Chronic sleep fragmentation during the sleep period induces hypothalamic endoplasmic reticulum stress and PTP1b-mediated leptin resistance in male mice

Sleep

Volumn 38, Issue 1, 2015, Pages 31-40

  Hakim, Fahed ^a   Wang, Yang ^a   Carreras, Alba ^a   Hirotsu, Camila ^a   Zhang, Jing ^a   Peris, Eduard ^a   Gozal, David ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Endoplasmic reticulum stress; Leptin resistance; Sleep fragmentation

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; GLUCOSE REGULATED PROTEIN 78; HEAT SHOCK PROTEIN 70; INITIATION FACTOR 2; INITIATION FACTOR 2ALPHA; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; PROTEIN TYROSINE PHOSPHATASE 1B; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TAUROURSODEOXYCHOLIC ACID; DDIT3 PROTEIN, MOUSE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; STAT3 PROTEIN, MOUSE; TAUROCHENODEOXYCHOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; FEEDING BEHAVIOR; FOOD INTAKE; HYPOTHALAMUS; IMMUNOPRECIPITATION; MALE; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RNA SPLICING; SIGNAL TRANSDUCTION; SLEEP DISORDER; SLEEP FRAGMENTATION; SLEEP TIME; SLEEP WAKING CYCLE; UNFOLDED PROTEIN RESPONSE; WEIGHT GAIN; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; COMPLICATION; DEFICIENCY; DRUG EFFECTS; EATING; GENETICS; HETEROZYGOTE; HYPERPHAGIA; METABOLISM; OBESITY; PATHOLOGY; PATHOPHYSIOLOGY; SLEEP; SLEEP DEPRIVATION; TRANSGENIC MOUSE;

ANIMALS; EATING; ENDOPLASMIC RETICULUM STRESS; HETEROZYGOTE; HYPERPHAGIA; HYPOTHALAMUS; LEPTIN; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OBESITY; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RECEPTORS, LEPTIN; SIGNAL TRANSDUCTION; SLEEP; SLEEP DEPRIVATION; STAT3 TRANSCRIPTION FACTOR; TAUROCHENODEOXYCHOLIC ACID; TRANSCRIPTION FACTOR CHOP; UNFOLDED PROTEIN RESPONSE;

EID: 84920385377     PISSN: 01618105     EISSN: 15509109     Source Type: Journal    
DOI: 10.5665/sleep.4320     Document Type: Article

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