메뉴 건너뛰기




Volumn , Issue , 2010, Pages 287-297

Lessons from the genome-wide association studies for complex multifactorial disorders and traits

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84920462056     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-540-37654-5_10     Document Type: Chapter
Times cited : (5)

References (72)
  • 1
    • 55449120805 scopus 로고    scopus 로고
    • Genetic mapping in human disease
    • Altshuler D, Daly MJ, Lander ES (2008) Genetic mapping in human disease. Science 322:881-888.
    • (2008) Science , vol.322 , pp. 881-888
    • Altshuler, D.1    Daly, M.J.2    Lander, E.S.3
  • 2
    • 33645130154 scopus 로고    scopus 로고
    • Mendelian disorders deserve more attention
    • Antonarakis SE, Beckmann JS (2006) Mendelian disorders deserve more attention. Nat Rev Genet 7:277-282.
    • (2006) Nat Rev Genet , vol.7 , pp. 277-282
    • Antonarakis, S.E.1    Beckmann, J.S.2
  • 3
    • 34447569298 scopus 로고    scopus 로고
    • Copy number variants and genetic traits: Closer to the resolution of phenotypic to genotypic variability
    • Beckmann JS, Estivill X, Antonarakis SE (2007) Copy number variants and genetic traits: closer to the resolution of phenotypic to genotypic variability. Nat Rev Genet 8: 639-646.
    • (2007) Nat Rev Genet , vol.8 , pp. 639-646
    • Beckmann, J.S.1    Estivill, X.2    Antonarakis, S.E.3
  • 4
    • 67349103704 scopus 로고    scopus 로고
    • Combined effects of MC4R and FTO common genetic variants on obesity in European general populations
    • Cauchi S, Stutzmann F, Cavalcanti-Proenca C, Durand E, Pouta A et al (2009) Combined effects of MC4R and FTO common genetic variants on obesity in European general populations. J Mol Med 87:537-546.
    • (2009) J Mol Med , vol.87 , pp. 537-546
    • Cauchi, S.1    Stutzmann, F.2    Cavalcanti-Proenca, C.3    Durand, E.4    Pouta, A.5
  • 5
    • 67650242330 scopus 로고    scopus 로고
    • Warfarin pharmacogenomics
    • PMID 19479657
    • Cavallari LH, Limdi NA (2009) Warfarin pharmacogenomics. Curr Opin Mol Ther 11(3):243-251 PMID 19479657.
    • (2009) Curr Opin Mol Ther , vol.11 , Issue.3 , pp. 243-251
    • Cavallari, L.H.1    Limdi, N.A.2
  • 7
    • 15744404330 scopus 로고    scopus 로고
    • The secular trend in human physical growth: A biological view
    • Cole TJ (2003) The secular trend in human physical growth: A biological view. Econ Hum Biol 1:161-168.
    • (2003) Econ Hum Biol , vol.1 , pp. 161-168
    • Cole, T.J.1
  • 8
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC et al (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261:921-923.
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3    Schmechel, D.E.4    Gaskell, P.C.5
  • 9
    • 70349963539 scopus 로고    scopus 로고
    • Pharmacogenomics of anticoagulants: Steps toward personal dosage
    • Daly AK (2009) Pharmacogenomics of anticoagulants: Steps toward personal dosage. Genome Med 1:10.
    • (2009) Genome Med , vol.1 , pp. 10
    • Daly, A.K.1
  • 10
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS et al (2006) A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314:1461-1463.
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3    Rioux, J.D.4    Silverberg, M.S.5
  • 12
    • 0343953074 scopus 로고    scopus 로고
    • Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency
    • Farooqi IS, Yeo GS, Keogh JM, Aminian S, Jebb SA et al (2000) Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J Clin Invest 106:271-279.
    • (2000) J Clin Invest , vol.106 , pp. 271-279
    • Farooqi, I.S.1    Yeo, G.S.2    Keogh, J.M.3    Aminian, S.4    Jebb, S.A.5
  • 13
    • 62549085618 scopus 로고    scopus 로고
    • Human genetic variation and its contribution to complex traits
    • Frazer KA, Murray SS, Schork NJ, Topol EJ (2009) Human genetic variation and its contribution to complex traits. Nat Rev Genet 10:241-251.
    • (2009) Nat Rev Genet , vol.10 , pp. 241-251
    • Frazer, K.A.1    Murray, S.S.2    Schork, N.J.3    Topol, E.J.4
  • 14
    • 65949107547 scopus 로고    scopus 로고
    • Common genetic variation and human traits
    • Goldstein DB (2009) Common genetic variation and human traits. N Engl J Med 360:1696-1698.
    • (2009) N Engl J Med , vol.360 , pp. 1696-1698
    • Goldstein, D.B.1
  • 16
    • 34547510624 scopus 로고    scopus 로고
    • Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
    • Gudmundsson J, Sulem P, Steinthorsdottir V, Bergthorsson JT, Thorleifsson G et al (2007) Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet 39:977-983.
    • (2007) Nat Genet , vol.39 , pp. 977-983
    • Gudmundsson, J.1    Sulem, P.2    Steinthorsdottir, V.3    Bergthorsson, J.T.4    Thorleifsson, G.5
  • 17
    • 21044453724 scopus 로고    scopus 로고
    • A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
    • Hageman GS, Anderson DH, Johnson LV, Hancox LS, Taiber AJ et al (2005) A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci USA 102:7227-7232.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 7227-7232
    • Hageman, G.S.1    Anderson, D.H.2    Johnson, L.V.3    Hancox, L.S.4    Taiber, A.J.5
  • 18
    • 34247482327 scopus 로고    scopus 로고
    • Multiple regions within 8q24 independently affect risk for prostate cancer
    • Haiman CA, Patterson N, Freedman ML, Myers SR, Pike MC et al (2007) Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet 39:638-644.
    • (2007) Nat Genet , vol.39 , pp. 638-644
    • Haiman, C.A.1    Patterson, N.2    Freedman, M.L.3    Myers, S.R.4    Pike, M.C.5
  • 19
    • 20244388812 scopus 로고    scopus 로고
    • Complement factor H variant increases the risk of age-related macular degeneration
    • Haines JL, Hauser MA, Schmidt S, Scott WK, Olson LM et al (2005) Complement factor H variant increases the risk of age-related macular degeneration. Science 308:419-421.
    • (2005) Science , vol.308 , pp. 419-421
    • Haines, J.L.1    Hauser, M.A.2    Schmidt, S.3    Scott, W.K.4    Olson, L.M.5
  • 20
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • Hindorff LA, Sethupathy P, Junkins HA, Ramos EM, Mehta JP et al (2009) Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci USA 106:9362-9367.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 9362-9367
    • Hindorff, L.A.1    Sethupathy, P.2    Junkins, H.A.3    Ramos, E.M.4    Mehta, J.P.5
  • 21
    • 65949124249 scopus 로고    scopus 로고
    • Genomewide association studies- illuminating biologic pathways
    • Hirschhorn JN (2009) Genomewide association studies- illuminating biologic pathways. N Engl J Med 360: 1699-1701.
    • (2009) N Engl J Med , vol.360 , pp. 1699-1701
    • Hirschhorn, J.N.1
  • 22
    • 66749185818 scopus 로고    scopus 로고
    • Progress in genome-wide association studies of human height
    • Hirschhorn JN, Lettre G (2009) Progress in genome-wide association studies of human height. Horm Res 71(Suppl 2): 5-13.
    • (2009) Horm Res , vol.71 , pp. 5-13
    • Hirschhorn, J.N.1    Lettre, G.2
  • 23
    • 65249164859 scopus 로고    scopus 로고
    • Validating, augmenting and refining genome-wide association signals
    • Ioannidis JP, Thomas G, Daly MJ (2009) Validating, augmenting and refining genome-wide association signals. Nat Rev Genet 10:318-329.
    • (2009) Nat Rev Genet , vol.10 , pp. 318-329
    • Ioannidis, J.P.1    Thomas, G.2    Daly, M.J.3
  • 24
    • 57649243614 scopus 로고    scopus 로고
    • Genome-based prediction of common diseases: Advances and prospects
    • Janssens AC, van Duijn CM (2008) Genome-based prediction of common diseases: Advances and prospects. Hum Mol Genet 17:R166-R173.
    • (2008) Hum Mol Genet , vol.17 , pp. R166-R173
    • Janssens, A.C.1    Van Duijn, C.M.2
  • 25
    • 41149120561 scopus 로고    scopus 로고
    • A critical appraisal of the scientifi c basis of commercial genomic profiles used to assess health risks and personalize health interventions
    • Janssens AC, Gwinn M, Bradley LA, Oostra BA, van Duijn CM, Khoury MJ (2008) A critical appraisal of the scientifi c basis of commercial genomic profiles used to assess health risks and personalize health interventions. Am J Hum Genet 82:593-599.
    • (2008) Am J Hum Genet , vol.82 , pp. 593-599
    • Janssens, A.C.1    Gwinn, M.2    Bradley, L.A.3    Oostra, B.A.4    Van Duijn, C.M.5    Khoury, M.J.6
  • 26
    • 38649132270 scopus 로고    scopus 로고
    • Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    • Kathiresan S, Melander O, Guiducci C, Surti A, Burtt NP et al (2008) Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet 40:189-197.
    • (2008) Nat Genet , vol.40 , pp. 189-197
    • Kathiresan, S.1    Melander, O.2    Guiducci, C.3    Surti, A.4    Burtt, N.P.5
  • 27
    • 58149327181 scopus 로고    scopus 로고
    • The regulation of direct-to-consumer genetic tests
    • Kaye J (2008) The regulation of direct-to-consumer genetic tests. Hum Mol Genet 17:R180-R183.
    • (2008) Hum Mol Genet , vol.17 , pp. R180-R183
    • Kaye, J.1
  • 28
    • 20244380171 scopus 로고    scopus 로고
    • Complement factor H polymorphism in age-related macular degeneration
    • Klein RJ, Zeiss C, Chew EY, Tsai JY, Sackler RS et al (2005) Complement factor H polymorphism in age-related macular degeneration. Science 308:385-389.
    • (2005) Science , vol.308 , pp. 385-389
    • Klein, R.J.1    Zeiss, C.2    Chew, E.Y.3    Tsai, J.Y.4    Sackler, R.S.5
  • 29
    • 65949099120 scopus 로고    scopus 로고
    • Genetic risk prediction-are we there yet?
    • Kraft P, Hunter DJ (2009) Genetic risk prediction-are we there yet? N Engl J Med 360:1701-1703.
    • (2009) N Engl J Med , vol.360 , pp. 1701-1703
    • Kraft, P.1    Hunter, D.J.2
  • 30
    • 62549098116 scopus 로고    scopus 로고
    • Beyond odds ratios-communicating disease risk based on genetic profiles
    • Kraft P, Wacholder S, Cornelis MC, Hu FB, Hayes RB et al (2009) Beyond odds ratios-communicating disease risk based on genetic profiles. Nat Rev Genet 10:264-269.
    • (2009) Nat Rev Genet , vol.10 , pp. 264-269
    • Kraft, P.1    Wacholder, S.2    Cornelis, M.C.3    Hu, F.B.4    Hayes, R.B.5
  • 31
    • 40849096166 scopus 로고    scopus 로고
    • The road to genome-wide association studies
    • Kruglyak L (2008) The road to genome-wide association studies. Nat Rev Genet 9:314-318.
    • (2008) Nat Rev Genet , vol.9 , pp. 314-318
    • Kruglyak, L.1
  • 32
    • 0029805706 scopus 로고    scopus 로고
    • The new genomics: Global views of biology
    • Lander ES (1996) The new genomics: global views of biology. Science 274:536-539.
    • (1996) Science , vol.274 , pp. 536-539
    • Lander, E.S.1
  • 33
    • 58149333555 scopus 로고    scopus 로고
    • Autoimmune diseases: Insights from genome-wide association studies
    • Lettre G, Rioux JD (2008) Autoimmune diseases: Insights from genome-wide association studies. Hum Mol Genet 17:R116-R121.
    • (2008) Hum Mol Genet , vol.17 , pp. R116-R121
    • Lettre, G.1    Rioux, J.D.2
  • 34
    • 42649092874 scopus 로고    scopus 로고
    • Identification of ten loci associated with height highlights new biological pathways in human growth
    • Lettre G, Jackson AU, Gieger C, Schumacher FR, Berndt SI et al (2008) Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet 40:584-591.
    • (2008) Nat Genet , vol.40 , pp. 584-591
    • Lettre, G.1    Jackson, A.U.2    Gieger, C.3    Schumacher, F.R.4    Berndt, S.I.5
  • 35
    • 50149117726 scopus 로고    scopus 로고
    • DNA polymorphisms at the BCL11A, HBS1LMYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease
    • Lettre G, Sankaran VG, Bezerra MA, Araujo AS, Uda M et al (2008) DNA polymorphisms at the BCL11A, HBS1LMYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proc Natl Acad Sci USA 105:11869-11874.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 11869-11874
    • Lettre, G.1    Sankaran, V.G.2    Bezerra, M.A.3    Araujo, A.S.4    Uda, M.5
  • 36
    • 67349208839 scopus 로고    scopus 로고
    • Genome-wide association study of blood pressure and hypertension
    • (in press)
    • Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ et al. (2009) Genome-wide association study of blood pressure and hypertension. Nat Genet (in press).
    • (2009) Nat Genet
    • Levy, D.1    Ehret, G.B.2    Rice, K.3    Verwoert, G.C.4    Launer, L.J.5
  • 37
    • 44349142294 scopus 로고    scopus 로고
    • Common variants near MC4R are associated with fat mass, weight and risk of obesity
    • Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH et al (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40:768-775.
    • (2008) Nat Genet , vol.40 , pp. 768-775
    • Loos, R.J.1    Lindgren, C.M.2    Li, S.3    Wheeler, E.4    Zhao, J.H.5
  • 38
    • 55649105963 scopus 로고    scopus 로고
    • Clinical risk factors, DNA variants, and the development of type 2 diabetes
    • Lyssenko V, Jonsson A, Almgren P, Pulizzi N, Isomaa B et al (2008) Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med 359:2220-2232.
    • (2008) N Engl J Med , vol.359 , pp. 2220-2232
    • Lyssenko, V.1    Jonsson, A.2    Almgren, P.3    Pulizzi, N.4    Isomaa, B.5
  • 39
    • 55549147191 scopus 로고    scopus 로고
    • Personal genomes: The case of the missing heritability
    • Maher B (2008) Personal genomes: The case of the missing heritability. Nature 456:18-21.
    • (2008) Nature , vol.456 , pp. 18-21
    • Maher, B.1
  • 40
    • 58949100205 scopus 로고    scopus 로고
    • IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production
    • Maier LM, Lowe CE, Cooper J, Downes K, Anderson DE et al (2009) IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet 5:e1000322.
    • (2009) PLoS Genet , vol.5 , pp. e1000322
    • Maier, L.M.1    Lowe, C.E.2    Cooper, J.3    Downes, K.4    Anderson, D.E.5
  • 41
    • 33748309136 scopus 로고    scopus 로고
    • Common variation in three genes, including a noncoding variant in CFH, strongly infl uences risk of age-related macular degeneration
    • Maller J, George S, Purcell S, Fagerness J, Altshuler D et al (2006) Common variation in three genes, including a noncoding variant in CFH, strongly infl uences risk of age-related macular degeneration. Nat Genet 38:1055-1059.
    • (2006) Nat Genet , vol.38 , pp. 1055-1059
    • Maller, J.1    George, S.2    Purcell, S.3    Fagerness, J.4    Altshuler, D.5
  • 43
    • 58149335215 scopus 로고    scopus 로고
    • Genome-wide association studies: Past, present and future
    • McCarthy MI, Hirschhorn JN (2008) Genome-wide association studies: Past, present and future. Hum Mol Genet 17:R100-R101.
    • (2008) Hum Mol Genet , vol.17 , pp. R100-R101
    • McCarthy, M.I.1    Hirschhorn, J.N.2
  • 44
    • 58149347486 scopus 로고    scopus 로고
    • Genome-wide association studies: Potential next steps on a genetic journey
    • McCarthy MI, Hirschhorn JN (2008) Genome-wide association studies: Potential next steps on a genetic journey. Hum Mol Genet 17:R156-R165.
    • (2008) Hum Mol Genet , vol.17 , pp. R156-R165
    • McCarthy, M.I.1    Hirschhorn, J.N.2
  • 45
    • 42349112088 scopus 로고    scopus 로고
    • Genome-wide association studies for complex traits: Consensus, uncertainty and challenges
    • McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J et al (2008) Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 9:356-369.
    • (2008) Nat Rev Genet , vol.9 , pp. 356-369
    • McCarthy, M.I.1    Abecasis, G.R.2    Cardon, L.R.3    Goldstein, D.B.4    Little, J.5
  • 46
    • 65249131713 scopus 로고    scopus 로고
    • Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
    • Nejentsev S, Walker N, Riches D, Egholm M, Todd JA (2009) Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 324: 387-389.
    • (2009) Science , vol.324 , pp. 387-389
    • Nejentsev, S.1    Walker, N.2    Riches, D.3    Egholm, M.4    Todd, J.A.5
  • 47
    • 67349085063 scopus 로고    scopus 로고
    • Genome-wide association study identifies eight loci associated with blood pressure
    • (in press)
    • Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, et al (2009) Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (in press).
    • (2009) Nat Genet
    • Newton-Cheh, C.1    Johnson, T.2    Gateva, V.3    Tobin, M.D.4    Bochud, M.5
  • 48
    • 34347338690 scopus 로고    scopus 로고
    • Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
    • Parkes M, Barrett JC, Prescott NJ, Tremelling M, Anderson CA et al (2007) Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet 39:830-832.
    • (2007) Nat Genet , vol.39 , pp. 830-832
    • Parkes, M.1    Barrett, J.C.2    Prescott, N.J.3    Tremelling, M.4    Anderson, C.A.5
  • 49
    • 36549003138 scopus 로고    scopus 로고
    • Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
    • Plenge RM, Cotsapas C, Davies L, Price AL, de Bakker PI et al (2007) Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet 39:1477-1482.
    • (2007) Nat Genet , vol.39 , pp. 1477-1482
    • Plenge, R.M.1    Cotsapas, C.2    Davies, L.3    Price, A.L.4    De Bakker, P.I.5
  • 50
    • 0036799545 scopus 로고    scopus 로고
    • The allelic architecture of human disease genes: Common disease-common variant...or not?
    • Pritchard JK, Cox NJ (2002) The allelic architecture of human disease genes: common disease-common variant...or not? Hum Mol Genet 11:2417-2423.
    • (2002) Hum Mol Genet , vol.11 , pp. 2417-2423
    • Pritchard, J.K.1    Cox, N.J.2
  • 51
    • 0035451780 scopus 로고    scopus 로고
    • On the allelic spectrum of human disease
    • Reich DE, Lander ES (2001) On the allelic spectrum of human disease. Trends Genet 17:502-510.
    • (2001) Trends Genet , vol.17 , pp. 502-510
    • Reich, D.E.1    Lander, E.S.2
  • 52
    • 34247554965 scopus 로고    scopus 로고
    • Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
    • Rioux JD, Xavier RJ, Taylor KD, Silverberg MS, Goyette P et al (2007) Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 39:596-604.
    • (2007) Nat Genet , vol.39 , pp. 596-604
    • Rioux, J.D.1    Xavier, R.J.2    Taylor, K.D.3    Silverberg, M.S.4    Goyette, P.5
  • 53
    • 0031128778 scopus 로고    scopus 로고
    • A model for susceptibility polymorphisms for complex diseases: Apolipoprotein E and Alzheimer disease
    • Roses AD (1997) A model for susceptibility polymorphisms for complex diseases: Apolipoprotein E and Alzheimer disease. Neurogenetics 1:3-11.
    • (1997) Neurogenetics , vol.1 , pp. 3-11
    • Roses, A.D.1
  • 54
    • 34247481814 scopus 로고    scopus 로고
    • Strong association of de novo copy number mutations with autism
    • Sebat J, Lakshmi B, Malhotra D, Troge J, Lese-Martin C et al (2007) Strong association of de novo copy number mutations with autism. Science 316:445-449.
    • (2007) Science , vol.316 , pp. 445-449
    • Sebat, J.1    Lakshmi, B.2    Malhotra, D.3    Troge, J.4    Lese-Martin, C.5
  • 55
    • 66349084139 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide scans for human adult stature identifi es novel Loci and associations with measures of skeletal frame size
    • Soranzo N, Rivadeneira F, Chinappen-Horsley U, Malkina I, Richards JB et al (2009) Meta-analysis of genome-wide scans for human adult stature identifi es novel Loci and associations with measures of skeletal frame size. PLoS Genet 5:e1000445.
    • (2009) PLoS Genet , vol.5 , pp. e1000445
    • Soranzo, N.1    Rivadeneira, F.2    Chinappen-Horsley, U.3    Malkina, I.4    Richards, J.B.5
  • 57
    • 79959503826 scopus 로고    scopus 로고
    • The international hapmap project
    • The International HapMap Consortium
    • The International HapMap Consortium (2003) The International HapMap Project. Nature 426:789-796.
    • (2003) Nature , vol.426 , pp. 789-796
  • 58
    • 79959524146 scopus 로고    scopus 로고
    • A haplotype map of the human genome
    • The International HapMap Consortium
    • The International HapMap Consortium (2005) A haplotype map of the human genome. Nature 437:1299-1320.
    • (2005) Nature , vol.437 , pp. 1299-1320
  • 59
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14, 000 cases of seven common diseases and 3, 000 shared controls
    • The Wellcome Trust Case Control Consortium, 661-678
    • The Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14, 000 cases of seven common diseases and 3, 000 shared controls. Nature 447: 661-678.
    • (2007) Nature , vol.447
  • 60
    • 58149163141 scopus 로고    scopus 로고
    • Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
    • Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P et al (2009) Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 41:18-24.
    • (2009) Nat Genet , vol.41 , pp. 18-24
    • Thorleifsson, G.1    Walters, G.B.2    Gudbjartsson, D.F.3    Steinthorsdottir, V.4    Sulem, P.5
  • 61
    • 33745592507 scopus 로고    scopus 로고
    • Statistical false positive or true disease pathway?
    • Todd JA (2006) Statistical false positive or true disease pathway? Nat Genet 38:731-733.
    • (2006) Nat Genet , vol.38 , pp. 731-733
    • Todd, J.A.1
  • 62
    • 53649098737 scopus 로고    scopus 로고
    • Pathway analysis of seven common diseases assessed by genome-wide association
    • Torkamani A, Topol EJ, Schork NJ (2008) Pathway analysis of seven common diseases assessed by genome-wide association. Genomics 92:265-272.
    • (2008) Genomics , vol.92 , pp. 265-272
    • Torkamani, A.1    Topol, E.J.2    Schork, N.J.3
  • 63
    • 40349092939 scopus 로고    scopus 로고
    • Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia
    • Uda M, Galanello R, Sanna S, Lettre G, Sankaran VG et al (2008) Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc Natl Acad Sci USA 105:1620-1625.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 1620-1625
    • Uda, M.1    Galanello, R.2    Sanna, S.3    Lettre, G.4    Sankaran, V.G.5
  • 64
    • 42349088634 scopus 로고    scopus 로고
    • Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia
    • Walsh T, McClellan JM, McCarthy SE, Addington AM, Pierce SB et al (2008) Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science 320:539-543.
    • (2008) Science , vol.320 , pp. 539-543
    • Walsh, T.1    McClellan, J.M.2    McCarthy, S.E.3    Addington, A.M.4    Pierce, S.B.5
  • 65
    • 56349100610 scopus 로고    scopus 로고
    • Reaching new heights: Insights into the genetics of human stature
    • Weedon MN, Frayling TM (2008) Reaching new heights: Insights into the genetics of human stature. Trends Genet 24:595-603.
    • (2008) Trends Genet , vol.24 , pp. 595-603
    • Weedon, M.N.1    Frayling, T.M.2
  • 66
    • 42649139571 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies 20 loci that influence adult height
    • Weedon MN, Lango H, Lindgren CM, Wallace C, Evans DM et al (2008) Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet 40: 575-583.
    • (2008) Nat Genet , vol.40 , pp. 575-583
    • Weedon, M.N.1    Lango, H.2    Lindgren, C.M.3    Wallace, C.4    Evans, D.M.5
  • 67
    • 0036137130 scopus 로고    scopus 로고
    • Linkage disequilibrium and the mapping of complex human traits
    • Weiss KM, Clark AG (2002) Linkage disequilibrium and the mapping of complex human traits. Trends Genet 18:19-24.
    • (2002) Trends Genet , vol.18 , pp. 19-24
    • Weiss, K.M.1    Clark, A.G.2
  • 68
    • 39049163023 scopus 로고    scopus 로고
    • Association between microdeletion and microduplication at 16p11.2 and autism
    • Weiss LA, Shen Y, Korn JM, Arking DE, Miller DT et al (2008) Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med 358: 667-675.
    • (2008) N Engl J Med , vol.358 , pp. 667-675
    • Weiss, L.A.1    Shen, Y.2    Korn, J.M.3    Arking, D.E.4    Miller, D.T.5
  • 69
    • 38649125868 scopus 로고    scopus 로고
    • Newly identifi ed loci that influence lipid concentrations and risk of coronary artery disease
    • Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL et al (2008) Newly identifi ed loci that infl uence lipid concentrations and risk of coronary artery disease. Nat Genet 40:161-169.
    • (2008) Nat Genet , vol.40 , pp. 161-169
    • Willer, C.J.1    Sanna, S.2    Jackson, A.U.3    Scuteri, A.4    Bonnycastle, L.L.5
  • 70
    • 58149163142 scopus 로고    scopus 로고
    • Six new loci associated with body mass index highlight a neuronal infl uence on body weight regulation
    • Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM et al (2009) Six new loci associated with body mass index highlight a neuronal infl uence on body weight regulation. Nat Genet 41:25-34.
    • (2009) Nat Genet , vol.41 , pp. 25-34
    • Willer, C.J.1    Speliotes, E.K.2    Loos, R.J.3    Li, S.4    Lindgren, C.M.5
  • 71
    • 0034892062 scopus 로고    scopus 로고
    • Complex genetic diseases: Controversy over the Croesus code
    • COMMENT2007
    • Wright AF, Hastie ND (2001) Complex genetic diseases: controversy over the Croesus code. Genome Biol 2: COMMENT2007.
    • (2001) Genome Biol , vol.2
    • Wright, A.F.1    Hastie, N.D.2
  • 72
    • 46249093584 scopus 로고    scopus 로고
    • Strong association of de novo copy number mutations with sporadic schizophrenia
    • Xu B, Roos JL, Levy S, van Rensburg EJ, Gogos JA, Karayiorgou M (2008) Strong association of de novo copy number mutations with sporadic schizophrenia. Nat Genet 40:880-885.
    • (2008) Nat Genet , vol.40 , pp. 880-885
    • Xu, B.1    Roos, J.L.2    Levy, S.3    Van, R.E.J.4    Gogos, J.A.5    Karayiorgou, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.