Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study

BMC Cancer

Volumn 10, Issue , 2010, Pages

  Naguib, Adam ^a   Mitrou, Panagiota N ^b   Gay, Laura J ^a   Cooke, James C ^a   Luben, Robert N ^b   Ball, Richard Y ^c   McTaggart, Alison ^b   Arends, Mark J ^b   Rodwell, Sheila A ^a,b  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c NORFOLK AND NORWICH UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN; B RAF KINASE; BRAF PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BRAF ONCOGENE; CANCER LOCALIZATION; CANCER STAGING; CODON; COHORT ANALYSIS; COLORECTAL CANCER; DIETARY INTAKE; FEMALE; FOOD INTAKE; GENE FREQUENCY; GENE LOCATION; GENE MUTATION; GENE SEQUENCE; GENETIC ASSOCIATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIFESTYLE; LIPOPROTEIN BLOOD LEVEL; MALE; MICROSATELLITE INSTABILITY; NUTRITIONAL ASSESSMENT; ONCOGENE K RAS; PROTO ONCOGENE; RISK ASSESSMENT; TUMOR DIFFERENTIATION; WHITE MEAT; ADENOCARCINOMA; ADENOMA; COLORECTAL TUMOR; DIET; GENETICS; MIDDLE AGED; MUTATION; ONCOGENE RAS; PATHOLOGY; PROSPECTIVE STUDY; UNITED KINGDOM;

ADENOCARCINOMA; ADENOMA; AGED; COLORECTAL NEOPLASMS; DIET; ENGLAND; FEMALE; GENES, RAS; HUMANS; LIFE STYLE; MALE; MIDDLE AGED; MUTATION; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS B-RAF;

EID: 77950356773     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-10-99     Document Type: Article

References (52)

1. Marshall CJ. Small GTPases and cell cycle regulation. Biochem Soc Trans 1999, 27(4):363-370.
2. Calistri D, Rengucci C, Seymour I, Lattuneddu A, Polifemo AM, Monti F, Saragoni L, Amadori D. Mutation analysis of p53, K-ras, and BRAF genes in colorectal cancer progression. J Cell Physiol 2005, 204(2):484-488. 10.1002/jcp.20310, 15702478.
3. Fransen K, Klintenas M, Osterstrom A, Dimberg J, Monstein HJ, Soderkvist P. Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas. Carcinogenesis 2004, 25(4):527-533. 10.1093/carcin/bgh049, 14688025.
4. Lee S, Cho NY, Choi M, Yoo EJ, Kim JH, Kang GH. Clinicopathological features of CpG island methylator phenotype-positive colorectal cancer and its adverse prognosis in relation to KRAS/BRAF mutation. Pathol Int 2008, 58(2):104-113.
5. Li WQ, Kawakami K, Ruszkiewicz A, Bennett G, Moore J, Iacopetta B. BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status. Mol Cancer 2006, 5:2. 10.1186/1476-4598-5-2, 1360090, 16403224.
6. Nagasaka T, Koi M, Kloor M, Gebert J, Vilkin A, Nishida N, Shin SK, Sasamoto H, Tanaka N, Matsubara N, et al. Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer. Gastroenterology 2008, 134(7):1950-1960. 1960 e1951, 10.1053/j.gastro.2008.02.094, 2543132, 18435933.
7. Samowitz WS, Albertsen H, Herrick J, Levin TR, Sweeney C, Murtaugh MA, Wolff RK, Slattery ML. Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. Gastroenterology 2005, 129(3):837-845. 10.1053/j.gastro.2005.06.020, 16143123.
8. Yuen ST, Davies H, Chan TL, Ho JW, Bignell GR, Cox C, Stephens P, Edkins S, Tsui WW, Chan AS, et al. Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia. Cancer Res 2002, 62(22):6451-6455.
9. Ogino S, Kawasaki T, Kirkner GJ, Kraft P, Loda M, Fuchs CS. Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample. J Mol Diagn 2007, 9(3):305-314. 10.2353/jmoldx.2007.060170, 1899428, 17591929.
10. Breivik J, Lothe RA, Meling GI, Rognum TO, Borresen-Dale AL, Gaudernack G. Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors. Int J Cancer 1997, 74(6):664-669. 10.1002/(SICI)1097-0215(19971219)74:6<664::AID-IJC18>3.0.CO;2-5, 9421366.
11. Brink M, de Goeij AF, Weijenberg MP, Roemen GM, Lentjes MH, Pachen MM, Smits KM, de Bruine AP, Goldbohm RA, Brandt PA. K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study. Carcinogenesis 2003, 24(4):703-710. 10.1093/carcin/bgg009, 12727799.
12. Poehlmann A, Kuester D, Meyer F, Lippert H, Roessner A, Schneider-Stock R. K-ras mutation detection in colorectal cancer using the Pyrosequencing technique. Pathol Res Pract 2007, 203(7):489-497. 10.1016/j.prp.2007.06.001, 17629419.
13. Samowitz WS, Curtin K, Schaffer D, Robertson M, Leppert M, Slattery ML. Relationship of Ki-ras mutations in colon cancers to tumor location, stage, and survival: a population-based study. Cancer Epidemiol Biomarkers Prev 2000, 9(11):1193-1197.
14. Slattery ML, Curtin K, Anderson K, Ma KN, Edwards S, Leppert M, Potter J, Schaffer D, Samowitz WS. Associations between dietary intake and Ki-ras mutations in colon tumors: a population-based study. Cancer Res 2000, 60(24):6935-6941.
15. Smith G, Carey FA, Beattie J, Wilkie MJ, Lightfoot TJ, Coxhead J, Garner RC, Steele RJ, Wolf CR. Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer. Proc Natl Acad Sci USA 2002, 99(14):9433-9438. 10.1073/pnas.122612899, 123158, 12093899.
16. Suchy B, Zietz C, Rabes HM. K-ras point mutations in human colorectal carcinomas: relation to aneuploidy and metastasis. Int J Cancer 1992, 52(1):30-33. 10.1002/ijc.2910520107, 1500224.
17. Zhang H, Nordenskjold B, Dufmats M, Soderkvist P, Sun XF. K-ras mutations in colorectal adenocarcinomas and neighbouring transitional mucosa. Eur J Cancer 1998, 34(13):2053-2057. 10.1016/S0959-8049(98)00283-4, 10070310.
18. Rajagopalan H, Bardelli A, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE. Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature 2002, 418(6901):934. 10.1038/418934a, 12198537.
19. Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, et al. Mutations of the BRAF gene in human cancer. Nature 2002, 417(6892):949-954. 10.1038/nature00766, 12068308.
20. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Nakamura Y, White R, Smits AM, Bos JL. Genetic alterations during colorectal-tumor development. N Engl J Med 1988, 319(9):525-532.
21. Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989, 49(17):4682-4689.
22. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005, 55(2):74-108. 10.3322/canjclin.55.2.74, 15761078.
23. Cummings JH, Bingham SA. Diet and the prevention of cancer. BMJ 1998, 317(7173):1636-1640. 1114436, 9848907.
24. Bautista D, Obrador A, Moreno V, Cabeza E, Canet R, Benito E, Bosch X, Costa J. Ki-ras mutation modifies the protective effect of dietary monounsaturated fat and calcium on sporadic colorectal cancer. Cancer Epidemiol Biomarkers Prev 1997, 6(1):57-61.
25. Weijenberg MP, Luchtenborg M, de Goeij AF, Brink M, van Muijen GN, de Bruine AP, Goldbohm RA, Brandt PA. Dietary fat and risk of colon and rectal cancer with aberrant MLH1 expression, APC or KRAS genes. Cancer Causes Control 2007, 18(8):865-879. 10.1007/s10552-007-9032-6, 2039842, 17636402.
26. Slattery ML, Curtin K, Sweeney C, Levin TR, Potter J, Wolff RK, Albertsen H, Samowitz WS. Diet and lifestyle factor associations with CpG island methylator phenotype and BRAF mutations in colon cancer. Int J Cancer 2007, 120(3):656-663. 10.1002/ijc.22342, 17096326.
27. Bingham SA, Welch AA, McTaggart A, Mulligan AA, Runswick SA, Luben R, Oakes S, Khaw KT, Wareham N, Day NE. Nutritional methods in the European Prospective Investigation of Cancer in Norfolk. Public Health Nutr 2001, 4(3):847-858. 10.1079/PHN2000102, 11415493.
28. Day N, Oakes S, Luben R, Khaw KT, Bingham S, Welch A, Wareham N. EPIC-Norfolk: study design and characteristics of the cohort. European Prospective Investigation of Cancer. Br J Cancer 1999, 80(Suppl 1):95-103.
29. Riboli E, Kaaks R. The EPIC Project: rationale and study design. European Prospective Investigation into Cancer and Nutrition. Int J Epidemiol 1997, 26(Suppl 1):S6-14. 10.1093/ije/26.suppl_1.S6, 9126529.
30. Wei S, Liang Z, Gao J, Wu S, Zhu H, Liu H, Liu T. Patterns of K-ras codon 12 and 13 mutations found in pancreatic adenocarcinoma of 30 Chinese patients by microdissection, PCR and direct sequencing. J Gastroenterol Hepatol 2005, 20(1):67-72. 10.1111/j.1440-1746.2004.03542.x, 15610449.
31. Ogino S, Kawasaki T, Brahmandam M, Yan L, Cantor M, Namgyal C, Mino-Kenudson M, Lauwers GY, Loda M, Fuchs CS. Sensitive sequencing method for KRAS mutation detection by Pyrosequencing. J Mol Diagn 2005, 7(3):413-421. 1867544, 16049314.
32. Sargeant LA, Khaw KT, Bingham S, Day NE, Luben RN, Oakes S, Welch A, Wareham NJ. Cigarette smoking and glycaemia: the EPIC-Norfolk Study. European Prospective Investigation into Cancer. Int J Epidemiol 2001, 30(3):547-554. 10.1093/ije/30.3.547, 11416081.
33. Wareham NJ, Jakes RW, Rennie KL, Schuit J, Mitchell J, Hennings S, Day NE. Validity and repeatability of a simple index derived from the short physical activity questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Public Health Nutr 2003, 6(4):407-413. 10.1079/PHN2002439, 12795830.
34. Welch AA, McTaggart A, Mulligan AA, Luben R, Walker N, Khaw KT, Day NE, Bingham SA. DINER (Data Into Nutrients for Epidemiological Research) - a new data-entry program for nutritional analysis in the EPIC-Norfolk cohort and the 7-day diary method. Public Health Nutr 2001, 4(6):1253-1265. 10.1079/PHN2001196, 11796089.
35. Boughdady IS, Kinsella AR, Haboubi NY, Schofield PF. K-ras gene mutations in adenomas and carcinomas of the colon. Surg Oncol 1992, 1(4):275-282. 10.1016/0960-7404(92)90088-3, 1341261.
36. Velho S, Moutinho C, Cirnes L, Albuquerque C, Hamelin R, Schmitt F, Carneiro F, Oliveira C, Seruca R. BRAF, KRAS and PIK3 CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?. BMC Cancer 2008, 8:255. 10.1186/1471-2407-8-255, 2553419, 18782444.
37. Loh K, Chia JA, Greco S, Cozzi SJ, Buttenshaw RL, Bond CE, Simms LA, Pike T, Young JP, Jass JR, et al. Bone morphogenic protein 3 inactivation is an early and frequent event in colorectal cancer development. Genes Chromosomes Cancer 2008, 47(6):449-460. 10.1002/gcc.20552, 18311777.
38. Jass JR. Colorectal cancer: a multipathway disease. Crit Rev Oncog 2006, 12(3-4):273-287.
39. Ang PW, Li WQ, Soong R, Iacopetta B. BRAF mutation is associated with the CpG island methylator phenotype in colorectal cancer from young patients. Cancer Lett 2009, 273(2):221-224. 10.1016/j.canlet.2008.08.001, 18778891.
40. Kambara T, Simms LA, Whitehall VL, Spring KJ, Wynter CV, Walsh MD, Barker MA, Arnold S, McGivern A, Matsubara N, et al. BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut 2004, 53(8):1137-1144. 10.1136/gut.2003.037671, 1774130, 15247181.
41. Soreide K, Slewa A, Stokkeland PJ, van Diermen B, Janssen EA, Soreide JA, Baak JP, Korner H. Microsatellite instability and DNA ploidy in colorectal cancer: potential implications for patients undergoing systematic surveillance after resection. Cancer 2009, 115(2):271-282. 10.1002/cncr.24024, 19109816.
42. Deng G, Kakar S, Tanaka H, Matsuzaki K, Miura S, Sleisenger MH, Kim YS. Proximal and distal colorectal cancers show distinct gene-specific methylation profiles and clinical and molecular characteristics. Eur J Cancer 2008, 44(9):1290-1301. 10.1016/j.ejca.2008.03.014, 18486467.
43. Forrester K, Almoguera C, Han K, Grizzle WE, Perucho M. Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature 1987, 327(6120):298-303. 10.1038/327298a0, 2438556.
44. Andreyev HJ, Norman AR, Cunningham D, Oates J, Dix BR, Iacopetta BJ, Young J, Walsh T, Ward R, Hawkins N, et al. Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer 2001, 85(5):692-696. 10.1054/bjoc.2001.1964, 2364126, 11531254.
45. Lee SY, Munerol B, Pollard S, Youdim KA, Pannala AS, Kuhnle GG, Debnam ES, Rice-Evans C, Spencer JP. The reaction of flavanols with nitrous acid protects against N-nitrosamine formation and leads to the formation of nitroso derivatives which inhibit cancer cell growth. Free Radic Biol Med 2006, 40(2):323-334. 10.1016/j.freeradbiomed.2005.08.031, 16413414.
46. Saffhill R, Margison GP, O'Connor PJ. Mechanisms of carcinogenesis induced by alkylating agents. Biochim Biophys Acta 1985, 823(2):111-145.
47. Chan TL, Zhao W, Leung SY, Yuen ST. BRAF and KRAS mutations in colorectal hyperplastic polyps and serrated adenomas. Cancer Res 2003, 63(16):4878-4881.
48. Rashid A, Zahurak M, Goodman SN, Hamilton SR. Genetic epidemiology of mutated K-ras proto-oncogene, altered suppressor genes, and microsatellite instability in colorectal adenomas. Gut 1999, 44(6):826-833. 1727525, 10323885.
49. James RM, Arends MJ, Plowman SJ, Brooks DG, Miles CG, West JD, Patek CE. K-ras proto-oncogene exhibits tumor suppressor activity as its absence promotes tumorigenesis in murine teratomas. Mol Cancer Res 2003, 1(11):820-825.
50. Sweeney C, Boucher KM, Samowitz WS, Wolff RK, Albertsen H, Curtin K, Caan BJ, Slattery ML. Oncogenetic tree model of somatic mutations and DNA methylation in colon tumors. Genes Chromosomes Cancer 2009, 48(1):1-9. 10.1002/gcc.20614, 18767147.
51. Day N, McKeown N, Wong M, Welch A, Bingham S. Epidemiological assessment of diet: a comparison of a 7-day diary with a food frequency questionnaire using urinary markers of nitrogen, potassium and sodium. Int J Epidemiol 2001, 30(2):309-317. 10.1093/ije/30.2.309, 11369735.
52. Nemes S, Jonasson JM, Genell A, Steineck G. Bias in odds ratios by logistic regression modelling and sample size. BMC Med Res Methodol 2009, 9:56. 10.1186/1471-2288-9-56, 2724427, 19635144.