메뉴 건너뛰기




Volumn 11, Issue 3, 2009, Pages 243-251

Warfarin pharmacogenomics

Author keywords

Cytochrome P450 2C9; Genotype; Pharmacogenomics; Vitamin K epoxide reductase; Warfarin

Indexed keywords

CYTOCHROME P450 2C9; OXIDOREDUCTASE; UNCLASSIFIED DRUG; VITAMIN K EPOXIDE REDUCTASE COMPLEX 1; WARFARIN;

EID: 67650242330     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (42)

References (72)
  • 1
    • 45949103309 scopus 로고    scopus 로고
    • Ansell J, Hirsh J, Hylek E, Jacobson A, Crowther M, Palareti G, American College of Chest Physicians: Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest (2008) 133(6 Suppl):160S-198S.
    • Ansell J, Hirsh J, Hylek E, Jacobson A, Crowther M, Palareti G, American College of Chest Physicians: Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest (2008) 133(6 Suppl):160S-198S.
  • 2
    • 0042387879 scopus 로고    scopus 로고
    • Effect of intensity of oral anticoagulation on stroke severity and mortality in atrial fbrillation
    • Hylek EM, Go AS, Chang Y, Jensvold NG, Henault LE, Selby JV, Singer DE: Effect of intensity of oral anticoagulation on stroke severity and mortality in atrial fbrillation. N Engl J Med (2003) 349(11):1019-1026.
    • (2003) N Engl J Med , vol.349 , Issue.11 , pp. 1019-1026
    • Hylek, E.M.1    Go, A.S.2    Chang, Y.3    Jensvold, N.G.4    Henault, L.E.5    Selby, J.V.6    Singer, D.E.7
  • 3
    • 0028343127 scopus 로고
    • Risk factors for intracranial hemorrhage in outpatients taking warfarin
    • Hylek EM, Singer DE: Risk factors for intracranial hemorrhage in outpatients taking warfarin. Ann Intern Med (1994) 120(11): 897-902.
    • (1994) Ann Intern Med , vol.120 , Issue.11 , pp. 897-902
    • Hylek, E.M.1    Singer, D.E.2
  • 4
    • 34447306023 scopus 로고    scopus 로고
    • Bleeding complications with warfarin use: A prevalent adverse effect resulting in regulatory action
    • Wysowski DK, Nourjah P, Swartz L: Bleeding complications with warfarin use: A prevalent adverse effect resulting in regulatory action. Arch Intern Med (2007) 167(13):1414-1419.
    • (2007) Arch Intern Med , vol.167 , Issue.13 , pp. 1414-1419
    • Wysowski, D.K.1    Nourjah, P.2    Swartz, L.3
  • 6
    • 38349026787 scopus 로고    scopus 로고
    • The effect of CYP2C19 genotypes on the pharmacokinetics of warfarin enantiomers
    • Uno T, Sugimoto K, Sugawara K, Tateishi T: The effect of CYP2C19 genotypes on the pharmacokinetics of warfarin enantiomers. J Clin Pharm Ther (2008) 33(1):67-73.
    • (2008) J Clin Pharm Ther , vol.33 , Issue.1 , pp. 67-73
    • Uno, T.1    Sugimoto, K.2    Sugawara, K.3    Tateishi, T.4
  • 8
    • 0036914221 scopus 로고    scopus 로고
    • Infuence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance
    • Scordo MG, Pengo V, Spina E, Dahl ML, Gusella M, Padrini R: Infuence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance. Clin Pharmacol Ther (2002) 72(6):702-710.
    • (2002) Clin Pharmacol Ther , vol.72 , Issue.6 , pp. 702-710
    • Scordo, M.G.1    Pengo, V.2    Spina, E.3    Dahl, M.L.4    Gusella, M.5    Padrini, R.6
  • 11
    • 0034041373 scopus 로고    scopus 로고
    • Catalytic activity of three variants (Ile, Leu, and Thr) at amino acid residue 359 in human CYP2C9 gene and simultaneous detection using single-strand conformation polymorphism analysis
    • Ieiri I, Tainaka H, Morita T, Hadama A, Mamiya K, Hayashibara M, Ninomiya H, Ohmori S, Kitada M, Tashiro N, Higuchi S et al: Catalytic activity of three variants (Ile, Leu, and Thr) at amino acid residue 359 in human CYP2C9 gene and simultaneous detection using single-strand conformation polymorphism analysis. Ther Drug Monit (2000) 22(3):237-244.
    • (2000) Ther Drug Monit , vol.22 , Issue.3 , pp. 237-244
    • Ieiri, I.1    Tainaka, H.2    Morita, T.3    Hadama, A.4    Mamiya, K.5    Hayashibara, M.6    Ninomiya, H.7    Ohmori, S.8    Kitada, M.9    Tashiro, N.10    Higuchi, S.11
  • 15
    • 27444433157 scopus 로고    scopus 로고
    • CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population
    • Allabi AC, Gala JL, Horsmans Y: CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population. Pharmacogenet Genomics (2005) 15(11):779-786.
    • (2005) Pharmacogenet Genomics , vol.15 , Issue.11 , pp. 779-786
    • Allabi, A.C.1    Gala, J.L.2    Horsmans, Y.3
  • 17
    • 44649169112 scopus 로고    scopus 로고
    • Pharmacogenomics of 4-hydroxycoumarin anticoagulants
    • Au N, Rettie AE: Pharmacogenomics of 4-hydroxycoumarin anticoagulants. Drug Metab Rev (2008) 40(2):355-375.
    • (2008) Drug Metab Rev , vol.40 , Issue.2 , pp. 355-375
    • Au, N.1    Rettie, A.E.2
  • 22
    • 51649084617 scopus 로고    scopus 로고
    • Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement
    • Wang D, Chen H, Momary KM, Cavallari LH, Johnson JA, Sadée W: Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement. Blood (2008) 112(4):1013-1021.
    • (2008) Blood , vol.112 , Issue.4 , pp. 1013-1021
    • Wang, D.1    Chen, H.2    Momary, K.M.3    Cavallari, L.H.4    Johnson, J.A.5    Sadée, W.6
  • 23
    • 44949234553 scopus 로고    scopus 로고
    • Infuence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans
    • Limdi NA, Arnett DK, Goldstein JA, Beasley TM, McGwin G, Adler BK, Acton RT: Infuence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans. Pharmacogenomics (2008) 9(5):511-526.
    • (2008) Pharmacogenomics , vol.9 , Issue.5 , pp. 511-526
    • Limdi, N.A.1    Arnett, D.K.2    Goldstein, J.A.3    Beasley, T.M.4    McGwin, G.5    Adler, B.K.6    Acton, R.T.7
  • 24
    • 34147162376 scopus 로고    scopus 로고
    • Pharmacogenetics of warfarin: Current status and future challenges
    • Wadelius M, Pirmohamed M: Pharmacogenetics of warfarin: Current status and future challenges. Pharmacogenomics J (2007) 7(2):99-111.
    • (2007) Pharmacogenomics J , vol.7 , Issue.2 , pp. 99-111
    • Wadelius, M.1    Pirmohamed, M.2
  • 25
    • 0033608466 scopus 로고    scopus 로고
    • Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications
    • Aithal GP, Day CP, Kesteven PJ, Daly AK: Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications. Lancet (1999) 353(9154):717- 719.
    • (1999) Lancet , vol.353 , Issue.9154 , pp. 717-719
    • Aithal, G.P.1    Day, C.P.2    Kesteven, P.J.3    Daly, A.K.4
  • 27
    • 62549143945 scopus 로고    scopus 로고
    • Infuence of CYP2C9 genotype on warfarin dose requirements - a systematic review and meta-analysis
    • Lindh JD, Holm L, Andersson ML, Rane A: Infuence of CYP2C9 genotype on warfarin dose requirements - a systematic review and meta-analysis. Eur J Clin Pharmacol (2009) 65(4): 365-375.
    • (2009) Eur J Clin Pharmacol , vol.65 , Issue.4 , pp. 365-375
    • Lindh, J.D.1    Holm, L.2    Andersson, M.L.3    Rane, A.4
  • 31
    • 1542782670 scopus 로고    scopus 로고
    • Use of pharmacogenetics and clinical factors to predict the maintenance dose of warfarin
    • Gage BF, Eby C, Milligan PE, Banet GA, Duncan JR, McLeod HL: Use of pharmacogenetics and clinical factors to predict the maintenance dose of warfarin. Thromb Haemost (2004) 91(1):87-94.
    • (2004) Thromb Haemost , vol.91 , Issue.1 , pp. 87-94
    • Gage, B.F.1    Eby, C.2    Milligan, P.E.3    Banet, G.A.4    Duncan, J.R.5    McLeod, H.L.6
  • 34
    • 40749123052 scopus 로고    scopus 로고
    • Warfarin pharmacogenetics: CYP2C9 and VKORC1 genotypes predict different sensitivity and resistance frequencies in the Ashkenazi and Sephardi Jewish populations
    • Scott SA, Edelmann L, Kornreich R, Desnick RJ: Warfarin pharmacogenetics: CYP2C9 and VKORC1 genotypes predict different sensitivity and resistance frequencies in the Ashkenazi and Sephardi Jewish populations. Am J Hum Genet (2008) 82(2):495-500.
    • (2008) Am J Hum Genet , vol.82 , Issue.2 , pp. 495-500
    • Scott, S.A.1    Edelmann, L.2    Kornreich, R.3    Desnick, R.J.4
  • 35
    • 11244332058 scopus 로고    scopus 로고
    • A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin
    • D'Andrea G, D'Ambrosio RL, Di Perna P, Chetta M, Santacroce R, Brancaccio V, Grandone E, Margaglione M: A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin. Blood (2005) 105(2):645-649.
    • (2005) Blood , vol.105 , Issue.2 , pp. 645-649
    • D'Andrea, G.1    D'Ambrosio, R.L.2    Di Perna, P.3    Chetta, M.4    Santacroce, R.5    Brancaccio, V.6    Grandone, E.7    Margaglione, M.8
  • 36
    • 23044440450 scopus 로고    scopus 로고
    • The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: Proposal for a new dosing regimen
    • Sconce EA, Khan TI, Wynne HA, Avery P, Monkhouse L, King BP, Wood P, Kesteven P, Daly AK, Kamali F: The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: Proposal for a new dosing regimen. Blood (2005) 106(7):2329-2333.
    • (2005) Blood , vol.106 , Issue.7 , pp. 2329-2333
    • Sconce, E.A.1    Khan, T.I.2    Wynne, H.A.3    Avery, P.4    Monkhouse, L.5    King, B.P.6    Wood, P.7    Kesteven, P.8    Daly, A.K.9    Kamali, F.10
  • 39
    • 63449117825 scopus 로고    scopus 로고
    • Takeuchi F, McGinnis R, Bourgeois S, Barnes C, Eriksson N, Soranzo N, Whittaker P, Ranganath V, Kumanduri V, McLaren W, Holm L et al: A genome-wide association study confrms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose. PLoS Genet (2009) 5(3):e1000433.
    • Takeuchi F, McGinnis R, Bourgeois S, Barnes C, Eriksson N, Soranzo N, Whittaker P, Ranganath V, Kumanduri V, McLaren W, Holm L et al: A genome-wide association study confrms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose. PLoS Genet (2009) 5(3):e1000433.
  • 40
    • 33645547905 scopus 로고    scopus 로고
    • Combined genetic profles of components and regulators of thea vitamin K-dependent γ-carboxylation system affect individual sensitivity to warfarin
    • Vecsler M, Loebstein R, Almog S, Kurnik D, Goldman B, Halkin H, Gak E: Combined genetic profles of components and regulators of thea vitamin K-dependent γ-carboxylation system affect individual sensitivity to warfarin. Thromb Haemost (2006) 95(2):205-211.
    • (2006) Thromb Haemost , vol.95 , Issue.2 , pp. 205-211
    • Vecsler, M.1    Loebstein, R.2    Almog, S.3    Kurnik, D.4    Goldman, B.5    Halkin, H.6    Gak, E.7
  • 41
    • 33646459330 scopus 로고    scopus 로고
    • The infuence of sequence variations in factor VII, γ-glutamyl carboxylase and vitamin K epoxide reductase complex genes on warfarin dose requirement
    • Herman D, Peternel P, Stegnar M, Breskvar K, Dolzan V: The infuence of sequence variations in factor VII, γ-glutamyl carboxylase and vitamin K epoxide reductase complex genes on warfarin dose requirement. Thromb Haemost (2006) 95(5):782-787.
    • (2006) Thromb Haemost , vol.95 , Issue.5 , pp. 782-787
    • Herman, D.1    Peternel, P.2    Stegnar, M.3    Breskvar, K.4    Dolzan, V.5
  • 42
    • 34248580622 scopus 로고    scopus 로고
    • Genotypes of vitamin K epoxide reductase, γ-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients
    • Kimura R, Miyashita K, Kokubo Y, Akaiwa Y, Otsubo R, Nagatsuka K, Otsuki T, Okayama A, Minematsu K, Naritomi H, Honda S et al: Genotypes of vitamin K epoxide reductase, γ-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients. Thromb Res (2007) 120(2):181-186.
    • (2007) Thromb Res , vol.120 , Issue.2 , pp. 181-186
    • Kimura, R.1    Miyashita, K.2    Kokubo, Y.3    Akaiwa, Y.4    Otsubo, R.5    Nagatsuka, K.6    Otsuki, T.7    Okayama, A.8    Minematsu, K.9    Naritomi, H.10    Honda, S.11
  • 43
    • 35448960483 scopus 로고    scopus 로고
    • γ-glutamyl carboxylase (GGCX) tagSNPs have limited utility for predicting warfarin maintenance dose
    • Rieder MJ, Reiner AP, Rettie AE: γ-glutamyl carboxylase (GGCX) tagSNPs have limited utility for predicting warfarin maintenance dose. J Thromb Haemost (2007) 5(11):2227-2234.
    • (2007) J Thromb Haemost , vol.5 , Issue.11 , pp. 2227-2234
    • Rieder, M.J.1    Reiner, A.P.2    Rettie, A.E.3
  • 48
    • 79959503826 scopus 로고    scopus 로고
    • The International HapMap Project
    • The Intsernational HapMap Consortium
    • The Intsernational HapMap Consortium: The International HapMap Project. Nature (2003) 426(6968):789-796.
    • (2003) Nature , vol.426 , Issue.6968 , pp. 789-796
  • 50
    • 42449136621 scopus 로고    scopus 로고
    • Dosing algorithm for warfarin using CYP2C9 and VKORC1 genotyping from a multi-ethnic population: Comparison with other equations
    • Wu AH, Wang P, Smith A, Haller C, Drake K, Linder M, Valdes R Jr: Dosing algorithm for warfarin using CYP2C9 and VKORC1 genotyping from a multi-ethnic population: Comparison with other equations. Pharmacogenomics (2008) 9(2):169-178.
    • (2008) Pharmacogenomics , vol.9 , Issue.2 , pp. 169-178
    • Wu, A.H.1    Wang, P.2    Smith, A.3    Haller, C.4    Drake, K.5    Linder, M.6    Valdes Jr, R.7
  • 52
    • 39449086981 scopus 로고    scopus 로고
    • CYP2C9 genotype-guided warfarin prescribing enhances the effcacy and safety of anticoagulation: A prospective randomized controlled study
    • Caraco Y, Blotnick S, Muszkat M: CYP2C9 genotype-guided warfarin prescribing enhances the effcacy and safety of anticoagulation: A prospective randomized controlled study. Clin Pharmacol Ther (2008) 83(3):460-470.
    • (2008) Clin Pharmacol Ther , vol.83 , Issue.3 , pp. 460-470
    • Caraco, Y.1    Blotnick, S.2    Muszkat, M.3
  • 56
    • 42049109764 scopus 로고    scopus 로고
    • PharmGKB and the International Warfarin Pharmacogenetics Consortium: The changing role for pharmacogenomic databases and single-drug pharmacogenetics
    • Owen RP, Altman RB, Klein TE: PharmGKB and the International Warfarin Pharmacogenetics Consortium: The changing role for pharmacogenomic databases and single-drug pharmacogenetics. Hum Mutat (2008) 29(4):456-460.
    • (2008) Hum Mutat , vol.29 , Issue.4 , pp. 456-460
    • Owen, R.P.1    Altman, R.B.2    Klein, T.E.3
  • 58
    • 79251468985 scopus 로고    scopus 로고
    • Barnes-Jewish Hospital at Washinton University Medical Center, St Louis, MO, USA
    • Warfarin Dosing: Barnes-Jewish Hospital at Washinton University Medical Center, St Louis, MO, USA (2008). http://www.warfarindosing.org
    • (2008) Warfarin Dosing
  • 59
    • 28144454744 scopus 로고    scopus 로고
    • Several-fold increase in risk of overanticoagulation by CYP2C9 mutations
    • Lindh JD, Lundgren S, Holm L, Alfredsson L, Rane A: Several-fold increase in risk of overanticoagulation by CYP2C9 mutations. Clin Pharmacol Ther (2005) 78(5):540-550.
    • (2005) Clin Pharmacol Ther , vol.78 , Issue.5 , pp. 540-550
    • Lindh, J.D.1    Lundgren, S.2    Holm, L.3    Alfredsson, L.4    Rane, A.5
  • 63
    • 0034283762 scopus 로고    scopus 로고
    • Infuence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment
    • Taube J, Halsall D, Baglin T: Infuence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment. Blood (2000) 96(5):1816-1819.
    • (2000) Blood , vol.96 , Issue.5 , pp. 1816-1819
    • Taube, J.1    Halsall, D.2    Baglin, T.3
  • 66
    • 38349126516 scopus 로고    scopus 로고
    • Limdi NA, McGwin G, Goldstein JA, Beasley TM, Arnett DK, Adler BK, Baird MF, Acton RT: Infuence of CYP2C9 and VKORC1 1173C/T genotype on the risk of hemorrhagic complications in African-American and European-American patients on warfarin. Clin Pharmacol Ther (20080 83(2):312-321.
    • Limdi NA, McGwin G, Goldstein JA, Beasley TM, Arnett DK, Adler BK, Baird MF, Acton RT: Infuence of CYP2C9 and VKORC1 1173C/T genotype on the risk of hemorrhagic complications in African-American and European-American patients on warfarin. Clin Pharmacol Ther (20080 83(2):312-321.
  • 69
    • 39449137238 scopus 로고    scopus 로고
    • On Behalf of the ACMG Working Group on Pharmacogenetic Testing of CYP2C9, VKORC1 Alleles for Warfarin Use: Pharmacogenetic testing of CYP2C9 and VKORC1 alleles for warfarin
    • Flockhart DA, O'Kane D, Williams MS, Watson MS; On Behalf of the ACMG Working Group on Pharmacogenetic Testing of CYP2C9, VKORC1 Alleles for Warfarin Use: Pharmacogenetic testing of CYP2C9 and VKORC1 alleles for warfarin. Genet Med (2008) 10(2):139-150.
    • (2008) Genet Med , vol.10 , Issue.2 , pp. 139-150
    • Flockhart, D.A.1    O'Kane, D.2    Williams, M.S.3    Watson, M.S.4
  • 70
    • 58749095297 scopus 로고    scopus 로고
    • Cost-effectiveness of using pharmacogenetic information in warfarin dosing for patients with nonvalvular atrial fbrillation
    • Eckman MH, Rosand J, Greenberg SM, Gage BF: Cost-effectiveness of using pharmacogenetic information in warfarin dosing for patients with nonvalvular atrial fbrillation. Ann Intern Med (2009) 150(2):73-83.
    • (2009) Ann Intern Med , vol.150 , Issue.2 , pp. 73-83
    • Eckman, M.H.1    Rosand, J.2    Greenberg, S.M.3    Gage, B.F.4
  • 71
    • 67650267115 scopus 로고    scopus 로고
    • Infuence of CYP2C9 and VKORC1 on warfarin response during initiation of therapy
    • doi.10.1016/j. bcmd.2009.01.019
    • Limdi NA, Wiener H, Goldstein JA, Acton RT, Beasley TM: Infuence of CYP2C9 and VKORC1 on warfarin response during initiation of therapy. Blood Cells Mol Dis (2009):doi.10.1016/j. bcmd.2009.01.019.
    • (2009) Blood Cells Mol Dis
    • Limdi, N.A.1    Wiener, H.2    Goldstein, J.A.3    Acton, R.T.4    Beasley, T.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.