Nosho K, Meyerhardt JA, et al. Cohort study of fatty acid synthase expression and patient survival in colon cancer. J Clin Oncol 2008;26:5713-5720.
    • (2008) J Clin Oncol , vol.26 , pp. 5713-5720
    • Ogino, S.1    Nosho, K.2    Meyerhardt, J.A.3
  • 118
    • 77949953247 scopus 로고    scopus 로고
    • Case-control study of overweight, obesity, and colorectal cancer risk, overall and by tumor microsatellite instability status
    • Campbell PT, Jacobs ET, Ulrich CM, et al. Case-control study of overweight, obesity, and colorectal cancer risk, overall and by tumor microsatellite instability status. J Natl Cancer Inst 2010;102:391-400.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 391-400
    • Campbell, P.T.1    Jacobs, E.T.2    Ulrich, C.M.3
  • 119
    • 84858134589 scopus 로고    scopus 로고
    • Body mass index and risk of colorectal cancer according to fatty acid synthase expression in the nurses' health study
    • Kuchiba A, Morikawa T, Yamauchi M, et al. Body mass index and risk of colorectal cancer according to fatty acid synthase expression in the nurses' health study. J Natl Cancer Inst 2012;104:415-420.
    • (2012) J Natl Cancer Inst , vol.104 , pp. 415-420
    • Kuchiba, A.1    Morikawa, T.2    Yamauchi, M.3
  • 120
    • 84856699420 scopus 로고    scopus 로고
    • Association of obesity with DNA mismatch repair status and clinical outcome in patients with stage II or III colon carcinoma participating in NCCTG and NSABP adjuvant chemotherapy trials
    • Sinicrope FA, Foster NR, Yoon HH, et al. Association of obesity with DNA mismatch repair status and clinical outcome in patients with stage II or III colon carcinoma participating in NCCTG and NSABP adjuvant chemotherapy trials. J Clin Oncol 2012;30: 406-412.
    • (2012) J Clin Oncol , vol.30 , pp. 406-412
    • Sinicrope, F.A.1    Foster, N.R.2    Yoon, H.H.3
  • 121
    • 84864607258 scopus 로고    scopus 로고
    • Body size and risk for colorectal cancers showing BRAF mutation or microsatellite instability: A pooled analysis
    • Hughes LA, Williamson EJ, van Engeland M, et al. Body size and risk for colorectal cancers showing BRAF mutation or microsatellite instability: a pooled analysis. Int J Epidemiol 2012;41:1060-1072.
    • (2012) Int J Epidemiol , vol.41 , pp. 1060-1072
    • Hughes, L.A.1    Williamson, E.J.2    Van M, E.3
  • 122
    • 33845672260 scopus 로고    scopus 로고
    • Association of smoking, CpG island methylator phenotype, and V600E BRAF mutations in colon cancer
    • Samowitz WS, Albertsen H, Sweeney C, et al. Association of smoking, CpG island methylator phenotype, and V600E BRAF mutations in colon cancer. J Natl Cancer Inst 2006;98:1731-1738.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1731-1738
    • Samowitz, W.S.1    Albertsen, H.2    Sweeney, C.3
  • 123
    • 70350109231 scopus 로고    scopus 로고
    • Associations between smoking, alcohol consumption, and colorectal cancer, overall and by tumor microsatellite instability status
    • Poynter JN, Haile RW, Siegmund KD, et al. Associations between smoking, alcohol consumption, and colorectal cancer, overall and by tumor microsatellite instability status. Cancer Epidemiol Biomarkers Prev 2009;18:2745-2750.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 2745-2750
    • Poynter, J.N.1    Haile, R.W.2    Siegmund, K.D.3
  • 124
    • 77949714884 scopus 로고    scopus 로고
    • Smoking, gender, and ethnicity predict somatic BRAF mutations in colorectal cancer
    • Rozek LS, Herron CM, Greenson JK, et al. Smoking, gender, and ethnicity predict somatic BRAF mutations in colorectal cancer. Cancer Epidemiol Biomarkers Prev 2010;19:838-843.
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , pp. 838-843
    • Rozek, L.S.1    Herron, C.M.2    Greenson, J.K.3
  • 125
    • 77955010927 scopus 로고    scopus 로고
    • Cigarette smoking and colorectal cancer risk by molecularly defined subtypes
    • Limsui D, Vierkant RA, Tillmans LS, et al. Cigarette smoking and colorectal cancer risk by molecularly defined subtypes. J Natl Cancer Inst 2010;102: 1012-1022.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 1012-1022
    • Limsui, D.1    Vierkant, R.A.2    Tillmans, L.S.3
  • 126
    • 66149133289 scopus 로고    scopus 로고
    • Somatic alterations, metabolizing genes and smoking in rectal cancer
    • Curtin K, Samowitz WS, Wolff RK, et al. Somatic alterations, metabolizing genes and smoking in rectal cancer. Int J Cancer 2009;125:158-164.
    • (2009) Int J Cancer , vol.125 , pp. 158-164
    • Curtin, K.1    Samowitz, W.S.2    Wolff, R.K.3
  • 127
    • 84876484863 scopus 로고    scopus 로고
    • A prospective study of duration of smoking cessation and colorectal cancer risk by epigenetics-related tumor classification
    • Nishihara R, Morikawa T, Kuchiba A, et al. A prospective study of duration of smoking cessation and colorectal cancer risk by epigenetics-related tumor classification. Am J Epidemiol 2013;178:84-100.
    • (2013) Am J Epidemiol , vol.178 , pp. 84-100
    • Nishihara, R.1    Morikawa, T.2    Kuchiba, A.3
  • 128
    • 53249145767 scopus 로고    scopus 로고
    • Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma
    • Riely GJ, Kris MG, Rosenbaum D, et al. Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. Clin Cancer Res 2008;14:5731-5734.
    • (2008) Clin Cancer Res , vol.14 , pp. 5731-5734
    • Riely, G.J.1    Kris, M.G.2    Rosenbaum, D.3
  • 129
    • 78751478263 scopus 로고    scopus 로고
    • Long exposure of environmental tobacco smoke associated with activating EGFR mutations in never-smokers with non-small cell lung cancer
    • Kawaguchi T, Ando M, Kubo A, et al. Long exposure of environmental tobacco smoke associated with activating EGFR mutations in never-smokers with non-small cell lung cancer. Clin Cancer Res 2011;17: 39-45.
    • (2011) Clin Cancer Res , vol.17 , pp. 39-45
    • Kawaguchi, T.1    Ando, M.2    Kubo, A.3
  • 130
    • 0344423822 scopus 로고    scopus 로고
    • Risk factors for Ki-ras protooncogene mutation in sporadic colorectal adenomas
    • Martinez ME, Maltzman T, Marshall JR, et al. Risk factors for Ki-ras protooncogene mutation in sporadic colorectal adenomas. Cancer Res 1999;59:5181-5185.
    • (1999) Cancer Res , vol.59 , pp. 5181-5185
    • Martinez, M.E.1    Maltzman, T.2    Marshall, J.R.3
  • 131
    • 77952712959 scopus 로고    scopus 로고
    • Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors
    • Baba Y, Huttenhower C, Nosho K, et al. Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors. Mol Cancer 2010;9:125.
    • (2010) Mol Cancer , vol.9 , pp. 125
    • Baba, Y.1    Huttenhower, C.2    Nosho, K.3
  • 132
    • 77951814373 scopus 로고    scopus 로고
    • Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency
    • Goel A, Xicola RM, Nguyen TP, et al. Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency. Gastroenterology 2010;138:1854-1862.
    • (2010) Gastroenterology , vol.138 , pp. 1854-1862
    • Goel, A.1    Xicola, R.M.2    Nguyen, T.P.3
  • 133
    • 84866707635 scopus 로고    scopus 로고
    • A high degree of LINE-1 hypomethylation is a unique feature of earlyonset colorectal cancer
    • Antelo M, Balaguer F, Shia J, et al. A high degree of LINE-1 hypomethylation is a unique feature of earlyonset colorectal cancer. PloS One 2012;7:e45357.
    • (2012) PloS One , vol.7 , pp. e45357
    • Antelo, M.1    Balaguer, F.2    Shia, J.3
  • 134
    • 84872587403 scopus 로고    scopus 로고
    • Prospective study of family history and colorectal cancer risk by tumor LINE-1 methylation level
    • Ogino S, Nishihara R, Lochhead P, et al. Prospective study of family history and colorectal cancer risk by tumor LINE-1 methylation level. J Natl Cancer Inst 2013;105:130-140.
    • (2013) J Natl Cancer Inst , vol.105 , pp. 130-140
    • Ogino, S.1    Nishihara, R.2    Lochhead, P.3
  • 135
    • 84872587403 scopus 로고    scopus 로고
    • Prospective study of family history and colorectal cancer risk by tumor LINE-1 methylation level
    • Ogino S, Nishihara R, Lochhead P, et al. Prospective study of family history and colorectal cancer risk by tumor LINE-1 methylation level. J Natl Cancer Inst 2013;105:130-140.
    • (2013) J Natl Cancer Inst , vol.105 , pp. 130-140
    • Ogino, S.1    Nishihara, R.2    Lochhead, P.3
  • 136
    • 34249673868 scopus 로고    scopus 로고
    • Aspirin and the risk of colorectal cancer in relation to the expression of COX-2
    • Chan AT, Ogino S, Fuchs CS. Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. N Engl J Med 2007;356:2131-2142.
    • (2007) N Engl J Med , vol.356 , pp. 2131-2142
    • Chan, A.T.1    Ogino, S.2    Fuchs, C.S.3
  • 137
    • 68849123400 scopus 로고    scopus 로고
    • Aspirin use and survival after diagnosis of colorectal cancer
    • Chan AT, Ogino S, Fuchs CS. Aspirin use and survival after diagnosis of colorectal cancer. JAMA 2009;302:649-658.
    • (2009) JAMA , vol.302 , pp. 649-658
    • Chan, A.T.1    Ogino, S.2    Fuchs, C.S.3
  • 138
    • 84867817838 scopus 로고    scopus 로고
    • Aspirin use, tumor PIK3CA mutation status, and colorectal cancer survival
    • Liao X, Lochhead P, Nishihara R, et al. Aspirin use, tumor PIK3CA mutation status, and colorectal cancer survival. N Engl J Med 2012;367:1596-1606.
    • (2012) N Engl J Med , vol.367 , pp. 1596-1606
    • Liao, X.1    Lochhead, P.2    Nishihara, R.3
  • 139
    • 84867791528 scopus 로고    scopus 로고
    • Aspirin-from prevention to targeted therapy
    • Pasche B. Aspirin-from prevention to targeted therapy. N Engl J Med 2012;367:1650-1651.
    • (2012) N Engl J Med , vol.367 , pp. 1650-1651
    • Pasche, B.1
  • 140
    • 0036121312 scopus 로고    scopus 로고
    • Epstein-barr viruspositive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma
    • Kang GH, Lee S, Kim WH, et al. Epstein-barr viruspositive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma. Am J Pathol 2002;160:787-794.
    • (2002) Am J Pathol , vol.160 , pp. 787-794
    • Kang, G.H.1    Lee, S.2    Kim, W.H.3
  • 141
    • 33744789155 scopus 로고    scopus 로고
    • CpG island methylation status in gastric carcinoma with and without infection of Epstein-Barr virus
    • Chang MS, Uozaki H, Chong JM, et al. CpG island methylation status in gastric carcinoma with and without infection of Epstein-Barr virus. Clin Cancer Res 2006;12:2995-3002.
    • (2006) Clin Cancer Res , vol.12 , pp. 2995-3002
    • Chang, M.S.1    Uozaki, H.2    Chong, J.M.3
  • 142
    • 78650644411 scopus 로고    scopus 로고
    • Epstein-Barr virus-specific methylation of human genes in gastric cancer cells
    • Ryan JL, Jones RJ, Kenney SC, et al. Epstein-Barr virus-specific methylation of human genes in gastric cancer cells. Infect Agent Cancer 2010;5:27.
    • (2010) Infect Agent Cancer , vol.5 , pp. 27
    • Ryan, J.L.1    Jones, R.J.2    Kenney, S.C.3
  • 143
    • 77952534140 scopus 로고    scopus 로고
    • Helicobacter pylori infection, oncogenic pathways and epigenetic mechanisms in gastric carcinogenesis
    • Ding SZ, Goldberg JB, Hatakeyama M. Helicobacter pylori infection, oncogenic pathways and epigenetic mechanisms in gastric carcinogenesis. Future Oncol 2010;6:851-862.
    • (2010) Future Oncol , vol.6 , pp. 851-862
    • Ding, S.Z.1    Goldberg, J.B.2    Hatakeyama, M.3
  • 144
    • 78649706953 scopus 로고    scopus 로고
    • Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans
    • Peterson AJ, Menheniott TR, O'Connor L, et al. Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans. Gastroenterology 2010;139:2005-2017.
    • (2010) Gastroenterology , vol.139 , pp. 2005-2017
    • Peterson, A.J.1    Menheniott, T.R.2    O'Connor, L.3
  • 145
    • 77957361278 scopus 로고    scopus 로고
    • Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors
    • Hernandez-Vargas H, Lambert MP, Le Calvez-Kelm F, et al. Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors. PloS One 2010;5:e9749.
    • (2010) PloS One , vol.5 , pp. e9749
    • Hernandez-Vargas, H.1    Lambert, M.P.2    Le Calvez-Kelm, F.3
  • 146
    • 53349171172 scopus 로고    scopus 로고
    • Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas
    • Gao W, Kondo Y, Shen L, et al. Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas. Carcinogenesis 2008; 29:1901-1910.
    • (2008) Carcinogenesis , vol.29 , pp. 1901-1910
    • Gao, W.1    Kondo, Y.2    Shen, L.3
  • 148
    • 84876470674 scopus 로고    scopus 로고
    • Molecular pathological epidemiology of epigenetics: Emerging integrative science to analyze environment, host, and disease
    • Ogino S, Lochhead P, Chan AT, et al. Molecular pathological epidemiology of epigenetics: Emerging integrative science to analyze environment, host, and disease. Mod Pathol 2013;26:465-484.
    • (2013) Mod Pathol , vol.26 , pp. 465-484
    • Ogino, S.1    Lochhead, P.2    Chan, A.T.3
  • 149
    • 84864620084 scopus 로고    scopus 로고
    • Commentary: Lifestyle factors and colorectal cancer microsatellite instability-molecular pathological epidemiology science, based on unique tumour principle
    • Ogino S, Giovannucci E. Commentary: lifestyle factors and colorectal cancer microsatellite instability-molecular pathological epidemiology science, based on unique tumour principle. In J Epidemiol 2012; 41:1072-1074.
    • (2012) J Epidemiol , vol.41 , pp. 1072-1074
    • Ogino, S.1    Giovannucci, E.2
  • 150
    • 84864613664 scopus 로고    scopus 로고
    • Interdisciplinary education to integrate pathology and epidemiology: Towards molecular and population-level health science
    • Ogino S, King EE, Beck AH, et al. Interdisciplinary education to integrate pathology and epidemiology: towards molecular and population-level health science. Am J Epidemiol 2012;176:659-667.
    • (2012) Am J Epidemiol , vol.176 , pp. 659-667
    • Ogino, S.1    King, E.E.2    Beck, A.H.3
  • 151
    • 84867725133 scopus 로고    scopus 로고
    • The 21st century epidemiologist
    • Ogino et al. respond to
    • Ogino S, Beck AH, King EE, et al. Ogino et al. respond to 'The 21st century epidemiologist'. Am J Epidemiol 2012;176:672-674.
    • (2012) Am J Epidemiol , vol.176 , pp. 672-674
    • Ogino, S.1    Beck, A.H.2    King, E.E.3
  • 152
    • 84864579906 scopus 로고    scopus 로고
    • How many molecular subtypes? Implications of the unique tumor principle in personalized medicine
    • Ogino S, Fuchs CS, Giovannucci E. How many molecular subtypes? Implications of the unique tumor principle in personalized medicine. Expert Rev Mol Diagn 2012;12:621-628.
    • (2012) Expert Rev Mol Diagn , vol.12 , pp. 621-628
    • Ogino, S.1    Fuchs, C.S.2    Giovannucci, E.3
  • 153
    • 80052929478 scopus 로고    scopus 로고
    • CpG island methylation in colorectal cancer: Past, present and future
    • Curtin K, Slattery ML, Samowitz WS. CpG island methylation in colorectal cancer: past, present and future. Pathol Res Int 2011;2011:902674.
    • (2011) Pathol Res Int , vol.2011 , pp. 902674
    • Curtin, K.1    Slattery, M.L.2    Samowitz, W.S.3
  • 154
    • 79953691450 scopus 로고    scopus 로고
    • Body size, physical activity and risk of colorectal cancer with or without the CpG island methylator phenotype (CIMP)
    • Hughes LA, Simons CC, van den Brandt PA, et al. Body size, physical activity and risk of colorectal cancer with or without the CpG island methylator phenotype (CIMP). PloS One 2011;6:e18571.
    • (2011) PloS One , vol.6 , pp. e18571
    • Hughes, L.A.1    Simons, C.C.2    Brandt Van Den, P.A.3
  • 155
    • 84857745821 scopus 로고    scopus 로고
    • Optimal lymph node harvest in rectal cancer (UICC Stages II and III) after preoperative 5-FU-based radiochemotherapy. Acetone compression is a new and highly efficient method
    • Gehoff A, Basten O, Sprenger T, et al. Optimal lymph node harvest in rectal cancer (UICC Stages II and III) after preoperative 5-FU-based radiochemotherapy. acetone compression is a new and highly efficient method. Am J Surg Pathol 2012;36:202-213.
    • (2012) Am J Surg Pathol , vol.36 , pp. 202-213
    • Gehoff, A.1    Basten, O.2    Sprenger, T.3
  • 156
    • 81255179895 scopus 로고    scopus 로고
    • The CpG island methylator phenotype in colorectal cancer: Progress and problems
    • Hughes LA, Khalid-de Bakker CA, Smits KM, et al. The CpG island methylator phenotype in colorectal cancer: progress and problems. Biochim Biophys Acta 2012;1825:77-85.
    • (2012) Biochim Biophys Acta , vol.1825 , pp. 77-85
    • Hughes, L.A.1    Khalid-De Bakker, C.A.2    Smits, K.M.3
  • 157
    • 84864562836 scopus 로고    scopus 로고
    • Gene discovery in familial cancer syndromes by exome sequencing: Prospects for the elucidation of familial colorectal cancer type X
    • Ku CS, Cooper DN, Wu M, et al. Gene discovery in familial cancer syndromes by exome sequencing: prospects for the elucidation of familial colorectal cancer type X. Mod Pathol 2012;25:1055-1068.
    • (2012) Mod Pathol , vol.25 , pp. 1055-1068
    • Ku, C.S.1    Cooper, D.N.2    Wu, M.3
  • 158
    • 84866235163 scopus 로고    scopus 로고
    • Molecular events in primary and metastatic colorectal carcinoma: A review
    • Kanthan R, Senger JL, Kanthan SC. Molecular events in primary and metastatic colorectal carcinoma: a review. Pathol Res Int 2012;2012:597497.
    • (2012) Pathol Res Int , vol.2012 , pp. 597497
    • Kanthan, R.1    Senger, J.L.2    Kanthan, S.C.3
  • 159
    • 84866091151 scopus 로고    scopus 로고
    • Serrated lesions of the colorectum: Review and recommendations from an expert panel
    • Rex DK, Ahnen DJ, Baron JA, et al. Serrated lesions of the colorectum: review and recommendations from an expert panel. Am J Gastroenterol 2012;107: 1315-1329.
    • (2012) Am J Gastroenterol , vol.107 , pp. 1315-1329
    • Rex, D.K.1    Ahnen, D.J.2    Baron, J.A.3
  • 160
    • 84869224992 scopus 로고    scopus 로고
    • Molecular epidemiology of EGFR and KRAS mutations in 3026 lung adenocarcinomas: Higher susceptibility of women to smoking-related KRAS-mutant cancers
    • Dogan S, Shen R, Ang DC, et al. Molecular epidemiology of EGFR and KRAS mutations in 3026 lung adenocarcinomas: higher susceptibility of women to smoking-related KRAS-mutant cancers. Clin Cancer Res 2012;18:6169-6177.
    • (2012) Clin Cancer Res , vol.18 , pp. 6169-6177
    • Dogan, S.1    Shen, R.2    Ang, D.C.3
  • 161
    • 84866852663 scopus 로고    scopus 로고
    • Cancer classification using the Immunoscore: A worldwide task force
    • Galon J, Franck P, Marincola FM, et al. Cancer classification using the Immunoscore: a worldwide task force. J Transl Med 2012;10:205.
    • (2012) J Transl Med , vol.10 , pp. 205
    • Galon, J.1    Franck, P.2    Marincola, F.M.3
  • 162
    • 84871515357 scopus 로고    scopus 로고
    • Integrative cancer epidemiology - The next generation
    • Spitz MR, Caporaso NE, Sellers TA. Integrative cancer epidemiology-the next generation. Cancer Discov 2012;2:1087-1090.
    • (2012) Cancer Discov , vol.2 , pp. 1087-1090
    • Spitz, M.R.1    Caporaso, N.E.2    Sellers, T.A.3
  • 163
    • 84878549248 scopus 로고    scopus 로고
    • Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features
    • Rosty C, Young JP, Walsh MD, et al. Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features. Mod Pathol 2013;26:825-834.
    • (2013) Mod Pathol , vol.26 , pp. 825-834
    • Rosty, C.1    Young, J.P.2    Walsh, M.D.3
  • 164
    • 84875733249 scopus 로고    scopus 로고
    • Associations of recreational physical activity and leisure time spent sitting with colorectal cancer survival
    • Campbell PT, Patel AV, Newton CC, Jacobs EJ, Gapstur SM. Associations of recreational physical activity and leisure time spent sitting with colorectal cancer survival. J Clin Oncol 2013;31:876-885.
    • (2013) J Clin Oncol , vol.31 , pp. 876-885
    • Campbell, P.T.1    Patel, A.V.2    Newton, C.C.3    Jacobs, E.J.4    Gapstur, S.M.5
  • 165
    • 84892438835 scopus 로고    scopus 로고
    • The mTOR pathway and the role of energy balance throughout life in colorectal cancer etiology and prognosis: Unravelling mechanisms through a multidimensional molecular epidemiologic approach
    • Weijenberg MP, Hughes LA, Bours MJ, et al. The mTOR pathway and the role of energy balance throughout life in colorectal cancer etiology and prognosis: unravelling mechanisms through a multidimensional molecular epidemiologic approach. Curr Nutr Rep 2013;2:19-26.
    • (2013) Curr Nutr Rep , vol.2 , pp. 19-26
    • Weijenberg, M.P.1    Hughes, L.A.2    Bours, M.J.3
  • 166
    • 84878261305 scopus 로고    scopus 로고
    • MGMTand MLH1 methylation in Helicobacter pylori-infected children and adults
    • Alvarez MC, Santos JC, Maniezzo N, et al. MGMTand MLH1 methylation in Helicobacter pylori-infected children and adults. World J Gastroenterol 2013;19: 3043-3051.
    • (2013) World J Gastroenterol , vol.19 , pp. 3043-3051
    • Alvarez, M.C.1    Santos, J.C.2    Maniezzo, N.3
  • 168
    • 84877764456 scopus 로고    scopus 로고
    • Genomic aberrations occuring in subsets of serrated colorectal lesions but not conventional adenomas
    • Burnett-Hartman AN, Newcomb PA, Potter JD, et al. Genomic aberrations occuring in subsets of serrated colorectal lesions but not conventional adenomas. Cancer Res 2013;73:2863-2872.
    • (2013) Cancer Res , vol.73 , pp. 2863-2872
    • Burnett-Hartman, A.N.1    Newcomb, P.A.2    Potter, J.D.3
  • 169
    • 84883706496 scopus 로고    scopus 로고
    • Lipogenesis and lipolysis: The pathways exploited by the cancer cells to acquire fatty acids
    • Zaidi N, Lupien L, Kuemmerle NB, et al. Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids. Prog Lipid Res 2013; 52:585-589.
    • (2013) Prog Lipid Res , vol.52 , pp. 585-589
    • Zaidi, N.1    Lupien, L.2    Kuemmerle, N.B.3
  • 170
    • 84884241711 scopus 로고    scopus 로고
    • Phospholipase A2G1B polymorphisms and risk of colorectal neoplasia
    • Abbenhardt C, Poole EM, Kulmacz RJ, et al. Phospholipase A2G1B polymorphisms and risk of colorectal neoplasia. Int J Mol Epidemiol Genet 2013;4:140-149.
    • (2013) Int J Mol Epidemiol Genet , vol.4 , pp. 140-149
    • Abbenhardt, C.1    Poole, E.M.2    Kulmacz, R.J.3
  • 171
    • 84885049499 scopus 로고    scopus 로고
    • The CpG island methylator phenotype: What's in a name?
    • Hughes LA, Melotte V, de Schrijver J, et al. The CpG island methylator phenotype: what's in a name? Cancer Res 2013;73:5858-5868.
    • (2013) Cancer Res , vol.73 , pp. 5858-5868
    • Hughes, L.A.1    Melotte, V.2    De J, S.3
  • 172
    • 84886743078 scopus 로고    scopus 로고
    • Potential role of gastrointestinal microbiota composition in prostate cancer risk
    • Amirian ES, Petrosino JF, Ajami NJ, et al. Potential role of gastrointestinal microbiota composition in prostate cancer risk. Infect Agent Cancer 2013;8:42.
    • (2013) Infect Agent Cancer , vol.8 , pp. 42
    • Amirian, E.S.1    Petrosino, J.F.2    Ajami, N.J.3
  • 173
    • 84883142215 scopus 로고    scopus 로고
    • Prognostic implication of the CpG island methylator phenotype in colorectal cancers depends on tumour location
    • Bae JM, Kim JH, Cho NY, Kim TY, Kang GH. Prognostic implication of the CpG island methylator phenotype in colorectal cancers depends on tumour location. Br J Cancer 2013;109:1004-1012.
    • (2013) Br J Cancer , vol.109 , pp. 1004-1012
    • Bae, J.M.1    Kim, J.H.2    Cho, N.Y.3    Kim, T.Y.4    Kang, G.H.5
  • 174
    • 84889767375 scopus 로고    scopus 로고
    • New insights on bariatric surgery outcomes
    • Ikramuddin S, Livingston EH. New insights on bariatric surgery outcomes. JAMA 2013;310: 2401-2402.
    • (2013) JAMA , vol.310 , pp. 2401-2402
    • Ikramuddin, S.1    Livingston, E.H.2
  • 175
    • 84890027933 scopus 로고    scopus 로고
    • Body mass index and microsatellite instability in colorectal cancer: A population-based study
    • Hoffmeister M, Blaker H, Kloor M, et al. Body mass index and microsatellite instability in colorectal cancer: a population-based study. Cancer Epidemiol Biomarkers Prev 2013;22:2303-2311.
    • (2013) Cancer Epidemiol Biomarkers Prev , vol.22 , pp. 2303-2311
    • Hoffmeister, M.1    Blaker, H.2    Kloor, M.3
  • 176
    • 84895788624 scopus 로고    scopus 로고
    • Influence of prediagnostic cigarette smoking on colorectal cancer survival: Overall and by tumour molecular phenotype
    • Zhu Y, Yang SR, Wang PP, et al. Influence of prediagnostic cigarette smoking on colorectal cancer survival: overall and by tumour molecular phenotype. Br J Cancer 2014;110:1359-1366.
    • (2014) Br J Cancer , vol.110 , pp. 1359-1366
    • Zhu, Y.1    Yang, S.R.2    Wang, P.P.3
  • 177
    • 84863718303 scopus 로고    scopus 로고
    • Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88
    • Larsson E, Tremaroli V, Lee YS, et al. Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88. Gut 2012;61:1124-1131.
    • (2012) Gut , vol.61 , pp. 1124-1131
    • Larsson, E.1    Tremaroli, V.2    Lee, Y.S.3
  • 178
    • 84860589077 scopus 로고    scopus 로고
    • Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum
    • Yamauchi M, Morikawa T, Kuchiba A, et al. Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum. Gut 2012;61:847-854.
    • (2012) Gut , vol.61 , pp. 847-854
    • Yamauchi, M.1    Morikawa, T.2    Kuchiba, A.3
  • 179
    • 79952674000 scopus 로고    scopus 로고
    • Interactome networks and human disease
    • Vidal M, Cusick ME, Barabasi AL. Interactome networks and human disease. Cell 2011;144:986-998.
    • (2011) Cell , vol.144 , pp. 986-998
    • Vidal, M.1    Cusick, M.E.2    Barabasi, A.L.3
  • 180
    • 84863509978 scopus 로고    scopus 로고
    • Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome
    • Wan ES, Qiu W, Baccarelli A, et al. Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome. Hum Mol Genet 2012;21:3073-3082.
    • (2012) Hum Mol Genet , vol.21 , pp. 3073-3082
    • Wan, E.S.1    Qiu, W.2    Baccarelli, A.3
  • 181
    • 84873476594 scopus 로고    scopus 로고
    • Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking
    • Shenker NS, Polidoro S, van Veldhoven K, et al. Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking. Hum Mol Genet 2013;22: 843-851.
    • (2013) Hum Mol Genet , vol.22 , pp. 843-851
    • Shenker, N.S.1    Polidoro, S.2    Van Veldhoven, K.3
  • 182
    • 1142299519 scopus 로고    scopus 로고
    • Relation of cigarette smoking and alcohol use to colorectal adenomas by subsite: The self-defense forces health study
    • Toyomura K, Yamaguchi K, Kawamoto H, et al. Relation of cigarette smoking and alcohol use to colorectal adenomas by subsite: the self-defense forces health study. Cancer Sci 2004;95:72-76.
    • (2004) Cancer Sci , vol.95 , pp. 72-76
    • Toyomura, K.1    Yamaguchi, K.2    Kawamoto, H.3
  • 183
    • 84861861103 scopus 로고    scopus 로고
    • Prevalence of different subtypes of serrated polyps and risk of synchronous advanced colorectal neoplasia in average-risk population undergoing first-time colonoscopy
    • Buda A, De Bona M, Dotti I, et al. Prevalence of different subtypes of serrated polyps and risk of synchronous advanced colorectal neoplasia in average-risk population undergoing first-time colonoscopy. Clin Transl Gasntroenterol 2012;3:e6.
    • (2012) Clin Transl Gasntroenterol , vol.3 , pp. e6
    • Buda, A.1    De Bona, M.2    Dotti, I.3
  • 184
    • 84868128686 scopus 로고    scopus 로고
    • Molecular dissection of premalignant colorectal lesions reveals early onset of the CpG Island methylator phenotype
    • Yamamoto E, Suzuki H, Yamano HO, et al. Molecular dissection of premalignant colorectal lesions reveals early onset of the CpG Island methylator phenotype. Am J Pathol 2012;181:1847-1861.
    • (2012) Am J Pathol , vol.181 , pp. 1847-1861
    • Yamamoto, E.1    Suzuki, H.2    Yamano, H.O.3
  • 185
    • 84878822005 scopus 로고    scopus 로고
    • Epigenetics and colorectal cancer pathogenesis
    • Bardhan K, Liu K. Epigenetics and colorectal cancer pathogenesis. Cancers 2013;5:676-713.
    • (2013) Cancers , vol.5 , pp. 676-713
    • Bardhan, K.1    Liu, K.2
  • 186
    • 84890472864 scopus 로고    scopus 로고
    • Molecular pathways involved in colorectal cancer: Implications for disease behavior and prevention
    • Colussi D, Brandi G, Bazzoli F, Ricciardiello L. Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention. Int J Mol Sci 2013;14:16365-16385.
    • (2013) Int J Mol Sci , vol.14 , pp. 16365-16385
    • Colussi, D.1    Brandi, G.2    Bazzoli, F.3    Ricciardiello, L.4
  • 187
    • 84867309005 scopus 로고    scopus 로고
    • BRAF mutation status and survival after colorectal cancer diagnosis according to patient and tumor characteristics
    • Phipps AI, Buchanan DD, Makar KW, et al. BRAF mutation status and survival after colorectal cancer diagnosis according to patient and tumor characteristics. Cancer Epidemiol Biomarkers Prev 2012;21: 1792-1798.
    • (2012) Cancer Epidemiol Biomarkers Prev , vol.21 , pp. 1792-1798
    • Phipps, A.I.1    Buchanan, D.D.2    Makar, K.W.3
  • 188
    • 84870339415 scopus 로고    scopus 로고
    • Mutation profiling and microsatellite instability in stage II and III colon cancer: An assessment of their prognostic and oxaliplatin predictive value
    • Gavin P, Colangelo LH, Fumagalli D, et al. Mutation profiling and microsatellite instability in stage II and III colon cancer: an assessment of their prognostic and oxaliplatin predictive value. Clin Cancer Res 2012;18:6531-6541.
    • (2012) Clin Cancer Res , vol.18 , pp. 6531-6541
    • Gavin, P.1    Colangelo, L.H.2    Fumagalli, D.3
  • 190
    • 77949759545 scopus 로고    scopus 로고
    • The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status
    • Dahlin AM, Palmqvist R, Henriksson ML, et al. The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status. Clin Cancer Res 2010;16: 1845-1855.
    • (2010) Clin Cancer Res , vol.16 , pp. 1845-1855
    • Dahlin, A.M.1    Palmqvist, R.2    Henriksson, M.L.3
  • 191
    • 80052926952 scopus 로고    scopus 로고
    • Comprehensive analysis of CpG island methylator phenotype (CIMP)-high,-low, and-negative colorectal cancers based on protein marker expression and molecular features
    • Zlobec I, Bihl M, Foerster A, Rufle A, Lugli A. Comprehensive analysis of CpG island methylator phenotype (CIMP)-high,-low, and-negative colorectal cancers based on protein marker expression and molecular features. J Pathol 2011;225:336-343.
    • (2011) J Pathol , vol.225 , pp. 336-343
    • Zlobec, I.1    Bihl, M.2    Foerster, A.3    Rufle, A.4    Lugli, A.5
  • 192
    • 77952449085 scopus 로고    scopus 로고
    • Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features
    • Ang PW, Loh M, Liem N, et al. Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features. BMC Cancer 2010;10:227.
    • (2010) BMC Cancer , vol.10 , pp. 227
    • Ang, P.W.1    Loh, M.2    Liem, N.3
  • 193
    • 84876495060 scopus 로고    scopus 로고
    • CpG island methylation, microsatellite instability, and BRAF mutations and their clinical application in the treatment of colon cancer
    • Wu C, Bekaii-Saab T. CpG island methylation, microsatellite instability, and BRAF mutations and their clinical application in the treatment of colon cancer. Chemother Res Prac 2012;2012:359041.
    • (2012) Chemother Res Prac , vol.2012 , pp. 359041
    • Wu, C.1    Bekaii-Saab, T.2
  • 194
    • 84875055696 scopus 로고    scopus 로고
    • Wholegenome methylation analysis of benign and malignant colorectal tumours
    • Beggs AD, Jones A, El-Bahwary M, et al. Wholegenome methylation analysis of benign and malignant colorectal tumours. J Pathol 2013;229:697-704.
    • (2013) J Pathol , vol.229 , pp. 697-704
    • Beggs, A.D.1    Jones, A.2    El-Bahwary, M.3
  • 195
    • 84868124205 scopus 로고    scopus 로고
    • The impact of CpG island methylator phenotype and microsatellite instability on tumour budding in colorectal cancer
    • Zlobec I, Bihl MP, Foerster A, Rufle A, Lugli A. The impact of CpG island methylator phenotype and microsatellite instability on tumour budding in colorectal cancer. Histopathology 2012;61:777-787.
    • (2012) Histopathology , vol.61 , pp. 777-787
    • Zlobec, I.1    Bihl, M.P.2    Foerster, A.3    Rufle, A.4    Lugli, A.5
  • 196
    • 70350228539 scopus 로고    scopus 로고
    • Synchronous colorectal cancer: Not just bad luck?
    • Leggett BA, Worthley DL. Synchronous colorectal cancer: not just bad luck? Gastroenterology 2009;137: 1559-1562.
    • (2009) Gastroenterology , vol.137 , pp. 1559-1562
    • Leggett, B.A.1    Worthley, D.L.2
  • 197
    • 77950356773 scopus 로고    scopus 로고
    • Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study
    • Naguib A, Mitrou PN, Gay LJ, et al. Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study. BMC Cancer 2010;10:99.
    • (2010) BMC Cancer , vol.10 , pp. 99
    • Naguib, A.1    Mitrou, P.N.2    Gay, L.J.3
  • 198
    • 40849151848 scopus 로고    scopus 로고
    • Cigarette smoking and KRAS oncogene mutations in sporadic colorectal cancer: Results from the Netherlands Cohort Study
    • Weijenberg MP, Aardening PW, de Kok TM, de Goeij AF, van den Brandt PA. Cigarette smoking and KRAS oncogene mutations in sporadic colorectal cancer: results from the Netherlands Cohort Study. Mutat Res 2008;652:54-64.
    • (2008) Mutat Res , vol.652 , pp. 54-64
    • Weijenberg, M.P.1    Aardening, P.W.2    De Tm, K.3    De Af, G.4    Brandt Van Den, P.A.5
  • 199
    • 0345616431 scopus 로고    scopus 로고
    • Cigarette smoking and genetic alterations in sporadic colon carcinomas
    • Diergaarde B, Vrieling A, van Kraats AA, et al. Cigarette smoking and genetic alterations in sporadic colon carcinomas. Carcinogenesis 2003;24:565-571.
    • (2003) Carcinogenesis , vol.24 , pp. 565-571
    • Diergaarde, B.1    Vrieling, A.2    Van Aa, K.3
  • 200
    • 0035500820 scopus 로고    scopus 로고
    • Lifestyle factors and Ki-ras mutations in colon cancer tumors
    • Slattery ML, Anderson K, Curtin K, et al. Lifestyle factors and Ki-ras mutations in colon cancer tumors. Mutat Res 2001;483:73-81.
    • (2001) Mutat Res , vol.483 , pp. 73-81
    • Slattery, M.L.1    Anderson, K.2    Curtin, K.3
  • 201
    • 84862313878 scopus 로고    scopus 로고
    • Cigarette smoking and colorectal cancer risk by KRAS mutation status among older women
    • Samadder NJ, Vierkant RA, Tillmans LS, et al. Cigarette smoking and colorectal cancer risk by KRAS mutation status among older women. Am J Gastroenterol 2012;107:782-789.
    • (2012) Am J Gastroenterol , vol.107 , pp. 782-789
    • Samadder, N.J.1    Vierkant, R.A.2    Tillmans, L.S.3
  • 202
    • 67549105888 scopus 로고    scopus 로고
    • Five-year efficacy and safety analysis of the Adenoma Prevention with Celecoxib Trial
    • Bertagnolli MM, Eagle CJ, Zauber AG, et al. Five-year efficacy and safety analysis of the Adenoma Prevention with Celecoxib Trial. Cancer Prev Res (Phila) 2009;2:310-321.
    • (2009) Cancer Prev Res (Phila) , vol.2 , pp. 310-321
    • Bertagnolli, M.M.1    Eagle, C.J.2    Zauber, A.G.3
  • 203
    • 84855191820 scopus 로고    scopus 로고
    • Prevention by daily soluble aspirin of colorectal adenoma recurrence: 4-year results of the APACC randomised trial
    • Benamouzig R, Uzzan B, Deyra J, et al. Prevention by daily soluble aspirin of colorectal adenoma recurrence: 4-year results of the APACC randomised trial. Gut 2012;61:255-261.
    • (2012) Gut , vol.61 , pp. 255-261
    • Benamouzig, R.1    Uzzan, B.2    Deyra, J.3
  • 204
    • 84879395305 scopus 로고    scopus 로고
    • Aspirin use and risk of colorectal cancer according to BRAF mutation status
    • Nishihara R, Lochhead P, Kuchiba A, et al. Aspirin use and risk of colorectal cancer according to BRAF mutation status. JAMA 2013;309:2563-2571.
    • (2013) JAMA , vol.309 , pp. 2563-2571
    • Nishihara, R.1    Lochhead, P.2    Kuchiba, A.3
  • 205
    • 84863399038 scopus 로고    scopus 로고
    • Effect of daily aspirin on risk of cancer metastasis: A study of incident cancers during randomised controlled trials
    • Rothwell PM, Wilson M, Price JF, et al. Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials. Lancet 2012;379:1591-1601.
    • (2012) Lancet , vol.379 , pp. 1591-1601
    • Rothwell, P.M.1    Wilson, M.2    Price, J.F.3
  • 206
    • 84860467522 scopus 로고    scopus 로고
    • Effects of regular aspirin on long-term cancer incidence and metastasis: A systematic comparison of evidence from observational studies versus randomised trials
    • Algra AM, Rothwell PM. Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials. Lancet Oncol 2012;13:518-527.
    • (2012) Lancet Oncol , vol.13 , pp. 518-527
    • Algra, A.M.1    Rothwell, P.M.2
  • 207
    • 84893098491 scopus 로고    scopus 로고
    • Nicotine-mediated cell proliferation and tumor progression in smokingrelated cancers
    • Schaal C, Chellappan SP. Nicotine-mediated cell proliferation and tumor progression in smokingrelated cancers. Mol Cancer Res 2014;12:14-23.
    • (2014) Mol Cancer Res , vol.12 , pp. 14-23
    • Schaal, C.1    Chellappan, S.P.2
  • 208
    • 34547221175 scopus 로고    scopus 로고
    • Induction of epithelial-mesenchymal transition-related genes by Benzo[a].Pyrene in lung cancer cells
    • Yoshino I, Kometani T, Shoji F, et al. Induction of epithelial-mesenchymal transition-related genes by Benzo[a]Pyrene in lung cancer cells. Cancer 2007;110:369-374.
    • (2007) Cancer , vol.110 , pp. 369-374
    • Yoshino, I.1    Kometani, T.2    Shoji, F.3
  • 209
    • 84881001606 scopus 로고    scopus 로고
    • Cigarette smoke induces epithelial to mesenchymal transition and increases the metastatic ability of breast cancer cells
    • Di Cello F, Flowers VL, Li HL, et al. Cigarette smoke induces epithelial to mesenchymal transition and increases the metastatic ability of breast cancer cells. Mol Cancer 12:90 2013.
    • (2013) Mol Cancer , vol.12 , pp. 90
    • Di Cello, F.1    Flowers, V.L.2    Li, H.L.3
  • 210
    • 79959636906 scopus 로고    scopus 로고
    • The physics of cancer: The role of physical interactions and mechanical forces in metastasis
    • Wirtz D, Konstantopoulos K, Searson PC. The physics of cancer: the role of physical interactions and mechanical forces in metastasis. Nat Rev Cancer 2011;11:512-522.
    • (2011) Nat Rev Cancer , vol.11 , pp. 512-522
    • Wirtz, D.1    Konstantopoulos, K.2    Searson, P.C.3
  • 211
    • 79551707743 scopus 로고    scopus 로고
    • Endogenous versus tumor-specific host response to breast carcinoma: A study of stromal response in synchronous breast primaries and biopsy site changes
    • Wu JM, Beck AH, Pate LL, et al. Endogenous versus tumor-specific host response to breast carcinoma: a study of stromal response in synchronous breast primaries and biopsy site changes. Clin Cancer Res 2011;17:437-446.
    • (2011) Clin Cancer Res , vol.17 , pp. 437-446
    • Wu, J.M.1    Beck, A.H.2    Pate, L.L.3
  • 212
    • 84864285794 scopus 로고    scopus 로고
    • Tumor microenvironment contributes to innate RAF-inhibitor resistance through HGF secretion
    • Straussman R, Morikawa T, Shee K, et al. Tumor microenvironment contributes to innate RAF-inhibitor resistance through HGF secretion. Nature 2012; 487:500-504.
    • (2012) Nature , vol.487 , pp. 500-504
    • Straussman, R.1    Morikawa, T.2    Shee, K.3
  • 214
    • 84860599697 scopus 로고    scopus 로고
    • Colorectal cancer: A tale of two sides or a continuum?
    • Yamauchi M, Lochhead P, Morikawa T, et al. Colorectal cancer: a tale of two sides or a continuum? Gut 2012;61:794-497.
    • (2012) Gut , vol.61 , pp. 794-497
    • Yamauchi, M.1    Lochhead, P.2    Morikawa, T.3
  • 215
    • 84863595550 scopus 로고    scopus 로고
    • The continuum model of selection in human tumors: General paradigm or niche product?
    • Leedham S, Tomlinson I. The continuum model of selection in human tumors: general paradigm or niche product? Cancer Res 2012;72:3131-3134.
    • (2012) Cancer Res , vol.72 , pp. 3131-3134
    • Leedham, S.1    Tomlinson, I.2
  • 216
    • 84855507957 scopus 로고    scopus 로고
    • Understanding the potential and challenges of adenoma treatment as a prevention opportunity: Insights from the BeWEL formative study
    • Stead M, Caswell S, Craigie AM, Eadie D, Anderson AS. Understanding the potential and challenges of adenoma treatment as a prevention opportunity: insights from the BeWEL formative study. Preven Med 2012;54:97-103.
    • (2012) Preven Med , vol.54 , pp. 97-103
    • Stead, M.1    Caswell, S.2    Craigie, A.M.3    Eadie, D.4    Anderson, A.S.5
  • 217
    • 73749086678 scopus 로고    scopus 로고
    • Bowel health to better health: A minimal contact lifestyle intervention for people at increased risk of colorectal cancer
    • Caswell S, Anderson AS, Steele RJ. Bowel health to better health: a minimal contact lifestyle intervention for people at increased risk of colorectal cancer. Br J Nutr 2009;102:1541-1546.
    • (2009) Br J Nutr , vol.102 , pp. 1541-1546
    • Caswell, S.1    Anderson, A.S.2    Steele, R.J.3
  • 218
    • 78449304532 scopus 로고    scopus 로고
    • Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer
    • Kim DH, Smith-Warner SA, Spiegelman D, et al. Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer. Cancer Causes Control 2010;21:1919-1930.
    • (2010) Cancer Causes Control , vol.21 , pp. 1919-1930
    • Kim, D.H.1    Smith-Warner, S.A.2    Spiegelman, D.3
  • 219
    • 79953180534 scopus 로고    scopus 로고
    • Folate intake and risk of colorectal cancer and adenoma: Modification by time
    • Lee JE, Willett WC, Fuchs CS, et al. Folate intake and risk of colorectal cancer and adenoma: modification by time. Am J Clin Nutr 2011;93:817-825.
    • (2011) Am J Clin Nutr , vol.93 , pp. 817-825
    • Lee, J.E.1    Willett, W.C.2    Fuchs, C.S.3
  • 220
    • 84872171323 scopus 로고    scopus 로고
    • Low colonocyte folate is associated with uracil misincorporation and global DNA hypomethylation in human colorectum
    • McGlynn AP, Wasson GR, O'Reilly SL, et al. Low colonocyte folate is associated with uracil misincorporation and global DNA hypomethylation in human colorectum. J Nutr 2013;143:27-33.
    • (2013) J Nutr , vol.143 , pp. 27-33
    • McGlynn, A.P.1    Wasson, G.R.2    O'Reilly, S.L.3
  • 222
    • 84875457313 scopus 로고    scopus 로고
    • Conventional and nanotechniques for DNA methylation profiling
    • Shanmuganathan R, Nazeema Banu B, Amirthalingam L, et al. Conventional and nanotechniques for DNA methylation profiling. J Mol Diagn 2013;15: 17-26.
    • (2013) J Mol Diagn , vol.15 , pp. 17-26
    • Shanmuganathan, R.1    Nazeema Banu, B.2    Amirthalingam, L.3
  • 223
    • 84882279485 scopus 로고    scopus 로고
    • Measuring the exposome: A powerful basis for evaluating environmental exposures and cancer risk
    • Wild CP, Scalbert A, Herceg Z. Measuring the exposome: a powerful basis for evaluating environmental exposures and cancer risk. Environ Mol Mutagen 2013;54:480-499.
    • (2013) Environ Mol Mutagen , vol.54 , pp. 480-499
    • Wild, C.P.1    Scalbert, A.2    Herceg, Z.3
  • 224
    • 84859463632 scopus 로고    scopus 로고
    • Epigenetic differences in normal colon mucosa of cancer patients suggest altered dietary metabolic pathways
    • Silviera ML, Smith BP, Powell J, Sapienza C. Epigenetic differences in normal colon mucosa of cancer patients suggest altered dietary metabolic pathways. Cancer Prev Res (Phila) 2012;5:374-384.
    • (2012) Cancer Prev Res (Phila) , vol.5 , pp. 374-384
    • Silviera, M.L.1    Smith, B.P.2    Powell, J.3    Sapienza, C.4
  • 225
    • 84870776420 scopus 로고    scopus 로고
    • Detection and differential diagnosis of colon cancer by a cumulative analysis of promoter methylation
    • Yang Q, Dong Y, Wu W, et al. Detection and differential diagnosis of colon cancer by a cumulative analysis of promoter methylation. Nat Commun 2012; 3:1206.
    • (2012) Nat Commun , vol.3 , pp. 1206
    • Yang, Q.1    Dong, Y.2    Wu, W.3
  • 226
    • 84861858540 scopus 로고    scopus 로고
    • Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization
    • Damania D, Roy HK, Subramanian H, et al. Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization. Cancer Res 2012;72:2720-2727.
    • (2012) Cancer Res , vol.72 , pp. 2720-2727
    • Damania, D.1    Roy, H.K.2    Subramanian, H.3
  • 227
    • 78650489811 scopus 로고    scopus 로고
    • Light-scattering technologies for field carcinogenesis detection: A modality for endoscopic prescreening
    • Backman V, Roy HK. Light-scattering technologies for field carcinogenesis detection: a modality for endoscopic prescreening. Gastroenterology 2011;140: 35-41.
    • (2011) Gastroenterology , vol.140 , pp. 35-41
    • Backman, V.1    Roy, H.K.2
  • 228
    • 84860910413 scopus 로고    scopus 로고
    • The predictive capacity of personal genome sequencing
    • Roberts NJ, Vogelstein JT, Parmigiani G, et al. The predictive capacity of personal genome sequencing. Sci Transl Med 2012;4:133ra58.
    • (2012) Sci Transl Med , vol.4 , pp. 133ra58
    • Roberts, N.J.1    Vogelstein, J.T.2    Parmigiani, G.3
  • 229
  • 230
    • 84884829249 scopus 로고    scopus 로고
    • Mapping human epigenomes
    • Rivera CM, Ren B. Mapping human epigenomes. Cell 2013;155:39-55.
    • (2013) Cell , vol.155 , pp. 39-55
    • Rivera, C.M.1    Ren, B.2
  • 231
    • 84855839546 scopus 로고    scopus 로고
    • Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers
    • Monick MM, Beach SR, Plume J, et al. Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers. Am J Med Genet B Neuropsychiatr Genet 2012;159B: 141-151.
    • (2012) Am J Med Genet B Neuropsychiatr Genet , vol.159 B , pp. 141-151
    • Monick, M.M.1    Beach, S.R.2    Plume, J.3
  • 232
    • 79952429678 scopus 로고    scopus 로고
    • Physical activity and global genomic DNA methylation in a cancer-free population
    • Zhang FF, Cardarelli R, Carroll J, et al. Physical activity and global genomic DNA methylation in a cancer-free population. Epigenetics 2011;6:293-299.
    • (2011) Epigenetics , vol.6 , pp. 293-299
    • Zhang, F.F.1    Cardarelli, R.2    Carroll, J.3
  • 233
    • 79960121131 scopus 로고    scopus 로고
    • The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood
    • Langevin SM, Houseman EA, Christensen BC, et al. The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood. Epigenetics 2011;6: 908-919.
    • (2011) Epigenetics , vol.6 , pp. 908-919
    • Langevin, S.M.1    Houseman, E.A.2    Christensen, B.C.3
  • 234
    • 84867845342 scopus 로고    scopus 로고
    • Transcriptome alterations induced by cigarette smoke
    • Brody JS. Transcriptome alterations induced by cigarette smoke. Int J Cancer 2012;131:2754-2762.
    • (2012) Int J Cancer , vol.131 , pp. 2754-2762
    • Brody, J.S.1
  • 235
    • 84882814866 scopus 로고    scopus 로고
    • Gender-specific transcriptomic response to environmental exposure in Flemish adults
    • De Coster S, van Leeuwen DM, Jennen DG, et al. Gender-specific transcriptomic response to environmental exposure in Flemish adults. Environ Mol Mutagen 2013;54:574-588.
    • (2013) Environ Mol Mutagen , vol.54 , pp. 574-588
    • De Coster, S.1    Van Leeuwen, D.M.2    Jennen, D.G.3
  • 236
    • 84870294886 scopus 로고    scopus 로고
    • A whole blood gene expression-based signature for smoking status
    • Beineke P, Fitch K, Tao H, et al. A whole blood gene expression-based signature for smoking status. BMC Med Genomics 2012;5:58.
    • (2012) BMC Med Genomics , vol.5 , pp. 58
    • Beineke, P.1    Fitch, K.2    Tao, H.3
  • 237
    • 38149073261 scopus 로고    scopus 로고
    • Supplementation of healthy volunteers with nutritionally relevant amounts of selenium increases the expression of lymphocyte protein biosynthesis genes
    • Pagmantidis V, Meplan C, van Schothorst EM, Keijer J, Hesketh JE. Supplementation of healthy volunteers with nutritionally relevant amounts of selenium increases the expression of lymphocyte protein biosynthesis genes. Am J Clin Nutr 2008;87: 181-189.
    • (2008) Am J Clin Nutr , vol.87 , pp. 181-189
    • Pagmantidis, V.1    Meplan, C.2    Van Em, S.3    Keijer, J.4    Hesketh, J.E.5
  • 238
    • 84865711795 scopus 로고    scopus 로고
    • Biomarkers intersect with the exposome
    • Rappaport SM. Biomarkers intersect with the exposome. Biomarkers 2012;17:483-489.
    • (2012) Biomarkers , vol.17 , pp. 483-489
    • Rappaport, S.M.1
  • 239
    • 84866378954 scopus 로고    scopus 로고
    • Protein microarrays, biosensors, and cellbased methods for secretome-wide extracellular proteinprotein interaction mapping
    • Gonzalez LC. Protein microarrays, biosensors, and cellbased methods for secretome-wide extracellular proteinprotein interaction mapping. Methods 2012;57:448-458.
    • (2012) Methods , vol.57 , pp. 448-458
    • Gonzalez, L.C.1
  • 240
    • 53049107370 scopus 로고    scopus 로고
    • Spectroscopic microvascular blood detection from the endoscopically normal colonic mucosa: Biomarker for neoplasia risk
    • Roy HK, Gomes A, Turzhitsky V, et al. Spectroscopic microvascular blood detection from the endoscopically normal colonic mucosa: biomarker for neoplasia risk. Gastroenterology 2008;135:1069-1078.
    • (2008) Gastroenterology , vol.135 , pp. 1069-1078
    • Roy, H.K.1    Gomes, A.2    Turzhitsky, V.3
  • 241
    • 66249090583 scopus 로고    scopus 로고
    • Association between rectal optical signatures and colonic neoplasia: Potential applications for screening
    • Roy HK, Turzhitsky V, Kim Y, et al. Association between rectal optical signatures and colonic neoplasia: potential applications for screening. Cancer Res 2009;69:4476-4483.
    • (2009) Cancer Res , vol.69 , pp. 4476-4483
    • Roy, H.K.1    Turzhitsky, V.2    Kim, Y.3
  • 242
    • 84895835938 scopus 로고    scopus 로고
    • Editorial: What is behind the remarkable increase in esophageal adenocarcinoma?
    • Shaheen NJ. Editorial: what is behind the remarkable increase in esophageal adenocarcinoma? Am J Gastroenterol 2014;109:345-347.
    • (2014) Am J Gastroenterol , vol.109 , pp. 345-347
    • Shaheen, N.J.1
  • 243
    • 84901917862 scopus 로고    scopus 로고
    • Associations of hormone replacement therapy and oral contraceptives with risk of colorectal cancer defined by clinicopathological factors, beta-catenin alterations, expression of cyclin D1, p53, and microsatelliteinstability
    • Brandstedt J, Wangefjord S, Nodin B, et al. Associations of hormone replacement therapy and oral contraceptives with risk of colorectal cancer defined by clinicopathological factors, beta-catenin alterations, expression of cyclin D1, p53, and microsatelliteinstability. BMC Cancer 2014;14:371.
    • (2014) BMC Cancer , vol.14 , pp. 371
    • Brandstedt, J.1    Wangefjord, S.2    Nodin, B.3
  • 244
    • 84905594502 scopus 로고    scopus 로고
    • The role of epigenetics in colorectal cancer
    • (e-pub ahead of print)
    • Coppede F. The role of epigenetics in colorectal cancer. Expert Rev Gastroenterol Hepatol 2014 (e-pub ahead of print).
    • (2014) Expert Rev Gastroenterol Hepatol
    • Coppede, F.1
  • 245
    • 84901499648 scopus 로고    scopus 로고
    • Epidemiological transition of colorectal cancer in developing countries: Environmental factors, molecular pathways, and opportunities for prevention
    • Bishehsari F, Mahdavinia M, Vacca M, et al. Epidemiological transition of colorectal cancer in developing countries: environmental factors, molecular pathways, and opportunities for prevention. World J Gastroenterol 2014;20:6055-6072.
    • (2014) World J Gastroenterol , vol.20 , pp. 6055-6072
    • Bishehsari, F.1    Mahdavinia, M.2    Vacca, M.3


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