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Volumn 10, Issue 4, 2009, Pages 264-269

Beyond odds ratios - Communicating disease risk based on genetic profiles

Author keywords

[No Author keywords available]

Indexed keywords

DIABETES MELLITUS; GENETIC ANALYSIS; GENOME; PRIORITY JOURNAL; PROSTATE CANCER; REVIEW; SENSITIVITY AND SPECIFICITY;

EID: 62549098116     PISSN: 14710056     EISSN: 14710064     Source Type: Journal    
DOI: 10.1038/nrg2516     Document Type: Review
Times cited : (132)

References (51)
  • 1
    • 43049146524 scopus 로고    scopus 로고
    • A HapMap harvest of insights into the genetics of common disease
    • Manolio, T. A., Brooks, L. D. & Collins, F. S. A HapMap harvest of insights into the genetics of common disease. J. Clin. Invest. 118, 1590-1605 (2008).
    • (2008) J. Clin. Invest , vol.118 , pp. 1590-1605
    • Manolio, T.A.1    Brooks, L.D.2    Collins, F.S.3
  • 2
    • 0031639661 scopus 로고    scopus 로고
    • Use and misuse of population attributable fractions
    • Rockhill, B., Newman, B. & Weinberg, C. Use and misuse of population attributable fractions. Am. J. Public Health 88, 15-19 (1998).
    • (1998) Am. J. Public Health , vol.88 , pp. 15-19
    • Rockhill, B.1    Newman, B.2    Weinberg, C.3
  • 3
    • 39749118602 scopus 로고    scopus 로고
    • Multiple loci identified in a genome-wide association study of prostate cancer
    • Thomas, G. et al. Multiple loci identified in a genome-wide association study of prostate cancer. Nature Genet. 40, 310-315 (2008).
    • (2008) Nature Genet , vol.40 , pp. 310-315
    • Thomas, G.1
  • 4
    • 40049098166 scopus 로고    scopus 로고
    • Cumulative association of five genetic variants with prostate cancer
    • Zheng, S. L. et al. Cumulative association of five genetic variants with prostate cancer. N. Engl. J. Med. 358, 910-919 (2008).
    • (2008) N. Engl. J. Med , vol.358 , pp. 910-919
    • Zheng, S.L.1
  • 5
    • 33750876203 scopus 로고    scopus 로고
    • Combining information from common type 2 diabetes risk polymorphisms improves disease prediction
    • Weedon, M. N. et al. Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. PLoS Med. 3, e374 (2006).
    • (2006) PLoS Med , vol.3
    • Weedon, M.N.1
  • 6
    • 40949149395 scopus 로고    scopus 로고
    • Polymorphisms associated with cholesterol and risk of cardiovascular events
    • Kathiresan, S. et al. Polymorphisms associated with cholesterol and risk of cardiovascular events. N. Engl. J. Med. 358, 1240-1249 (2008).
    • (2008) N. Engl. J. Med , vol.358 , pp. 1240-1249
    • Kathiresan, S.1
  • 7
    • 45549110226 scopus 로고    scopus 로고
    • Coates, R. J., Khoury, M. J. & Gwinn, M. Five genetic variants associated with prostate cancer. N. Engl. J. Med. 358, 2738; author reply 2741 (2008).
    • Coates, R. J., Khoury, M. J. & Gwinn, M. Five genetic variants associated with prostate cancer. N. Engl. J. Med. 358, 2738; author reply 2741 (2008).
  • 8
    • 45549110226 scopus 로고    scopus 로고
    • Gartner, C. E., Barendregt, J. J. & Hall, W. D. Five genetic variants associated with prostate cancer. N. Engl. J. Med. 358, 2738-2739; author reply 2741 (2008).
    • Gartner, C. E., Barendregt, J. J. & Hall, W. D. Five genetic variants associated with prostate cancer. N. Engl. J. Med. 358, 2738-2739; author reply 2741 (2008).
  • 9
    • 45549102585 scopus 로고    scopus 로고
    • Janssens, A. C. & van Duijn, C. M. Five genetic variants associated with prostate cancer. N. Engl. J. Med. 358, 2739; author reply 2741 (2008).
    • Janssens, A. C. & van Duijn, C. M. Five genetic variants associated with prostate cancer. N. Engl. J. Med. 358, 2739; author reply 2741 (2008).
  • 10
    • 57049083981 scopus 로고    scopus 로고
    • Association of three genetic loci with uric acid concentration and risk of gout: A genome-wide association study
    • Dehghan, A. et al. Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet 372, 1953-1961 (2008).
    • (2008) Lancet , vol.372 , pp. 1953-1961
    • Dehghan, A.1
  • 11
    • 33748309136 scopus 로고    scopus 로고
    • Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration
    • Maller, J. et al. Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration. Nature Genet. 38, 1055-1059 (2006).
    • (2006) Nature Genet , vol.38 , pp. 1055-1059
    • Maller, J.1
  • 12
    • 57649243614 scopus 로고    scopus 로고
    • Genome-based prediction of common diseases: Advances and prospects
    • Janssens, A. C. & van Duijn, C. M. Genome-based prediction of common diseases: advances and prospects. Hum. Mol. Genet. 17, R166-R173 (2008).
    • (2008) Hum. Mol. Genet , vol.17
    • Janssens, A.C.1    van Duijn, C.M.2
  • 13
    • 20444374342 scopus 로고    scopus 로고
    • eds Khoury, M. J, Little, J. & Burke, W, Oxford Univ. Press, Oxford
    • Haddow, J. & Palomaki, G. in Human Genome Epidemiology (eds Khoury, M. J., Little, J. & Burke, W.) 217-233 (Oxford Univ. Press, Oxford, 2003).
    • (2003) Human Genome Epidemiology , pp. 217-233
    • Haddow, J.1    Palomaki, G.2
  • 15
    • 50549104256 scopus 로고    scopus 로고
    • Why most discovered true associations are inflated
    • Ioannidis, J. P. Why most discovered true associations are inflated. Epidemiology 19, 640-648 (2008).
    • (2008) Epidemiology , vol.19 , pp. 640-648
    • Ioannidis, J.P.1
  • 16
    • 50549083074 scopus 로고    scopus 로고
    • Curses - winner's and otherwise - in genetic epidemiology
    • discussion 657-658
    • Kraft, P. Curses - winner's and otherwise - in genetic epidemiology. Epidemiology 19, 649-651; discussion 657-658 (2008).
    • (2008) Epidemiology , vol.19 , pp. 649-651
    • Kraft, P.1
  • 17
    • 26944437969 scopus 로고    scopus 로고
    • Genetic epidemiology and public health: Hope, hype, and future prospects
    • Davey Smith, G. et al. Genetic epidemiology and public health: hope, hype, and future prospects. Lancet 366, 1484-1498 (2005).
    • (2005) Lancet , vol.366 , pp. 1484-1498
    • Davey Smith, G.1
  • 18
    • 37349116252 scopus 로고    scopus 로고
    • The continuum of translation research in genomic medicine: How can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention?
    • Khoury, M. J. et al. The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention? Genet. Med. 9, 665-674 (2007).
    • (2007) Genet. Med , vol.9 , pp. 665-674
    • Khoury, M.J.1
  • 19
    • 38049130261 scopus 로고    scopus 로고
    • Letting the genome out of the bottle - will we get our wish?
    • Hunter, D. J., Khoury, M. J. & Drazen, J. M. Letting the genome out of the bottle - will we get our wish? N. Engl. J. Med. 358, 105-107 (2008).
    • (2008) N. Engl. J. Med , vol.358 , pp. 105-107
    • Hunter, D.J.1    Khoury, M.J.2    Drazen, J.M.3
  • 20
    • 33747878216 scopus 로고    scopus 로고
    • What is the clinical utility of genetic testing?
    • Grosse, S. D. & Khoury, M. J. What is the clinical utility of genetic testing? Genet. Med. 8, 448-450 (2006).
    • (2006) Genet. Med , vol.8 , pp. 448-450
    • Grosse, S.D.1    Khoury, M.J.2
  • 21
    • 33845700525 scopus 로고    scopus 로고
    • The limitations of risk factors as prognostic tools
    • Ware, J. H. The limitations of risk factors as prognostic tools. N. Engl. J. Med. 355, 2615-2617 (2006).
    • (2006) N. Engl. J. Med , vol.355 , pp. 2615-2617
    • Ware, J.H.1
  • 22
    • 2342571696 scopus 로고    scopus 로고
    • Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker
    • Pepe, M. S., Janes, H., Longton, G., Leisenring, W. & Newcomb, P. Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker. Am. J. Epidemiol. 159, 882-890 (2004).
    • (2004) Am. J. Epidemiol , vol.159 , pp. 882-890
    • Pepe, M.S.1    Janes, H.2    Longton, G.3    Leisenring, W.4    Newcomb, P.5
  • 23
    • 0033547616 scopus 로고    scopus 로고
    • When can a risk factor be used as a worthwhile screening test?
    • Wald, N. J., Hackshaw, A. K. & Frost, C. D. When can a risk factor be used as a worthwhile screening test? BMJ 319, 1562-1565 (1999).
    • (1999) BMJ , vol.319 , pp. 1562-1565
    • Wald, N.J.1    Hackshaw, A.K.2    Frost, C.D.3
  • 24
    • 62549093212 scopus 로고    scopus 로고
    • New take on a prostate drug, and a new debate
    • online, 〈 〉 15 Jun
    • Kolata, G. New take on a prostate drug, and a new debate. New York Times [online], 〈 http://www.nytimes.com/2008/06/15/health/15prostate. html 〉 (15 Jun 2008).
    • (2008) New York Times
    • Kolata, G.1
  • 25
    • 0037812658 scopus 로고    scopus 로고
    • The influence of finasteride on the development of prostate cancer
    • Thompson, I. M. et al. The influence of finasteride on the development of prostate cancer. N. Engl. J. Med. 349, 215-224 (2003).
    • (2003) N. Engl. J. Med , vol.349 , pp. 215-224
    • Thompson, I.M.1
  • 26
    • 34748863567 scopus 로고    scopus 로고
    • Finasteride and high-grade prostate cancer in the Prostate Cancer Prevention Trial
    • Lucia, M. S. et al. Finasteride and high-grade prostate cancer in the Prostate Cancer Prevention Trial. J. Natl Cancer Inst. 99, 1375-1383 (2007).
    • (2007) J. Natl Cancer Inst , vol.99 , pp. 1375-1383
    • Lucia, M.S.1
  • 28
    • 39549102840 scopus 로고    scopus 로고
    • Prostate-specific antigen screening: Friend or foe?
    • quiz 490
    • Linn, M. M., Ball, R. A. & Maradiegue, A. Prostate-specific antigen screening: friend or foe? Urol. Nurs. 27, 481-489; quiz 490 (2007).
    • (2007) Urol. Nurs , vol.27 , pp. 481-489
    • Linn, M.M.1    Ball, R.A.2    Maradiegue, A.3
  • 29
    • 38049031795 scopus 로고    scopus 로고
    • Screening for prostate cancer in U.S. men ACPM position statement on preventive practice
    • Lim, L. S. & Sherin, K. Screening for prostate cancer in U.S. men ACPM position statement on preventive practice. Am. J. Prev. Med. 34, 164-170 (2008).
    • (2008) Am. J. Prev. Med , vol.34 , pp. 164-170
    • Lim, L.S.1    Sherin, K.2
  • 30
    • 33644810298 scopus 로고    scopus 로고
    • JBS 2: Joint British Societies' guidelines on prevention of cardiovascular disease in clinical practice. Heart 91 (Suppl. 5), v1-v52 (2005).
    • JBS 2: Joint British Societies' guidelines on prevention of cardiovascular disease in clinical practice. Heart 91 (Suppl. 5), v1-v52 (2005).
  • 31
    • 38449088899 scopus 로고    scopus 로고
    • Screening and follow-up of the patient at high risk for breast cancer
    • Willey, S. C. & Cocilovo, C. Screening and follow-up of the patient at high risk for breast cancer. Obstet. Gynecol. 110, 1404-1416 (2007).
    • (2007) Obstet. Gynecol , vol.110 , pp. 1404-1416
    • Willey, S.C.1    Cocilovo, C.2
  • 33
    • 0034535334 scopus 로고    scopus 로고
    • On the use of population-based registries in the clinical validation of genetic tests for disease susceptibility
    • Yang, Q., Khoury, M. J., Coughlin, S. S., Sun, F. & Flanders, W. D. On the use of population-based registries in the clinical validation of genetic tests for disease susceptibility. Genet. Med. 2, 186-192 (2000).
    • (2000) Genet. Med , vol.2 , pp. 186-192
    • Yang, Q.1    Khoury, M.J.2    Coughlin, S.S.3    Sun, F.4    Flanders, W.D.5
  • 34
    • 22144490275 scopus 로고    scopus 로고
    • On criteria for evaluating models of absolute risk
    • Gail, M. H. & Pfeiffer, R. M. On criteria for evaluating models of absolute risk. Biostatistics 6, 227-239 (2005).
    • (2005) Biostatistics , vol.6 , pp. 227-239
    • Gail, M.H.1    Pfeiffer, R.M.2
  • 35
    • 34250006413 scopus 로고    scopus 로고
    • Genome-wide association study identifies novel breast cancer susceptibility loci
    • Easton, D. F. et al. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 447, 1087-1093 (2007).
    • (2007) Nature , vol.447 , pp. 1087-1093
    • Easton, D.F.1
  • 36
    • 39749129053 scopus 로고    scopus 로고
    • Multiple newly identified loci associated with prostate cancer susceptibility
    • Eeles, R. A. et al. Multiple newly identified loci associated with prostate cancer susceptibility. Nature Genet. 40, 316-321 (2008).
    • (2008) Nature Genet , vol.40 , pp. 316-321
    • Eeles, R.A.1
  • 37
    • 0032537990 scopus 로고    scopus 로고
    • Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
    • Fisher, B. et al. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J. Natl Cancer Inst. 90, 1371-1388 (1998).
    • (1998) J. Natl Cancer Inst , vol.90 , pp. 1371-1388
    • Fisher, B.1
  • 38
    • 45949085378 scopus 로고    scopus 로고
    • Polygenes, risk prediction, and targeted prevention of breast cancer
    • Pharoah, P. D., Antoniou, A. C., Easton, D. F. & Ponder, B. A. Polygenes, risk prediction, and targeted prevention of breast cancer. N. Engl. J. Med. 358, 2796-2803 (2008).
    • (2008) N. Engl. J. Med , vol.358 , pp. 2796-2803
    • Pharoah, P.D.1    Antoniou, A.C.2    Easton, D.F.3    Ponder, B.A.4
  • 39
    • 0033520748 scopus 로고    scopus 로고
    • Weighing the risks and benefits of tamoxifen treatment for preventing breast cancer
    • Gail, M. H. et al. Weighing the risks and benefits of tamoxifen treatment for preventing breast cancer. J. Natl Cancer Inst. 91, 1829-1846 (1999).
    • (1999) J. Natl Cancer Inst , vol.91 , pp. 1829-1846
    • Gail, M.H.1
  • 40
    • 34447293807 scopus 로고    scopus 로고
    • The genomics gold rush
    • Topol, E. J., Murray, S. S. & Frazer, K. A. The genomics gold rush. JAMA 298, 218-221 (2007).
    • (2007) JAMA , vol.298 , pp. 218-221
    • Topol, E.J.1    Murray, S.S.2    Frazer, K.A.3
  • 42
    • 0022353142 scopus 로고
    • Estimating the population attributable risk for multiple risk factors using case-control data
    • Bruzzi, P., Green, S. B., Byar, D. P., Brinton, L. A. & Schairer, C. Estimating the population attributable risk for multiple risk factors using case-control data. Am. J. Epidemiol. 122, 904-914 (1985).
    • (1985) Am. J. Epidemiol , vol.122 , pp. 904-914
    • Bruzzi, P.1    Green, S.B.2    Byar, D.P.3    Brinton, L.A.4    Schairer, C.5
  • 43
    • 0015154543 scopus 로고
    • Attributable risk percent in case-control studies
    • Cole, P. & MacMahon, B. Attributable risk percent in case-control studies. Br. J. Prev. Soc. Med. 25, 242-244 (1971).
    • (1971) Br. J. Prev. Soc. Med , vol.25 , pp. 242-244
    • Cole, P.1    MacMahon, B.2
  • 44
    • 34247548755 scopus 로고    scopus 로고
    • Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
    • Yeager, M. et al. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nature Genet. 39, 645-649 (2007).
    • (2007) Nature Genet , vol.39 , pp. 645-649
    • Yeager, M.1
  • 45
    • 33745312587 scopus 로고    scopus 로고
    • Adiponectin genetic variability, plasma adiponectin, and cardiovascular risk in patients with type 2 diabetes
    • Qi, L. et al. Adiponectin genetic variability, plasma adiponectin, and cardiovascular risk in patients with type 2 diabetes. Diabetes 55, 1512-1516 (2006).
    • (2006) Diabetes , vol.55 , pp. 1512-1516
    • Qi, L.1
  • 46
    • 34548032087 scopus 로고    scopus 로고
    • Genome-wide association studies provide new insights into type 2 diabetes aetiology
    • Frayling, T. M. Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nature Rev. Genet. 8, 657-662 (2007).
    • (2007) Nature Rev. Genet , vol.8 , pp. 657-662
    • Frayling, T.M.1
  • 47
    • 34249895023 scopus 로고    scopus 로고
    • Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    • Zeggini, E. et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316, 1336-1341 (2007).
    • (2007) Science , vol.316 , pp. 1336-1341
    • Zeggini, E.1
  • 48
    • 41149116631 scopus 로고    scopus 로고
    • Using the optimal receiver operating characteristic curve to design a predictive genetic test, exemplified with type 2 diabetes
    • Lu, Q. & Elston, R. C. Using the optimal receiver operating characteristic curve to design a predictive genetic test, exemplified with type 2 diabetes. Am. J. Hum. Genet. 82, 641-651 (2008).
    • (2008) Am. J. Hum. Genet , vol.82 , pp. 641-651
    • Lu, Q.1    Elston, R.C.2
  • 49
    • 33747881836 scopus 로고    scopus 로고
    • Predictive testing for complex diseases using multiple genes: Fact or fiction?
    • Janssens, A. C. et al. Predictive testing for complex diseases using multiple genes: fact or fiction? Genet. Med. 8, 395-400 (2006).
    • (2006) Genet. Med , vol.8 , pp. 395-400
    • Janssens, A.C.1
  • 50
    • 38849091997 scopus 로고    scopus 로고
    • Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond
    • discussion 207-212
    • Pencina, M. J., D'Agostino, R. B. Sr, D'Agostino, R. B. Jr & Vasan, R. S. Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat. Med. 27, 157-172; discussion 207-212 (2008).
    • (2008) Stat. Med , vol.27 , pp. 157-172
    • Pencina, M.J.1    D'Agostino Sr, R.B.2    D'Agostino Jr, R.B.3    Vasan, R.S.4
  • 51
    • 33847109797 scopus 로고    scopus 로고
    • Use and misuse of the receiver operating characteristic curve in risk prediction
    • Cook, N. R. Use and misuse of the receiver operating characteristic curve in risk prediction. Circulation 115, 928-935 (2007).
    • (2007) Circulation , vol.115 , pp. 928-935
    • Cook, N.R.1


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