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Volumn 138, Issue 5, 2010, Pages

Aberrant DNA Methylation in Hereditary Nonpolyposis Colorectal Cancer Without Mismatch Repair Deficiency

Author keywords

Colorectal Cancer; Microsatellite Stable, Hereditary Nonpolyposis Colorectal Cancer; Non Lynch HNPCC

Indexed keywords

B RAF KINASE; K RAS PROTEIN; LONG INTERSPERSED NUCLEOTIDE ELEMENT 1 PROTEIN; NEUROGENIN 1; PROTEIN CACNAG1; PROTEIN MLH1; RAF PROTEIN; RAS PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRANSCRIPTION FACTOR RUNX3; UNCLASSIFIED DRUG;

EID: 77951814373     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.01.035     Document Type: Article
Times cited : (95)

References (44)
  • 2
    • 0025848680 scopus 로고
    • The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)
    • Vasen H.F., Mecklin J.P., Khan P.M., et al. The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). Dis Colon Rectum 34 (1991) 424-425
    • (1991) Dis Colon Rectum , vol.34 , pp. 424-425
    • Vasen, H.F.1    Mecklin, J.P.2    Khan, P.M.3
  • 3
    • 0033063711 scopus 로고    scopus 로고
    • HNPCC I: new clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch Syndrome) proposed by the International Collaborative Group on HNPCC
    • Vasen H.F.A., Watson P., Mecklin J.-P., et al. HNPCC I: new clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch Syndrome) proposed by the International Collaborative Group on HNPCC. Gastroenterology 116 (1999) 1453-1456
    • (1999) Gastroenterology , vol.116 , pp. 1453-1456
    • Vasen, H.F.A.1    Watson, P.2    Mecklin, J.-P.3
  • 4
    • 0031023727 scopus 로고    scopus 로고
    • Genetic testing is important in families with a history suggestive of hereditary non-polyposis colorectal cancer even if the Amsterdam criteria are not fulfilled
    • Beck N.E., Tomlinson I.P., Homfray T., et al. Genetic testing is important in families with a history suggestive of hereditary non-polyposis colorectal cancer even if the Amsterdam criteria are not fulfilled. Br J Surg 84 (1997) 233-237
    • (1997) Br J Surg , vol.84 , pp. 233-237
    • Beck, N.E.1    Tomlinson, I.P.2    Homfray, T.3
  • 5
    • 0037390446 scopus 로고    scopus 로고
    • The hereditary nonpolyposis colorectal cancer syndrome: genetics and clinical implications
    • Chung D.C., and Rustgi A.K. The hereditary nonpolyposis colorectal cancer syndrome: genetics and clinical implications. Ann Intern Med 138 (2003) 560-570
    • (2003) Ann Intern Med , vol.138 , pp. 560-570
    • Chung, D.C.1    Rustgi, A.K.2
  • 6
    • 0032749569 scopus 로고    scopus 로고
    • Germ-line msh6 mutations in colorectal cancer
    • Kolodner R.D., Tytell J.D., Schmeits J.L., et al. Germ-line msh6 mutations in colorectal cancer. Cancer Res 59 (1999) 5068-5074
    • (1999) Cancer Res , vol.59 , pp. 5068-5074
    • Kolodner, R.D.1    Tytell, J.D.2    Schmeits, J.L.3
  • 7
    • 3142748325 scopus 로고    scopus 로고
    • Mismatch repair gene PMS2: disease-causing germline mutations are frequent in patients whose tumors stain negative for PMS2 protein, but paralogous genes obscure mutation detection and interpretation
    • Nakagawa H., Lockman J.C., Frankel W.L., et al. Mismatch repair gene PMS2: disease-causing germline mutations are frequent in patients whose tumors stain negative for PMS2 protein, but paralogous genes obscure mutation detection and interpretation. Cancer Res 64 (2004) 4721-4727
    • (2004) Cancer Res , vol.64 , pp. 4721-4727
    • Nakagawa, H.1    Lockman, J.C.2    Frankel, W.L.3
  • 8
    • 0027158031 scopus 로고
    • Clues to the pathogenesis of familial colorectal cancer
    • Aaltonen L.A., Peltomaki P., Leach F.S., et al. Clues to the pathogenesis of familial colorectal cancer. Science 260 (1993) 812-816
    • (1993) Science , vol.260 , pp. 812-816
    • Aaltonen, L.A.1    Peltomaki, P.2    Leach, F.S.3
  • 9
    • 0032723363 scopus 로고    scopus 로고
    • Signaling mismatch repair in cancer
    • Fishel R. Signaling mismatch repair in cancer. Nat Med 5 (1999) 1239-1241
    • (1999) Nat Med , vol.5 , pp. 1239-1241
    • Fishel, R.1
  • 10
    • 27144484911 scopus 로고    scopus 로고
    • Differential features of colorectal cancers fulfilling Amsterdam criteria without involvement of the mutator pathway
    • Llor X., Pons E., Xicola R.M., et al. Differential features of colorectal cancers fulfilling Amsterdam criteria without involvement of the mutator pathway. Clin Cancer Res 11 (2005) 7304-7310
    • (2005) Clin Cancer Res , vol.11 , pp. 7304-7310
    • Llor, X.1    Pons, E.2    Xicola, R.M.3
  • 11
    • 28144453808 scopus 로고    scopus 로고
    • HNPCC-clinical and molecular evidence for a new entity of hereditary colorectal cancer
    • Mueller-Koch Y., Vogelsang H., Kopp R., et al. HNPCC-clinical and molecular evidence for a new entity of hereditary colorectal cancer. Gut 14 (2005) 14
    • (2005) Gut , vol.14 , pp. 14
    • Mueller-Koch, Y.1    Vogelsang, H.2    Kopp, R.3
  • 12
    • 20244386256 scopus 로고    scopus 로고
    • Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X
    • Lindor N.M., Rabe K., Petersen G.M., et al. Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X. JAMA 293 (2005) 1979-1985
    • (2005) JAMA , vol.293 , pp. 1979-1985
    • Lindor, N.M.1    Rabe, K.2    Petersen, G.M.3
  • 13
    • 27144484911 scopus 로고    scopus 로고
    • Differential features of colorectal cancers fulfilling Amsterdam criteria without involvement of the mutator pathway
    • Llor X., Pons E., Xicola R.M., et al. Differential features of colorectal cancers fulfilling Amsterdam criteria without involvement of the mutator pathway. Clin Cancer Res 11 (2005) 7304-7310
    • (2005) Clin Cancer Res , vol.11 , pp. 7304-7310
    • Llor, X.1    Pons, E.2    Xicola, R.M.3
  • 14
    • 27144497647 scopus 로고    scopus 로고
    • Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations
    • Abdel-Rahman W.M., Ollikainen M., Kariola R., et al. Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations. Oncogene 17 (2005) 17
    • (2005) Oncogene , vol.17 , pp. 17
    • Abdel-Rahman, W.M.1    Ollikainen, M.2    Kariola, R.3
  • 15
    • 35348918876 scopus 로고    scopus 로고
    • Molecular analysis of colorectal cancer tumors from patients with mismatch repair proficient hereditary nonpolyposis colorectal cancer suggests novel carcinogenic pathways
    • Sanchez-de-Abajo A., de la Hoya M., van Puijenbroek M., et al. Molecular analysis of colorectal cancer tumors from patients with mismatch repair proficient hereditary nonpolyposis colorectal cancer suggests novel carcinogenic pathways. Clin Cancer Res 13 (2007) 5729-5735
    • (2007) Clin Cancer Res , vol.13 , pp. 5729-5735
    • Sanchez-de-Abajo, A.1    de la Hoya, M.2    van Puijenbroek, M.3
  • 16
    • 33846192840 scopus 로고    scopus 로고
    • The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer
    • Goel A., Nagasaka T., Arnold C.N., et al. The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. Gastroenterology 132 (2007) 127-138
    • (2007) Gastroenterology , vol.132 , pp. 127-138
    • Goel, A.1    Nagasaka, T.2    Arnold, C.N.3
  • 17
    • 44849132638 scopus 로고    scopus 로고
    • Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer
    • Nagasaka T., Koi M., Kloor M., et al. Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer. Gastroenterology 134 (2008) 1950-1960e1
    • (2008) Gastroenterology , vol.134
    • Nagasaka, T.1    Koi, M.2    Kloor, M.3
  • 18
    • 64249108224 scopus 로고    scopus 로고
    • Large genomic rearrangements and germline epimutations in Lynch syndrome
    • Gylling A., Ridanpaa M., Vierimaa O., et al. Large genomic rearrangements and germline epimutations in Lynch syndrome. Int J Cancer 124 (2009) 2333-2340
    • (2009) Int J Cancer , vol.124 , pp. 2333-2340
    • Gylling, A.1    Ridanpaa, M.2    Vierimaa, O.3
  • 19
    • 0023254051 scopus 로고
    • Alterations in DNA methylation in human colon neoplasia
    • Feinberg A.P., and Vogelstein B. Alterations in DNA methylation in human colon neoplasia. Semin Surg Oncol 3 (1987) 149-151
    • (1987) Semin Surg Oncol , vol.3 , pp. 149-151
    • Feinberg, A.P.1    Vogelstein, B.2
  • 20
    • 0021950948 scopus 로고
    • Hypomethylation of DNA from benign and malignant human colon neoplasms
    • Goelz S.E., Vogelstein B., Hamilton S.R., et al. Hypomethylation of DNA from benign and malignant human colon neoplasms. Science 228 (1985) 187-190
    • (1985) Science , vol.228 , pp. 187-190
    • Goelz, S.E.1    Vogelstein, B.2    Hamilton, S.R.3
  • 21
    • 16544395591 scopus 로고    scopus 로고
    • DNA methylation and cancer
    • Das P.M., and Singal R. DNA methylation and cancer. J Clin Oncol 22 (2004) 4632-4642
    • (2004) J Clin Oncol , vol.22 , pp. 4632-4642
    • Das, P.M.1    Singal, R.2
  • 22
    • 33847712926 scopus 로고    scopus 로고
    • Performance of different microsatellite marker panels for detection of mismatch repair-deficient colorectal tumors
    • Xicola R.M., Llor X., Pons E., et al. Performance of different microsatellite marker panels for detection of mismatch repair-deficient colorectal tumors. J Natl Cancer Inst 99 (2007) 244-252
    • (2007) J Natl Cancer Inst , vol.99 , pp. 244-252
    • Xicola, R.M.1    Llor, X.2    Pons, E.3
  • 23
    • 0041333110 scopus 로고    scopus 로고
    • BRAF mutations in metastatic melanoma: a possible association with clinical outcome
    • Kumar R., Angelini S., Czene K., et al. BRAF mutations in metastatic melanoma: a possible association with clinical outcome. Clin Cancer Res 9 (2003) 3362-3368
    • (2003) Clin Cancer Res , vol.9 , pp. 3362-3368
    • Kumar, R.1    Angelini, S.2    Czene, K.3
  • 24
    • 0026017886 scopus 로고
    • The residues of Ras and Rap proteins that determine their GAP specificities
    • Maruta H., Holden J., Sizeland A., et al. The residues of Ras and Rap proteins that determine their GAP specificities. J Biol Chem 266 (1991) 11661-11668
    • (1991) J Biol Chem , vol.266 , pp. 11661-11668
    • Maruta, H.1    Holden, J.2    Sizeland, A.3
  • 25
    • 33745541234 scopus 로고    scopus 로고
    • CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
    • Weisenberger D.J., Siegmund K.D., Campan M., et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet 38 (2006) 787-793
    • (2006) Nat Genet , vol.38 , pp. 787-793
    • Weisenberger, D.J.1    Siegmund, K.D.2    Campan, M.3
  • 26
    • 2342557977 scopus 로고    scopus 로고
    • A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements
    • Yang A.S., Estecio M.R., Doshi K., et al. A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res 32 (2004) e38
    • (2004) Nucleic Acids Res , vol.32
    • Yang, A.S.1    Estecio, M.R.2    Doshi, K.3
  • 27
    • 33744918070 scopus 로고    scopus 로고
    • DNA methylation changes after 5-aza-2′-deoxycytidine therapy in patients with leukemia
    • Yang A.S., Doshi K.D., Choi S.W., et al. DNA methylation changes after 5-aza-2′-deoxycytidine therapy in patients with leukemia. Cancer Res 66 (2006) 5495-5503
    • (2006) Cancer Res , vol.66 , pp. 5495-5503
    • Yang, A.S.1    Doshi, K.D.2    Choi, S.W.3
  • 28
    • 29344455676 scopus 로고    scopus 로고
    • The relationship between global methylation level, loss of heterozygosity, and microsatellite instability in sporadic colorectal cancer
    • Matsuzaki K., Deng G., Tanaka H., et al. The relationship between global methylation level, loss of heterozygosity, and microsatellite instability in sporadic colorectal cancer. Clin Cancer Res 11 (2005) 8564-8569
    • (2005) Clin Cancer Res , vol.11 , pp. 8564-8569
    • Matsuzaki, K.1    Deng, G.2    Tanaka, H.3
  • 29
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones P.A., and Baylin S.B. The fundamental role of epigenetic events in cancer. Nat Rev Genet 3 (2002) 415-428
    • (2002) Nat Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 30
    • 0033587747 scopus 로고    scopus 로고
    • CpG island methylator phenotype in colorectal cancer
    • Toyota M., Ahuja N., Ohe-Toyota M., et al. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci U S A 96 (1999) 8681-8686
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 8681-8686
    • Toyota, M.1    Ahuja, N.2    Ohe-Toyota, M.3
  • 31
    • 33745500432 scopus 로고    scopus 로고
    • CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies
    • Ogino S., Cantor M., Kawasaki T., et al. CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies. Gut 55 (2006) 1000-1006
    • (2006) Gut , vol.55 , pp. 1000-1006
    • Ogino, S.1    Cantor, M.2    Kawasaki, T.3
  • 32
    • 10344260184 scopus 로고    scopus 로고
    • CpG island methylator phenotype in cancer
    • Issa J.P. CpG island methylator phenotype in cancer. Nat Rev Cancer 4 (2004) 988-993
    • (2004) Nat Rev Cancer , vol.4 , pp. 988-993
    • Issa, J.P.1
  • 33
    • 0034681117 scopus 로고    scopus 로고
    • Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype
    • Toyota M., Ohe-Toyota M., Ahuja N., et al. Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. Proc Natl Acad Sci U S A 97 (2000) 710-715
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 710-715
    • Toyota, M.1    Ohe-Toyota, M.2    Ahuja, N.3
  • 34
    • 34247570795 scopus 로고    scopus 로고
    • Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample
    • Ogino S., Kawasaki T., Kirkner G.J., et al. Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample. J Mol Diagn 9 (2007) 305-314
    • (2007) J Mol Diagn , vol.9 , pp. 305-314
    • Ogino, S.1    Kawasaki, T.2    Kirkner, G.J.3
  • 35
    • 44849132638 scopus 로고    scopus 로고
    • Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer
    • Nagasaka T., Koi M., Kloor M., et al. Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer. Gastroenterology 134 (2008) 1950-1960
    • (2008) Gastroenterology , vol.134 , pp. 1950-1960
    • Nagasaka, T.1    Koi, M.2    Kloor, M.3
  • 36
    • 49649100284 scopus 로고    scopus 로고
    • Epigenetic signatures of familial cancer are characteristic of tumor type and family category
    • Joensuu E.I., Abdel-Rahman W.M., Ollikainen M., et al. Epigenetic signatures of familial cancer are characteristic of tumor type and family category. Cancer Res 68 (2008) 4597-4605
    • (2008) Cancer Res , vol.68 , pp. 4597-4605
    • Joensuu, E.I.1    Abdel-Rahman, W.M.2    Ollikainen, M.3
  • 37
    • 34250639863 scopus 로고    scopus 로고
    • Distinction of hereditary nonpolyposis colorectal cancer and sporadic microsatellite-unstable colorectal cancer through quantification of MLH1 methylation by real-time PCR
    • Bettstetter M., Dechant S., Ruemmele P., et al. Distinction of hereditary nonpolyposis colorectal cancer and sporadic microsatellite-unstable colorectal cancer through quantification of MLH1 methylation by real-time PCR. Clin Cancer Res 13 (2007) 3221-3228
    • (2007) Clin Cancer Res , vol.13 , pp. 3221-3228
    • Bettstetter, M.1    Dechant, S.2    Ruemmele, P.3
  • 38
    • 43049130760 scopus 로고    scopus 로고
    • LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
    • Ogino S., Kawasaki T., Nosho K., et al. LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. Int J Cancer 122 (2008) 2767-2773
    • (2008) Int J Cancer , vol.122 , pp. 2767-2773
    • Ogino, S.1    Kawasaki, T.2    Nosho, K.3
  • 39
    • 33644825262 scopus 로고    scopus 로고
    • Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage
    • Suzuki K., Suzuki I., Leodolter A., et al. Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage. Cancer Cell 9 (2006) 199-207
    • (2006) Cancer Cell , vol.9 , pp. 199-207
    • Suzuki, K.1    Suzuki, I.2    Leodolter, A.3
  • 40
    • 33749037187 scopus 로고    scopus 로고
    • Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers
    • Rodriguez J., Frigola J., Vendrell E., et al. Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers. Cancer Res 66 (2006) 8462-9468
    • (2006) Cancer Res , vol.66 , pp. 8462-9468
    • Rodriguez, J.1    Frigola, J.2    Vendrell, E.3
  • 41
    • 67650462249 scopus 로고    scopus 로고
    • DNA hypomethylation in the origin and pathogenesis of human diseases
    • Pogribny I.P., and Beland F.A. DNA hypomethylation in the origin and pathogenesis of human diseases. Cell Mol Life Sci 66 (2009) 2249-2261
    • (2009) Cell Mol Life Sci , vol.66 , pp. 2249-2261
    • Pogribny, I.P.1    Beland, F.A.2
  • 42
    • 27944504788 scopus 로고    scopus 로고
    • Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia
    • Roman-Gomez J., Jimenez-Velasco A., Agirre X., et al. Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia. Oncogene 24 (2005) 7213-7223
    • (2005) Oncogene , vol.24 , pp. 7213-7223
    • Roman-Gomez, J.1    Jimenez-Velasco, A.2    Agirre, X.3
  • 43
    • 57349138824 scopus 로고    scopus 로고
    • A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer
    • Ogino S., Nosho K., Kirkner G.J., et al. A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer. J Natl Cancer Inst 100 (2008) 1734-1738
    • (2008) J Natl Cancer Inst , vol.100 , pp. 1734-1738
    • Ogino, S.1    Nosho, K.2    Kirkner, G.J.3
  • 44
    • 0034548712 scopus 로고    scopus 로고
    • K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression
    • Guerrero S., Casanova I., Farre L., et al. K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression. Cancer Res 60 (2000) 6750-6756
    • (2000) Cancer Res , vol.60 , pp. 6750-6756
    • Guerrero, S.1    Casanova, I.2    Farre, L.3


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