Altered glucose metabolism in Harvey-ras transformed MCF10A cells

Molecular Carcinogenesis

Volumn 54, Issue 2, 2015, Pages 111-120

  Zheng, Wei ^a   Tayyari, Fariba ^a   Gowda, G A Nagana ^a,d   Raftery, Daniel ^a,d   Mclamore, Eric S ^a   Porterfield, D Marshall ^a,b   Donkin, Shawn S ^a   Bequette, Brian ^c   Teegarden, Dorothy ^a  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Breast cancer; Glucose; Metabolism; Ras

Indexed keywords

GLUCOSE 6 PHOSPHATE DEHYDROGENASE; HEXOKINASE; HEXOKINASE 2; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE A; LACTIC ACID; PHOSPHOGLYCERATE KINASE; PHOSPHOGLYCERATE KINASE 1; PYRUVATE KINASE; PYRUVATE KINASE M1; PYRUVATE KINASE M2; UNCLASSIFIED DRUG; GLUCOSE; HRAS PROTEIN, HUMAN; PROTEIN P21;

AEROBIC GLYCOLYSIS; ARTICLE; BREAST CARCINOGENESIS; CITRIC ACID CYCLE; CONTROLLED STUDY; ENERGY METABOLISM; GENE EXPRESSION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; HUMAN; HUMAN CELL; MCF CELL LINE; MCF10A CELL LINE; ONCOGENE H RAS; PENTOSE PHOSPHATE CYCLE; BREAST TUMOR; CELL MEMBRANE; CELL TRANSFORMATION; FEMALE; GENETICS; METABOLISM; TUMOR CELL LINE;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MEMBRANE; CELL TRANSFORMATION, NEOPLASTIC; CITRIC ACID CYCLE; ENERGY METABOLISM; FEMALE; GLUCOSE; HUMANS; LACTIC ACID; PROTO-ONCOGENE PROTEINS P21(RAS);

EID: 84920617888     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22079     Document Type: Article

References (50)

1. Warburg O. On the origin of cancer cells. Science 1956; 123:309-314.
2. Feron O. Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells. Radiother Oncol 2009; 92:329-333.
3. Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 2009; 324:1029-1033.
4. Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 2004; 4:891-899.
5. Spitz DR, Sim JE, Ridnour LA, Galoforo SS, Lee YJ. Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism? Ann N Y Acad Sci 2000; 899:349-362.
6. Caro-Maldonado A, Tait SW, Ramirez-Peinado S, et al. Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells. Cell Death Differ 2010; 17:1335-1344.
7. Cao X, Fang L, Gibbs S, et al. Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia. Cancer Chemother Pharmacol 2007; 59:495-505.
8. Pelicano H, Martin DS, Xu RH, Huang P. Glycolysis inhibition for anticancer treatment. Oncogene 2006; 25:4633-4646.
9. Pylayeva-Gupta Y, Grabocka E, Bar-Sagi D. RAS oncogenes: Weaving a tumorigenic web. Nat Rev Cancer 2011; 11:761-774.
10. Kiaris H, Spandidos D. Mutations of ras genes in human tumors (review). Int J Oncol 1995; 7:413-421.
11. Khleif SN, Abrams SI, Hamilton JM, et al. A phase I vaccine trial with peptides reflecting ras oncogene mutations of solid tumors. J Immunother 1999; 22:155-165.
12. Eckert LB, Repasky GA, Ulku AS, et al. Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis. Cancer Res 2004; 64:4585-4592.
13. von Lintig FC, Dreilinger AD, Varki NM, Wallace AM, Casteel DE, Boss GR. Ras activation in human breast cancer. Breast Cancer Res Treat 2000; 62:51-62.
14. Slamon DJ, Godolphin W, Jones LA, et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989; 244:707-712.
15. Dunn KL, Espino PS, Drobic B, He S, Davie JR. The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling. Biochem Cell Biol 2005; 83:1-14.
16. Malaney S, Daly RJ. The ras signaling pathway in mammary tumorigenesis and metastasis. J Mammary Gland Biol Neoplasia 2001; 6:101-113.
17. Gaglio D, Metallo CM, Gameiro PA, et al. Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth. Mol Syst Biol 2011; 7:523.
18. Heppner GH, Wolman SR. MCF-10AT: A model for human breast cancer development. Breast J 1999; 5:122-129.
19. Imbalzano KM, Tatarkova I, Imbalzano AN, Nickerson JA. Increasingly transformed MCF-10A cells have a progressively tumor-like phenotype in three-dimensional basement membrane culture. Cancer Cell Int 2009; 9:7.
20. Bradley SA, Ouyang A, Purdie J, Smitka TA, Wang T, Kaerner A. Fermentanomics: Monitoring mammalian cell cultures with NMR spectroscopy. J Am Chem Soc 2010; 132:9531-9533.
21. Asiago VM, Alvarado LZ, Shanaiah N, et al. Early detection of recurrent breast cancer using metabolite profiling. Cancer Res 2010; 70:8309-8318.
22. Gowda GA, Zhang S, Gu H, Asiago V, Shanaiah N, Raftery D. Metabolomics-based methods for early disease diagnostics. Expert Rev Mol Diagn 2008; 8:617-633.
23. 1H NMR analysis of urine. Metabolomics 2012; 8:323-334.
24. Brauman JI. Least square analysis and simplification of multi-isotope mass spectra. Anal Chem 1966; 607-610.
25. Bequette BJ, Sunny NE, El-Kadi SW, Owens SL. Application of stable isotopes and mass isotopomer distribution analysis to the study of intermediary metabolism of nutrients. J Anim Sci 2006; 84:E50-E59.
26. Berthold HK, Wykes LJ, Jahoor F, Klein PD, Reeds PJ. The use of uniformly labelled substrates and mass isotopomer analysis to study intermediary metabolism. Proc Nutr Soc 1994; 53:345-354.
27. McLamore ES, Shi J, Jaroch D, et al. A self referencing platinum nanoparticle decorated enzyme-based microbiosensor for real time measurement of physiological glucose transport. Biosens Bioelectron 2010; 26:2237-2245.
28. McLamore ES, Porterfield DM. Non-invasive tools for measuring metabolism and biophysical analyte transport: Self-referencing physiological sensing. Chem Soc Rev 2011; 40:5308-5320.
29. Christofk HR, Vander Heiden MG, Harris MH, et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008; 452:230-233.
30. Tian WN, Braunstein LD, Pang J, et al. Importance of glucose-6-phosphate dehydrogenase activity for cell growth. J Biol Chem 1998; 273:10609-10617.
31. Metallo CM, Vander Heiden MG. Metabolism strikes back: Metabolic flux regulates cell signaling. Genes Dev 2010; 24:2717-2722.
32. Locasale JW, Cantley LC. Metabolic flux and the regulation of mammalian cell growth. Cell Metab 2011; 14:443-451.
33. Michelakis ED, Sutendra G, Dromparis P, et al. Metabolic modulation of glioblastoma with dichloroacetate. Sci Transl Med 2010; 2:31-34.
34. Vander Heiden MG, Christofk HR, Schuman E, et al. Identification of small molecule inhibitors of pyruvate kinase M2. Biochem Pharmacol 2010; 79:1118-1124.
35. Chen C, Pore N, Behrooz A, Ismail-Beigi F, Maity A. Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J Biol Chem 2001; 276:9519-9525.
36. Mathupala SP, Heese C, Pedersen PL. Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53. J Biol Chem 1997; 272:22776-22780.
37. Noguchi Y, Okamoto T, Marat D, et al. Expression of facilitative glucose transporter 1 mRNA in colon cancer was not regulated by k-ras. Cancer Lett 2000; 154:137-142.
38. Osthus RC, Shim H, Kim S, et al. Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem 2000; 275:21797-21800.
39. Finley LW, Carracedo A, Lee J, et al. SIRT3 opposes reprogramming of cancer cell metabolism through HIF1alpha destabilization. Cancer Cell 2011; 19:416-428.
40. Yeung SJ, Pan J, Lee MH. Roles of p53, MYC and HIF-1 in regulating glycolysis-The seventh hallmark of cancer. Cell Mol Life Sci 2008; 65:3981-3999.
41. Hwang TL, Liang Y, Chien KY, Yu JS. Overexpression and elevated serum levels of phosphoglycerate kinase 1 in pancreatic ductal adenocarcinoma. Proteomics 2006; 6:2259-2272.
42. Cook CC, Kim A, Terao S, Gotoh A, Higuchi M. Consumption of oxygen: A mitochondrial-generated progression signal of advanced cancer. Cell Death Dis 2012; 3:e258.
43. Gillies RJ, Robey I, Gatenby RA. Causes and consequences of increased glucose metabolism of cancers. J Nucl Med 2008; 49:24S-42S.
44. Robey IF, Stephen RM, Brown KS, Baggett BK, Gatenby RA, Gillies RJ. Regulation of the Warburg effect in early-passage breast cancer cells. Neoplasia 2008; 10:745-756.
45. Jones RG, Thompson CB. Tumor suppressors and cell metabolism: A recipe for cancer growth. Genes Dev 2009; 23:537-548.
46. Kim JW, Dang CV. Cancer's molecular sweet tooth and the Warburg effect. Cancer Res 2006; 66:8927-8930.
47. Ishikawa K, Takenaga K, Akimoto M, et al. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science 2008; 320:661-664.
48. Baracca A, Chiaradonna F, Sgarbi G, Solaini G, Alberghina L, Lenaz G. Mitochondrial Complex I decrease is responsible for bioenergetic dysfunction in K-ras transformed cells. Biochim Biophys Acta 2010; 1797:314-323.
49. Denko NC. Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat Rev Cancer 2008; 8:705-713.
50. Kuo W, Lin J, Tang TK. Human glucose-6-phosphate dehydrogenase (G6PD) gene transforms NIH 3T3 cells and induces tumors in nude mice. Int J Cancer 2000; 85:857-864.