MCF-10AT: A model for human breast cancer development

Breast Journal

Volumn 5, Issue 2, 1999, Pages 122-129

  Heppner, Gloria H ^a,b   Wolman, Sandra R ^a,c  

^a KARMANOS CANCER INSTITUTE   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Preneoplasia estrogen responsiveness; Proliferative breast disease

Indexed keywords

ESTROGEN; PROTEIN P53;

ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER GROWTH; CANCER PREVENTION; DIAGNOSTIC APPROACH ROUTE; DIET SUPPLEMENTATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENCE; IMMUNOHISTOCHEMISTRY; KARYOTYPING; ONCOGENE RAS;

EID: 0032936146     PISSN: 1075122X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1524-4741.1999.00136.x     Document Type: Article

References (27)

1. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;61:759-67.
2. Page DL, Anderson TJ. Diagnostic histopathology of the breast. Edinburgh: Churchill Livingstone, 1987:120-45.
3. 3H mice. Cancer Res 1959;19:515-20.
4. Medina D. Preneoplasia in mammary tumorigenesis. In: Dickson RB, Lippman ME, eds. Mammary tumor cell cycle, differentiation and metastasis. Boston: Kluwer Academic, 1996:36-69.
5. Cardiff RD. The biology of mammary transgenes: five rules. J Mamm Gland Biol Neoplas 1996;1:61-73.
6. Nielsen KV, Madsen MW, Briand P. In vitro karotype evolution and cytogenetic instability in the non-tumorigenic human breast epithelial cell line HMT-3522. Cancer Genet Cytogenet, 1994;78:189-99.
7. Stampfer MR, Bartley JC. Induction of transformation and continuous cell lines from normal human mammary cells after exposure to benzo (α) pyrene. Proc Natl Acad Sci USA 1985;82:2394-98.
8. Stamps AC, Davies SC, Burman J, O'Hare MJ. Analyses of proviral integration in human mammary epithelial cell lines immortalized by retroviral infection with a temperature-sensitive SV40 T-antigen construct. Int J Cancer 1994;57:865-74.
9. Chang S, Keen J, Lane EB, Taylor-Papadimitriou J. Establishment and characterization of SV40-transformed human breast epithelial cell lines. Cancer Res, 1982;42:2040-53.
10. Caron de Fromentel C, Nardeux PC, Soressi T, et al. Epithelial HBL-100 cell line derived from milk of an apparently health woman harbors SV40 genetic information. Exp Cell Res 1985;16:83-94.
11. Miller FR, Soule HD, Tait L, et al. Xenograft model of progressive human proliferative breast disease. J Natl Cancer Inst 1993;85:1725-32.
12. Pauley RJ, Soule HD, Tait L, et al. The MCF10 family of spontaneously immortalized human breast epithelial cell lines: models of preneoplastic progression. Eur J Cancer Prev 1993;2:67-76.
13. Dawson PJ, Wolman SR, Tait L, Heppner GH, Miller FR. MCF-10AT: a model for the evolution of cancer from proliferative breast disease. Am J Pathol 1996;148:313-19.
14. Soule HD, Maloney TM, Wolman SR, et al. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. Cancer Res 1990;50:6075-86.
15. Tait L, Dawson PJ, Wolman SR, Galea K, Miller FR. Multipotent human breast stem cell line MCF10AT. Int J Oncol 1996;9:263-67.
16. Shekhar PVM, Chen M-L, Werdell J, Heppner GH, Miller FR, Christman JK. Activation of the endogenous receptor (ER) gene in MCF10AneoT cells, a potential factor in neoplastic progression of MCF10AT xenografts. Proc AACR 1995;36:1523.
17. Shekhar PVM, Werdell J, Basrur VS. Environmental estrogen Stimulation of growth and estrogen receptor function in preneoplastic and cancerous human breast cell lines. J Natl Cancer Inst 1997;89:1774-82.
18. Shekhar PVM, Welte R, Christman JK, Wang H, Werdell J. Altered p53 conformation: a novel mechanism of wildtype p53 functional inactivation in a model for early human breast cancer. Int J Oncol 1997;11:1087-94.
19. Inavani S, Mora L, Miller FR, Dawson PJ. Altered expression of c-erbB-2, DF3, B27.3, p53, and Ki-67 with progression and differentiation to two different histologic types of invasive carcinoma in the MCF-10AT human xenograft model of proliferative breast disease. Int J Oncol 1998;12:369-75.
20. Clark GM, McGuire WL. Follow-up study of HER-2/ neu amplification in primary breast cancer. Cancer Res 1991; 51:944-48.
21. Clark GJ, Kinch MS, Gilmer TM, Der Burridge K, CJ. Overexpression of the Ras-related TC21/R-Ras2 protein may contribute to the development of human breast cancers. Oncogene 1996;12:169-76.
22. Miller FR, Pauley RJ, Wang B. Activated c-Ha-ras is not sufficient to produce the preneoplastic phenotype of human breast stem cell line MCF-10AT. Anticancer Res 1996;16: 1765-70.
23. Santner SJ, Miller F, Dawson P, et al. MCF-10CA1 cell lines: new highly tumorigenic derivatives of the MCF-10AT system. Proc AACR 1998;39:1383.
24. Wolman SR, Mohamed AN, Heppner GH, Soule HD. Chromosomal markers of immortalization: studies in human breast epithelium. Genes Chromosomes Cancer 1994;10:59-65.
25. Shekhar MPV, Nangia-Makker P, Sandra R, et al. Direct action of estrogen on sequence of progression of human preneoplastic breast disease. Am J Pathol 1998;152:1129-32.
26. Calaf G, Russo J. Transformation of human breast epithelial cells by chemical carcinogen. Carcinogenesis 1993;14: 483-92.
27. Calaf G, Zhang PL, Alvarado MV, Estrade S, Russo J. C-Ha ras enhances the neoplastic transformation of human breast epithelial cells treated with chemical carcinogens, Int J Oncol 1995;6:5-11.