Linkage disequilibrium and the mapping of complex human traits

Trends in Genetics

Volumn 18, Issue 1, 2002, Pages 19-24

  Weiss, Kenneth M ^a   Clark, Andrew G ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; DNA POLYMORPHISM; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENETIC ANALYSIS; GENETIC PREDISPOSITION; GENOME; HAPLOTYPE; HUMAN; MEDICAL RESEARCH; MOLECULAR EVOLUTION; MULTIFACTORIAL INHERITANCE; POPULATION GENETICS; PRIORITY JOURNAL; RELIABILITY; REVIEW; SAMPLING;

CHROMOSOME MAPPING; GENETICS, POPULATION; GENOME, HUMAN; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM;

EID: 0036137130     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(01)02550-1     Document Type: Review

References (34)

1. Genetic epidemiology of single-nucleotide polymorphisms
2. Allelic association between marker loci
3. Single nucleotide polymorphism and linkage disequilibrium within the TCR alpha/delta locus
4. Linkage disequilibrium between microsatellite markers extends beyond 1 cM on chromosome 20 in Finns
5. Linkage disequilibrium in the human genome
6. The genome-wide distribution of background linkage disequilibrium in a population isolate
7. The power to detect linkage disequilibrium with quantitative traits in selected samples
8. The extent of linkage disequilibrium in four populations with distinct demographic histories
9. Haplotype variation and linkage disequilibrium in 313 human genes
10. Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase
11. Apolipoprotein E variation at the sequence haplotype level: Implications for the origin and maintenance of a major human polymorphism
12. Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion
13. Genetic homogeneity of Icelanders: Fact or fiction?
14. The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes
15. Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28
16. Linkage disequilibrium in humans: Models and data
17. Why is there so little intragenic linkage disequilibrium in humans?
18. Gene conversion and different population histories may explain the contrast between polymorphism and linkage disequilibrium levels
19. Recombinational and mutational hotspots within the human lipoprotein lipase gene
20. High resolution analysis of haplotype diversity and meiotic crossover in the human TAP2 recombination hotspot
21. Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex
22. Analysis of mutational changes at the HLA locus in single human sperm
23. Sequence variation and linkage disequilibrium in the human T-cell receptor beta (TCRB) locus
24. A DNA polymorphism discovery resource for research on human genetic variation
25. Gametic disequilibrium measures: Proceed with caution
26. A comparison of linkage disequilibrium measures for fine-scale mapping
27. Functional organisation of genetic material as a product of molecular evolution
28. Inference of population structure using multilocus genotype data
29. Estimation of population parameters and recombination rates from single nucleotide polymorphisms
30. High-resolution haplotype structure in the human genome
31. Haplotype tagging for the identification of common disease genes
32. Archaic African and Asian lineages in the genetic ancestry of modern humans
33. Spatial and temporal distribution of the neutral polymorphisms in the last ZFX intron: Analysis of the haplotype structure and genealogy