The monocarboxylate transporter 4 is required for glycolytic reprogramming and inflammatory response in macrophages

Journal of Biological Chemistry

Volumn 290, Issue 1, 2015, Pages 46-55

  Tan, Zheng ^a,b   Xie, Na ^a   Banerjee, Sami ^a   Cui, Huachun ^a   Fu, Mingui ^c   Thannickal, Victor J ^a   Liu, Gang ^a  

^a and Clinical Center   (United States)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; ENZYME ACTIVITY; FEEDBACK; PATHOLOGY;

EXTRACELLULAR ENVIRONMENTS; FEEDBACK MECHANISMS; GLYCOLYTIC ENZYME; INFLAMMATORY RESPONSE; INTRACELLULAR ACCUMULATION; INTRACELLULAR LACTATE; MACROPHAGE ACTIVATION; PROINFLAMMATORY;

MACROPHAGES;

6 PHOSPHOFRUCTO 2 KINASE; FRUCTOSE 2,6 BIPHOSPHATASE 3; HEXOKINASE; HEXOKINASE 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LACTIC ACID; LIPOPOLYSACCHARIDE; MONOCARBOXYLATE TRANSPORTER 4; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 2 AGONIST; TOLL LIKE RECEPTOR 3 AGONIST; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 4 AGONIST; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; MONOCARBOXYLATE TRANSPORTER; MUSCLE PROTEIN; MYD88 PROTEIN, MOUSE; SLC16A4 PROTEIN, HUMAN; SLC16A4 PROTEIN, MOUSE; TLR2 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPLASM; ENZYME PHOSPHORYLATION; GLYCOLYSIS; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; INFLAMMATION; INNATE IMMUNITY; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; C57BL MOUSE; DRUG EFFECTS; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; LUNG ALVEOLUS MACROPHAGE; MACROPHAGE; METABOLISM; MONONUCLEAR CELL; PATHOLOGY; PERITONEUM MACROPHAGE; PRIMARY CELL CULTURE; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION REGULATION; GLYCOLYSIS; HEXOKINASE; HUMANS; IMMUNITY, INNATE; INFLAMMATION; LACTIC ACID; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MACROPHAGES, ALVEOLAR; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; MONOCARBOXYLIC ACID TRANSPORTERS; MUSCLE PROTEINS; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHOFRUCTOKINASE-2; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 84920507166     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.603589     Document Type: Article

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